{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T10:20:23Z","timestamp":1779877223905,"version":"3.53.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1007\/s00784-021-03919-3","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T01:02:53Z","timestamp":1617238973000},"page":"6201-6209","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of non-steroidal anti-inflammatory drugs on pulpal and periapical inflammation induced by lipopolysaccharide"],"prefix":"10.1007","volume":"25","author":[{"given":"Fernanda Regina","family":"Ribeiro-Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya Fernanda Manfrin","family":"Arnez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio Santos","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Assed Bezerra","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia Pac\u00edfico Lucisano","family":"Politi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra Mussolino","family":"de Queiroz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Nelson-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a Assed Bezerra","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00facia Helena","family":"Faccioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8559-532X","authenticated-orcid":false,"given":"Francisco Wanderley Garcia","family":"Paula-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,1]]},"reference":[{"issue":"3","key":"3919_CR1","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1159\/000092235","volume":"40","author":"YL Lee","year":"2006","unstructured":"Lee YL, Liu J, Clarkson BH, Lin CP, Godovikova V, Ritchie HH (2006) Dentin-pulp complex responses to carious lesions. Caries Res 40(3):256\u2013264","journal-title":"Caries Res"},{"issue":"4","key":"3919_CR2","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1177\/0022034509334070","volume":"88","author":"FW Paula-Silva","year":"2009","unstructured":"Paula-Silva FW, Ghosh A, Silva LA, Kapila YL (2009) TNF-alpha promotes an odontoblastic phenotype in dental pulp cells. J Dent Res 88(4):339\u2013344","journal-title":"J Dent Res"},{"issue":"4","key":"3919_CR3","first-page":"e1","volume":"2","author":"I Graunaite","year":"2012","unstructured":"Graunaite I, Lodiene G, Maciulskiene V (2012) Pathogenesis of apical periodontitis: a literature review. J Oral Maxillofac Res 2(4):e1","journal-title":"J Oral Maxillofac Res"},{"issue":"27","key":"3919_CR4","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.2174\/1381612033454054","volume":"9","author":"J Cl\u00e0ria","year":"2003","unstructured":"Cl\u00e0ria J (2003) Cyclooxygenase-2 biology. Curr Pharm Des 9(27):2177\u20132190","journal-title":"Curr Pharm Des"},{"issue":"7","key":"3919_CR5","doi-asserted-by":"publisher","first-page":"861","DOI":"10.14219\/jada.archive.2003.0284","volume":"134","author":"F Zhang","year":"2003","unstructured":"Zhang F, Engebretson SP, Morton RS, Cavanaugh PF Jr, Subbaramaiah K, Dannenberg AJ (2003) The overexpression of cyclo-oxygenase-2 in chronic periodontitis. J Am Dent Assoc 134(7):861\u2013867","journal-title":"J Am Dent Assoc"},{"issue":"2","key":"3919_CR6","first-page":"77","volume":"60","author":"J Kov\u00e1c","year":"2011","unstructured":"Kov\u00e1c J, Kov\u00e1c D (2011) Histopathology and etiopathogenesis of chronic apical periodontitis--periapical granuloma. Epidemiol Mikrobiol Imunol 60(2):77\u201386","journal-title":"Epidemiol Mikrobiol Imunol"},{"issue":"6","key":"3919_CR7","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.joen.2012.02.021","volume":"38","author":"FC Martinho","year":"2012","unstructured":"Martinho FC, Chiesa WM, Leite FR, Cirelli JA, Gomes BP (2012) Correlation between clinical\/radiographic features and inflammatory cytokine networks produced by macrophages stimulated with endodontic content. J Endod 38(6):740\u2013745","journal-title":"J Endod"},{"issue":"11","key":"3919_CR8","doi-asserted-by":"publisher","first-page":"e50244","DOI":"10.1371\/journal.pone.0050244","volume":"7","author":"L Xiao","year":"2012","unstructured":"Xiao L, Ornatowska M, Zhao G et al (2012) Lipopolysaccharide-induced