{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:49:01Z","timestamp":1793195341885,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T00:00:00Z","timestamp":1622246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T00:00:00Z","timestamp":1622246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["424009\/2018-8"],"award-info":[{"award-number":["424009\/2018-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s00784-021-04008-1","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T23:29:52Z","timestamp":1622244592000},"page":"4329-4340","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Binary and WHO dysplasia grading systems for the prediction of malignant transformation of oral leukoplakia and erythroplakia: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1437-2871","authenticated-orcid":false,"given":"Brunno Santos","family":"de Freitas Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle Coelho Ribeiro","family":"Batista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Ferro","family":"de Souza Roriz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena Rosa","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Gabriela Costa","family":"Normando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan Roger","family":"dos Santos Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Alves Garcia","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Paula","family":"Yamamoto-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,29]]},"reference":[{"key":"4008_CR1","unstructured":"Ferlay J, Colombet M, Bray F (2018) Cancer incidence in five continents, CI5plus: IARC CancerBase No. 9 [Internet]. Lyon, France: International Agency for Research on Cancer. Available from: http:\/\/ci5.iarc.fr. Accessed 12 Dec 2020"},{"key":"4008_CR2","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.oraloncology.2008.06.002","volume":"45","author":"S Warnakulasuriya","year":"2009","unstructured":"Warnakulasuriya S (2009) Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 45:309\u2013316. https:\/\/doi.org\/10.1016\/j.oraloncology.2008.06.002","journal-title":"Oral Oncol"},{"key":"4008_CR3","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s13005-015-0063-z","volume":"11","author":"E Omar","year":"2015","unstructured":"Omar E (2015) Current concepts and future of noninvasive procedures for diagnosing oral squamous cell carcinoma - a systematic review. Head Face Med 11:6. https:\/\/doi.org\/10.1186\/s13005-015-0063-z","journal-title":"Head Face Med"},{"key":"4008_CR4","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1111\/j.1600-0714.2007.00582.x","volume":"36","author":"S Warnakulasuriya","year":"2007","unstructured":"Warnakulasuriya S, Johnson NW, Van Der Waal I (2007) Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med 36:575\u2013580. https:\/\/doi.org\/10.1111\/j.1600-0714.2007.00582.x","journal-title":"J Oral Pathol Med"},{"key":"4008_CR5","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-019-01020-6","author":"Woo S Bin","year":"2019","unstructured":"Bin Woo S (2019) Oral epithelial dysplasia and premalignancy. Head Neck Pathol. https:\/\/doi.org\/10.1007\/s12105-019-01020-6","journal-title":"Head Neck Pathol"},{"key":"4008_CR6","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/prd.12259","volume":"80","author":"WM Tilakaratne","year":"2000","unstructured":"Tilakaratne WM, Jayasooriya PR, Jayasuriya NS (2000) De Silva RK (2019) Oral epithelial dysplasia: causes, quantification, prognosis, and management challenges. Periodontol 80:126\u2013147. https:\/\/doi.org\/10.1111\/prd.12259","journal-title":"Periodontol"},{"key":"4008_CR7","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/j.1600-0714.2007.00584.x","volume":"37","author":"S Warnakulasuriya","year":"2008","unstructured":"Warnakulasuriya S, Reibel J, Bouquot J, Dabelsteen E (2008) Oral epithelial dysplasia classification systems: predictive value, utility, weaknesses and scope for improvement. J Oral Pathol Med 37:127\u2013133. https:\/\/doi.org\/10.1111\/j.1600-0714.2007.00584.x","journal-title":"J Oral Pathol Med"},{"key":"4008_CR8","unstructured":"Takata T, Slootweg P (2017) Tumours of the oral cavity and mobile tongue: epithelial precursor lesions. