{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:01:38Z","timestamp":1791460898775,"version":"4.3.4"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:00:00Z","timestamp":1649894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:00:00Z","timestamp":1649894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s00784-022-04479-w","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T14:02:42Z","timestamp":1649944962000},"page":"5061-5070","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evaluation of salivary and serum methylated arginine metabolites and nitric oxide synthase in advanced periodontitis patients"],"prefix":"10.1007","volume":"26","author":[{"given":"Volkan","family":"\u015eeng\u00fcl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeliha","family":"G\u00fcney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7868-4217","authenticated-orcid":false,"given":"\u015eivge","family":"Kurgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canan","family":"\u00d6nder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhittin A.","family":"Serdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meral","family":"G\u00fcnhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,14]]},"reference":[{"issue":"5","key":"4479_CR1","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/0092-8674(92)90301-r","volume":"70","author":"CJ Lowenstein","year":"1992","unstructured":"Lowenstein CJ, Snyder SH (1992) Nitric oxide A novel biologic messenger. Cell 70(5):705\u2013707. https:\/\/doi.org\/10.1016\/0092-8674(92)90301-r","journal-title":"Cell"},{"issue":"2","key":"4479_CR2","first-page":"109","volume":"43","author":"S Moncada","year":"1991","unstructured":"Moncada S, Palmer RM, Higgs E (1991) Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 43(2):109\u2013142","journal-title":"Pharmacol Rev"},{"key":"4479_CR3","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1002\/9780470123119.ch8","volume":"65","author":"DJ Stuehr","year":"1992","unstructured":"Stuehr DJ, Griffith OW (1992) Mammalian nitric oxide synthase. Adv Enzymol 65:287\u2013331. https:\/\/doi.org\/10.1002\/9780470123119.ch8","journal-title":"Adv Enzymol"},{"issue":"3","key":"4479_CR4","doi-asserted-by":"publisher","first-page":"227","DOI":"10.7326\/0003-4819-120-3-199402010-00009","volume":"120","author":"CJ Lowenstein","year":"1994","unstructured":"Lowenstein CJ, Dinerman JL, Snyder SH (1994) Nitric oxide: a physiologic messenger. Ann Intern Med 120(3):227\u2013237. https:\/\/doi.org\/10.7326\/0003-4819-120-3-199402010-00009","journal-title":"Ann Intern Med"},{"issue":"3","key":"4479_CR5","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.it.2015.01.003","volume":"36","author":"C Bogdan","year":"2015","unstructured":"Bogdan C (2015) Nitric oxide synthase in innate and adaptive immunity: an update. Trends Immunol 36(3):161\u2013178. https:\/\/doi.org\/10.1016\/j.it.2015.01.003","journal-title":"Trends Immunol"},{"issue":"9","key":"4479_CR6","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nrd4623","volume":"14","author":"JO Lundberg","year":"2015","unstructured":"Lundberg JO, Gladwin MT, Weitzberg E (2015) Strategies to increase nitric oxide signalling in cardiovascular disease. Nat Rev Drug Discov 14(9):623\u2013641. https:\/\/doi.org\/10.1038\/nrd4623","journal-title":"Nat Rev Drug Discov"},{"key":"4479_CR7","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.niox.2015.01.006","volume":"45","author":"A Quillon","year":"2015","unstructured":"Quillon A, Fromy B (2015) Debret R (2015) Endothelium microenvironment sensing leading to nitric oxide mediated vasodilation: a review of nervous and biomechanical signals. Nitric Oxide 45:20\u201326. https:\/\/doi.org\/10.1016\/j.niox.2015.01.006","journal-title":"Nitric Oxide"},{"issue":"6","key":"4479_CR8","doi-asserted-by":"publisher","first-page":"525","DOI":"10.3109\/01443615.2012.693985","volume":"32","author":"B Demir","year":"2012","unstructured":"Demir B, Demir S, Pasa S (2012) The role of homocysteine, asymmetric dimethylarginine and nitric oxide in preeclampsia. J Obstet Gynaecol 32(6):525\u2013528. https:\/\/doi.org\/10.3109\/01443615.2012.693985","journal-title":"J Obstet Gynaecol"},{"issue":"5","key":"4479_CR9","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1161\/01.hyp.16.5.477","volume":"16","author":"LJ Ignarro","year":"1990","unstructured":"Ignarro LJ (1990) Nitric oxide. A novel signal transduction mechanism for transcellular communication. Hypertension 16(5):477\u2013483. https:\/\/doi.org\/10.1161\/01.hyp.16.5.477","journal-title":"Hypertension"},{"issue":"5","key":"4479_CR10","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1172\/JCI115481","volume":"88","author":"JP Cooke","year":"1991","unstructured":"Cooke JP, Rossitch JRE, Andon NA, Loscalzo J, Dzau VJ (1991) Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator. J Clin Invest 88(5):1663\u20131671. https:\/\/doi.org\/10.1172\/JCI115481","journal-title":"J Clin Invest"},{"issue":"7","key":"4479_CR11","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1161\/01.cir.94.7.1682","volume":"94","author":"PS Tsao","year":"1996","unstructured":"Tsao PS, Buitrago R, Chan JR, Cooke JP (1996) Fluid flow inhibits endothelial adhesiveness. Nitric oxide and transcriptional regulation of VCAM-1. Circulation 