{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:08:47Z","timestamp":1790741327604,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW109-TDU-B-212-114004"],"award-info":[{"award-number":["MOHW109-TDU-B-212-114004"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 108-2321-B-039-003"],"award-info":[{"award-number":["MOST 108-2321-B-039-003"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007404","name":"Clinical Trial Center, China Medical University Hospital","doi-asserted-by":"publisher","award":["DMR-109-126"],"award-info":[{"award-number":["DMR-109-126"]}],"id":[{"id":"10.13039\/100007404","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPG3I0152"],"award-info":[{"award-number":["CMRPG3I0152"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005866","name":"Far Eastern Memorial Hospital","doi-asserted-by":"publisher","award":["FEMH-2020-C-030"],"award-info":[{"award-number":["FEMH-2020-C-030"]}],"id":[{"id":"10.13039\/501100005866","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tseng-Lien Lin Foundation,\u00a0Taichung, Taiwan."}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1007\/s00784-021-03938-0","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T02:43:43Z","timestamp":1618454623000},"page":"6377-6384","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Bidirectional relationship between temporomandibular disorder and ankylosing spondylitis: a population-based cohort study"],"prefix":"10.1007","volume":"25","author":[{"given":"Yi-Fang","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9211-1407","authenticated-orcid":false,"given":"Chung-Ta","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hsin","family":"Muo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan-Ming","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hao","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"3938_CR1","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1016\/j.mcna.2014.08.009","volume":"98","author":"SS De Rossi","year":"2014","unstructured":"De Rossi SS, Greenberg MS, Liu F, Steinkeler A (2014) Temporomandibular disorders: Evaluation and management. Med Clin North Am 98:1353\u20131384. https:\/\/doi.org\/10.1016\/j.mcna.2014.08.009","journal-title":"Med Clin North Am"},{"key":"3938_CR2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/S0901-5027(97)80838-7","volume":"26","author":"GW Gynther","year":"1997","unstructured":"Gynther GW, Holmlund AB, Reinholt FP, Lindblad S (1997) Temporomandibular joint involvement in generalized osteoarthritis and rheumatoid arthritis: A clinical, arthroscopic, histologic, and immunohistochemical study. Int J Oral Maxillofac Surg 26:10\u201316","journal-title":"Int J Oral Maxillofac Surg"},{"key":"3938_CR3","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1016\/s0140-6736(07)60635-7","volume":"369","author":"J Braun","year":"2007","unstructured":"Braun J, Sieper J (2007) Ankylosing spondylitis. Lancet (London, England) 369:1379\u20131390. https:\/\/doi.org\/10.1016\/s0140-6736(07)60635-7","journal-title":"Lancet (London, England)"},{"key":"3938_CR4","volume-title":"Diagnosis of bone and joint disorders","author":"D Resnick","year":"1995","unstructured":"Resnick D, Niwayama G (1995) Ankylosing spondylitis. In: Resnick D (ed) Diagnosis of bone and joint disorders. WB Saunders, Philadelphia"},{"key":"3938_CR5","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.cyto.2015.11.005","volume":"77","author":"SV Kellesarian","year":"2016","unstructured":"Kellesarian SV, Al-Kheraif AA, Vohra F, Ghanem A, Malmstrom H, Romanos GE, Javed F (2016) Cytokine profile in the synovial fluid of patients with temporomandibular joint disorders: A systematic review. Cytokine 77:98\u2013106. https:\/\/doi.org\/10.1016\/j.cyto.2015.11.005","journal-title":"Cytokine"},{"key":"3938_CR6","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1056\/NEJMra1406182","volume":"374","author":"JD Taurog","year":"2016","unstructured":"Taurog JD, Chhabra A, Colbert RA (2016) Ankylosing spondylitis and axial spondyloarthritis. N Engl J Med 374:2563\u20132574. https:\/\/doi.org\/10.1056\/NEJMra1406182","journal-title":"N Engl J Med"},{"key":"3938_CR7","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1136\/ard.34.1.87","volume":"34","author":"C Davidson","year":"1975","unstructured":"Davidson C, Wojtulewski JA, Bacon PA, Winstock D (1975) Temporo-mandibular joint disease in ankylosing spondylitis. Ann Rheum Dis 34:87\u201391","journal-title":"Ann Rheum Dis"},{"key":"3938_CR8","first-page":"35","volume":"4","author":"B Wenneberg","year":"1990","unstructured":"Wenneberg B, Kononen M, Kallenberg A (1990) Radiographic changes in the temporomandibular joint of patients with rheumatoid