{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T07:31:12Z","timestamp":1788852672037,"version":"build-2803163510"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T00:00:00Z","timestamp":1622246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T00:00:00Z","timestamp":1622246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s00784-021-03985-7","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T05:04:27Z","timestamp":1622264667000},"page":"159-169","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of the dimensions, morphology, and position of the mandibular condyles in individuals with neurofibromatosis 1: a case-control study"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4795-5248","authenticated-orcid":false,"given":"Larissa","family":"de Oliveira Reis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocharles Cavalcante","family":"Fontenele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina Lopes","family":"Devito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin Soares","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a de Castro","family":"Domingos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,29]]},"reference":[{"key":"3985_CR1","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1007\/BF03262818","volume":"12","author":"E Bardellini","year":"2011","unstructured":"Bardellini E, Amadori F, Flocchini P, Conti G, Piana G, Majorana A (2011) Oral findings in 50 children with neurofibromatosis type 1. A case control study. Eur J Paediatr Dent 12:256\u2013260","journal-title":"Eur J Paediatr Dent"},{"key":"3985_CR2","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1590\/0004-282X20130241","volume":"72","author":"LOC Rodrigues","year":"2014","unstructured":"Rodrigues LOC, Batista PB, Goloni-Bertollo EM, Souza-Costa D, Eliam L, Eliam M, Cunha KSG, Darrigo Junior LG, Ferraz Filho JRL, Geller M, Gianordoli-Nascimento IF, Madeira LG, Malloy-Diniz LF, Mendes HM, Miranda DM, Pavarino EC, Baptista-Pereira L, Rezende NA, Rodrigues LO, Silva CM, Souza JF, Souza MLR, Stangherlin A, Valadares ER, Vidigal PVT (2014) Neurofibromatoses: part 1 - diagnosis and differential diagnosis. Arq Neuropsiquiatr 72:241\u2013250. https:\/\/doi.org\/10.1590\/0004-282X20130241","journal-title":"Arq Neuropsiquiatr"},{"key":"3985_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1010-5182(02)00160-9","volume":"31","author":"RE Friedrich","year":"2003","unstructured":"Friedrich RE, Giese M, Schmelzle R, Mautner VF, Scheuer HA (2003) Jaw malformations plus displacement and numerical aberrations of teeth in neurofibromatosis type 1: a descriptive analysis of 48 patients based on panoramic radiographs and oral findings. J Cranio-Maxillofac Surg 31:1\u20139. https:\/\/doi.org\/10.1016\/S1010-5182(02)00160-9","journal-title":"J Cranio-Maxillofac Surg"},{"key":"3985_CR4","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s13023-015-0239-4","volume":"10","author":"KS Cunha","year":"2015","unstructured":"Cunha KS, Rozza-De-Menezes RE, Luna EB et al (2015) High prevalence of hyposalivation in individuals with neurofibromatosis 1: a case-control study. Orphanet J Rare Dis 10:8\u201311. https:\/\/doi.org\/10.1186\/s13023-015-0239-4","journal-title":"Orphanet J Rare Dis"},{"key":"3985_CR5","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/0030-4220(84)90350-5","volume":"58","author":"SD Shapiro","year":"1984","unstructured":"Shapiro SD, Abramovitch K, Van Dis MK et al (1984) Neurofibromatosis: oral and radiographic manifestations. Oral Surg 58:493\u2013498","journal-title":"Oral Surg"},{"key":"3985_CR6","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1016\/j.joms.2011.06.204","volume":"70","author":"V Visnapuu","year":"2012","unstructured":"Visnapuu V, Peltonen S, Tammisalo T, Peltonen J, Happonen RP (2012) Radiographic findings in the jaws of patients