{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:50:30Z","timestamp":1783975830549,"version":"3.55.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s00784-021-04257-0","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T11:07:10Z","timestamp":1637838430000},"page":"1121-1135","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The roles of ANRIL polymorphisms in periodontitis: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4260-5978","authenticated-orcid":false,"given":"Ayla","family":"\u00d6zt\u00fcrk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet O\u011fuz","family":"Ada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,25]]},"reference":[{"key":"4257_CR1","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1177\/0022034519842510","volume":"98","author":"L Nibali","year":"2019","unstructured":"Nibali L, Bayliss-Chapman J, Almofareh S, Zhou Y, Divaris KVieira A (2019) What is the heritability of periodontitis? A systematic review. J Dent Res 98:632\u2013641","journal-title":"J Dent Res"},{"key":"4257_CR2","doi-asserted-by":"crossref","unstructured":"Loos BG, van Dyke TE (2000) The role of inflammation and genetics in periodontal disease. Periodontol 2020(83):26\u201339","DOI":"10.1111\/prd.12297"},{"issue":"5","key":"4257_CR3","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/j.1600-0757.1994.tb00020.x","volume":"2000","author":"AD Haffajee","year":"1994","unstructured":"Haffajee AD, Socransky SS (1994) Microbial etiological agents of destructive periodontal diseases. Periodontol 2000(5):78\u2013111","journal-title":"Periodontol"},{"key":"4257_CR4","doi-asserted-by":"crossref","unstructured":"Shaddox LM, Morford LA, Nibali L (2000) Periodontal health and disease: the contribution of genetics. Periodontol 2021(85):161\u2013181","DOI":"10.1111\/prd.12357"},{"key":"4257_CR5","doi-asserted-by":"crossref","unstructured":"Morelli T, Agler CS, Divaris K (2000) Genomics of periodontal disease and tooth morbidity. Periodontol 2020(82):143\u2013156","DOI":"10.1111\/prd.12320"},{"issue":"32","key":"4257_CR6","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1046\/j.0906-6713.2002.03202.x","volume":"2000","author":"ME Nunn","year":"2003","unstructured":"Nunn ME (2003) Understanding the etiology of periodontitis: an overview of periodontal risk factors. Periodontol 2000(32):11\u201323","journal-title":"Periodontol"},{"issue":"29","key":"4257_CR7","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1034\/j.1600-0757.2002.290109.x","volume":"2000","author":"JM Albandar","year":"2002","unstructured":"Albandar JM (2002) Global risk factors and risk indicators for periodontal diseases. Periodontol 2000(29):177\u2013206","journal-title":"Periodontol"},{"key":"4257_CR8","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1902\/jop.2000.71.11.1699","volume":"71","author":"BS Michalowicz","year":"2000","unstructured":"Michalowicz BS, Diehl SR, Gunsolley JC, Sparks BS, Brooks CN, Koertge TE, Califano JV, Burmeister JA, Schenkein HA (2000) Evidence of a substantial genetic basis for risk of adult periodontitis. J Periodontol 71:1699\u20131707","journal-title":"J Periodontol"},{"key":"4257_CR9","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1007\/s40496-014-0037-4","volume":"1","author":"ML Laine","year":"2014","unstructured":"Laine ML, Jepsen SLoos BG (2014) Progress in the identification of genetic factors in periodontitis. Current Oral Health Reports 1:272\u2013278","journal-title":"Current Oral Health Reports"},{"key":"4257_CR10","doi-asserted-by":"publisher","first-page":"e1000378","DOI":"10.1371\/journal.pgen.1000378","volume":"5","author":"AS Schaefer","year":"2009","unstructured":"Schaefer AS, Richter GM, Groessner-Schreiber B, Noack B, Nothnagel M, El Mokhtari N-E, Loos BG, Jepsen SSchreiber S (2009) Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis. PLoS Genet 5:e1000378","journal-title":"PLoS