{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:43:55Z","timestamp":1791902635607,"version":"4.3.4"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:00:00Z","timestamp":1633651200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:00:00Z","timestamp":1633651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objective of this study was to examine the association between the oral microbiome and pregnancy outcomes, specifically healthy or preterm low birth weight (PLBW) in individuals with and without periodontal disease (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>In this prospective clinical trial, we recruited 186 pregnant women, 17 of whom exhibited PD and delivered PLBW infants (PD-PLBW group). Of the remaining women, 155 presented PD and delivered healthy infants; 18 of these subjects with similar periodontal condition and age matched to the PD-PLBW group, and they became the PD-HD group. From the total group, 11 women exhibited healthy gingiva and had a healthy delivery (HD) and healthy infants (H-HD group), and 3 exhibited healthy gingiva and delivered PLBW infants (H-PLBW group). Periodontal parameters were recorded, and subgingival plaque and serum were collected during 26\u201328 gestational weeks. For the plaque samples, microbial abundance and diversity were accessed by 16S rRNA sequencing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Women with PD showed an enrichment in the genus\n                      <jats:italic>Porphyromonas<\/jats:italic>\n                      ,\n                      <jats:italic>Treponema<\/jats:italic>\n                      , and\n                      <jats:italic>Filifactor<\/jats:italic>\n                      , whereas women with healthy gingiva showed an enrichment in\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      ,\n                      <jats:italic>Actinomyces<\/jats:italic>\n                      , and\n                      <jats:italic>Corynebacterium<\/jats:italic>\n                      , independently of the birth status. Although no significant difference was found in the beta diversity between the 4 groups, women that had PLBW infants presented a significantly lower abundance of the genus\n                      <jats:italic>Neisseria<\/jats:italic>\n                      , independently of PD status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Lower levels of\n                      <jats:italic>Neisseria<\/jats:italic>\n                      align with preterm low birth weight in pregnant women, whereas a higher abundance of\n                      <jats:italic>Treponema, Porphyromonas<\/jats:italic>\n                      ,\n                      <jats:italic>Fretibacterium<\/jats:italic>\n                      , and\n                      <jats:italic>Filifactor<\/jats:italic>\n                      and a lower abundance of\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      may contribute to periodontal disease during pregnancy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>\n                      The oral commensal\n                      <jats:italic>Neisseria<\/jats:italic>\n                      have potential in the prediction of PLBW.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-021-04214-x","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T19:14:47Z","timestamp":1633720487000},"page":"2465-2478","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Clinical study showing a lower abundance of Neisseria in the oral microbiome aligns with low birth weight pregnancy outcomes"],"prefix":"10.1007","volume":"26","author":[{"given":"Changchang","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyi","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Radaic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanhong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1330-0654","authenticated-orcid":false,"given":"Yvonne","family":"Kapila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,8]]},"reference":[{"key":"4214_CR1","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/s41579-018-0089-x","volume":"16","author":"RJ Lamont","year":"2018","unstructured":"Lamont RJ, Koo H, Hajishengallis G (2018) The oral microbiota: