{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:41:56Z","timestamp":1792813316807,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,5,23]],"date-time":"2021-05-23T00:00:00Z","timestamp":1621728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,23]],"date-time":"2021-05-23T00:00:00Z","timestamp":1621728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"DGKFO","award":["none"],"award-info":[{"award-number":["none"]}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2014\/20715-7, 2017\/07137-2"],"award-info":[{"award-number":["2014\/20715-7, 2017\/07137-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DE1593\/5-1"],"award-info":[{"award-number":["DE1593\/5-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","award":["88881.144012\/2017-01"],"award-info":[{"award-number":["88881.144012\/2017-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001655","name":"Deutscher Akademischer Austauschdienst","doi-asserted-by":"publisher","award":["57391253"],"award-info":[{"award-number":["57391253"]}],"id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>The aim of this in vitro and in vivo study was to investigate the interaction of periodontitis and orthodontic tooth movement on interleukin (IL)-6 and C-X-C motif chemokine 2 (CXCL2).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>The effect of periodontitis and\/or orthodontic tooth movement (OTM) on alveolar bone and gingival IL-6 and CXCL2 expressions was studied in rats by histology and RT-PCR, respectively. The animals were assigned to four groups (control, periodontitis, OTM, and combination of periodontitis and OTM). The IL-6 and CXCL2 levels were also studied in human gingival biopsies from periodontally healthy and periodontitis subjects by RT-PCR and immunohistochemistry. Additionally, the synthesis of IL-6 and CXCL2 in response to the periodontopathogen <jats:italic>Fusobacterium nucleatum<\/jats:italic> and\/or mechanical strain was studied in periodontal fibroblasts by RT-PCR and ELISA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Periodontitis caused an increase in gingival levels of IL-6 and CXCL2 in the animal model. Moreover, orthodontic tooth movement further enhanced the bacteria-induced periodontal destruction and gingival IL-6 gene expression. Elevated IL-6 and CXCL2 gingival levels were also found in human periodontitis. Furthermore, mechanical strain increased the stimulatory effect of <jats:italic>F. nucleatum<\/jats:italic> on IL-6 protein in vitro.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our study suggests that orthodontic tooth movement can enhance bacteria-induced periodontal inflammation and thus destruction and that IL-6 may play a pivotal role in this process.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>Orthodontic tooth movement should only be performed after periodontal therapy. In case of periodontitis relapse, orthodontic therapy should be suspended until the periodontal inflammation has been successfully treated and thus the periodontal disease is controlled again.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-021-03988-4","type":"journal-article","created":{"date-parts":[[2021,5,23]],"date-time":"2021-05-23T00:02:12Z","timestamp":1621728132000},"page":"171-181","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Interaction of periodontitis and orthodontic tooth movement\u2014an in vitro and in vivo study"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0545-746X","authenticated-orcid":false,"given":"Birgit","family":"Rath-Deschner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andressa V. B.","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenja","family":"Beisel-Memmert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Nokhbehsaim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrun","family":"Eick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joni A.","family":"Cirelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Deschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"J\u00e4ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Damanaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,23]]},"reference":[{"key":"3988_CR1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/sj.bdj.2015.46","volume":"218","author":"L