Genet"},{"key":"4257_CR11","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1111\/jcpe.12092","volume":"40","author":"AS Schaefer","year":"2013","unstructured":"Schaefer AS, Bochenek G, Manke T, Nothnagel M, Graetz C, Thien A, Jockel-Schneider Y, Harks I, Staufenbiel IWijmenga C (2013) Validation of reported genetic risk factors for periodontitis in a large-scale replication study. J Clin Periodontol 40:563\u2013572","journal-title":"J Clin Periodontol"},{"key":"4257_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2350-11-119","volume":"11","author":"FD Ernst","year":"2010","unstructured":"Ernst FD, Uhr K, Teumer A, Fangh\u00e4nel J, Schulz S, Noack B, Gonzales J, Reichert S, Eickholz PHoltfreter B (2010) Replication of the association of chromosomal region 9p21. 3 with generalized aggressive periodontitis (gAgP) using an independent case-control cohort. BMC Med Genet 11:1\u20139","journal-title":"BMC Med Genet"},{"key":"4257_CR13","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1096\/fj.10-172452","volume":"25","author":"E Pasmant","year":"2011","unstructured":"Pasmant E, Sabbagh A, Vidaud MBi\u00e8che I (2011) ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS. FASEB J 25:444\u2013448","journal-title":"FASEB J"},{"key":"4257_CR14","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1056\/NEJMoa072366","volume":"357","author":"NJ Samani","year":"2007","unstructured":"Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund PWichmann H-E (2007) Genomewide association analysis of coronary artery disease. N Engl J Med 357:443\u2013453","journal-title":"N Engl J Med"},{"key":"4257_CR15","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1126\/science.1142447","volume":"316","author":"R McPherson","year":"2007","unstructured":"McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR, Hinds DA, Pennacchio LA, Tybjaerg-Hansen AFolsom AR (2007) A common allele on chromosome 9 associated with coronary heart disease. Science 316:1488\u20131491","journal-title":"Science"},{"key":"4257_CR16","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1126\/science.1142842","volume":"316","author":"A Helgadottir","year":"2007","unstructured":"Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, Blondal T, Jonasdottir A, Jonasdottir A, Sigurdsson A, Baker APalsson A (2007) A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science 316:1491\u20131493","journal-title":"Science"},{"key":"4257_CR17","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.3390\/ijms14011278","volume":"14","author":"A Congrains","year":"2013","unstructured":"Congrains A, Kamide K, Ohishi MRakugi H (2013) ANRIL: molecular mechanisms and implications in human health. Int J Mol Sci 14:1278\u20131292","journal-title":"Int J Mol Sci"},{"key":"4257_CR18","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1177\/0022034517699786","volume":"96","author":"G Aarabi","year":"2017","unstructured":"Aarabi G, Zeller T, Seedorf H, Reissmann D, Heydecke G, Schaefer ASeedorf U (2017) Genetic susceptibility contributing to periodontal and cardiovascular disease. J Dent Res 96:610\u2013617","journal-title":"J Dent Res"},{"key":"4257_CR19","doi-asserted-by":"publisher","first-page":"4516","DOI":"10.1093\/hmg\/ddt299","volume":"22","author":"G Bochenek","year":"2013","unstructured":"Bochenek G, H\u00e4sler R, El Mokhtari N-E, K\u00f6nig IR, Loos BG, Jepsen S, Rosenstiel P, Schreiber SSchaefer AS (2013) The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10. Hum Mol Genet 22:4516\u20134527","journal-title":"Hum Mol Genet"},{"key":"4257_CR20","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1080\/15476286.2015.1122164","volume":"13","author":"X Zhou","year":"2016","unstructured":"Zhou X, Han X, Wittfeldt A, Sun J, Liu C, Wang X, Gan L-M, Cao HLiang Z (2016) Long non-coding RNA ANRIL regulates inflammatory responses as a novel component of NF-\u03baB