dynamic communities and host interactions. Nat Rev Microbiol 16:745\u2013759. https:\/\/doi.org\/10.1038\/s41579-018-0089-x","journal-title":"Nat Rev Microbiol"},{"key":"4214_CR2","doi-asserted-by":"crossref","unstructured":"Allan Radaic YK (2021) The oralome and its dysbiosis: new insights into oral microbiome-host interaction. Computational Struct Biotechnol","DOI":"10.1016\/j.csbj.2021.02.010"},{"key":"4214_CR3","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/j.2041-1014.2012.00663.x","volume":"27","author":"G Hajishengallis","year":"2012","unstructured":"Hajishengallis G, Lamont RJ (2012) Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology. Mol Oral Microbiol 27:409\u2013419. https:\/\/doi.org\/10.1111\/j.2041-1014.2012.00663.x","journal-title":"Mol Oral Microbiol"},{"key":"4214_CR4","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1177\/0022034514528212","volume":"93","author":"Y Jiao","year":"2014","unstructured":"Jiao Y, Hasegawa M, Inohara N (2014) The role of oral pathobionts in dysbiosis during periodontitis development. J Dent Res 93:539\u2013546. https:\/\/doi.org\/10.1177\/0022034514528212","journal-title":"J Dent Res"},{"key":"4214_CR5","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.tem.2015.03.001","volume":"26","author":"KE Kholy","year":"2015","unstructured":"Kholy KE, Genco RJ, Van Dyke TE (2015) Oral infections and cardiovascular disease. Trends Endocrinol Metab 26:315\u2013321. https:\/\/doi.org\/10.1016\/j.tem.2015.03.001","journal-title":"Trends Endocrinol Metab"},{"key":"4214_CR6","doi-asserted-by":"publisher","unstructured":"Ohlrich EJ, Cullinan MP, Leichter JW (2010) Diabetes, periodontitis, and the subgingival microbiota. J Oral Microbiol 2, doi: https:\/\/doi.org\/10.3402\/jom.v2i0.5818","DOI":"10.3402\/jom.v2i0.5818"},{"key":"4214_CR7","doi-asserted-by":"publisher","first-page":"237ra265","DOI":"10.1126\/scitranslmed.3008599","volume":"6","author":"K Aagaard","year":"2014","unstructured":"Aagaard K et al (2014) The placenta harbors a unique microbiome. Sci Transl Med 6:237ra265. https:\/\/doi.org\/10.1126\/scitranslmed.3008599","journal-title":"Sci Transl Med"},{"key":"4214_CR8","doi-asserted-by":"publisher","first-page":"551","DOI":"10.2147\/IJWH.S142730","volume":"9","author":"CM Cobb","year":"2017","unstructured":"Cobb CM et al (2017) The oral microbiome and adverse pregnancy outcomes. Int J Womens Health 9:551\u2013559. https:\/\/doi.org\/10.2147\/IJWH.S142730","journal-title":"Int J Womens Health"},{"issue":"83","key":"4214_CR9","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1111\/prd.12295","volume":"2000","author":"E Figuero","year":"2020","unstructured":"Figuero E, Han YW, Furuichi Y (2020) Periodontal diseases and adverse pregnancy outcomes: mechanisms. Periodontol 2000(83):175\u2013188. https:\/\/doi.org\/10.1111\/prd.12295","journal-title":"Periodontol"},{"issue":"83","key":"4214_CR10","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/prd.12294","volume":"2000","author":"YA Bobetsis","year":"2020","unstructured":"Bobetsis YA, Graziani F, Gursoy M, Madianos PN (2020) Periodontal disease and adverse pregnancy outcomes. Periodontol 2000(83):154\u2013174. https:\/\/doi.org\/10.1111\/prd.12294","journal-title":"Periodontol"},{"key":"4214_CR11","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1177\/0022034513487559","volume":"92","author":"YW Han","year":"2013","unstructured":"Han YW, Wang X (2013) Mobile microbiome: oral bacteria in extra-oral infections and inflammation. J Dent Res 92:485\u2013491. https:\/\/doi.org\/10.1177\/0022034513487559","journal-title":"J Dent Res"},{"key":"4214_CR12","doi-asserted-by":"publisher","unstructured":"Ye C et al (2020) The periodontopathic bacteria in placenta, saliva and subgingival plaque of threatened preterm labor and preterm low birth weight cases: a longitudinal study in Japanese pregnant women. Clin Oral Investig. https:\/\/doi.org\/10.1007\/s00784-020-03287-4","DOI":"10.1007\/s00784-020-03287-4"},{"key":"4214_CR13","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/j.1600-051x.1998.tb02419.x","volume":"25","author":"SS Socransky","year":"1998","unstructured":"Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr (1998) Microbial