with neurofibromatosis 1. J Oral Maxillofac Surg 70:1351\u20131357. https:\/\/doi.org\/10.1016\/j.joms.2011.06.204","journal-title":"J Oral Maxillofac Surg"},{"key":"3985_CR7","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/j.1600-0722.2011.00811.x","volume":"119","author":"E Heerv\u00e4","year":"2011","unstructured":"Heerv\u00e4 E, Peltonen S, Pirttiniemi P, Happonen RP, Visnapuu V, Peltonen J (2011) Short mandible, maxilla and cranial base are common in patients with neurofibromatosis 1. Eur J Oral Sci 119:121\u2013127. https:\/\/doi.org\/10.1111\/j.1600-0722.2011.00811.x","journal-title":"Eur J Oral Sci"},{"key":"3985_CR8","doi-asserted-by":"publisher","first-page":"e168","DOI":"10.4317\/medoral.22155","volume":"23","author":"EB Luna","year":"2018","unstructured":"Luna EB, Janini MER, Lima F, Pontes RA, Guedes F, Geller M, da Silva L, Motta A, Cunha K (2018) Craniomaxillofacial morphology alterations in children, adolescents and adults with neurofibromatosis 1: a cone beam computed tomography analysis of a Brazilian sample. Med Oral Patol Oral Cir Bucal 23:e168\u2013e179. https:\/\/doi.org\/10.4317\/medoral.22155","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"3985_CR9","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1007\/BF03262818","volume":"12","author":"E Bardellini","year":"2011","unstructured":"Bardellini E, Amadori F, Flocchini P, Conti G, Piana G, Majorana A (2011) Oral findings in 50 children with neurofibromatosis type 1. A case control study. Eur J Paediatr Dent 12:256\u2013260","journal-title":"Eur J Paediatr Dent"},{"key":"3985_CR10","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/j.jcms.2018.04.018","volume":"46","author":"RE Friedrich","year":"2018","unstructured":"Friedrich RE, Reul A (2018) A combination of skeletal deformations of the dorsal mandible and temporomandibular region detected in orthopantomograms of patients with neurofibromatosis type 1 indicates an associated ipsilateral plexiform neurofibroma. J Cranio-Maxillofac Surg 46:1091\u20131104. https:\/\/doi.org\/10.1016\/j.jcms.2018.04.018","journal-title":"J Cranio-Maxillofac Surg"},{"key":"3985_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13023-018-0881-8","volume":"13","author":"V Visnapuu","year":"2018","unstructured":"Visnapuu V, Peltonen S, Alivuotila L, Happonen RP, Peltonen J (2018) Craniofacial and oral alterations in patients with neurofibromatosis 1. Orphanet J Rare Dis 13:1\u20139. https:\/\/doi.org\/10.1186\/s13023-018-0881-8","journal-title":"Orphanet J Rare Dis"},{"key":"3985_CR12","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/S1079-2104(96)80338-6","volume":"81","author":"L Lee","year":"1996","unstructured":"Lee L, Yan YH, Pharoah MJ (1996) Radiographic features of the mandible in neurofibromatosis: a report of 10 cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 81:361\u2013367. https:\/\/doi.org\/10.1016\/S1079-2104(96)80338-6","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"3985_CR13","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.oooo.2017.01.006","volume":"123","author":"L Khojastepour","year":"2017","unstructured":"Khojastepour L, Vojdani M, Forghani M (2017) The association between condylar bone changes revealed in cone beam computed tomography and clinical dysfunction index in patients with or without temporomandibular joint disorders. Oral Surg Oral Med Oral Pathol Oral Radiol 123:600\u2013605. https:\/\/doi.org\/10.1016\/j.oooo.2017.01.006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"3985_CR14","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1001\/archneur.1988.00520290115023","volume":"45","author":"D Stumpf","year":"1988","unstructured":"Stumpf D, Alksne J, Annegers J et al (1988) Neurofibromatosis: conference statement. Arch Neurol 45:575\u2013578. https:\/\/doi.org\/10.1001\/archneur.1988.00520290115023","journal-title":"Arch