Christensen","year":"2015","unstructured":"Christensen L, Luther F (2015) Adults seeking orthodontic treatment: expectations, periodontal and TMD issues. Br Dent J 218:111\u2013117. https:\/\/doi.org\/10.1038\/sj.bdj.2015.46","journal-title":"Br Dent J"},{"key":"3988_CR2","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/prd.12126","volume":"72","author":"E Kanasi","year":"2016","unstructured":"Kanasi E, Ayilavarapu S, Jones J (2016) The aging population: demographics and the biology of aging. Periodontol 2000 72:13\u201318. https:\/\/doi.org\/10.1111\/prd.12126","journal-title":"Periodontol 2000"},{"key":"3988_CR3","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0140-6736(19)31146-8","volume":"394","author":"MA Peres","year":"2019","unstructured":"Peres MA, Macpherson LMD, Weyant RJ, Daly B, Venturelli R, Mathur MR, Listl S, Celeste RK, Guarnizo-Herre\u00f1o CC, Kearns C, Benzian H, Allison P, Watt RG (2019) Oral diseases: a global public health challenge. Lancet 394:249\u2013260. https:\/\/doi.org\/10.1016\/S0140-6736(19)31146-8","journal-title":"Lancet"},{"key":"3988_CR4","doi-asserted-by":"publisher","first-page":"469.e1","DOI":"10.1016\/j.ajodo.2005.10.007","volume":"129","author":"V Krishnan","year":"2006","unstructured":"Krishnan V, Davidovitch Z (2006) Cellular, molecular, and tissue-level reactions to orthodontic force. Am J Orthod Dentofac Orthop 129:469.e1\u2013469.32. https:\/\/doi.org\/10.1016\/j.ajodo.2005.10.007","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"3988_CR5","doi-asserted-by":"publisher","first-page":"S149","DOI":"10.1111\/jcpe.12945","volume":"45 Suppl 20","author":"MS Tonetti","year":"2018","unstructured":"Tonetti MS, Greenwell H, Kornman KS (2018) Staging and grading of periodontitis: framework and proposal of a new classification and case definition. J Clin Periodontol 45 Suppl 20:S149\u2013S161. https:\/\/doi.org\/10.1111\/jcpe.12945","journal-title":"J Clin Periodontol"},{"key":"3988_CR6","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1902\/jop.2005.76.6.859","volume":"76","author":"MA Brunsvold","year":"2005","unstructured":"Brunsvold MA (2005) Pathologic tooth migration. J Periodontol 76:859\u2013866. https:\/\/doi.org\/10.1902\/jop.2005.76.6.859","journal-title":"J Periodontol"},{"key":"3988_CR7","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/jcpe.12835","volume":"45","author":"E Zas\u010diurinskien\u0117","year":"2018","unstructured":"Zas\u010diurinskien\u0117 E, Basevi\u010dien\u0117 N, Lindsten R, Slotte C, Jansson H, Bjerklin K (2018) Orthodontic treatment simultaneous to or after periodontal cause-related treatment in periodontitis susceptible patients. Part I: clinical outcome. A randomized clinical trial. J Clin Periodontol 45:213\u2013224. https:\/\/doi.org\/10.1111\/jcpe.12835","journal-title":"J Clin Periodontol"},{"key":"3988_CR8","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.ajodo.2015.05.026","volume":"148","author":"T Cao","year":"2015","unstructured":"Cao T, Xu L, Shi J, Zhou Y (2015) Combined orthodontic-periodontal treatment in periodontal patients with anteriorly displaced incisors. Am J Orthod Dentofac Orthop 148:805\u2013813. https:\/\/doi.org\/10.1016\/j.ajodo.2015.05.026","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"3988_CR9","doi-asserted-by":"publisher","first-page":"e35","DOI":"10.11607\/prd.2345","volume":"35","author":"K Jepsen","year":"2015","unstructured":"Jepsen K, Jaeger A, Jepsen S (2015) Esthetic and functional rehabilitation of a severely compromised central incisor: an interdisciplinary approach. Int J Periodontics Restorative Dent 35:e35\u2013e43. https:\/\/doi.org\/10.11607\/prd.2345","journal-title":"Int J Periodontics Restorative Dent"},{"key":"3988_CR10","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1902\/jop.2005.76.4.655","volume":"76","author":"D Cardaropoli","year":"2005","unstructured":"Cardaropoli D, Re S (2005) Interdental papilla augmentation procedure following orthodontic treatment in a periodontal patient. J