expression of microsomal prostaglandin E synthase-1 mediates late-phase PGE2 production in bone marrow derived macrophages. PLoS One 7(11):e50244","journal-title":"PLoS One"},{"issue":"4","key":"3919_CR9","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1097\/00004770-200304000-00010","volume":"29","author":"J Isett","year":"2003","unstructured":"Isett J, Reader A, Gallatin E, Beck M, Padgett D (2003) Effect of an intraosseous injection of depo-medrol on pulpal concentrations of PGE2 and IL-8 in untreated irreversible pulpitis. J Endod 29(4):268\u2013271","journal-title":"J Endod"},{"issue":"6","key":"3919_CR10","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1111\/iej.12030","volume":"46","author":"M Elsalhy","year":"2013","unstructured":"Elsalhy M, Azizieh F, Raghupathy R (2013) Cytokines as diagnostic markers of pulpal inflammation. Int Endod J 46(6):573\u2013580","journal-title":"Int Endod J"},{"issue":"3","key":"3919_CR11","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1034\/j.1399-302x.2000.150301.x","volume":"15","author":"IJ M\u00e1rton","year":"2000","unstructured":"M\u00e1rton IJ, Kiss C (2000) Protective and destructive immune reactions in apical periodontitis. Oral Microbiol Immunol 15(3):139\u2013150","journal-title":"Oral Microbiol Immunol"},{"issue":"5","key":"3919_CR12","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.joen.2012.12.017","volume":"39","author":"A Virtej","year":"2013","unstructured":"Virtej A, L\u00f8es SS, Berggreen E, Bletsa A (2013) Localization and signaling patterns of vascular endothelial growth factors and receptors in human periapical lesions. J Endod 39(5):605\u2013611","journal-title":"J Endod"},{"issue":"2","key":"3919_CR13","doi-asserted-by":"publisher","first-page":"164","DOI":"10.4103\/0972-0707.128061","volume":"17","author":"PA Saraf","year":"2014","unstructured":"Saraf PA, Kamat S, Puranik RS, Puranik S, Saraf SP, Singh BP (2014) Comparative evaluation of immunohistochemistry, histopathology and conventional radiography in differentiating periapical lesions. J Conserv Dent 17(2):164\u2013168","journal-title":"J Conserv Dent"},{"issue":"2","key":"3919_CR14","doi-asserted-by":"publisher","first-page":"559","DOI":"10.3892\/mmr.2016.6041","volume":"15","author":"N Ma","year":"2017","unstructured":"Ma N, Yang D, Okamura H, Teramachi J, Hasegawa T, Qiu L, Haneji T (2017) Involvement of interleukin 23 induced by Porphyromonas endodontalis lipopolysaccharide in osteoclastogenesis. Mol Med Rep 15(2):559\u2013566","journal-title":"Mol Med Rep"},{"key":"3919_CR15","doi-asserted-by":"publisher","first-page":"e20190699","DOI":"10.1590\/1678-7757-2019-0699","volume":"28","author":"FWG Paula-Silva","year":"2020","unstructured":"Paula-Silva FWG, Ribeiro-Santos FR, Petean IBF et al (2020) Root canal contamination or exposure to lipopolysaccharide differentially modulate prostaglandin E 2 and leukotriene B 4 signaling in apical periodontitis. J Appl Oral Sci 28:e20190699","journal-title":"J Appl Oral Sci"},{"issue":"6","key":"3919_CR16","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1902\/jop.2000.71.6.1009","volume":"71","author":"MM Bezerra","year":"2000","unstructured":"Bezerra MM, de Lima V, Alencar VB et al (2000) Selective cyclooxygenase-2 inhibition prevents alveolar bone loss in experimental periodontitis in rats. J Periodontol 71(6):1009\u20131014","journal-title":"J Periodontol"},{"issue":"3","key":"3919_CR17","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1034\/j.1600-0447.2002.11227.x","volume":"110","author":"SK Lin","year":"2002","unstructured":"Lin SK, Kok SH, Kuo MY et al (2002) Sequential expressions of MMP-1, TIMP-1, IL-6, and COX-2 genes in induced periapical lesions in rats. Eur J Oral Sci 110(3):246\u2013253","journal-title":"Eur J Oral Sci"},{"issue":"12","key":"3919_CR18","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1902\/jop.2004.75.12.1613","volume":"75","author":"BC Gurgel","year":"2004","unstructured":"Gurgel BC, Duarte PM, Nociti FH Jr et al (2004) Impact of an anti-inflammatory therapy and its