Neurol"},{"key":"3985_CR15","doi-asserted-by":"publisher","first-page":"880","DOI":"10.2319\/072007-339.1","volume":"78","author":"B Schlueter","year":"2008","unstructured":"Schlueter B, Kim KB, Oliver D, Sortiropoulos G (2008) Cone beam computed tomography 3D reconstruction of the mandibular condyle. Angle Orthod 78:880\u2013888. https:\/\/doi.org\/10.2319\/072007-339.1","journal-title":"Angle Orthod"},{"key":"3985_CR16","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.ajodo.2005.08.034","volume":"128","author":"ML Hilgers","year":"2005","unstructured":"Hilgers ML, Scarfe WC, Scheetz JP, Farman AG (2005) Accuracy of linear temporomandibular joint measurements with cone beam computed tomography and digital cephalometric radiography. Am J Orthod Dentofac Orthop 128:803\u2013811","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"3985_CR17","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.tripleo.2009.02.023.Research","volume":"107","author":"M Ahmad","year":"2009","unstructured":"Ahmad M, Hollender L, Anderson Q et al (2009) Research diagnostic criteria for temporomandibular disorders (RDC\/TMD): development of image analysis criteria and examiner reliability for image analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107:612\u2013625. https:\/\/doi.org\/10.1016\/j.tripleo.2009.02.023.Research","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"3985_CR18","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/0030-4220(86)90270-7","volume":"62","author":"A Pullinger","year":"1986","unstructured":"Pullinger A, Hollender L (1986) Variation in condyle-fossa relationships according to different methods of evaluation in tomograms. Oral Surg Oral Med Oral Pathol 62:719\u2013727. https:\/\/doi.org\/10.1016\/0030-4220(86)90270-7","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"3985_CR19","doi-asserted-by":"publisher","first-page":"159","DOI":"10.2307\/2529310","volume":"33","author":"JR Landis","year":"1977","unstructured":"Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Int Biometr Soc 33:159\u2013174. https:\/\/doi.org\/10.2307\/2529310","journal-title":"Int Biometr Soc"},{"key":"3985_CR20","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1037\/1040-3590.6.4.284","volume":"6","author":"DV Cicchetti","year":"1994","unstructured":"Cicchetti DV (1994) Guidelines, criteria, and rules of thumb for evaluating normed and standardized assessment instruments in psychology. Psychol Assess 6:284\u2013290. https:\/\/doi.org\/10.1037\/1040-3590.6.4.284","journal-title":"Psychol Assess"},{"key":"3985_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1590\/1807-3107BOR-2015.vol29.0120","volume":"29","author":"DBS Ladeira","year":"2015","unstructured":"Ladeira DBS, da Cruz AD, de Almeida SM (2015) Digital panoramic radiography for diagnosis of the temporomandibular joint: CBCT as the gold standard. Braz Oral Res 29:1\u20137. https:\/\/doi.org\/10.1590\/1807-3107BOR-2015.vol29.0120","journal-title":"Braz Oral Res"},{"key":"3985_CR22","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.oooo.2011.11.020","volume":"114","author":"ZL Zhang","year":"2012","unstructured":"Zhang ZL, Cheng JG, Li G, Zhang JZ, Zhang ZY, Ma XC (2012) Measurement accuracy of temporomandibular joint space in Promax 3-dimensional cone-beam computerized tomography images. Oral Surg Oral Med Oral Pathol Oral Radiol 114:112\u2013117. https:\/\/doi.org\/10.1016\/j.oooo.2011.11.020","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"3985_CR23","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1259\/dmfr\/17815139","volume":"41","author":"ML Dos Anjos Pontual","year":"2012","unstructured":"Dos Anjos Pontual ML, Freire JSL, Barbosa JMN et al (2012) Evaluation of bone changes in the temporomandibular joint using cone beam CT. Dentomaxillofac Radiol 