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. World heal. Organ. Classif. Head Neck Tumours, 4th ed. IARC Press, Lyon, pp. 112\u20134"},{"key":"4008_CR9","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.oooo.2012.10.015","volume":"115","author":"P Nankivell","year":"2013","unstructured":"Nankivell P, Williams H, Matthews P, Suortamo S, Snead D, McConkey C et al (2013) The binary oral dysplasia grading system: validity testing and suggested improvement. Oral Surg Oral Med Oral Pathol Oral Radiol 115:87\u201394. https:\/\/doi.org\/10.1016\/j.oooo.2012.10.015","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"4008_CR10","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.oooo.2018.03.012","volume":"125","author":"NG Nikitakis","year":"2018","unstructured":"Nikitakis NG, Pentenero M, Georgaki M, Poh CF, Peterson DE, Edwards P et al (2018) Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: current knowledge and future implications. Oral Surg Oral Med Oral Pathol Oral Radiol 125:650\u2013669. https:\/\/doi.org\/10.1016\/j.oooo.2018.03.012","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"4008_CR11","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.oraloncology.2017.07.003","volume":"72","author":"C Rivera","year":"2017","unstructured":"Rivera C, Oliveira AK, Costa RAP, De Rossi T, Paes Leme AF (2017) Prognostic biomarkers in oral squamous cell carcinoma: a systematic review. Oral Oncol 72:38\u201347. https:\/\/doi.org\/10.1016\/j.oraloncology.2017.07.003","journal-title":"Oral Oncol"},{"key":"4008_CR12","volume-title":"World Health Organization pathology and genetics of head and neck tumours","author":"L Barnes","year":"2005","unstructured":"Barnes L, Eveson J, Reichart P (2005) World Health Organization pathology and genetics of head and neck tumours, 1st edn. WHO, Lyon","edition":"1"},{"key":"4008_CR13","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/S1079-2104(05)80201-X","volume":"80","author":"LM Abbey","year":"2015","unstructured":"Abbey LM, Kaugars GE, Gunsolley JC, Burns JC, Page DG, Svirsky JA et al (2015) Intraexaminer and interexaminer reliability in the diagnosis of oral epithelial dysplasia. Oral Surgery Oral Med Oral Pathol Oral Radiol Endodontol 80:188\u2013191. https:\/\/doi.org\/10.1016\/S1079-2104(05)80201-X","journal-title":"Oral Surgery Oral Med Oral Pathol Oral Radiol Endodontol"},{"key":"4008_CR14","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/s1368-8375(01)00050-1","volume":"38","author":"R K\u00fcffer","year":"2002","unstructured":"K\u00fcffer R, Lombardi T (2002) Premalignant lesions of the oral mucosa. A discussion about the place of oral intraepithelial neoplasia (OIN). Oral Oncol. 38:125\u201330. https:\/\/doi.org\/10.1016\/s1368-8375(01)00050-1","journal-title":"Oral Oncol."},{"key":"4008_CR15","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.oraloncology.2005.12.014","volume":"42","author":"O Kujan","year":"2006","unstructured":"Kujan O, Oliver RJ, Khattab A, Roberts SA, Thakker N, Sloan P (2006) Evaluation of a new binary system of grading oral epithelial dysplasia for prediction of malignant transformation. Oral Oncol 42:987\u2013993. https:\/\/doi.org\/10.1016\/j.oraloncology.2005.12.014","journal-title":"Oral Oncol"},{"key":"4008_CR16","doi-asserted-by":"publisher","first-page":"261","DOI":"10.4103\/0973-029X.185928","volume":"20","author":"L Krishnan","year":"2016","unstructured":"Krishnan L, Karpagaselvi K, Kumarswamy J, Sudheendra U, Santosh K, Patil A (2016) Inter- and intra-observer variability in three grading systems for oral epithelial dysplasia. J Oral Maxillofac Pathol 20:261. https:\/\/doi.org\/10.4103\/0973-029X.185928","journal-title":"J Oral Maxillofac Pathol"},{"key":"4008_CR17","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.1007\/s00405-020-06036-1","volume":"277","author":"F Yan","year":"2020","unstructured":"Yan F, Reddy PD, Nguyen SA, Chi AC, Neville BW, Day TA (2020) Grading systems of oral cavity pre-malignancy: a systematic review and meta-analysis. Eur Arch Oto-Rhino-Laryngol 277:2967\u20132976. https:\/\/doi.org\/10.1007\/s00405-020-06036-1","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"key":"4008_CR18","doi-asserted-by":"publisher","unstructured":"Page M, McKenzie J, Bossuyt P, Boutron I, Hoffman T, Mulrow C et al (2020) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. MetaArXiv Prepr 2020. https:\/\/doi.org\/10.31222\/osf.io\/v7gm2","DOI":"10.31222\/osf.io\/v7gm2"},{"key":"4008_CR19","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","volume":"5","author":"M Ouzzani","year":"2016","unstructured":"Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A (2016) Rayyan\u2014a web and mobile app for systematic reviews. Syst Rev 5:210. https:\/\/doi.org\/10.1186\/s13643-016-0384-4","journal-title":"Syst Rev"},{"key":"4008_CR20","unstructured":"Sch\u00fcnemann HJ, Oxman AD, Vist GE, Higgins JPT, Deeks JJ, Glasziou P et al (2011) Interpreting results and drawing conclusions. In: Higgins J, Green S (eds) Cochrane handbook for systematic reviews of interventions. The Cochrane Collaboration; Chapter 12.2.1: The GRADE