complexes in subgingival plaque. J Clin Periodontol 25:134\u2013144. https:\/\/doi.org\/10.1111\/j.1600-051x.1998.tb02419.x","journal-title":"J Clin Periodontol"},{"key":"4214_CR14","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3389\/fcimb.2015.00069","volume":"5","author":"A Salminen","year":"2015","unstructured":"Salminen A et al (2015) Quantitative PCR analysis of salivary pathogen burden in periodontitis. Front Cell Infect Microbiol 5:69. https:\/\/doi.org\/10.3389\/fcimb.2015.00069","journal-title":"Front Cell Infect Microbiol"},{"key":"4214_CR15","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s00404-011-2012-9","volume":"285","author":"P Swati","year":"2012","unstructured":"Swati P et al (2012) Simultaneous detection of periodontal pathogens in subgingival plaque and placenta of women with hypertension in pregnancy. Arch Gynecol Obstet 285:613\u2013619. https:\/\/doi.org\/10.1007\/s00404-011-2012-9","journal-title":"Arch Gynecol Obstet"},{"key":"4214_CR16","doi-asserted-by":"publisher","first-page":"553","DOI":"10.3109\/00016357.2012.697576","volume":"71","author":"E Ercan","year":"2013","unstructured":"Ercan E et al (2013) Evaluation of periodontal pathogens in amniotic fluid and the role of periodontal disease in pre-term birth and low birth weight. Acta Odontol Scand 71:553\u2013559. https:\/\/doi.org\/10.3109\/00016357.2012.697576","journal-title":"Acta Odontol Scand"},{"key":"4214_CR17","doi-asserted-by":"publisher","first-page":"e56131","DOI":"10.1371\/journal.pone.0056131","volume":"8","author":"X Wang","year":"2013","unstructured":"Wang X et al (2013) Comparative microbial analysis of paired amniotic fluid and cord blood from pregnancies complicated by preterm birth and early-onset neonatal sepsis. PLoS One 8:e56131. https:\/\/doi.org\/10.1371\/journal.pone.0056131","journal-title":"PLoS One"},{"key":"4214_CR18","doi-asserted-by":"publisher","first-page":"e0137249","DOI":"10.1371\/journal.pone.0137249","volume":"10","author":"M Ao","year":"2015","unstructured":"Ao M et al (2015) Dental infection of Porphyromonas gingivalis induces preterm birth in mice. PLoS One 10:e0137249. https:\/\/doi.org\/10.1371\/journal.pone.0137249","journal-title":"PLoS One"},{"key":"4214_CR19","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1177\/0022034515583531","volume":"94","author":"OJ Park","year":"2015","unstructured":"Park OJ et al (2015) Pyrosequencing analysis of subgingival microbiota in distinct periodontal conditions. J Dent Res 94:921\u2013927. https:\/\/doi.org\/10.1177\/0022034515583531","journal-title":"J Dent Res"},{"key":"4214_CR20","doi-asserted-by":"publisher","first-page":"e0127077","DOI":"10.1371\/journal.pone.0127077","volume":"10","author":"BY Hong","year":"2015","unstructured":"Hong BY et al (2015) Microbiome profiles in periodontitis in relation to host and disease characteristics. PLoS One 10:e0127077. https:\/\/doi.org\/10.1371\/journal.pone.0127077","journal-title":"PLoS One"},{"key":"4214_CR21","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3389\/fcimb.2018.00024","volume":"8","author":"W Lin","year":"2018","unstructured":"Lin W et al (2018) Ecological shifts of supragingival microbiota in association with pregnancy. Front Cell Infect Microbiol 8:24. https:\/\/doi.org\/10.3389\/fcimb.2018.00024","journal-title":"Front Cell Infect Microbiol"},{"key":"4214_CR22","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1080\/14767058.2016.1186636","volume":"30","author":"Y Chen","year":"2017","unstructured":"Chen Y, Wu L, Zou L, Li G, Zhang W (2017) Update on the birth weight standard and its diagnostic value in small for gestational age (SGA) infants in China. J Matern Fetal Neonatal Med 30:801\u2013807. https:\/\/doi.org\/10.1080\/14767058.2016.1186636","journal-title":"J Matern Fetal Neonatal Med"},{"key":"4214_CR23","doi-asserted-by":"publisher","first-page":"623427","DOI":"10.1155\/2015\/623427","volume":"2015","author":"M Wu","year":"2015","unstructured":"Wu M, Chen SW, Jiang SY (2015) Relationship between gingival inflammation and pregnancy. Mediators Inflamm 2015:623427. https:\/\/doi.org\/10.1155\/2015\/623427","journal-title":"Mediators