withdrawal on the progression of experimental periodontitis in rats. J Periodontol 75(12):1613\u20131618","journal-title":"J Periodontol"},{"issue":"3","key":"3919_CR19","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.joen.2009.12.030","volume":"36","author":"M Oleson","year":"2010","unstructured":"Oleson M, Drum M, Reader A, Nusstein J, Beck M (2010) Effect of preoperative ibuprofen on the success of the inferior alveolar nerve block in patients with irreversible pulpitis. J Endod 36(3):379\u2013382","journal-title":"J Endod"},{"issue":"2","key":"3919_CR20","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.joen.2012.10.011","volume":"39","author":"S Shahi","year":"2013","unstructured":"Shahi S, Mokhtari H, Rahimi S, Yavari HR, Narimani S, Abdolrahimi M, Nezafati S (2013) Effect of premedication with ibuprofen and dexamethasone on success rate of inferior alveolar nerve block for teeth with asymptomatic irreversible pulpitis: a randomized clinical trial. J Endod 39(2):160\u2013162","journal-title":"J Endod"},{"issue":"9","key":"3919_CR21","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1016\/j.joen.2020.06.009","volume":"46","author":"V Nguyen","year":"2020","unstructured":"Nguyen V, Chen YW, Johnson JD, Paranjpe A (2020) In vivo evaluation of effect of preoperative ibuprofen on proinflammatory mediators in irreversible pulpitis cases. J Endod 46(9):1210\u20131216","journal-title":"J Endod"},{"key":"3919_CR22","doi-asserted-by":"publisher","unstructured":"Li JY, Wang SN, Dong YM (2021) The effect of topical application of meloxicam on inflamed dental pulp. J Dent Sci. https:\/\/doi.org\/10.1016\/j.jds.2020.11.010","DOI":"10.1016\/j.jds.2020.11.010"},{"key":"3919_CR23","doi-asserted-by":"publisher","unstructured":"Petean IBF, Almeida-J\u00fanior LA, Arnez MF, Queiroz AM, Silva RAB, Silva LAB, Faccioli LH, Paula-Silva FWG (2021) Celecoxib treatment dampens LPS-induced periapical bone reabsorption in a mouse model. Int Endod J. https:\/\/doi.org\/10.1111\/iej.13472","DOI":"10.1111\/iej.13472"},{"key":"3919_CR24","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1111\/j.1754-4505.2001.tb00256.x","volume":"21","author":"EP Stoller","year":"2001","unstructured":"Stoller EP, Gilbert GH, Pyle MA, Duncan RP (2001) Coping with tooth pain: a qualitative study of lay management strategies and professional consultation. Spec Care Dentist 21:208\u2013215","journal-title":"Spec Care Dentist"},{"key":"3919_CR25","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S1079-2104(02)91732-4","volume":"96","author":"JM Nusstein","year":"2003","unstructured":"Nusstein JM, Beck M (2003) Comparison of preoperative pain and medication use in emergency patients presenting with irreversible pulpitis or teeth with necrotic pulps. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:207\u2013214","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"12","key":"3919_CR26","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1016\/j.joen.2006.07.015","volume":"32","author":"AK Mickel","year":"2006","unstructured":"Mickel AK, Wright AP, Chogle S, Jones JJ, Kantorovich I, Curd F (2006) An analysis of current analgesic preferences for endodontic pain management. J Endod 32(12):1146\u20131154","journal-title":"J Endod"},{"issue":"10","key":"3919_CR27","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1016\/j.adaj.2016.05.010","volume":"147","author":"A Aminoshariae","year":"2016","unstructured":"Aminoshariae A, Kulild JC, Donaldson M, Hersh EV (2016) Evidence-based recommendations for analgesic efficacy to treat pain of endodontic origin: A systematic review of randomized controlled trials. J Am Dent Assoc 147(10):826\u2013839","journal-title":"J Am Dent Assoc"},{"key":"3919_CR28","doi-asserted-by":"publisher","first-page":"e20180641","DOI":"10.1590\/1678-7757-2018-0641","volume":"27","author":"FR Ribeiro-Santos","year":"2019","unstructured":"Ribeiro-Santos FR, Silva GGD, Petean IBF et al (2019) Periapical bone response to bacterial lipopolysaccharide is shifted upon cyclooxygenase blockage. J Appl Oral Sci 27:e20180641","journal-title":"J Appl Oral Sci"},{"issue":"3","key":"3919_CR29","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.joen.2015.12.003","volume":"42","author":"FW Paula-Silva","year":"2016","unstructured":"Paula-Silva FW, Petean IB, da Silva LA, Faccioli LH (2016) Dual role of 5-lipoxygenase in osteoclastogenesis in bacterial-induced apical periodontitis. J Endod 42(3):447\u2013454","journal-title":"J Endod"},{"key":"3919_CR30","doi-asserted-by":"publisher","first-page":"104670","DOI":"10.1016\/j.archoralbio.2020.104670","volume":"112","author":"FWG Paula-Silva","year":"2020","unstructured":"Paula-Silva FWG, Arnez MFM, Petean IBF et al (2020) Effects of 5-lipoxygenase gene disruption on inflammation, osteoclastogenesis and bone resorption in polymicrobial apical periodontitis. Arch Oral Biol 112:104670","journal-title":"Arch Oral Biol"},{"issue":"5","key":"3919_CR31","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.joen.2010.12.005","volume":"37","author":"FC Martinho","year":"2011","unstructured":"Martinho FC, Chiesa WM, Leite FR, Cirelli JA, Gomes BP (2011) Antigenicity of primary endodontic infection against macrophages by the levels of PGE(2) production. J Endod 37(5):602\u2013607","journal-title":"J Endod"},{"issue":"3","key":"3919_CR32","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0099-2399(06)81737-1","volume":"17","author":"S McNicholas","year":"1991","unstructured":"McNicholas S, Torabinejad M, Blankenship J, Bakland L (1991) The concentration of prostaglandin E2 in human periradicular lesions. J Endod 17(3):97\u2013100","journal-title":"J Endod"},{"issue":"11","key":"3919_CR33","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1097\/01.don.0000158010.43884.59","volume":"31","author":"NO Alptekin","year":"2005","unstructured":"Alptekin NO, Ari H, Haliloglu S, Alptekin T, Serpek B, Ataoglu T (2005) The effect of endodontic therapy on periapical exudate neutrophil elastase and prostaglandin-E2 levels. J Endod 31(11):791\u2013795","journal-title":"J Endod"},{"issue":"12","key":"3919_CR34","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1016\/j.joen.2018.09.002","volume":"44","author":"PR \u00c1lvares","year":"2018","unstructured":"\u00c1lvares PR, de Arruda JAA, Oliveira Silva LV et al (2018) Immunohistochemical analysis of cyclooxygenase-2 and tumor necrosis factor alpha in periapical lesions. J Endod 44(12):1783\u20131787","journal-title":"J Endod"},{"issue":"3","key":"3919_CR35","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0099-2399(89)80131-1","volume":"15","author":"BR Oguntebi","year":"1989","unstructured":"Oguntebi BR, Barker BF, Anderson DM, Sakumura J (1989) The effect of indomethacin on experimental dental periapical lesions in rats. J Endod 15(3):117\u2013121","journal-title":"J Endod"},{"key":"3919_CR36","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S0099-2399(96)80266-4","volume":"22","author":"N Kawashima","year":"1996","unstructured":"Kawashima N, Okiji T, Kosaka T, Suda H (1996) Kinects of macrophages and lymphoid cells during the development of experimentally induced periapical lesions in rat molars: a quantitative immunohistochemical study. J Endod 22:311\u2013316","journal-title":"J Endod"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-03919-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-021-03919-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-03919-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T11:10:27Z","timestamp":1634814627000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-021-03919-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,1]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["3919"],"URL":"https:\/\/doi.org\/10.1007\/s00784-021-03919-3","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,1]]},"assertion":[{"value":"7 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed. The study was approved by the Institutional Animal Research Ethics Committee (process #13.1.266.53.6).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study, formal consent is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}