41:24\u201329. https:\/\/doi.org\/10.1259\/dmfr\/17815139","journal-title":"Dentomaxillofac Radiol"},{"key":"3985_CR24","doi-asserted-by":"publisher","first-page":"67","DOI":"10.17219\/dmp\/112392","volume":"57","author":"N Ko\u00e7","year":"2020","unstructured":"Ko\u00e7 N (2020) Evaluation of osteoarthritic changes in the temporomandibular joint and their correlations with age: a retrospective CBCT study. Dent Med Probl 57:67\u201372. https:\/\/doi.org\/10.17219\/dmp\/112392","journal-title":"Dent Med Probl"},{"key":"3985_CR25","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.oooo.2017.11.001","volume":"125","author":"SJ Ahn","year":"2018","unstructured":"Ahn SJ, Chang MS, Choi JH, Yang IH, An JS, Heo MS (2018) Relationships between temporomandibular joint disk displacements and condylar volume. Oral Surg Oral Med Oral Pathol Oral Radiol 125:192\u2013198. https:\/\/doi.org\/10.1016\/j.oooo.2017.11.001","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"3985_CR26","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1016\/j.ijom.2015.06.023","volume":"44","author":"S C\u00f6mert Kili\u00e7","year":"2015","unstructured":"C\u00f6mert Kili\u00e7 S, Kili\u00e7 N, S\u00fcmb\u00fcll\u00fc MA (2015) Temporomandibular joint osteoarthritis: cone beam computed tomography findings, clinical features, and correlations. Int J Oral Maxillofac Surg 44:1268\u20131274. https:\/\/doi.org\/10.1016\/j.ijom.2015.06.023","journal-title":"Int J Oral Maxillofac Surg"},{"key":"3985_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40902-017-0117-1","volume":"39","author":"S Bae","year":"2017","unstructured":"Bae S, Park M-S, Han J-W, Kim Y-J (2017) Correlation between pain and degenerative bony changes on cone-beam computed tomography images of temporomandibular joints. Maxillofac Plast Reconstruct Surg 39:1\u20136. https:\/\/doi.org\/10.1186\/s40902-017-0117-1","journal-title":"Maxillofac Plast Reconstruct Surg"},{"key":"3985_CR28","doi-asserted-by":"publisher","first-page":"259","DOI":"10.4103\/1119-3077.164336","volume":"19","author":"MO Borahan","year":"2016","unstructured":"Borahan MO, Mayil M, Pekiner FN (2016) Using cone beam computed tomography to examine the prevalence of condylar bony changes in a Turkish subpopulation. Niger J Clin Pract 19:259\u2013266. https:\/\/doi.org\/10.4103\/1119-3077.164336","journal-title":"Niger J Clin Pract"},{"key":"3985_CR29","first-page":"16057","volume":"8","author":"Y Li","year":"2015","unstructured":"Li Y, Guo X, Sun X, Wang N, Xie M, Zhang J, Lv Y, Han W, Hu M, Liu H (2015) Characteristics of temporomandibular joint in patients with temporomandibular joint complaint. Int J Clin Exp Med 8:16057\u201316063","journal-title":"Int J Clin Exp Med"},{"key":"3985_CR30","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12880-019-0334-4","volume":"19","author":"A Shokri","year":"2019","unstructured":"Shokri A, Jamalpour MR, Khavid A, Mohseni Z, Sadeghi M (2019) Effect of exposure parameters of cone beam computed tomography on metal artifact reduction around the dental implants in various bone densities. BMC Med Imaging 19:34. https:\/\/doi.org\/10.1186\/s12880-019-0334-4","journal-title":"BMC Med Imaging"},{"key":"3985_CR31","doi-asserted-by":"publisher","first-page":"169","DOI":"10.5624\/isd.2012.42.3.169","volume":"42","author":"B Cho","year":"2012","unstructured":"Cho B, Jung Y (2012) Osteoarthritic changes and condylar positioning of the temporomandibular joint in Korean children and adolescents. Imaging Sci Dent 42:169\u2013174","journal-title":"Imaging Sci Dent"},{"key":"3985_CR32","doi-asserted-by":"publisher","first-page":"32","DOI":"10.4067\/s0717-95022014000100006","volume":"32","author":"N Alves","year":"2014","unstructured":"Alves N, Deana NF, Schilling QA, Gonz\u00e1lez VA, Schilling LJ, Pastenes RC (2014) Evaluaci\u00f3n de la Posici\u00f3n