Approach, Chichester"},{"key":"4008_CR21","doi-asserted-by":"publisher","first-page":"123","DOI":"10.15171\/ijhpm.2014.71","volume":"3","author":"Z Munn","year":"2014","unstructured":"Munn Z, Moola S, Riitano D, Lisy K (2014) The development of a critical appraisal tool for use in systematic reviews addressing questions of prevalence. Int J Heal Policy Manag 3:123\u20138. https:\/\/doi.org\/10.15171\/ijhpm.2014.71","journal-title":"Int J Heal Policy Manag"},{"key":"4008_CR22","doi-asserted-by":"publisher","first-page":"4563","DOI":"10.1007\/s00784-020-03322-4","volume":"24","author":"PR Jayasooriya","year":"2020","unstructured":"Jayasooriya PR, Dayaratne K, Dissanayake UB, Warnakulasuriya S (2020) Malignant transformation of oral leukoplakia: a follow-up study. Clin Oral Investig 24:4563\u20134569. https:\/\/doi.org\/10.1007\/s00784-020-03322-4","journal-title":"Clin Oral Investig"},{"key":"4008_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/809248","volume":"2013","author":"A Diajil","year":"2013","unstructured":"Diajil A, Robinson CM, Sloan P, Thomson PJ (2013) Clinical outcome following oral potentially malignant disorder treatment: a 100 patient cohort study. Int J Dent 2013:1\u20138. https:\/\/doi.org\/10.1155\/2013\/809248","journal-title":"Int J Dent"},{"key":"4008_CR24","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.oooo.2013.09.017","volume":"117","author":"F Dost","year":"2014","unstructured":"Dost F, L\u00ea Cao K, Ford PJ, Ades C, Farah CS (2014) Malignant transformation of oral epithelial dysplasia: a real-world evaluation of histopathologic grading. Oral Surg Oral Med Oral Pathol Oral Radiol 117:343\u2013352. https:\/\/doi.org\/10.1016\/j.oooo.2013.09.017","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"4008_CR25","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1111\/j.1600-0714.2011.01033.x","volume":"40","author":"WM Tilakaratne","year":"2011","unstructured":"Tilakaratne WM, Sherriff M, Morgan PR, Odell EW (2011) Grading oral epithelial dysplasia: analysis of individual features. J Oral Pathol Med 40:533\u2013540. https:\/\/doi.org\/10.1111\/j.1600-0714.2011.01033.x","journal-title":"J Oral Pathol Med"},{"key":"4008_CR26","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.oooo.2015.05.023","volume":"120","author":"PM Speight","year":"2015","unstructured":"Speight PM, Abram TJ, Floriano PN, James R, Vick J, Thornhill MH et al (2015) Interobserver agreement in dysplasia grading: toward an enhanced gold standard for clinical pathology trials. Oral Surg Oral Med Oral Pathol Oral Radiol 120:474-482.e2. https:\/\/doi.org\/10.1016\/j.oooo.2015.05.023","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"4008_CR27","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1111\/jop.13056","volume":"49","author":"K Ranganathan","year":"2020","unstructured":"Ranganathan K, Kavitha L, Sharada P, Bavle RM, Rao RS, Pattanshetty SM et al (2020) Intra-observer and inter-observer variability in two grading systems for oral epithelial dysplasia: a multi-centre study in India. J Oral Pathol Med. 49:948\u201355. https:\/\/doi.org\/10.1111\/jop.13056","journal-title":"J Oral Pathol Med."},{"key":"4008_CR28","doi-asserted-by":"publisher","first-page":"639","DOI":"10.2471\/BLT.16.187468","volume":"95","author":"CS Kosack","year":"2017","unstructured":"Kosack CS, Page A-L, Klatser PR (2017) A guide to aid the selection of diagnostic tests. Bull World Health Organ 95:639\u2013645. https:\/\/doi.org\/10.2471\/BLT.16.187468","journal-title":"Bull World Health Organ"},{"key":"4008_CR29","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1002\/hed.21131","volume":"31","author":"HM Mehanna","year":"2009","unstructured":"Mehanna HM, Rattay T, Smith J, McConkey CC (2009) Treatment and follow-up of oral dysplasia \u2013 a systematic review and meta-analysis. Head Neck 31:1600\u20139. https:\/\/doi.org\/10.1002\/hed.21131","journal-title":"Head Neck"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-04008-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-021-04008-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-04008-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T18:16:25Z","timestamp":1646072185000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-021-04008-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,29]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["4008"],"URL":"https:\/\/doi.org\/10.1007\/s00784-021-04008-1","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,29]]},"assertion":[{"value":"22 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors. For this type of study, formal consent is not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}