{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T17:27:49Z","timestamp":1793208469189,"version":"4.5.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T00:00:00Z","timestamp":1638403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T00:00:00Z","timestamp":1638403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s00784-021-04310-y","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T01:53:56Z","timestamp":1638410036000},"page":"3287-3297","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Outcomes of root canal therapy or full pulpotomy using two endodontic biomaterials in mature permanent teeth: a randomized controlled trial"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6691-0478","authenticated-orcid":false,"given":"Saeed","family":"Asgary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Jafar","family":"Eghbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Shahravan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eshaghali","family":"Saberi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza Akbarzadeh","family":"Baghban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ardavan","family":"Parhizkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,2]]},"reference":[{"key":"4310_CR1","first-page":"119","volume":"6","author":"F Moazami","year":"2011","unstructured":"Moazami F, Sahebi S, Sobhnamayan F, Alipour A (2011) Success rate of nonsurgical endodontic treatment of nonvital teeth with variable periradicular lesions. Iran Endod J 6:119\u2013124","journal-title":"Iran Endod J"},{"key":"4310_CR2","first-page":"493","volume":"32","author":"S Friedman","year":"2004","unstructured":"Friedman S, Mor C (2004) The success of endodontic therapy\u2013healing and functionality. J Calif Dent Assoc 32:493\u2013503","journal-title":"J Calif Dent Assoc"},{"key":"4310_CR3","first-page":"74","volume":"5","author":"S Asgary","year":"2010","unstructured":"Asgary S, Shadman B, Ghalamkarpour Z, Shahravan A, Ghoddusi J, Bagherpour A, Akbarzadeh Baghban A, Hashemipour M, Ghasemian Pour M (2010) Periapical status and quality of root canal fillings and coronal restorations in Iranian population. Iran Endod J 5:74\u201382","journal-title":"Iran Endod J"},{"key":"4310_CR4","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.tripleo.2008.06.007","volume":"106","author":"JF Siqueira Jr","year":"2008","unstructured":"Siqueira JF Jr, Rocas IN, Riche FN, Provenzano JC (2008) Clinical outcome of the endodontic treatment of teeth with apical periodontitis using an antimicrobial protocol. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:757\u2013762. https:\/\/doi.org\/10.1016\/j.tripleo.2008.06.007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"4310_CR5","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1111\/iej.12793","volume":"50","author":"WJ Wolters","year":"2017","unstructured":"Wolters WJ, Duncan HF, Tomson PL, Karim IE, McKenna G, Dorri M, Stangvaltaite L, van der Sluis LWM (2017) Minimally invasive endodontics: a new diagnostic system for assessing pulpitis and subsequent treatment needs. Int Endod J 50:825\u2013829. https:\/\/doi.org\/10.1111\/iej.12793","journal-title":"Int Endod J"},{"key":"4310_CR6","first-page":"23","volume":"9","author":"S Yazdani","year":"2014","unstructured":"Yazdani S, Jadidfard MP, Tahani B, Kazemian A, Dianat O, Alim Marvasti L (2014) Health technology assessment of CEM pulpotomy in permanent molars with irreversible pulpitis. Iran Endod J 9:23\u201329","journal-title":"Iran Endod J"},{"key":"4310_CR7","doi-asserted-by":"publisher","first-page":"75","DOI":"10.7508\/iej.2016.01.015","volume":"11","author":"S Asgary","year":"2016","unstructured":"Asgary S, Nourzadeh M, Eghbal MJ (2016) Miniature pulpotomy of symptomatic mature