arthritis, psoriatic, arthritis, and ankylosing spondylitis. J Craniomandib Disord Facial Oral Pain 4:35\u201339","journal-title":"J Craniomandib Disord Facial Oral Pain"},{"key":"3938_CR9","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1136\/ard.56.2.103","volume":"56","author":"C Ramos-Remus","year":"1997","unstructured":"Ramos-Remus C, Major P, Gomez-Vargas A, Petrikowski G, Hernandez-Chavez A, Gonzalez-Marin E, Russell AS (1997) Temporomandibular joint osseous morphology in a consecutive sample of ankylosing spondylitis patients. Ann Rheum Dis 56:103\u2013107. https:\/\/doi.org\/10.1136\/ard.56.2.103","journal-title":"Ann Rheum Dis"},{"key":"3938_CR10","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.ijom.2006.08.001","volume":"35","author":"LM Helenius","year":"2006","unstructured":"Helenius LM, Tervahartiala P, Helenius I, Al-Sukhun J, Kivisaari L, Suuronen R, Kautiainen H, Hallikainen D, Lindqvist C, Leirisalo-Repo M (2006) Clinical, radiographic and MRI findings of the temporomandibular joint in patients with different rheumatic diseases. Int J Oral Maxillofac Surg 35:983\u2013989. https:\/\/doi.org\/10.1016\/j.ijom.2006.08.001","journal-title":"Int J Oral Maxillofac Surg"},{"key":"3938_CR11","doi-asserted-by":"publisher","first-page":"126","DOI":"10.4081\/reumatismo.2013.126","volume":"65","author":"FJ Aceves-Avila","year":"2013","unstructured":"Aceves-Avila FJ, Chavez-Lopez M, Chavira-Gonzalez JR, Ramos-Remus C (2013) Temporomandibular joint dysfunction in various rheumatic diseases. Reumatismo 65:126\u2013130. https:\/\/doi.org\/10.4081\/reumatismo.2013.126","journal-title":"Reumatismo"},{"key":"3938_CR12","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s00296-020-04563-y","volume":"40","author":"E Bilgin","year":"2020","unstructured":"Bilgin E, Bilgin E, \u00d6zdemir O, Kalyoncu U (2020) Temporomandibular disorders in ankylosing spondylitis: A cross-sectional, monocentric study. Rheumatol Int 40:933\u2013940. https:\/\/doi.org\/10.1007\/s00296-020-04563-y","journal-title":"Rheumatol Int"},{"key":"3938_CR13","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1002\/acr.22180","volume":"66","author":"L van Hoeven","year":"2014","unstructured":"van Hoeven L, Luime J, Han H, Vergouwe Y, Weel A (2014) Identifying axial spondyloarthritis in Dutch primary care patients, ages 20-45 years, with chronic low back pain. Arthritis Care Res 66:446\u2013453. https:\/\/doi.org\/10.1002\/acr.22180","journal-title":"Arthritis Care Res"},{"key":"3938_CR14","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s00784-019-02866-4","volume":"24","author":"YF Huang","year":"2020","unstructured":"Huang YF, Liu SP, Muo CH, Tsai CH, Chang CT (2020) The association between dental therapy timelines and osteoradionecrosis: A nationwide population-based cohort study. Clin Oral Investig 24:455\u2013463. https:\/\/doi.org\/10.1007\/s00784-019-02866-4","journal-title":"Clin Oral Investig"},{"key":"3938_CR15","doi-asserted-by":"publisher","unstructured":"Yildizer Keris E, Yaman SD, Demirag MD, Haznedaroglu S (2017) Temporomandibular joint findings in patients with rheumatoid arthritis, ankylosing spondylitis, and primary Sjogren\u2019s syndrome. J Investig Clin Dent 8. https:\/\/doi.org\/10.1111\/jicd.12255","DOI":"10.1111\/jicd.12255"},{"key":"3938_CR16","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s00296-002-0237-4","volume":"23","author":"E Feldtkeller","year":"2003","unstructured":"Feldtkeller E, Khan MA, van der Heijde D, van der Linden S, Braun J (2003) Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with ankylosing spondylitis. Rheumatol Int 23:61\u201366. https:\/\/doi.org\/10.1007\/s00296-002-0237-4","journal-title":"Rheumatol Int"},{"key":"3938_CR17","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1007\/s10067-008-0877-1","volume":"27","author":"H Bodur","year":"2008","unstructured":"Bodur H, Ataman S, Akbulut L, Evcik D, Kavuncu V, Kaya T, Gunaydin R, Kuran B, Kotevoglu N, Bal A, Aydog E, Altay Z, Ugurlu H, Kocabas H, Olmez N, Yazgan P, Gursoy S, Madenci E, Ozel S, Delialioglu SU (2008) Characteristics and medical management of patients with rheumatoid arthritis and ankylosing spondylitis. Clin Rheumatol 27:1119\u20131125. https:\/\/doi.org\/10.1007\/s10067-008-0877-1","journal-title":"Clin Rheumatol"},{"key":"3938_CR18","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1002\/art.41042","volume":"71","author":"MM Ward","year":"2019","unstructured":"Ward MM, Deodhar A, Gensler LS, Dubreuil M, Yu D, Khan MA, Haroon N, Borenstein D, Wang R, Biehl A, Fang MA, Louie G, Majithia V, Ng B, Bigham R, Pianin M, Shah AA, Sullivan N, Turgunbaev M, Oristaglio J, Turner A, Maksymowych WP, Caplan L (2019) 2019 update of the American College of