Inflamm"},{"issue":"6","key":"4214_CR24","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1600-0757.1994.tb00028.x","volume":"2000","author":"S Amar","year":"1994","unstructured":"Amar S, Chung KM (1994) Influence of hormonal variation on the periodontium in women. Periodontol 2000(6):79\u201387. https:\/\/doi.org\/10.1111\/j.1600-0757.1994.tb00028.x","journal-title":"Periodontol"},{"key":"4214_CR25","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1742-4755-9-3","volume":"9","author":"M Vogt","year":"2012","unstructured":"Vogt M, Sallum AW, Cecatti JG, Morais SS (2012) Factors associated with the prevalence of periodontal disease in low-risk pregnant women. Reprod Health 9:3. https:\/\/doi.org\/10.1186\/1742-4755-9-3","journal-title":"Reprod Health"},{"key":"4214_CR26","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1111\/j.1600-051X.2005.00703.x","volume":"32","author":"KL Moss","year":"2005","unstructured":"Moss KL, Beck JD, Offenbacher S (2005) Clinical risk factors associated with incidence and progression of periodontal conditions in pregnant women. J Clin Periodontol 32:492\u2013498. https:\/\/doi.org\/10.1111\/j.1600-051X.2005.00703.x","journal-title":"J Clin Periodontol"},{"key":"4214_CR27","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1046\/j.1365-2842.2003.01058.x","volume":"30","author":"DQ Taani","year":"2003","unstructured":"Taani DQ, Habashneh R, Hammad MM, Batieha A (2003) The periodontal status of pregnant women and its relationship with socio-demographic and clinical variables. J Oral Rehabil 30:440\u2013445. https:\/\/doi.org\/10.1046\/j.1365-2842.2003.01058.x","journal-title":"J Oral Rehabil"},{"key":"4214_CR28","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1177\/002203450208100113","volume":"81","author":"NJ Lopez","year":"2002","unstructured":"Lopez NJ, Smith PC, Gutierrez J (2002) Higher risk of preterm birth and low birth weight in women with periodontal disease. J Dent Res 81:58\u201363. https:\/\/doi.org\/10.1177\/002203450208100113","journal-title":"J Dent Res"},{"key":"4214_CR29","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1902\/jop.1959.30.1.51","volume":"30","author":"SP Ramfjord","year":"1959","unstructured":"Ramfjord SP (1959) Indices for prevalence and incidence of periodontal disease. J Periodontol 30:51\u201359","journal-title":"J Periodontol"},{"key":"4214_CR30","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","volume":"30","author":"AM Bolger","year":"2014","unstructured":"Bolger AM, Lohse M, Usadel B (2014) Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics 30:2114\u20132120. https:\/\/doi.org\/10.1093\/bioinformatics\/btu170","journal-title":"Bioinformatics"},{"key":"4214_CR31","doi-asserted-by":"publisher","first-page":"2860","DOI":"10.1038\/s41598-017-03066-4","volume":"7","author":"LF Gomez-Arango","year":"2017","unstructured":"Gomez-Arango LF et al (2017) Contributions of the maternal oral and gut microbiome to placental microbial colonization in overweight and obese pregnant women. Sci Rep 7:2860. https:\/\/doi.org\/10.1038\/s41598-017-03066-4","journal-title":"Sci Rep"},{"issue":"Suppl 14","key":"4214_CR32","doi-asserted-by":"publisher","first-page":"S181","DOI":"10.1111\/jcpe.12063","volume":"40","author":"M Ide","year":"2013","unstructured":"Ide M, Papapanou PN (2013) Epidemiology of association between maternal periodontal disease and adverse pregnancy outcomes--systematic review. J Clin Periodontol 40(Suppl 14):S181\u2013S194. https:\/\/doi.org\/10.1111\/jcpe.12063","journal-title":"J Clin Periodontol"},{"key":"4214_CR33","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1902\/jop.1996.67.10s.1103","volume":"67","author":"S Offenbacher","year":"1996","unstructured":"Offenbacher S et al (1996) Periodontal infection as a possible risk factor for preterm low birth weight. J Periodontol 67:1103\u20131113. https:\/\/doi.org\/10.1902\/jop.1996.67.10s.1103","journal-title":"J Periodontol"},{"key":"4214_CR34","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1902\/annals.1998.3.1.233","volume":"3","author":"S Offenbacher","year":"1998","unstructured":"Offenbacher S et al (1998) Potential pathogenic mechanisms of periodontitis associated pregnancy complications. Ann Periodontol 3:233\u2013250. https:\/\/doi.org\/10.1902\/annals.1998.3.1.233","journal-title":"Ann