permanent teeth: a report of two cases. Iran Endod J 11:75\u201378. https:\/\/doi.org\/10.7508\/iej.2016.01.015","journal-title":"Iran Endod J"},{"key":"4310_CR8","first-page":"295","volume":"9","author":"S Asgary","year":"2014","unstructured":"Asgary S, Fazlyab M, Sabbagh S, Eghbal MJ (2014) Outcomes of different vital pulp therapy techniques on symptomatic permanent teeth: a case series. Iran Endod J 9:295\u2013300","journal-title":"Iran Endod J"},{"key":"4310_CR9","doi-asserted-by":"publisher","first-page":"284","DOI":"10.7508\/iej.2015.03.015","volume":"10","author":"S Asgary","year":"2015","unstructured":"Asgary S, Kemal Caliskan M (2015) Vital pulp therapy of a mature molar with concurrent hyperplastic pulpitis, internal root resorption and periradicular periodontitis: a case report. Iran Endod J 10:284\u2013286. https:\/\/doi.org\/10.7508\/iej.2015.03.015","journal-title":"Iran Endod J"},{"key":"4310_CR10","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-04007-2","author":"F Eggmann","year":"2021","unstructured":"Eggmann F, Gasser TJW, Hecker H, Amato M, Weiger R, Zaugg LK (2021) Partial pulpotomy without age restriction: a retrospective assessment of permanent teeth with carious pulp exposure. Clin Oral Investig. https:\/\/doi.org\/10.1007\/s00784-021-04007-2","journal-title":"Clin Oral Investig"},{"key":"4310_CR11","doi-asserted-by":"publisher","first-page":"85","DOI":"10.7508\/iej.2016.02.002","volume":"11","author":"SA Mousavi","year":"2016","unstructured":"Mousavi SA, Ghoddusi J, Mohtasham N, Shahnaseri S, Paymanpour P, Kinoshita J (2016) Human pulp response to direct pulp capping and miniature pulpotomy with MTA after application of topical dexamethasone: a randomized clinical trial. Iran Endod J 11:85\u201390. https:\/\/doi.org\/10.7508\/iej.2016.02.002","journal-title":"Iran Endod J"},{"key":"4310_CR12","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s00784-013-1003-6","volume":"18","author":"S Asgary","year":"2014","unstructured":"Asgary S, Eghbal MJ, Ghoddusi J (2014) Two-year results of vital pulp therapy in permanent molars with irreversible pulpitis: an ongoing multicenter randomized clinical trial. Clin Oral Investig 18:635\u2013641. https:\/\/doi.org\/10.1007\/s00784-013-1003-6","journal-title":"Clin Oral Investig"},{"key":"4310_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jdent.2019.03.010","volume":"84","author":"Y Li","year":"2019","unstructured":"Li Y, Sui B, Dahl C, Bergeron B, Shipman P, Niu L, Chen J, Tay FR (2019) Pulpotomy for carious pulp exposures in permanent teeth: a systematic review and meta-analysis. J Dent 84:1\u20138. https:\/\/doi.org\/10.1016\/j.jdent.2019.03.010","journal-title":"J Dent"},{"key":"4310_CR14","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-03960-2","author":"DJX Leong","year":"2021","unstructured":"Leong DJX, Yap AU (2021) Vital pulp therapy in carious pulp-exposed permanent teeth: an umbrella review. Clin Oral Investig. https:\/\/doi.org\/10.1007\/s00784-021-03960-2","journal-title":"Clin Oral Investig"},{"key":"4310_CR15","doi-asserted-by":"publisher","first-page":"121","DOI":"10.4103\/JCD.JCD_179_19","volume":"23","author":"K Zafar","year":"2020","unstructured":"Zafar K, Nazeer MR, Ghafoor R, Khan FR (2020) Success of pulpotomy in mature permanent teeth with irreversible pulpitis: a systematic review. J Conserv Dent 23:121\u2013125. https:\/\/doi.org\/10.4103\/JCD.JCD_179_19","journal-title":"J Conserv Dent"},{"key":"4310_CR16","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.joen.2017.12.010","volume":"44","author":"S Asgary","year":"2018","unstructured":"Asgary S, Hassanizadeh R, Torabzadeh H, Eghbal MJ (2018) Treatment outcomes of 4 vital pulp therapies in mature molars. J Endod 