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Seven midline and twenty bilateral hard tissue landmarks were identified for the evaluation of facial asymmetry and outcomes were assessed against age- and gender-matched control subjects.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In the asymmetry group, bilateral landmarks exhibited significant deviation in the mandible and midface regions. Before surgery, asymmetry was more severe at the mandibular midline and sites close to it, in the asymmetry group. Bimaxillary surgery proved to be highly effective, with a significant correction of the menton to a clinically normal value (2.90\u00a0mm, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). After surgery, significant residual asymmetry was observed at the mental foramen (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) in the R-L direction. Moreover, significant asymmetry persisted at the sigmoid notch (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) in the S-I direction.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Mandibular midline landmarks and chin peripheral regions contribute significantly to overall facial asymmetry characteristics. Despite significant correction after bimaxillary surgery, asymmetry persisted at several sites, thereby requiring secondary correction. Comprehensive 3D presurgical planning is central for asymmetry correction in a single surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>The present study specifies the location of residual asymmetry sites and advocates the correction of those sites during initial surgery.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-022-04463-4","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T13:13:04Z","timestamp":1648041184000},"page":"4947-4966","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Three-dimensional assessment of facial asymmetry in Class III subjects. 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