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SAPM P<jats:sub>11<\/jats:sub>-4 (with and without root conditioning with 24% EDTA (T1, T2)), Emdogain\u00ae (C) and a sham intervention (S) were randomly applied on the four defects at each time point. Four weeks after the second surgery and treatment, the animals were sacrificed, the mandibles measured by micro-computed tomography (\u00b5-CT) and sections of the tissue were stained and evaluated histologically.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Clinically and histologically, no safety concerns or pathological issues due to the treatments were observed in any of the study groups at any time point. All groups showed overall similar results after 4 and 12\u00a0weeks of healing regarding new cementum, functionality of newly formed periodontal ligament and recovery of height and volume of the new alveolar bone and mineral density.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>A controlled clinical study in humans should be performed in a next step as no adverse effects or safety issues, which might affect clinical usage of the product, were observed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>The synthetic SAPM P<jats:sub>11<\/jats:sub>-4 may offer an alternative to the animal-derived product Emdogain\u00ae in the future.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-021-04297-6","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T11:03:23Z","timestamp":1641812603000},"page":"3151-3166","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy and safety of P11-4 for the treatment of periodontal defects in dogs"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3643-6821","authenticated-orcid":false,"given":"Claudine","family":"Bommer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Waller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Hilbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Wiedemeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Mathes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"issue":"1","key":"4297_CR1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/prd.12374","volume":"86","author":"RP Darveau","year":"2021","unstructured":"Darveau RP, Curtis MA (2021) Oral biofilms revisited: A novel host tissue of bacteriological origin. 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