pathway. RNA Biol 13:98\u2013108","journal-title":"RNA Biol"},{"key":"4257_CR21","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1136\/jmg.2010.078998","volume":"48","author":"AS Schaefer","year":"2011","unstructured":"Schaefer AS, Richter GM, Dommisch H, Reinartz M, Nothnagel M, Noack B, Laine ML, Folwaczny M, Groessner-Schreiber BLoos BG (2011) CDKN2BAS is associated with periodontitis in different European populations and is activated by bacterial infection. J Med Genet 48:38\u201347","journal-title":"J Med Genet"},{"key":"4257_CR22","doi-asserted-by":"publisher","first-page":"283","DOI":"10.3343\/alm.2015.35.3.283","volume":"35","author":"YH Lee","year":"2015","unstructured":"Lee YH (2015) Meta-analysis of genetic association studies. Ann Lab Med 35:283","journal-title":"Ann Lab Med"},{"key":"4257_CR23","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.jclinepi.2009.06.006","volume":"62","author":"A Liberati","year":"2009","unstructured":"Liberati A, Altman DG, Tetzlaff J, Mulrow C, G\u00f8tzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen JMoher D (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 62:e1\u2013e34","journal-title":"J Clin Epidemiol"},{"key":"4257_CR24","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1111\/jcpe.12128","volume":"40","author":"L Nibali","year":"2013","unstructured":"Nibali L (2013) Suggested guidelines for systematic reviews of periodontal genetic association studies. J Clin Periodontol 40:753\u2013756","journal-title":"J Clin Periodontol"},{"issue":"Suppl 18","key":"4257_CR25","doi-asserted-by":"publisher","first-page":"S52","DOI":"10.1111\/jcpe.12639","volume":"44","author":"L Nibali","year":"2017","unstructured":"Nibali L, Di Iorio A, Tu YK, Vieira AR (2017) Host genetics role in the pathogenesis of periodontal disease and caries. J Clin Periodontol 44(Suppl 18):S52\u2013s78","journal-title":"J Clin Periodontol"},{"key":"4257_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12859-017-1990-4","volume":"18","author":"J Martorell-Marugan","year":"2017","unstructured":"Martorell-Marugan J, Toro-Dominguez D, Alarcon-Riquelme ME, Carmona-Saez P (2017) MetaGenyo: a web tool for meta-analysis of genetic association studies. BMC Bioinformatics 18:1\u20136","journal-title":"BMC Bioinformatics"},{"key":"4257_CR27","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1002\/JPER.18-0071","volume":"90","author":"T Taiete","year":"2019","unstructured":"Taiete T, Casati MZ, Stolf CS, Corr\u00eaa MG, Santamaria MP, Andere NMRB, Coletta RD, Sallum EA, Nociti J\u00fanior FH, Silv\u00e9rio KG (2019) Validation of reported GLT6D1 (rs1537415), IL10 (rs6667202), and ANRIL (rs1333048) single nucleotide polymorphisms for aggressive periodontitis in a Brazilian population. J Periodontol 90:44\u201351","journal-title":"J Periodontol"},{"key":"4257_CR28","first-page":"561","volume":"19","author":"D Chen","year":"2010","unstructured":"Chen D, Feng K, Wang L-M, Zhang T-LZeng C (2010) Correlation between single nucleotide polymorphism and periodontitis susceptibility in Shanghai Chinese patients. Shanghai kou qiang yi xue=. Shanghai J Stomatol 19:561\u2013564","journal-title":"Shanghai J Stomatol"},{"key":"4257_CR29","first-page":"659","volume":"21","author":"D Chen","year":"2012","unstructured":"Chen D, Wei N, Bao X-n, Wang L-m, Zhou C-f, Zhang Y-l, Zhang J (2012) Association of variants in chromosome 9p21. 