Condilary del Espacio Articular en ATM de Individuos Chilenos con Trastornos Temporomandibulares. Int J Morphol 32:32\u201335. https:\/\/doi.org\/10.4067\/s0717-95022014000100006","journal-title":"Int J Morphol"},{"key":"3985_CR33","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1359\/JBMR.040130","volume":"19","author":"T Kuorilehto","year":"2004","unstructured":"Kuorilehto T, Nissinen M, Koivunen J, Benson MD, Peltonen J (2004) NF1 tumor suppressor protein and mRNA in skeletal tissues of developing and adult normal mouse and NF1-deficient embryos. J Bone Miner Res 19:983\u2013989. https:\/\/doi.org\/10.1359\/JBMR.040130","journal-title":"J Bone Miner Res"},{"key":"3985_CR34","doi-asserted-by":"publisher","first-page":"3910","DOI":"10.1093\/hmg\/ddr310","volume":"20","author":"W Wang","year":"2011","unstructured":"Wang W, Nyman JS, Ono K, Stevenson DA, Yang X, Elefteriou F (2011) Mice lacking Nf1 in osteochondroprogenitor cells display skeletal dysplasia similar to patients with neurofibromatosis type I. Hum Mol Genet 20:3910\u20133924. https:\/\/doi.org\/10.1093\/hmg\/ddr310","journal-title":"Hum Mol Genet"},{"key":"3985_CR35","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1177\/0022034515598135","volume":"94","author":"Y Jing","year":"2015","unstructured":"Jing Y, Zhou X, Han X, Jing J, von der Mark K, Wang J, de Crombrugghe B, Hinton RJ, Feng JQ (2015) Chondrocytes directly transform into bone cells in mandibular condyle growth. J Dent Res 94:1668\u20131675. https:\/\/doi.org\/10.1177\/0022034515598135","journal-title":"J Dent Res"},{"key":"3985_CR36","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.jdsr.2013.07.004","volume":"49","author":"I Mizoguchi","year":"2013","unstructured":"Mizoguchi I, Toriya N, Nakao Y (2013) Growth of the mandible and biological characteristics of the mandibular condylar cartilage. Japan Dent Sci Rev 49:139\u2013150. https:\/\/doi.org\/10.1016\/j.jdsr.2013.07.004","journal-title":"Japan Dent Sci Rev"},{"key":"3985_CR37","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.jcms.2017.02.011","volume":"45","author":"RE Friedrich","year":"2017","unstructured":"Friedrich RE, Lehmann JM, Rother J, Christ G, zu Eulenburg C, Scheuer HT, Scheuer HA (2017) A lateral cephalometry study of patients with neurofibromatosis type 1. J Cranio-Maxillofac Surg 45:809\u2013820. https:\/\/doi.org\/10.1016\/j.jcms.2017.02.011","journal-title":"J Cranio-Maxillofac Surg"},{"key":"3985_CR38","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s10654-016-0149-3","volume":"31","author":"S Greenland","year":"2016","unstructured":"Greenland S, Senn SJ, Rothman KJ, Carlin JB, Poole C, Goodman SN, Altman DG (2016) Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations. Eur J Epidemiol 31:337\u2013350. https:\/\/doi.org\/10.1007\/s10654-016-0149-3","journal-title":"Eur J Epidemiol"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-03985-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-021-03985-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-03985-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T06:19:59Z","timestamp":1643177999000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-021-03985-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,29]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["3985"],"URL":"https:\/\/doi.org\/10.1007\/s00784-021-03985-7","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,29]]},"assertion":[{"value":"20 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in this study were conducted in accordance with the ethical standards of the local Research Ethics Committee (protocol number # 2487442), and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study, formal consent is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare that they have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}