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Clinical attachment level (CAL; primary outcome), probing pocket depth (PPD), gingival recession depth (RD), full-mouth bleeding scores (FMBS), full-mouth plaque scores (FMPS), radiographic linear defect depth (RLDD) and radiographic defect bone density (RDBD) (secondary-outcomes) were examined at baseline, 3 and 6 months post-surgically.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>OFD+AA\/PRF and OFD+PRF demonstrated significant intragroup CAL gain and PPD reduction at 3 and 6 months (<jats:italic>p<\/jats:italic> &lt; 0.001). OFD+AA\/PRF and OFD+PRF showed no differences regarding FMBS or FMPS (<jats:italic>p<\/jats:italic> &gt; 0.05). OFD+AA\/PRF demonstrated significant RD reduction of 0.90 \u00b1 0.50 mm and 0.80 \u00b1 0.71 mm at 3 and 6 months, while OFD+PRF showed RD reduction of 0.10 \u00b1 0.77 mm at 3 months, with an RD-increase of 0.20 \u00b1 0.82 mm at 6 months (<jats:italic>p<\/jats:italic> &lt; 0.05). OFD+AA\/PRF and OFD+PRF demonstrated significant RLDD reduction (2.29 \u00b1 0.61 mm and 1.63 \u00b1 0.46 mm; <jats:italic>p<\/jats:italic> &lt; 0.05) and RDBD-increase (14.61 \u00b1 5.39% and 12.58 \u00b1 5.03%; <jats:italic><jats:underline>p<\/jats:underline><\/jats:italic> &gt; 0.05). Stepwise linear regression analysis showed that baseline RLDD and FMBS at 6 months were significant predictors of CAL reduction (<jats:italic>p<\/jats:italic> &lt; 0.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>OFD+PRF with\/without AA significantly improved periodontal parameters 6 months post-surgically. Augmenting PRF with AA additionally enhanced gingival tissue gain and radiographic defect fill.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>PRF, with or without AA, could significantly improve periodontal parameters. Supplementing PRF with AA could additionally augment radiographic linear defect fill and reduce gingival recession depth.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-021-03929-1","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T03:13:31Z","timestamp":1618197211000},"page":"6309-6319","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Clinical and radiographic effects of ascorbic acid-augmented platelet-rich fibrin versus platelet-rich fibrin alone in intra-osseous defects of stage-III periodontitis patients: a randomized controlled clinical trial"],"prefix":"10.1007","volume":"25","author":[{"given":"Mohamed Talaat","family":"Elbehwashy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal Mohamed","family":"Hosny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Elfana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Nawar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6261-3609","authenticated-orcid":false,"given":"Karim","family":"Fawzy El-Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,12]]},"reference":[{"issue":"Suppl 1","key":"3929_CR1","doi-asserted-by":"publisher","first-page":"S173","DOI":"10.1002\/JPER.17-0721","volume":"89","author":"PN Papapanou","year":"2018","unstructured":"Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, Flemmig TF, Garcia R, Giannobile WV, Graziani F, Greenwell H, Herrera D, Kao RT, Kebschull M, Kinane DF, Kirkwood KL, Kocher T, Kornman KS, Kumar PS, Loos BG, Machtei E, Meng H, Mombelli A, Needleman I, Offenbacher S, Seymour GJ, Teles R, Tonetti MS (2018) Periodontitis: Consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions. 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