3 and chronic periodontitis in the han chinese population. Shanghai kou qiang yi xue= Shanghai J Stomatol 21:659\u2013662","journal-title":"Shanghai kou qiang yi xue= Shanghai J Stomatol"},{"key":"4257_CR30","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.gene.2019.06.002","volume":"710","author":"M Mangalarapu","year":"2019","unstructured":"Mangalarapu M, Vinukonda S, Komaravalli PL, Nagula P, Koduganti RR, Korripally PSagurthi SR (2019) Association of CDKN2BAS gene polymorphism with periodontitis and coronary artery disease from South Indian population. Gene 710:324\u2013332","journal-title":"Gene"},{"key":"4257_CR31","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1161\/CIRCGENETICS.114.000554","volume":"8","author":"AS Schaefer","year":"2015","unstructured":"Schaefer AS, Bochenek G, Jochens A, Ellinghaus D, Dommisch H, G\u00fczeldemir-Ak\u00e7akanat E, Graetz C, Harks I, Jockel-Schneider YWeinspach K (2015) Genetic evidence for PLASMINOGEN as a shared genetic risk factor of coronary artery disease and periodontitis. Circ Cardiovasc Genet 8:159\u2013167","journal-title":"Circ Cardiovasc Genet"},{"key":"4257_CR32","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1111\/jre.12555","volume":"53","author":"S Schulz","year":"2018","unstructured":"Schulz S, Seitter L, Werdan K, Hofmann B, Schaller HG, Schlitt AReichert S (2018) Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease. J Periodontal Res 53:714\u2013720","journal-title":"J Periodontal Res"},{"key":"4257_CR33","doi-asserted-by":"publisher","first-page":"e0137335","DOI":"10.1371\/journal.pone.0137335","volume":"10","author":"WJ Teeuw","year":"2015","unstructured":"Teeuw WJ, Laine ML, Bizzarro SLoos BG (2015) A lead ANRIL polymorphism is associated with elevated CRP levels in periodontitis: a pilot case-control study. PLoS One 10:e0137335","journal-title":"PLoS One"},{"key":"4257_CR34","doi-asserted-by":"publisher","first-page":"154932","DOI":"10.1016\/j.cyto.2019.154932","volume":"127","author":"S Reichert","year":"2020","unstructured":"Reichert S, Seitter L, Schaller H-G, Schlitt ASchulz S (2020) ANRIL polymorphisms (rs1333049 and rs3217992) in relation to plasma CRP levels among in-patients with CHD. Cytokine 127:154932","journal-title":"Cytokine"},{"key":"4257_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","volume":"4","author":"GC Armitage","year":"1999","unstructured":"Armitage GC (1999) Development of a classification system for periodontal diseases and conditions. Ann Periodontol 4:1\u20136","journal-title":"Ann Periodontol"},{"key":"4257_CR36","doi-asserted-by":"publisher","first-page":"420","DOI":"10.3389\/fimmu.2019.00420","volume":"10","author":"S Castellanos-Rubio AGhosh","year":"2019","unstructured":"Castellanos-Rubio AGhosh S (2019) Disease-associated SNPs in inflammation-related lncRNAs. Front Immunol 10:420","journal-title":"Front Immunol"},{"key":"4257_CR37","doi-asserted-by":"crossref","unstructured":"Bian M, Yu Y, Li Y, Zhou Z, Wu X, Ye XYu J (2021) Upregulating the expression of LncRNA ANRIL promotes osteogenesis via the miR-7-5p\/IGF-1R Axis in the inflamed periodontal ligament stem cells. Front Cell Developmental Biol 9","DOI":"10.3389\/fcell.2021.604400"},{"key":"4257_CR38","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s13287-020-02105-8","volume":"12","author":"Y Wang","year":"2021","unstructured":"Wang Y, Lv F, Huang L, Zhang H, Li B, Zhou W, Li X, Du Y, Pan YWang R (2021) Human amnion-derived mesenchymal stem cells promote osteogenic differentiation of lipopolysaccharide-induced human bone marrow mesenchymal stem cells via ANRIL\/miR-125a\/APC axis. Stem Cell Res Ther 12:35","journal-title":"Stem Cell Res Ther"},{"key":"4257_CR39","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.ihj.2019.10.004","volume":"71","author":"B Kalpana","year":"2019","unstructured":"Kalpana B, Murthy DK, Balakrishna N (2019) 9p21.3 coronary artery disease risk locus and interferon alpha 21: association study in an Asian Indian population. Indian Heart J 71:476\u2013480","journal-title":"Indian Heart J"},{"key":"4257_CR40","doi-asserted-by":"crossref","unstructured":"Makeeva OA, Sleptsov AA, Kulish EV, Barbarash OL, Mazur AM, Prokhorchuk EB, Chekanov NN, Stepanov VAPuzyrev VP (2015) Genomic study of cardiovascular continuum comorbidity. Acta Naturae (7): 