44:529\u2013535. https:\/\/doi.org\/10.1016\/j.joen.2017.12.010","journal-title":"J Endod"},{"key":"4310_CR17","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/iej.12841","volume":"51","author":"M Parirokh","year":"2018","unstructured":"Parirokh M, Torabinejad M, Dummer PMH (2018) Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview - part I: vital pulp therapy. Int Endod J 51:177\u2013205. https:\/\/doi.org\/10.1111\/iej.12841","journal-title":"Int Endod J"},{"key":"4310_CR18","doi-asserted-by":"publisher","unstructured":"Chen Y, Chen X, Zhang Y, Zhou F, Deng J, Zou J and Wang Y (2019) Materials for pulpotomy in immature permanent teeth: a systematic review and meta-analysis. BMC Oral Health 19:227. https:\/\/doi.org\/10.1186\/s12903-019-0917-z","DOI":"10.1186\/s12903-019-0917-z"},{"key":"4310_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5395\/rde.2015.40.1.1","volume":"40","author":"S Utneja","year":"2015","unstructured":"Utneja S, Nawal RR, Talwar S, Verma M (2015) Current perspectives of bio-ceramic technology in endodontics: calcium enriched mixture cement - review of its composition, properties and applications. Restor Dent Endod 40:1\u201313. https:\/\/doi.org\/10.5395\/rde.2015.40.1.1","journal-title":"Restor Dent Endod"},{"key":"4310_CR20","doi-asserted-by":"publisher","first-page":"359873","DOI":"10.5402\/2012\/359873","volume":"2012","author":"M Adel","year":"2012","unstructured":"Adel M, Nima MM, Shivaie Kojoori S, Norooz Oliaie H, Naghavi N, Asgary S (2012) Comparison of endodontic biomaterials as apical barriers in simulated open apices. ISRN Dent 2012:359873. https:\/\/doi.org\/10.5402\/2012\/359873","journal-title":"ISRN Dent"},{"key":"4310_CR21","first-page":"151","volume":"30","author":"S Asgary","year":"2017","unstructured":"Asgary S, Eghbal MJ, Bagheban AA (2017) Long-term outcomes of pulpotomy in permanent teeth with irreversible pulpitis: a multi-center randomized controlled trial. Am J Dent 30:151\u2013155","journal-title":"Am J Dent"},{"key":"4310_CR22","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.tripleo.2004.01.004","volume":"98","author":"BS Alley","year":"2004","unstructured":"Alley BS, Kitchens GG, Alley LW, Eleazer PD (2004) A comparison of survival of teeth following endodontic treatment performed by general dentists or by specialists. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98:115\u2013118. https:\/\/doi.org\/10.1016\/j.tripleo.2004.01.004","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"4310_CR23","doi-asserted-by":"publisher","unstructured":"American Association of Endodontists (2021) AAE position statement on vital pulp therapy. J Endod 47:1340\u20131344. https:\/\/doi.org\/10.1016\/j.joen.2021.07.015","DOI":"10.1016\/j.joen.2021.07.015"},{"key":"4310_CR24","doi-asserted-by":"publisher","first-page":"5853412","DOI":"10.1155\/2020\/5853412","volume":"2020","author":"MJ Eghbal","year":"2020","unstructured":"Eghbal MJ, Haeri A, Shahravan A, Kazemi A, Moazami F, Mozayeni MA, Saberi E, Samiei M, Vatanpour M, Akbarzade Baghban A, Fazlyab M, Parhizkar A, Ahmadi M, Akbarian Rad N, Bijari S, Bineshmarvasti D, Davoudi P, Dehghan R, Dehghani M, Ebrahimi H, Emami N, Farajian N, Fereidooni R, Ghobadi G, Ghodrati M, Gohari A, Hashemi A, Hosseini M, Karami E, Kheirabadi N, Kozegari S, Labaf Ghasemi H, Majidi A, Malekzadeh P, Mehrabi V, Mohammadi M, Moradi Eslami L, Noghani A, Omatali N, Pourhatami N, Rahbani Nobar B, Rahmani S, Shafaq P, Soofiabadi S, Teimoori S, Vatandoost F, Asgary S (2020) Postendodontic pain after pulpotomy or root canal treatment in mature teeth with carious pulp exposure: a multicenter randomized controlled trial. Pain Res Manag 2020:5853412. https:\/\/doi.org\/10.1155\/2020\/5853412","journal-title":"Pain Res