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Afterwards, orthodontic separators were placed, and subjects were randomly assigned to one of the two experimental groups: Group Pain (GP: 18 males; 14 females mean age 25.22 \u00b1 2.28 years) had separators removed after 24 h; Group Strain (GS: 14 males; 17 females, mean age 24.03 \u00b1 3.06 years) had separators removed after 7 days. The OTA measurement was repeated in both groups immediately after orthodontic separators removal (T1). A within-group comparison (T1 vs T0) was performed for each testing thickness (ANOVA for repeated measurements, with Bonferroni correction for multiple testing) (<jats:italic>p<\/jats:italic> &lt; 0.005).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>GP showed statistically significant reduction of the OTA at T1, as compared to T0, for the thicknesses 24 \u03bcm (<jats:italic>p<\/jats:italic> = 0.004) and 32 \u03bcm (<jats:italic>p<\/jats:italic> = 0.001). No significant reduction was observed in GS (all <jats:italic>p<\/jats:italic> &gt; 0.005).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Acute periodontal pain tends to disturb the tactile ability of the teeth, while strain of the PDL in absence of painful sensation determines a return to OTA baseline values.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>The reduction of OTA might explain the uncomfortable occlusal sensation referred by patients during acute periodontal pain.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-021-03971-z","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T22:03:32Z","timestamp":1620252212000},"page":"6833-6840","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of acute pain and strain of the periodontium due to orthodontic separation on the occlusal tactile acuity of healthy individuals"],"prefix":"10.1007","volume":"25","author":[{"given":"Rosaria","family":"Bucci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michail","family":"Koutris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Simeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Lobbezoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambrosina","family":"Michelotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,5]]},"reference":[{"key":"3971_CR1","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1097\/AJP.0000000000000499","volume":"34","author":"W Adamczyk","year":"2018","unstructured":"Adamczyk W, Luedtke K, Saulicz E (2018) Lumbar tactile acuity in patients with low back pain and healthy controls: systematic review and meta-analysis. 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