Periodontol"},{"key":"4214_CR35","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1902\/jop.2010.090667","volume":"81","author":"JI Ryu","year":"2010","unstructured":"Ryu JI et al (2010) Health behaviors, periodontal conditions, and periodontal pathogens in spontaneous preterm birth: a case-control study in Korea. J Periodontol 81:855\u2013863. https:\/\/doi.org\/10.1902\/jop.2010.090667","journal-title":"J Periodontol"},{"key":"4214_CR36","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s00404-013-2741-z","volume":"288","author":"C Ye","year":"2013","unstructured":"Ye C et al (2013) The anti-phospholipid antibody-dependent and independent effects of periodontopathic bacteria on threatened preterm labor and preterm birth. Arch Gynecol Obstet 288:65\u201372. https:\/\/doi.org\/10.1007\/s00404-013-2741-z","journal-title":"Arch Gynecol Obstet"},{"key":"4214_CR37","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1111\/omi.12227","volume":"33","author":"S Liang","year":"2018","unstructured":"Liang S et al (2018) Periodontal infection with Porphyromonas gingivalis induces preterm birth and lower birth weight in rats. Mol Oral Microbiol 33:312\u2013321. https:\/\/doi.org\/10.1111\/omi.12227","journal-title":"Mol Oral Microbiol"},{"key":"4214_CR38","doi-asserted-by":"publisher","first-page":"3282","DOI":"10.1099\/mic.0.043174-0","volume":"156","author":"M Contreras","year":"2010","unstructured":"Contreras M et al (2010) The bacterial microbiota in the oral mucosa of rural Amerindians. Microbiology (Reading) 156:3282\u20133287. https:\/\/doi.org\/10.1099\/mic.0.043174-0","journal-title":"Microbiology (Reading)"},{"key":"4214_CR39","doi-asserted-by":"publisher","first-page":"201","DOI":"10.2334\/josnusd.16-0856","volume":"59","author":"Y Yamashita","year":"2017","unstructured":"Yamashita Y, Takeshita T (2017) The oral microbiome and human health. J Oral Sci 59:201\u2013206. https:\/\/doi.org\/10.2334\/josnusd.16-0856","journal-title":"J Oral Sci"},{"key":"4214_CR40","doi-asserted-by":"publisher","unstructured":"Meuric V et al. (2017) Signature of microbial dysbiosis in periodontitis. Appl Environ Microbiol 83, doi:https:\/\/doi.org\/10.1128\/AEM.00462-17","DOI":"10.1128\/AEM.00462-17"},{"key":"4214_CR41","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1755-8794-4-22","volume":"4","author":"W Crielaard","year":"2011","unstructured":"Crielaard W et al (2011) Exploring the oral microbiota of children at various developmental stages of their dentition in the relation to their oral health. BMC Med Genomics 4:22. https:\/\/doi.org\/10.1186\/1755-8794-4-22","journal-title":"BMC Med Genomics"},{"key":"4214_CR42","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1186\/1471-2180-9-259","volume":"9","author":"E Zaura","year":"2009","unstructured":"Zaura E, Keijser BJ, Huse SM, Crielaard W (2009) Defining the healthy \u201ccore microbiome\u201d of oral microbial communities. BMC Microbiol 9:259. https:\/\/doi.org\/10.1186\/1471-2180-9-259","journal-title":"BMC Microbiol"},{"key":"4214_CR43","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.micpath.2015.09.009","volume":"94","author":"AP Vieira Colombo","year":"2016","unstructured":"Vieira Colombo AP, Magalhaes CB, Hartenbach FA (2016) Martins do Souto, R. & Maciel da Silva-Boghossian, C. Periodontal-disease-associated biofilm: a reservoir for pathogens of medical importance. Microb Pathog 94:27\u201334. https:\/\/doi.org\/10.1016\/j.micpath.2015.09.009","journal-title":"Microb Pathog"},{"key":"4214_CR44","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/dnares\/dst037","volume":"21","author":"HS Said","year":"2014","unstructured":"Said HS et al (2014) Dysbiosis of salivary microbiota in inflammatory bowel disease and its association with oral immunological biomarkers. DNA Res 21:15\u201325. https:\/\/doi.org\/10.1093\/dnares\/dst037","journal-title":"DNA Res"},{"key":"4214_CR45","doi-asserted-by":"publisher","first-page":"6777","DOI":"10.1158\/0008-5472.CAN-17-1296","volume":"77","author":"BA Peters","year":"2017","unstructured":"Peters BA et al (2017) Oral microbiome composition reflects prospective risk for esophageal cancers. Cancer Res 