Manag"},{"key":"4310_CR25","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00784-014-1244-z","volume":"19","author":"S Asgary","year":"2015","unstructured":"Asgary S, Eghbal MJ, Fazlyab M, Baghban AA, Ghoddusi J (2015) Five-year results of vital pulp therapy in permanent molars with irreversible pulpitis: a non-inferiority multicenter randomized clinical trial. Clin Oral Investig 19:335\u2013341. https:\/\/doi.org\/10.1007\/s00784-014-1244-z","journal-title":"Clin Oral Investig"},{"key":"4310_CR26","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s00784-012-0712-6","volume":"17","author":"S Asgary","year":"2013","unstructured":"Asgary S, Eghbal MJ, Ghoddusi J, Yazdani S (2013) One-year results of vital pulp therapy in permanent molars with irreversible pulpitis: an ongoing multicenter, randomized, non-inferiority clinical trial. Clin Oral Investig 17:431\u2013439. https:\/\/doi.org\/10.1007\/s00784-012-0712-6","journal-title":"Clin Oral Investig"},{"key":"4310_CR27","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.progpolymsci.2015.02.004","volume":"53","author":"FM Chen","year":"2016","unstructured":"Chen FM, Liu X (2016) Advancing biomaterials of human origin for tissue engineering. Prog Polym Sci 53:86\u2013168. https:\/\/doi.org\/10.1016\/j.progpolymsci.2015.02.004","journal-title":"Prog Polym Sci"},{"key":"4310_CR28","doi-asserted-by":"publisher","first-page":"8896740","DOI":"10.1155\/2020\/8896740","volume":"2020","author":"P Zarean","year":"2020","unstructured":"Zarean P, Zarean P, Ravaghi A, Zare Jahromi M, Sadrameli M (2020) Comparison of MTA, CEM cement, and Biodentine as coronal plug during internal bleaching: an in vitro study. Int J Dent 2020:8896740. https:\/\/doi.org\/10.1155\/2020\/8896740","journal-title":"Int J Dent"},{"key":"4310_CR29","unstructured":"Hosseinzade M, Soflou RK, Valian A and Nojehdehian H (2016) Physicochemical properties of MTA, CEM, hydroxyapatite and nano hydroxyapatite-chitosan dental cements. Biomedical Research (0970\u2013938X) 1:27(2)"},{"key":"4310_CR30","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.tripleo.2008.06.006","volume":"106","author":"S Asgary","year":"2008","unstructured":"Asgary S, Eghbal MJ, Parirokh M, Ghanavati F, Rahimi H (2008) A comparative study of histologic response to different pulp capping materials and a novel endodontic cement. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:609\u2013614. https:\/\/doi.org\/10.1016\/j.tripleo.2008.06.006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"4310_CR31","doi-asserted-by":"publisher","first-page":"64","DOI":"10.4012\/dmj.2013-123","volume":"33","author":"N Naghavi","year":"2014","unstructured":"Naghavi N, Ghoddusi J, Sadeghnia HR, Asadpour E, Asgary S (2014) Genotoxicity and cytotoxicity of mineral trioxide aggregate and calcium enriched mixture cements on L929 mouse fibroblast cells. Dent Mater J 33:64\u201369. https:\/\/doi.org\/10.4012\/dmj.2013-123","journal-title":"Dent Mater J"},{"key":"4310_CR32","doi-asserted-by":"publisher","first-page":"427","DOI":"10.4103\/0972-0707.87218","volume":"14","author":"A Nosrat","year":"2011","unstructured":"Nosrat A, Asgary S, Eghbal MJ, Ghoddusi J, Bayat-Movahed S (2011) Calcium-enriched mixture cement as artificial apical barrier: a case series. J Conserv Dent 14:427\u2013431. https:\/\/doi.org\/10.4103\/0972-0707.87218","journal-title":"J Conserv Dent"},{"key":"4310_CR33","doi-asserted-by":"publisher","first-page":"457","DOI":"10.22037\/iej.v13i4.20970","volume":"13","author":"R Haghgoo","year":"2018","unstructured":"Haghgoo R, Asgary S, Montazeri R (2018) Histopathological evaluation of primary teeth after pulp capping with calcium-enriched mixture and bioactive glass. Iran Endod J 