Periodontol 76:655\u2013661. https:\/\/doi.org\/10.1902\/jop.2005.76.4.655","journal-title":"J Periodontol"},{"key":"3988_CR11","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/0889-5406(93)70011-C","volume":"103","author":"JL Wennstr\u00f6m","year":"1993","unstructured":"Wennstr\u00f6m JL, Stokland BL, Nyman S, Thilander B (1993) Periodontal tissue response to orthodontic movement of teeth with infrabony pockets. Am J Orthod Dentofac Orthop 103:313\u2013319. https:\/\/doi.org\/10.1016\/0889-5406(93)70011-C","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"3988_CR12","first-page":"25","volume":"13","author":"B Signat","year":"2011","unstructured":"Signat B, Roques C, Poulet P, Duffaut D (2011) Fusobacterium nucleatum in periodontal health and disease. Curr Issues Mol Biol 13:25\u201336","journal-title":"Curr Issues Mol Biol"},{"key":"3988_CR13","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1007\/s00784-011-0654-4","volume":"16","author":"J He","year":"2012","unstructured":"He J, Huang W, Pan Z, Cui H, Qi G, Zhou X, Chen H (2012) Quantitative analysis of microbiota in saliva, supragingival, and subgingival plaque of Chinese adults with chronic periodontitis. Clin Oral Investig 16:1579\u20131588. https:\/\/doi.org\/10.1007\/s00784-011-0654-4","journal-title":"Clin Oral Investig"},{"key":"3988_CR14","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1902\/jop.2009.090051","volume":"80","author":"G Dabija-Wolter","year":"2009","unstructured":"Dabija-Wolter G, Cimpan MR, Costea DE, Johannessen AC, S\u00f8rnes S, Neppelberg E, Al-Haroni M, Skaug N, Bakken V (2009) Fusobacterium nucleatum enters normal human oral fibroblasts in vitro. J Periodontol 80:1174\u20131183. https:\/\/doi.org\/10.1902\/jop.2009.090051","journal-title":"J Periodontol"},{"key":"3988_CR15","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/j.1574-695X.2008.00481.x","volume":"54","author":"A Saito","year":"2008","unstructured":"Saito A, Inagaki S, Kimizuka R, Okuda K, Hosaka Y, Nakagawa T, Ishihara K (2008) Fusobacterium nucleatum enhances invasion of human gingival epithelial and aortic endothelial cells by Porphyromonas gingivalis. FEMS Immunol Med Microbiol 54:349\u2013355. https:\/\/doi.org\/10.1111\/j.1574-695X.2008.00481.x","journal-title":"FEMS Immunol Med Microbiol"},{"key":"3988_CR16","doi-asserted-by":"publisher","first-page":"4729","DOI":"10.1128\/IAI.66.10.4729-4732.1998","volume":"66","author":"DJ Bradshaw","year":"1998","unstructured":"Bradshaw DJ, Marsh PD, Watson GK, Allison C (1998) Role of Fusobacterium nucleatum and coaggregation in anaerobe survival in planktonic and biofilm oral microbial communities during aeration. Infect Immun 66:4729\u20134732. https:\/\/doi.org\/10.1128\/IAI.66.10.4729-4732.1998","journal-title":"Infect Immun"},{"key":"3988_CR17","doi-asserted-by":"publisher","first-page":"591","DOI":"10.3390\/ijms22020591","volume":"22","author":"B Rath-Deschner","year":"2021","unstructured":"Rath-Deschner B, Nogueira AVB, Memmert S, Nokhbehsaim M, Augusto Cirelli J, Eick S, Miosge N, Kirschneck C, Kesting M, Deschner J, J\u00e4ger A, Damanaki A (2021) Regulation of anti-apoptotic SOD2 and BIRC3 in periodontal cells and tissues. Int J Mol Sci 22:591. https:\/\/doi.org\/10.3390\/ijms22020591","journal-title":"Int J Mol Sci"},{"key":"3988_CR18","doi-asserted-by":"publisher","first-page":"151648","DOI":"10.1016\/j.aanat.2020.151648","volume":"234","author":"B Rath-Deschner","year":"2021","unstructured":"Rath-Deschner B, Memmert S, Damanaki A, de Molon RS, Nokhbehsaim M, Eick S, Kirschneck C, Cirelli JA, Deschner J, J\u00e4ger A, Nogueira AVB (2021) CXCL5, CXCL8, and CXCL10 regulation by bacteria and mechanical forces in periodontium. Ann Anat 234:151648. https:\/\/doi.org\/10.1016\/j.aanat.2020.151648","journal-title":"Ann Anat"},{"key":"3988_CR19","doi-asserted-by":"publisher","first-page":"3661","DOI":"10.1007\/s00784-020-03244-1","volume":"24","author":"B Rath-Deschner","year":"2020","unstructured":"Rath-Deschner B, Memmert S, Damanaki A, Nokhbehsaim M, Eick S, Cirelli JA, G\u00f6tz W, Deschner J, J\u00e4ger A, Nogueira AVB (2020) CXCL1, CCL2, and CCL5 modulation