89-99.","DOI":"10.32607\/20758251-2015-7-3-89-99"},{"key":"4257_CR41","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1126\/science.1142364","volume":"316","author":"E Zeggini","year":"2007","unstructured":"Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM (2007) Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316:1336\u20131341","journal-title":"Science"},{"key":"4257_CR42","doi-asserted-by":"crossref","unstructured":"Huang X, Zhang WShao Z (2018) Association between long non-coding RNA polymorphisms and cancer risk: a meta-analysis. Biosci Rep 38","DOI":"10.1042\/BSR20180365"},{"key":"4257_CR43","doi-asserted-by":"publisher","first-page":"e22569","DOI":"10.1097\/MD.0000000000022569","volume":"99","author":"Y-N Zhang","year":"2020","unstructured":"Zhang Y-N, Qiang BFu L-J (2020) Association of ANRIL polymorphisms with coronary artery disease: a systemic meta-analysis. Medicine 99:e22569\u2013e22569","journal-title":"Medicine"},{"key":"4257_CR44","first-page":"e001441","volume":"10","author":"B Schmidt","year":"2017","unstructured":"Schmidt B, Fr\u00f6lich S, Dragano N, Frank M, Eisele L, Pechlivanis S, Forstner AJ, N\u00f6then MM, Mahabadi AA, Erbel R (2017) Socioeconomic status interacts with the genetic effect of a chromosome 9p21. 3 common variant to influence coronary artery calcification and incident coronary events in the Heinz Nixdorf Recall study (risk factors, evaluation of coronary calcium, and lifestyle). Circulation: Cardiovascular. Genetics 10:e001441","journal-title":"Genetics"},{"key":"4257_CR45","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/gm51","volume":"1","author":"K Silander","year":"2009","unstructured":"Silander K, Tang H, Myles S, Jakkula E, Timpson NJ, Cavalli-Sforza LPeltonen L (2009) Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease. Genome Med 1:51","journal-title":"Genome Med"},{"key":"4257_CR46","doi-asserted-by":"publisher","first-page":"e1000899","DOI":"10.1371\/journal.pgen.1000899","volume":"6","author":"MS Cunnington","year":"2010","unstructured":"Cunnington MS, Koref MS, Mayosi BM, Burn JKeavney B (2010) Chromosome 9p21 SNPs associated with multiple disease phenotypes correlate with ANRIL expression. PLoS Genet 6:e1000899","journal-title":"PLoS Genet"},{"key":"4257_CR47","first-page":"29","volume":"394","author":"F Aguilo","year":"2016","unstructured":"Aguilo F, Di Cecilia SWalsh MJ (2016) Long non-coding RNA ANRIL and polycomb in human cancers and cardiovascular disease. Curr Top Microbiol Immunol 394:29\u201339","journal-title":"Curr Top Microbiol Immunol"},{"key":"4257_CR48","doi-asserted-by":"publisher","first-page":"e97522","DOI":"10.1371\/journal.pone.0097522","volume":"9","author":"L Jing","year":"2014","unstructured":"Jing L, Su LRing BZ (2014) Ethnic background and genetic variation in the evaluation of cancer risk: a systematic review. PLoS One 9:e97522","journal-title":"PLoS One"},{"key":"4257_CR49","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1177\/154411130301400605","volume":"14","author":"T Kinane DHart","year":"2003","unstructured":"Kinane DHart T (2003) Genes and gene polymorphisms associated with periodontal disease. Crit Rev Oral Biol Med 14:430\u2013449","journal-title":"Crit Rev Oral Biol Med"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-04257-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-021-04257-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-04257-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T18:50:20Z","timestamp":1675968620000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-021-04257-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,25]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["4257"],"URL":"https:\/\/doi.org\/10.1007\/s00784-021-04257-0","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,25]]},"assertion":[{"value":"6 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Formal consent is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}