13:457\u2013460. https:\/\/doi.org\/10.22037\/iej.v13i4.20970","journal-title":"Iran Endod J"},{"key":"4310_CR34","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1007\/s00784-018-2472-4","volume":"23","author":"BN Celik","year":"2019","unstructured":"Celik BN, Mutluay MS, Arikan V, Sari S (2019) The evaluation of MTA and Biodentine as a pulpotomy materials for carious exposures in primary teeth. Clin Oral Investig 23:661\u2013666. https:\/\/doi.org\/10.1007\/s00784-018-2472-4","journal-title":"Clin Oral Investig"},{"key":"4310_CR35","doi-asserted-by":"publisher","first-page":"103158","DOI":"10.1016\/j.jdent.2019.06.005","volume":"88","author":"S Cushley","year":"2019","unstructured":"Cushley S, Duncan HF, Lappin MJ, Tomson PL, Lundy FT, Cooper P, Clarke M, El Karim IA (2019) Pulpotomy for mature carious teeth with symptoms of irreversible pulpitis: a systematic review. J Dent 88:103158. https:\/\/doi.org\/10.1016\/j.jdent.2019.06.005","journal-title":"J Dent"},{"key":"4310_CR36","doi-asserted-by":"publisher","unstructured":"Santos JM, Pereira JF, Marques A, Sequeira DB and Friedman S (2021) Vital pulp therapy in permanent mature posterior teeth with symptomatic irreversible pulpitis: a systematic review of treatment outcomes. Medicina 57:573.\u00a0https:\/\/doi.org\/10.3390\/medicina57060573","DOI":"10.3390\/medicina57060573"},{"key":"4310_CR37","doi-asserted-by":"publisher","first-page":"e6747","DOI":"10.7759\/cureus.6747","volume":"12","author":"D Sadaf","year":"2020","unstructured":"Sadaf D (2020) Success of coronal pulpotomy in permanent teeth with irreversible pulpitis: an evidence-based review. Cureus 12:e6747. https:\/\/doi.org\/10.7759\/cureus.6747","journal-title":"Cureus"},{"key":"4310_CR38","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1080\/00016357.2019.1614217","volume":"77","author":"M Zanini","year":"2019","unstructured":"Zanini M, Hennequin M, Cousson PY (2019) Which procedures and materials could be applied for full pulpotomy in permanent mature teeth? A systematic review. Acta Odontol Scand 77:541\u2013551. https:\/\/doi.org\/10.1080\/00016357.2019.1614217","journal-title":"Acta Odontol Scand"},{"key":"4310_CR39","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.joen.2010.12.004","volume":"37","author":"P Aguilar","year":"2011","unstructured":"Aguilar P, Linsuwanont P (2011) Vital pulp therapy in vital permanent teeth with cariously exposed pulp: a systematic review. J Endod 37:581\u2013587. https:\/\/doi.org\/10.1016\/j.joen.2010.12.004","journal-title":"J Endod"},{"key":"4310_CR40","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jdent.2019.05.022","volume":"86","author":"D Ricucci","year":"2019","unstructured":"Ricucci D, Siqueira JF Jr, Li Y, Tay FR (2019) Vital pulp therapy: histopathology and histobacteriology-based guidelines to treat teeth with deep caries and pulp exposure. J Dent 86:41\u201352. https:\/\/doi.org\/10.1016\/j.jdent.2019.05.022","journal-title":"J Dent"},{"key":"4310_CR41","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1016\/j.jdent.2014.06.007","volume":"42","author":"HE Alqaderi","year":"2014","unstructured":"Alqaderi HE, Al-Mutawa SA, Qudeimat MA (2014) MTA pulpotomy as an alternative to root canal treatment in children\u2019s permanent teeth in a dental public health setting. J Dent 42:1390\u20131395. https:\/\/doi.org\/10.1016\/j.jdent.2014.06.007","journal-title":"J Dent"},{"key":"4310_CR42","doi-asserted-by":"publisher","first-page":"128","DOI":"10.14744\/eej.2020.82574","volume":"6","author":"S Asgary","year":"2021","unstructured":"Asgary S, Parhizkar A (2021) Importance of \u2018time\u2019 on \u2018haemostasis\u2019 in vital pulp therapy - letter to the editor. Eur Endod J 6:128\u2013129. https:\/\/doi.org\/10.14744\/eej.2020.82574","journal-title":"Eur