Rheumatology\/Spondylitis Association of America\/Spondyloarthritis Research and Treatment Network recommendations for the treatment of ankylosing spondylitis and nonradiographic axial spondyloarthritis. Arthritis Rheum 71:1599\u20131613. https:\/\/doi.org\/10.1002\/art.41042","journal-title":"Arthritis Rheum"},{"key":"3938_CR19","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/bf00197671","volume":"22","author":"JH Rundback","year":"1993","unstructured":"Rundback JH, Rosenberg ZS, Solomon G (1993) The radiographic features of rheumatoid arthritis in HLA-B27-positive patients. Skelet Radiol 22:263\u2013267. https:\/\/doi.org\/10.1007\/bf00197671","journal-title":"Skelet Radiol"},{"key":"3938_CR20","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1136\/ard.2005.041103","volume":"65","author":"E Jaakkola","year":"2006","unstructured":"Jaakkola E, Herzberg I, Laiho K, Barnardo MCNM, Pointon JJ, Kauppi M, Kaarela K, Tuomilehto-Wolf E, Tuomilehto J, Wordsworth BP, Brown MA (2006) Finnish HLA studies confirm the increased risk conferred by HLA-B27 homozygosity in ankylosing spondylitis. Ann Rheum Dis 65:775\u2013780. https:\/\/doi.org\/10.1136\/ard.2005.041103","journal-title":"Ann Rheum Dis"},{"key":"3938_CR21","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1007\/s11926-010-0122-1","volume":"12","author":"M Magrey","year":"2010","unstructured":"Magrey M, Khan MA (2010) Osteoporosis in ankylosing spondylitis. Curr Rheumatol Rep 12:332\u2013336. https:\/\/doi.org\/10.1007\/s11926-010-0122-1","journal-title":"Curr Rheumatol Rep"},{"key":"3938_CR22","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s00198-020-05593-9","volume":"32","author":"T Li","year":"2020","unstructured":"Li T, Liu WB, Tian FF, Jiang JJ, Wang Q, Hu FQ, Hu WH, Zhang XS (2020) Gender-specific SBNO2 and VPS13B as a potential driver of osteoporosis development in male ankylosing spondylitis. Osteoporos Int 32:311\u2013320. https:\/\/doi.org\/10.1007\/s00198-020-05593-9","journal-title":"Osteoporos Int"},{"key":"3938_CR23","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.tripleo.2005.04.010","volume":"100","author":"E Dervis","year":"2005","unstructured":"Dervis E (2005) Oral implications of osteoporosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:349\u2013356. https:\/\/doi.org\/10.1016\/j.tripleo.2005.04.010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"3938_CR24","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/scd.12441","volume":"40","author":"A Dumbuya","year":"2020","unstructured":"Dumbuya A, Gomes AF, Marchini L, Zeng E, Comnick CL, Melo SLS (2020) Bone changes in the temporomandibular joints of older adults: A cone-beam computed tomography study. Spec Care Dentist 40:84\u201389. https:\/\/doi.org\/10.1111\/scd.12441","journal-title":"Spec Care Dentist"},{"key":"3938_CR25","first-page":"133","volume":"56","author":"RP Manishkina","year":"1984","unstructured":"Manishkina RP, Andrusenko AB, Donskov SI, Kalinin AP, Klinova EG (1984) The HLA system and Itsenko-Cushing disease. Ter Arkh 56:133\u2013135","journal-title":"Ter Arkh"},{"key":"3938_CR26","first-page":"115","volume":"68","author":"IV Davydova","year":"1990","unstructured":"Davydova IV, Andrusenko AB (1990) The role of glucocorticoid receptors and HLA antigens in the pathogenesis of Cushing\u2019s syndrome. Klin Med (Mosk) 68:115\u2013119","journal-title":"Klin Med (Mosk)"},{"key":"3938_CR27","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1016\/j.joms.2019.01.047","volume":"77","author":"YF Huang","year":"2019","unstructured":"Huang YF, Liu SP, Muo CH, Chang CT, Tsai CH, Morisky DE (2019) Sialadenitis may be associated with an increased risk for osteoradionecrosis: A nationwide population-based cohort study. J Oral Maxillofac Surg 77:1392\u20131400. https:\/\/doi.org\/10.1016\/j.joms.2019.01.047","journal-title":"J Oral Maxillofac Surg"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-03938-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-021-03938-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-03938-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T07:13:14Z","timestamp":1634800394000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-021-03938-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,14]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["3938"],"URL":"https:\/\/doi.org\/10.1007\/s00784-021-03938-0","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,14]]},"assertion":[{"value":"10 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the Research Ethics Committee of China Medical University and Hospital, Taiwan, and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study, formal consent is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}