{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:59:58Z","timestamp":1784674798426,"version":"3.55.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T00:00:00Z","timestamp":1647648000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T00:00:00Z","timestamp":1647648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100012940","name":"Universit\u00e4tsklinikum T\u00fcbingen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012940","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract\n<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>We aimed to determine the neurocognitive development of cleft palate patients with and without Robin sequence (RS).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>Children with isolated RS with cleft palate and children with cleft palate only (CPO) were contacted at the age of 5\u20136\u00a0years. All RS children had undergone initial polygraphic sleep study (PG) with a mixed-obstructive apnea index (MOAI) of\u2009\u2265\u20093\/h and were consequently treated with the Tuebingen palatal plate. A standardized clinical examination as well as a neuropediatric and neuropsychological examination included the Wechsler Pre-school and Primary Scale of Intelligence (WPPSI-III), Kaufman Assessment Battery for Children (K-ABC), and an assessment of developmental milestones.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In total, 44 children (22RS, 22CPO) were included. RS children were younger at study (70.5\u2009\u00b1\u20097.3 and 75.2\u2009\u00b1\u20097.5\u00a0months; <jats:italic>P<\/jats:italic>\u2009=\u2009.035). Both groups achieved the evaluated milestones within the normed time frame. WPPSI-III and K-ABC results showed no group differences. Mean values for Verbal IQ (101.8\u2009\u00b1\u200911.1 vs. 97.1\u2009\u00b1\u200915.7), Performance IQ (102.9\u2009\u00b1\u200912.1 vs. 99.6\u2009\u00b1\u200914.5), Processing Speed Quotient (98.9\u2009\u00b1\u200915.6 vs. 94.5\u2009\u00b1\u200915.7), Full-Scale IQ (103.2\u2009\u00b1\u200912.1 vs. 98.4\u2009\u00b1\u200915.3), and Sequential Processing Scale (102.1\u2009\u00b1\u200913.1 vs. 94.2\u2009\u00b1\u200917.3) were within the reference range (IQ 85\u2013115) for RS and CPO children, respectively, indicating average performance of both groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>No neurocognitive, physical, or mental impairments were detected suggesting that RS children having upper airway obstruction (UAO) treated early and effectively may use their potential for an age-appropriate neurocognitive development.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>Tuebingen palatal plate treatment successfully releases UAO. Thus, isolated RS does not necessarily result in developmental delay or an impaired neurocognitive outcome.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>Deutsches Register Klinischer Studien, DRKS00006831, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.drks.de\/drks_web\/\">https:\/\/www.drks.de\/drks_web\/<\/jats:ext-link><\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-022-04448-3","type":"journal-article","created":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T17:02:31Z","timestamp":1647709351000},"page":"4817-4823","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Neurocognitive development in isolated Robin sequence treated with the Tuebingen palatal plate"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0760-7169","authenticated-orcid":false,"given":"Andreas","family":"Naros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Steiner-Wilke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Bacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Koos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Blumenstock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Wiechers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian F.","family":"Poets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegmar","family":"Reinert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Krimmel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,19]]},"reference":[{"key":"4448_CR1","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1001\/jamapediatrics.2016.0796","volume":"170","author":"CC Breugem","year":"2016","unstructured":"Breugem CC, Evans KN, Poets CF et al (2016) Best practices for the diagnosis and evaluation of infants with robin sequence a clinical consensus report. 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