by microbial and biomechanical signals in periodontal cells and tissues-in vitro and in vivo studies. Clin Oral Investig 24:3661\u20133670. https:\/\/doi.org\/10.1007\/s00784-020-03244-1","journal-title":"Clin Oral Investig"},{"key":"3988_CR20","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1093\/intimm\/dxaa078","volume":"33","author":"T Hirano","year":"2021","unstructured":"Hirano T (2021) IL-6 in inflammation, autoimmunity and cancer. Int Immunol 33:127\u2013148. https:\/\/doi.org\/10.1093\/intimm\/dxaa078","journal-title":"Int Immunol"},{"key":"3988_CR21","doi-asserted-by":"publisher","first-page":"31","DOI":"10.2147\/OARRR.S291388","volume":"13","author":"A Sebba","year":"2021","unstructured":"Sebba A (2021) Pain: a review of interleukin-6 and its roles in the pain of rheumatoid arthritis. Open Access Rheumatol 13:31\u201343. https:\/\/doi.org\/10.2147\/OARRR.S291388","journal-title":"Open Access Rheumatol"},{"key":"3988_CR22","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1080\/10641963.2019.1693585","volume":"42","author":"LY Guo","year":"2020","unstructured":"Guo LY, Yang F, Peng LJ, Li YB, Wang AP (2020) CXCL2, a new critical factor and therapeutic target for cardiovascular diseases. Clin Exp Hypertens 42:428\u2013437. https:\/\/doi.org\/10.1080\/10641963.2019.1693585","journal-title":"Clin Exp Hypertens"},{"key":"3988_CR23","doi-asserted-by":"publisher","first-page":"3043","DOI":"10.3748\/wjg.v23.i17.3043","volume":"23","author":"CC Qin","year":"2017","unstructured":"Qin CC, Liu YN, Hu Y, Yang Y, Chen Z (2017) Macrophage inflammatory protein-2 as mediator of inflammation in acute liver injury. World J Gastroenterol 23:3043\u20133052. https:\/\/doi.org\/10.3748\/wjg.v23.i17.3043","journal-title":"World J Gastroenterol"},{"key":"3988_CR24","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1111\/j.1600-0765.2006.00903.x","volume":"41","author":"PM Duarte","year":"2006","unstructured":"Duarte PM, Gon\u00e7alves P, Casati MZ, de Toledo S, Sallum EA, Nociti FH Jr (2006) Estrogen and alendronate therapies may prevent the influence of estrogen deficiency on the tooth-supporting alveolar bone: a histometric study in rats. J Periodontal Res 41:541\u2013546. https:\/\/doi.org\/10.1111\/j.1600-0765.2006.00903.x","journal-title":"J Periodontal Res"},{"key":"3988_CR25","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1002\/art.24781","volume":"60","author":"R Axmann","year":"2009","unstructured":"Axmann R, B\u00f6hm C, Kr\u00f6nke G, Zwerina J, Smolen J, Schett G (2009) Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo. Arthritis Rheum 60:2747\u20132756. https:\/\/doi.org\/10.1002\/art.24781","journal-title":"Arthritis Rheum"},{"key":"3988_CR26","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.aanat.2016.10.004","volume":"210","author":"C Kirschneck","year":"2017","unstructured":"Kirschneck C, Fangh\u00e4nel J, Wahlmann U, Wolf M, Rold\u00e1n JC, Proff P (2017) Interactive effects of periodontitis and orthodontic tooth movement on dental root resorption, tooth movement velocity and alveolar bone loss in a rat model. Ann Anat 210:32\u201343. https:\/\/doi.org\/10.1016\/j.aanat.2016.10.004","journal-title":"Ann Anat"},{"key":"3988_CR27","doi-asserted-by":"publisher","first-page":"5535","DOI":"10.2147\/DDDT.S289753","volume":"14","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Zhuang D, Zhang Y, Lu H, Zhang H, Li T, Bi L (2020) Super activated platelet lysate, a novel autologous platelet lysate, regulates the expression of inflammasome and cytokine in the experimental periodontitis in rats. Drug Des Devel Ther 14:5535\u20135543. https:\/\/doi.org\/10.2147\/DDDT.S289753","journal-title":"Drug Des Devel Ther"},{"key":"3988_CR28","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.molimm.2019.11.003","volume":"117","author":"Z Zhang","year":"2020","unstructured":"Zhang Z, Yuan W, Deng J, Wang D, Zhang T, Peng L, Tian H, Wang Z, Ma J (2020) Granulocyte colony stimulating factor (G-CSF) regulates neutrophils infiltration and periodontal tissue destruction in an experimental periodontitis. Mol Immunol 117:110\u2013121. https:\/\/doi.org\/10.1016\/j.molimm.2019.11.003","journal-title":"Mol