{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:50:59Z","timestamp":1784663459876,"version":"3.55.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"japan society for the promotion of science","doi-asserted-by":"publisher","award":["#17K17165"],"award-info":[{"award-number":["#17K17165"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"japan society for the promotion of science","doi-asserted-by":"publisher","award":["#17H04390"],"award-info":[{"award-number":["#17H04390"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"japan society for the promotion of science","doi-asserted-by":"publisher","award":["#20K18600)"],"award-info":[{"award-number":["#20K18600)"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>The FTO gene has been reported as an obesity-associated gene and is also considered a risk gene for osteoarthritis (OA). However, its exact function is unclear, and there is conflicting evidence on the involvement of FTO polymorphisms in OA via obesity. The purpose of this study was to determine the effects of FTO polymorphism rs8044769 alleles on OA in the temporomandibular joint (TMJ), which is minimally affected by body weight.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>A total of 324 TMJs (113 with OA and 211 without OA, serving as controls) from 162 Japanese patients with temporomandibular disorders and undergoing MRI examination were analyzed. Genotyping was conducted, and multivariate analysis was performed after adjusting for the effects of age, sex, body mass index, and TMJ disc abnormalities.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Mean age, BMI, and sex did not differ between the TMJs with OA and the TMJs without OA, but a significant difference was found for positional and dynamic disc abnormalities (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The allele frequency of FTO polymorphisms also differed significantly between the TMJs with OA and the TMJs without OA (<jats:italic>P<\/jats:italic>\u2009=\u20090.011). Moreover, logistic regression analysis showed no significant association between BMI (<jats:italic>P<\/jats:italic>\u2009=\u20090.581) and the occurrence of TMJOA but also indicated that the CC allele of rs8044769 is a risk factor for TMJOA (<jats:italic>P<\/jats:italic>\u2009=\u20090.040).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our results show that rs8044769 in the FTO gene might be involved in TMJOA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>The present study provides a basis for a deeper understanding of the mechanism underlying degenerative skeletal diseases and the more effective selection and development of treatment strategies based on the patients\u2019 genetic characteristics.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-021-04278-9","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T11:02:44Z","timestamp":1637665364000},"page":"2965-2973","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Involvement of an FTO gene polymorphism in the temporomandibular joint osteoarthritis"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0468-7730","authenticated-orcid":false,"given":"Ryota","family":"Takaoka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Kuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Yatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichi","family":"Ishigaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Kayashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Koishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Egusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsutoshi","family":"Nakatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Shimamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"issue":"5855","key":"4278_CR1","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1126\/science.1151710","volume":"318","author":"T Gerken","year":"2007","unstructured":"Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O\u2019Rahilly S, Schofield CJ (2007) The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318(5855):1469\u20131472","journal-title":"Science"},{"issue":"5826","key":"4278_CR2","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1126\/science.1141634","volume":"316","author":"TM Frayling","year":"2007","unstructured":"Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy MI (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316(5826):889\u2013894","journal-title":"Science"},{"issue":"7419","key":"4278_CR3","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/nature11401","volume":"490","author":"J Yang","year":"2012","unstructured":"Yang J, Loos RJ, Powell JE, Medland SE, Speliotes EK, Chasman DI, Rose LM, Thorleifsson G, Steinthorsdottir V, M\u00e4gi R, Waite L, Smith AV, Yerges-Armstrong LM, Monda KL, Hadley D, Mahajan A, Li G, Kapur K, Vitart V, Huffman JE, Wang SR, Palmer C, Esko T, Fischer K, Zhao JH, Demirkan A, Isaacs A, Feitosa MF, Luan J, Heard-Costa NL, White C, Jackson AU, Preuss M, Ziegler A, Eriksson J, Kutalik Z, Frau F, Nolte IM, Van Vliet-Ostaptchouk JV, Hottenga JJ, Jacobs KB, Verweij N, Goel A, Medina-Gomez C, Estrada K, Bragg-Gresham JL, Sanna S, Sidore C, Tyrer J, Teumer A, Prokopenko I, Mangino M, Lindgren CM, Assimes TL, Shuldiner AR, Hui J, Beilby JP, McArdle WL, Hall P, Haritunians T, Zgaga L, Kolcic I, Polasek O, Zemunik T, Oostra BA, Junttila MJ, Gr\u00f6nberg H, Schreiber S, Peters A, Hicks AA, Stephens J, Foad NS, Laitinen J, Pouta A, Kaakinen M, Willemsen G, Vink JM, Wild SH, Navis G, Asselbergs FW, Homuth G, John U, Iribarren C, Harris T, Launer L, Gudnason V, O\u2019Connell JR, Boerwinkle E, Cadby G, Palmer LJ, James AL, Musk AW, Ingelsson E, Psaty BM, Beckmann JS, Waeber G, Vollenweider P, Hayward C, Wright AF, Rudan I, Groop LC, Metspalu A, Khaw KT, van Duijn CM, Borecki IB, Province MA, Wareham NJ, Tardif JC, Huikuri HV, Cupples LA, Atwood LD, Fox CS, Boehnke M, Collins FS, Mohlke KL, Erdmann J, Schunkert H, Hengstenberg C, Stark K, Lorentzon M, Ohlsson C, Cusi D, Staessen JA, Van der Klauw MM, Pramstaller PP, Kathiresan S, Jolley JD, Ripatti S, Jarvelin MR, de Geus EJ, Boomsma DI, Penninx B, Wilson JF, Campbell H, Chanock SJ, van der Harst P, Hamsten A, Watkins H, Hofman A, Witteman JC, Zillikens MC, Uitterlinden AG, Rivadeneira F, Kiemeney LA, Vermeulen SH, Abecasis GR, Schlessinger D, Schipf S, Stumvoll M, T\u00f6njes A, Spector TD, North KE, Lettre G, McCarthy MI, Berndt SI, Heath AC, Madden PA, Nyholt DR, Montgomery GW, Martin NG, McKnight B, Strachan DP, Hill WG, Snieder H, Ridker PM, Thorsteinsdottir U, Stefansson K, Frayling TM, Hirschhorn JN, Goddard ME, Visscher PM (2012) FTO genotype is associated with phenotypic variability of body mass index. Nature 490(7419):267\u2013272","journal-title":"Nature"},{"issue":"4","key":"4278_CR4","doi-asserted-by":"publisher","first-page":"R1185","DOI":"10.1152\/ajpregu.00839.2007","volume":"294","author":"G Stratigopoulos","year":"2008","unstructured":"Stratigopoulos G, Padilla SL, LeDuc CA, Watson E, Hattersley AT, McCarthy MI, Zeltser LM, Chung WK, Leibel RL (2008) Regulation of Fto\/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol 294(4):R1185\u2013R1196","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"9","key":"4278_CR5","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.1242\/dev.120.9.2601","volume":"120","author":"F van der Hoeven","year":"1994","unstructured":"van der Hoeven F, Schimmang T, Volkmann A, Mattei MG, Kyewski B, R\u00fcther U (1994) Programmed cell death is affected in the novel mouse mutant Fused toes (Ft). Development 120(9):2601\u20132607","journal-title":"Development"},{"issue":"4","key":"4278_CR6","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1007\/s00335-001-2142-7","volume":"13","author":"T Peters","year":"2002","unstructured":"Peters T, Ausmeier K, Dildrop R, R\u00fcther U (2002) The mouse Fused toes (Ft) mutation is the result of a 1.6-Mb deletion including the entire Iroquois B gene cluster. Mamm Genome 13(4):186\u20131888","journal-title":"Mamm Genome"},{"issue":"5","key":"4278_CR7","doi-asserted-by":"publisher","first-page":"2062","DOI":"10.1210\/en.2007-1457","volume":"149","author":"R Fredriksson","year":"2008","unstructured":"Fredriksson R, H\u00e4gglund M, Olszewski PK, Stephansson O, Jacobsson JA, Olszewska AM, Levine AS, Lindblom J, Schi\u00f6th HB (2008) The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Endocrinology 149(5):2062\u20132071","journal-title":"Endocrinology"},{"issue":"1","key":"4278_CR8","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1097\/BOR.0000000000000352","volume":"29","author":"SC Warner","year":"2017","unstructured":"Warner SC, Valdes AM (2017) Genetic association studies in osteoarthritis: is it fairytale? Curr Opin Rheumatol 29(1):103\u2013109","journal-title":"Curr Opin Rheumatol"},{"issue":"3","key":"4278_CR9","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.joca.2017.09.009","volume":"26","author":"MJ Peffers","year":"2018","unstructured":"Peffers MJ, Balaskas P, Smagul A (2018) Osteoarthritis year in review 2017: genetics and epigenetics. Osteoarthr Cartil 26(3):304\u2013311","journal-title":"Osteoarthr Cartil"},{"issue":"3","key":"4278_CR10","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.joca.2018.10.004","volume":"27","author":"MA Jeffries","year":"2019","unstructured":"Jeffries MA (2019) Osteoarthritis year in review 2018: genetics and epigenetics. Osteoarthr Cartil 27(3):371\u2013377","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"4278_CR11","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/nrrheum.2010.191","volume":"7","author":"AM Valdes","year":"2011","unstructured":"Valdes AM, Spector TD (2011) Genetic epidemiology of hip and knee osteoarthritis. Nat Rev Rheumatol 7(1):23\u201332","journal-title":"Nat Rev Rheumatol"},{"issue":"9844","key":"4278_CR12","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/S0140-6736(12)60681-3","volume":"380","author":"E Zeggini","year":"2012","unstructured":"Zeggini E, Panoutsopoulou K, Southam L, Rayner NW, Day-Williams AG, Lopes MC, Boraska V, Esko T, Evangelou E, Hoffman A, Houwing-Duistermaat JJ, Ingvarsson T, Jonsdottir I, Jonnson H, Kerkhof HJ, Kloppenburg M, Bos SD, Mangino M, Metrustry S, Slagboom PE, Thorleifsson G, Raine EV, Ratnayake M, Ricketts M, Beazley C, Blackburn H, Bumpstead S, Elliott KS, Hunt SE, Potter SC, Shin SY, Yadav VK, Zhai G, Sherburn K, Dixon K, Arden E, Aslam N, Battley PK, Carluke I, Doherty S, Gordon A, Joseph J, Keen R, Koller NC, Mitchell S, O\u2019Neill F, Paling E, Reed MR, Rivadeneira F, Swift D, Walker K, Watkins B, Wheeler M, Birrell F, Ioannidis JP, Meulenbelt I, Metspalu A, Rai A, Salter D, Stefansson K, Stykarsdottir U, Uitterlinden AG, van Meurs JB, Chapman K, Deloukas P, Ollier WE, Wallis GA, Arden N, Carr A, Doherty M, McCaskie A, Willkinson JM, Ralston SH, Valdes AM, Spector TD, Loughlin J (2012) Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet 380(9844):815\u2013823","journal-title":"Lancet"},{"issue":"12","key":"4278_CR13","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1136\/annrheumdis-2013-203772","volume":"73","author":"K Panoutsopoulou","year":"2014","unstructured":"Panoutsopoulou K, Metrustry S, Doherty SA, Laslett LL, Maciewicz RA, Hart DJ, Zhang W, Muir KR, Wheeler M, Cooper C, Spector TD, Cicuttini FM, Jones G, Arden NK, Doherty M, Zeggini E, Valdes AM (2014) The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a Mendelian randomisation study. Ann Rheum Dis 73(12):2082\u20132086","journal-title":"Ann Rheum Dis"},{"issue":"9864","key":"4278_CR14","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/S0140-6736(13)60167-1","volume":"381","author":"H Pang","year":"2013","unstructured":"Pang H, Luo F, Dai F, Wu XH, Xu JZ (2013) Genome-wide association study for osteoarthritis. Lancet 381(9864):372\u2013373; discussion 373","journal-title":"Lancet"},{"issue":"3","key":"4278_CR15","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1002\/ajpa.23914","volume":"170","author":"AP Winburn","year":"2019","unstructured":"Winburn AP, Stock MK (2019) Reconsidering osteoarthritis as a skeletal indicator of age at death. Am J Phys Anthropol 170(3):459\u2013473","journal-title":"Am J Phys Anthropol"},{"key":"4278_CR16","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.physbeh.2015.08.006","volume":"151","author":"CA Isabel","year":"2015","unstructured":"Isabel CA, Moys\u00e9s MR, van der Bilt A, Gameiro GH, Ribeiro JC, Pereira LJ (2015) The relationship between masticatory and swallowing behaviors and body weight. Physiol Behav 151:314\u2013319","journal-title":"Physiol Behav"},{"issue":"3","key":"4278_CR17","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/S1079-2104(05)80233-1","volume":"79","author":"R de Leeuw","year":"1995","unstructured":"de Leeuw R, Boering G, Stegenga B, de Bont LG (1995) Radiographic signs of temporomandibular joint osteoarthrosis and internal derangement 30 years after nonsurgical treatment. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 79(3):382\u2013392","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"4","key":"4278_CR18","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1001\/archotol.1989.01860280067019","volume":"115","author":"CH Wilkes","year":"1989","unstructured":"Wilkes CH (1989) Internal derangements of the temporomandibular joint. Pathological variations. Arch Otolaryngol Head Neck Surg 115(4):469\u2013477","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"3","key":"4278_CR19","doi-asserted-by":"publisher","first-page":"4445","DOI":"10.1096\/fj.201902287R","volume":"34","author":"A Ruscitto","year":"2020","unstructured":"Ruscitto A, Morel MM, Shawber CJ, Reeve G, Lecholop MK, Bonthius D, Yao H, Embree MC (2020) Evidence of vasculature and chondrocyte to osteoblast transdifferentiation in craniofacial synovial joints: implications for osteoarthritis diagnosis and therapy. Faseb j 34(3):4445\u20134461","journal-title":"Faseb j"},{"issue":"3","key":"4278_CR20","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1148\/radiology.186.3.8430181","volume":"186","author":"MM Tasaki","year":"1993","unstructured":"Tasaki MM, Westesson PL (1993) Temporomandibular joint: diagnostic accuracy with sagittal and coronal MR imaging. Radiology 186(3):723\u2013729","journal-title":"Radiology"},{"issue":"11","key":"4278_CR21","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1016\/S0278-2391(98)90606-1","volume":"56","author":"PL Westesson","year":"1998","unstructured":"Westesson PL, Larheim TA, Tanaka H (1998) Posterior disc displacement in the temporomandibular joint. J Oral Maxillofac Surg 56(11):1266\u20131273; discussion 1273-4","journal-title":"J Oral Maxillofac Surg"},{"issue":"3","key":"4278_CR22","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1148\/radiology.169.3.3186996","volume":"169","author":"RW Katzberg","year":"1988","unstructured":"Katzberg RW, Westesson PL, Tallents RH, Anderson R, Kurita K, Manzione JV Jr, Totterman S (1988) Temporomandibular joint: MR assessment of rotational and sideways disk displacements. Radiology 169(3):741\u2013748","journal-title":"Radiology"},{"issue":"1","key":"4278_CR23","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/S0720-048X(97)00102-2","volume":"28","author":"JM Foucart","year":"1998","unstructured":"Foucart JM, Carpentier P, Pajoni D, Marguelles-Bonnet R, Pharaboz C (1998) MR of 732 TMJs: anterior, rotational, partial and sideways disc displacements. Eur J Radiol 28(1):86\u201394","journal-title":"Eur J Radiol"},{"issue":"3","key":"4278_CR24","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0889-5406(96)70148-8","volume":"109","author":"MM Tasaki","year":"1996","unstructured":"Tasaki MM, Westesson PL, Isberg AM, Ren YF, Tallents RH (1996) Classification and prevalence of temporomandibular joint disk displacement in patients and symptom-free volunteers. Am J Orthod Dentofacial Orthop 109(3):249\u2013262","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"2","key":"4278_CR25","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.joca.2016.11.011","volume":"25","author":"JB van Meurs","year":"2017","unstructured":"van Meurs JB (2017) Osteoarthritis year in review 2016: genetics, genomics and epigenetics. Osteoarthr Cartil 25(2):181\u2013189","journal-title":"Osteoarthr Cartil"},{"issue":"6","key":"4278_CR26","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1038\/ng2048","volume":"39","author":"C Dina","year":"2007","unstructured":"Dina C, Meyre D, Gallina S, Durand E, K\u00f6rner A, Jacobson P, Carlsson LM, Kiess W, Vatin V, Lecoeur C, Delplanque J, Vaillant E, Pattou F, Ruiz J, Weill J, Levy-Marchal C, Horber F, Potoczna N, Hercberg S, Le Stunff C, Bougn\u00e8res P, Kovacs P, Marre M, Balkau B, Cauchi S, Ch\u00e8vre JC, Froguel P (2007) Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 39(6):724\u2013726","journal-title":"Nat Genet"},{"issue":"7292","key":"4278_CR27","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1038\/nature08921","volume":"464","author":"Z Han","year":"2010","unstructured":"Han Z, Niu T, Chang J, Lei X, Zhao M, Wang Q, Cheng W, Wang J, Feng Y, Chai J (2010) Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature 464(7292):1205\u20131209","journal-title":"Nature"},{"issue":"1","key":"4278_CR28","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s13018-018-0769-2","volume":"13","author":"J Dai","year":"2018","unstructured":"Dai J, Ying P, Shi D, Hou H, Sun Y, Xu Z, Chen D, Zhang G, Ni M, Teng H, Wang Y, Jiang Q (2018) FTO variant is not associated with osteoarthritis in the Chinese Han population: replication study for a genome-wide association study identified risk loci. J Orthop Surg Res 13(1):65","journal-title":"J Orthop Surg