Endod J"},{"key":"4310_CR43","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.joen.2016.10.027","volume":"43","author":"P Linsuwanont","year":"2017","unstructured":"Linsuwanont P, Wimonsutthikul K, Pothimoke U, Santiwong B (2017) Treatment outcomes of mineral trioxide aggregate pulpotomy in vital permanent teeth with carious pulp exposure: the retrospective study. J Endod 43:225\u2013230. https:\/\/doi.org\/10.1016\/j.joen.2016.10.027","journal-title":"J Endod"},{"key":"4310_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jdent.2015.12.005","volume":"44","author":"H Alqaderi","year":"2016","unstructured":"Alqaderi H, Lee CT, Borzangy S, Pagonis TC (2016) Coronal pulpotomy for cariously exposed permanent posterior teeth with closed apices: a systematic review and meta-analysis. J Dent 44:1\u20137. https:\/\/doi.org\/10.1016\/j.jdent.2015.12.005","journal-title":"J Dent"},{"key":"4310_CR45","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1007\/s10266-010-0127-2","volume":"98","author":"S Asgary","year":"2010","unstructured":"Asgary S, Eghbal MJ (2010) The effect of pulpotomy using a calcium-enriched mixture cement versus one-visit root canal therapy on postoperative pain relief in irreversible pulpitis: a randomized clinical trial. Odontology 98:126\u2013133. https:\/\/doi.org\/10.1007\/s10266-010-0127-2","journal-title":"Odontology"},{"key":"4310_CR46","doi-asserted-by":"publisher","first-page":"S161","DOI":"10.1016\/j.joen.2020.06.037","volume":"46","author":"G Schmalz","year":"2020","unstructured":"Schmalz G, Widbiller M, Galler KM (2020) Clinical perspectives of pulp regeneration. J Endod 46:S161\u2013S174. https:\/\/doi.org\/10.1016\/j.joen.2020.06.037","journal-title":"J Endod"},{"key":"4310_CR47","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/aej.12392","volume":"46","author":"LM Lin","year":"2020","unstructured":"Lin LM, Ricucci D, Saoud TM, Sigurdsson A, Kahler B (2020) Vital pulp therapy of mature permanent teeth with irreversible pulpitis from the perspective of pulp biology. Aust Endod J 46:154\u2013166. https:\/\/doi.org\/10.1111\/aej.12392","journal-title":"Aust Endod J"},{"key":"4310_CR48","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.joen.2017.10.012","volume":"44","author":"N Parinyaprom","year":"2018","unstructured":"Parinyaprom N, Nirunsittirat A, Chuveera P, Na Lampang S, Srisuwan T, Sastraruji T, Bua-On P, Simprasert S, Khoipanich I, Sutharaphan T, Theppimarn S, Ue-Srichai N, Tangtrakooljaroen W, Chompu-Inwai P (2018) Outcomes of direct pulp capping by using either ProRoot mineral trioxide aggregate or Biodentine in permanent teeth with carious pulp exposure in 6- to 18-year-old patients: a randomized controlled trial. J Endod 44:341\u2013348. https:\/\/doi.org\/10.1016\/j.joen.2017.10.012","journal-title":"J Endod"},{"key":"4310_CR49","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s00784-016-1798-z","volume":"21","author":"MK Caliskan","year":"2017","unstructured":"Caliskan MK, Guneri P (2017) Prognostic factors in direct pulp capping with mineral trioxide aggregate or calcium hydroxide: 2- to 6-year follow-up. Clin Oral Investig 21:357\u2013367. https:\/\/doi.org\/10.1007\/s00784-016-1798-z","journal-title":"Clin Oral Investig"},{"key":"4310_CR50","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1037\/0021-9010.88.4.680","volume":"88","author":"S Oreg","year":"2003","unstructured":"Oreg S (2003) Resistance to change: developing an individual differences measure. J Appl Psychol 88:680\u2013693. https:\/\/doi.org\/10.1037\/0021-9010.88.4.680","journal-title":"J Appl Psychol"},{"key":"4310_CR51","volume-title":"Conflict of interest in medical research, education, and practice","author":"MJ Field","year":"2009","unstructured":"Field