Immunol"},{"key":"3988_CR29","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1111\/jcpe.12557","volume":"43","author":"AF Stadler","year":"2016","unstructured":"Stadler AF, Angst PD, Arce RM, Gomes SC, Oppermann RV, Susin C (2016) Gingival crevicular fluid levels of cytokines\/chemokines in chronic periodontitis: a meta-analysis. J Clin Periodontol 43:727\u2013745. https:\/\/doi.org\/10.1111\/jcpe.12557","journal-title":"J Clin Periodontol"},{"key":"3988_CR30","doi-asserted-by":"publisher","first-page":"104960","DOI":"10.1016\/j.archoralbio.2020.104960","volume":"121","author":"L Chen","year":"2021","unstructured":"Chen L, Hua Y (2021) Autophagy of periodontal ligament inhibits inflammation and reduces the decline of bone density during orthodontic tooth movement of mice. Arch Oral Biol 121:104960. https:\/\/doi.org\/10.1016\/j.archoralbio.2020.104960","journal-title":"Arch Oral Biol"},{"key":"3988_CR31","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1089\/107999099313271","volume":"19","author":"N Alhashimi","year":"1999","unstructured":"Alhashimi N, Frithiof L, Brudvik P, Bakhiet M (1999) Chemokines are upregulated during orthodontic tooth movement. J Interf Cytokine Res 19:1047\u20131052. https:\/\/doi.org\/10.1089\/107999099313271","journal-title":"J Interf Cytokine Res"},{"key":"3988_CR32","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/S1995-7645(13)60133-9","volume":"6","author":"JH Yang","year":"2013","unstructured":"Yang JH, Li ZC, Kong WD, Zhang W, Jia YP, Zhang YL, Liu LB, Han XP (2013) Effect of orthodontic force on inflammatory periodontal tissue remodeling and expression of IL-6 and IL-8 in rats. Asian Pac J Trop Med 6:757\u2013761. https:\/\/doi.org\/10.1016\/S1995-7645(13)60133-9","journal-title":"Asian Pac J Trop Med"},{"key":"3988_CR33","doi-asserted-by":"publisher","first-page":"2584","DOI":"10.1016\/j.jbiomech.2009.07.013","volume":"42","author":"B Rath-Deschner","year":"2009","unstructured":"Rath-Deschner B, Deschner J, Reimann S, Jager A, Gotz W (2009) Regulatory effects of biomechanical strain on the insulin-like growth factor system in human periodontal cells. J Biomech 42:2584\u20132589. https:\/\/doi.org\/10.1016\/j.jbiomech.2009.07.013","journal-title":"J Biomech"},{"key":"3988_CR34","doi-asserted-by":"publisher","unstructured":"Fragkioudakis I, Riggio MP, Apatzidou DA (2021) Understanding the microbial components of periodontal diseases and periodontal treatment-induced microbiological shifts. J Med Microbiol 70. https:\/\/doi.org\/10.1099\/jmm.0.001247","DOI":"10.1099\/jmm.0.001247"},{"key":"3988_CR35","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/prd.12331","volume":"84","author":"G Hajishengallis","year":"2020","unstructured":"Hajishengallis G, Chavakis T, Lambris JD (2020) Current understanding of periodontal disease pathogenesis and targets for host-modulation therapy. Periodontol 2000 84:14\u201334. https:\/\/doi.org\/10.1111\/prd.12331","journal-title":"Periodontol 2000"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-03988-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-021-03988-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-03988-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T06:19:56Z","timestamp":1643177996000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-021-03988-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,23]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["3988"],"URL":"https:\/\/doi.org\/10.1007\/s00784-021-03988-4","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,23]]},"assertion":[{"value":"3 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the Ethics Committee of the University of Bonn (043\/11) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. All procedures performed in this study were in accordance with the ethical standards of the Ethical Committee for Animal Use (CEUA) of the School of Dentistry at Araraquara \u2013 UNESP (23\/2012) and performed in accordance with the guideline from the Brazilian College for Animal Experimentation (COBEA). All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}