Res"},{"key":"4278_CR29","doi-asserted-by":"publisher","first-page":"17457","DOI":"10.1038\/s41598-020-74326-z","volume":"10","author":"J Du","year":"2020","unstructured":"Du J, Jiang Q, Mei L, Yang R, Wen J, Lin S, Li H (2020) Effect of high fat diet and excessive compressive mechanical force on pathologic changes of temporomandibular joint. Sci Rep 10:17457","journal-title":"Sci Rep"},{"issue":"11","key":"4278_CR30","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1038\/ijo.2015.96","volume":"39","author":"T Ohkuma","year":"2015","unstructured":"Ohkuma T, Hirakawa Y, Nakamura U, Kiyohara Y, Kitazono T, Ninomiya T (2015) Association between eating rate and obesity: a systematic review and meta-analysis. Int J Obes (Lond) 39(11):1589\u20131596","journal-title":"Int J Obes (Lond)"},{"issue":"5","key":"4278_CR31","doi-asserted-by":"publisher","first-page":"e12743","DOI":"10.1111\/ijpo.12743","volume":"16","author":"G Idris","year":"2021","unstructured":"Idris G, Smith C, Galland B, Taylor R, Robertson CJ, Bennani H, Farella M (2021) Relationship between chewing features and body mass index in young adolescents. Pediatr Obes 16(5):e12743","journal-title":"Pediatr Obes"},{"issue":"3","key":"4278_CR32","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1177\/0022034516679396","volume":"96","author":"EL Schiffman","year":"2017","unstructured":"Schiffman EL, Ahmad M, Hollender L, Kartha K, Ohrbach R, Truelove EL, Zhang L, Hodges JS, Sommers E, Anderson GC, Gonzalez YM, Guo X, Look JO (2017) Longitudinal stability of common TMJ structural disorders. J Dent Res 96(3):270\u2013276","journal-title":"J Dent Res"},{"issue":"6","key":"4278_CR33","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.ijom.2008.02.011","volume":"37","author":"MI Campos","year":"2008","unstructured":"Campos MI, Campos PS, Cangussu MC, Guimaraes RC, Line SR (2008) Analysis of magnetic resonance imaging characteristics and pain in temporomandibular joints with and without degenerative changes of the condyle. Int J Oral Maxillofac Surg 37(6):529\u2013534","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"3","key":"4278_CR34","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.ijom.2015.09.016","volume":"45","author":"IM Dias","year":"2016","unstructured":"Dias IM, Cordeiro PC, Devito KL, Tavares ML, Leite IC, TeschRde S (2016) Evaluation of temporomandibular joint disc displacement as a risk factor for osteoarthrosis. Int J Oral Maxillofac Surg 45(3):313\u2013317","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"9","key":"4278_CR35","first-page":"3396","volume":"85","author":"CA Stratakis","year":"2000","unstructured":"Stratakis CA, Lafferty A, Taymans SE, Gafni RI, Meck JM, Blancato J (2000) Anisomastia associated with interstitial duplication of chromosome 16, mental retardation, obesity, dysmorphic facies, and digital anomalies: molecular mapping of a new syndrome by fluorescent in situ hybridization and microsatellites to 16q13 (D16S419-D16S503). J Clin Endocrinol Metab 85(9):3396\u20133401","journal-title":"J Clin Endocrinol Metab"},{"key":"4278_CR36","first-page":"5190587","volume":"2020","author":"J Liu","year":"2020","unstructured":"Liu J, Wang G, Peng Z (2020) Association between the MMP-1-1607 1G\/2G polymorphism and osteoarthritis risk: a systematic review and meta-analysis. Biomed Res Int 2020:5190587","journal-title":"Biomed Res Int"},{"issue":"3","key":"4278_CR37","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.jcms.2011.04.006","volume":"40","author":"HS Roh","year":"2012","unstructured":"Roh HS, Kim W, Kim YK, Lee JY (2012) Relationships between disk displacement, joint effusion, and degenerative changes of the TMJ in TMD patients based on MRI findings. J Craniomaxillofac Surg 40(3):283\u2013286","journal-title":"J Craniomaxillofac Surg"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-04278-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-021-04278-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-04278-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T05:24:15Z","timestamp":1646457855000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-021-04278-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,23]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["4278"],"URL":"https:\/\/doi.org\/10.1007\/s00784-021-04278-9","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,23]]},"assertion":[{"value":"10 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}