MJ, Lo B (2009) Conflict of interest in medical research, education, and practice. National Academies Press, Washangton DC"},{"key":"4310_CR52","first-page":"334","volume":"55","author":"R De Moor","year":"1984","unstructured":"De Moor R, Hommez G (1984) (2000) The importance of apical and coronal leakage in the success or failure of endodontic treatment. Rev Belge Med Dent 55:334\u2013344","journal-title":"Rev Belge Med Dent"},{"key":"4310_CR53","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.joen.2019.11.009","volume":"46","author":"SY Tan","year":"2020","unstructured":"Tan SY, Yu VSH, Lim KC, Tan BCK, Neo CLJ, Shen L, Messer HH (2020) Long-term pulpal and restorative outcomes of pulpotomy in mature permanent teeth. J Endod 46:383\u2013390. https:\/\/doi.org\/10.1016\/j.joen.2019.11.009","journal-title":"J Endod"},{"key":"4310_CR54","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1111\/j.1365-2591.2012.02016.x","volume":"45","author":"IA Mejare","year":"2012","unstructured":"Mejare IA, Axelsson S, Davidson T, Frisk F, Hakeberg M, Kvist T, Norlund A, Petersson A, Portenier I, Sandberg H, Tranaeus S, Bergenholtz G (2012) Diagnosis of the condition of the dental pulp: a systematic review. Int Endod J 45:597\u2013613. https:\/\/doi.org\/10.1111\/j.1365-2591.2012.02016.x","journal-title":"Int Endod J"},{"key":"4310_CR55","first-page":"874","volume":"27","author":"H Farid","year":"2015","unstructured":"Farid H, Khan FR, Pasha L, Shinwari MS (2015) Are pulp sensibility tests still sensible? J Ayub Med Coll Abbottabad 27:874\u2013877","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"4310_CR56","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1111\/iej.13059","volume":"52","author":"HF Duncan","year":"2019","unstructured":"Duncan HF, Bjorndal L, van der Sluis L, Rechenberg DK, Simon S, Cooper PR, Ricucci D, Galler K (2019) Third European Society of Endodontology (ESE) research meeting: ACTA, Amsterdam, The Netherlands, 26th October 2018: Deep caries and the exposed pulp: current and emerging therapeutic perspectives. Int Endod J 52:135\u2013138. https:\/\/doi.org\/10.1111\/iej.13059","journal-title":"Int Endod J"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-04310-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-021-04310-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-021-04310-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T19:17:37Z","timestamp":1744139857000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-021-04310-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,2]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["4310"],"URL":"https:\/\/doi.org\/10.1007\/s00784-021-04310-y","relation":{},"ISSN":["1432-6981","1436-3771"],"issn-type":[{"value":"1432-6981","type":"print"},{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,2]]},"assertion":[{"value":"31 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in this trial were in accordance with the ethical standards of the institutional and\/or national research committee and approved by Ethics Committee of Research Institute for Dental Sciences (IR.SBMU.RIDS.REC.1395.320) and Shahid Beheshti University of Medical Sciences (IR.SBMU.RETECH.REC.1397.1187). The study was conducted in compliance with the ethical principles of the \u201cDeclaration of Helsinki\u201d and \u201cGeneral Ethics Guideline\u201d in Medical Sciences Research (which has a human component) in Iran.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Dr. Asgary is the inventor of CEM cement (Endodontic Filling Material; USA, 7,942,961, 2011 May 17). All other authors declare that there are no conflict of interest regarding the publication of this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}