77:6777\u20136787. https:\/\/doi.org\/10.1158\/0008-5472.CAN-17-1296","journal-title":"Cancer Res"},{"key":"4214_CR46","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1136\/gutjnl-2011-300784","volume":"61","author":"JJ Farrell","year":"2012","unstructured":"Farrell JJ et al (2012) Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer. Gut 61:582\u2013588. https:\/\/doi.org\/10.1136\/gutjnl-2011-300784","journal-title":"Gut"},{"key":"4214_CR47","doi-asserted-by":"publisher","first-page":"e5821","DOI":"10.1097\/MD.0000000000005821","volume":"96","author":"M Noguera-Julian","year":"2017","unstructured":"Noguera-Julian M et al (2017) Oral microbiome in HIV-associated periodontitis. Med (Baltimore) 96:e5821. https:\/\/doi.org\/10.1097\/MD.0000000000005821","journal-title":"Med (Baltimore)"},{"key":"4214_CR48","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.chom.2019.07.003","volume":"26","author":"WJ Kim","year":"2019","unstructured":"Kim WJ et al (2019) Commensal Neisseria kill Neisseria gonorrhoeae through a DNA-dependent mechanism. Cell Host Microbe 26:228\u2013239 e228. https:\/\/doi.org\/10.1016\/j.chom.2019.07.003","journal-title":"Cell Host Microbe"},{"key":"4214_CR49","doi-asserted-by":"publisher","first-page":"30388","DOI":"10.1038\/srep30388","volume":"6","author":"AD Paropkari","year":"2016","unstructured":"Paropkari AD, Leblebicioglu B, Christian LM, Kumar PS (2016) Smoking, pregnancy and the subgingival microbiome. Sci Rep 6:30388. https:\/\/doi.org\/10.1038\/srep30388","journal-title":"Sci Rep"},{"key":"4214_CR50","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/j.1399-302X.2007.00391.x","volume":"23","author":"M Yokoyama","year":"2008","unstructured":"Yokoyama M et al (2008) Relationship between Campylobacter rectus and periodontal status during pregnancy. Oral Microbiol Immunol 23:55\u201359. https:\/\/doi.org\/10.1111\/j.1399-302X.2007.00391.x","journal-title":"Oral Microbiol Immunol"},{"key":"4214_CR51","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.3389\/fmicb.2018.02360","volume":"9","author":"P Balan","year":"2018","unstructured":"Balan P et al (2018) Keystone species in pregnancy gingivitis: a snapshot of oral microbiome during pregnancy and postpartum period. Front Microbiol 9:2360. https:\/\/doi.org\/10.3389\/fmicb.2018.02360","journal-title":"Front Microbiol"},{"key":"4214_CR52","doi-asserted-by":"publisher","first-page":"15807","DOI":"10.1038\/s41598-020-72807-9","volume":"10","author":"C Ye","year":"2020","unstructured":"Ye C et al (2020) Unculturable and culturable periodontal-related bacteria are associated with periodontal inflammation during pregnancy and with preterm low birth weight delivery. Sci Rep 10:15807. https:\/\/doi.org\/10.1038\/s41598-020-72807-9","journal-title":"Sci Rep"},{"key":"4214_CR53","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.jogn.2018.12.003","volume":"48","author":"I Yang","year":"2019","unstructured":"Yang I, Knight AK, Dunlop AL, Corwin EJ (2019) Characterizing the subgingival microbiome of pregnant African American women. J Obstet Gynecol Neonatal Nurs 48:140\u2013152. https:\/\/doi.org\/10.1016\/j.jogn.2018.12.003","journal-title":"J Obstet Gynecol Neonatal Nurs"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-04214-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-021-04214-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-04214-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T00:14:19Z","timestamp":1646439259000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-021-04214-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,8]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["4214"],"URL":"https:\/\/doi.org\/10.1007\/s00784-021-04214-x","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,8]]},"assertion":[{"value":"23 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"A written informed consent was received from each subject who participated in this study in the Department of Periodontology, West China Hospital of Stomatology, Sichuan University. The study was approved by the Institutional Ethics Committee of West China Hospital of Stomatology, Sichuan University (No WCHSIRB-OT-2016-053).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}