94(7):1682\u20131689. https:\/\/doi.org\/10.1161\/01.cir.94.7.1682","journal-title":"Circulation"},{"issue":"1","key":"4479_CR12","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/s0014-2999(96)00701-7","volume":"317","author":"H Muhl","year":"1996","unstructured":"Muhl H, Sandau K, Brune B, Briner VA, Pfeilschifter J (1996) Nitric oxide donors induce apoptos is in glomerular mesangial cells, epithelial cells and endothelial cells. Eur J Pharmacol 317(1):137\u2013149. https:\/\/doi.org\/10.1016\/s0014-2999(96)00701-7","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"4479_CR13","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1902\/jop.2017.170023","volume":"88","author":"MF Moura","year":"2017","unstructured":"Moura MF, Navarro TP, Silva TA, Cota LOM, Soares Dutra Oliveira AM, Costa FO (2017) Periodontitis and endothelial dysfunction: periodontal clinical parameters and levels of salivary markers interleukin-1\u03b2, tumor necrosis factor-\u03b1, matrix metalloproteinase-2, tissue inhibitor of metalloproteinases-2 complex, and nitric oxide. J Periodontol 88(8):778\u2013787. https:\/\/doi.org\/10.1902\/jop.2017.170023","journal-title":"J Periodontol"},{"issue":"6","key":"4479_CR14","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1161\/01.ATV.0000128897.54893.26","volume":"24","author":"P Vallance","year":"2004","unstructured":"Vallance P, Leiper J (2004) Cardiovascular biology of asymmetric dimetylarginine: dimethylarginine dimethylaminohydrolase pathway. Arterioscler Thromb Vasc Biol 24(6):1023\u20131030. https:\/\/doi.org\/10.1161\/01.ATV.0000128897.54893.26","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"4479_CR15","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1074\/jbc.M603606200","volume":"282","author":"AJ Cardounel","year":"2007","unstructured":"Cardounel AJ, Cui H, Samouilov A, Johnson W, Kearns P, Tsai AL, Berka V, Zweier JL (2007) Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function. J Biol Chem 282(2):879\u2013887. https:\/\/doi.org\/10.1074\/jbc.M603606200","journal-title":"J Biol Chem"},{"issue":"5","key":"4479_CR16","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1253\/circj.cj-13-1334","volume":"78","author":"A Sobczak","year":"2014","unstructured":"Sobczak A, Prokopowicz A, Radek M, Szula M, Zaciera M, Kurek J, Goniewicz ML (2014) Tobacco smoking decreases plasma concentration of the emerging cardiovascular risk marker. L-homoarginine Circ J 78(5):1254\u20131258. https:\/\/doi.org\/10.1253\/circj.cj-13-1334","journal-title":"L-homoarginine Circ J"},{"key":"4479_CR17","doi-asserted-by":"publisher","unstructured":"Isola G, Alibrandi A, Curr\u00f2 M, Matarese M, Ricca S, Matarese G, Ientile R, Kocher T (2020) Evaluation of salivary and serum ADMA levels in patients with periodontal and cardiovascular disease as subclinical marker of cardiovascular risk. J Periodontol. https:\/\/doi.org\/10.1002\/JPER.19-0446. Online ahead of print.","DOI":"10.1002\/JPER.19-0446"},{"issue":"1","key":"4479_CR18","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13075-017-1232-1","volume":"19","author":"T Dimitroulas","year":"2017","unstructured":"Dimitroulas T, Hodson J, Sandoo A, Smith J, Kitas GD (2017) Endothelial injury in rheumatoid arthritis: a crosstalk between dimethylarginines and systemic inflammation. Arthritis Res Ther 19(1):32. https:\/\/doi.org\/10.1186\/s13075-017-1232-1","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"4479_CR19","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s13054-017-1782-2","volume":"21","author":"MS Winkler","year":"2017","unstructured":"Winkler MS, Kluge S, Holzmann M, Moritz E, Robbe L, Bauer A, Zahrte C, Priefler M, Schwedhelm E, B\u00f6ger RH, Goetz AE, Nierhaus A, Zoellner C (2017) Markers of nitric oxide are associated with sepsis severity: an observational study. Crit Care 21(1):189. https:\/\/doi.org\/10.1186\/s13054-017-1782-2","journal-title":"Crit Care"},{"issue":"3","key":"4479_CR20","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1136\/heart.85.3.342","volume":"85","author":"P Vallance","year":"2001","unstructured":"Vallance P, Chan N (2001) Endothelial function and nitric oxide: clinical relevance. Heart 85(3):342\u2013350. https:\/\/doi.org\/10.1136\/heart.85.3.342","journal-title":"Heart"},{"issue":"2","key":"4479_CR21","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1111\/jre.12390","volume":"52","author":"S Almeida","year":"2017","unstructured":"Almeida S, Figueredo CM, Lemos C, Bregman R, Fischer RG (2017) Periodontal treatment in patients with chronic kidney disease: a pilot study. J Period Res 52(2):262\u2013267. https:\/\/doi.org\/10.1111\/jre.12390","journal-title":"J Period Res"},{"issue":"1","key":"4479_CR22","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/jcpe.12945","volume":"89","author":"MS Tonetti","year":"2018","unstructured":"Tonetti MS, Greenwell H, Kornman KS (2018) Staging and grading of periodontitis: framework and proposal of a new classification and case definition. Review J Periodontol 89(1):159\u2013172. https:\/\/doi.org\/10.1111\/jcpe.12945","journal-title":"Review J Periodontol"},{"key":"4479_CR23","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/j.1600-051X.2006.00892.x","volume":"33","author":"N Buduneli","year":"2006","unstructured":"Buduneli N, Kardesler L, Isik H, Willis CS 3rd, Hawkins SI, Kinane DF, Scott DA (2006) Effects of smoking and gingival inflammation on salivary antioxidant capacity. J Clin Periodontol 33:159\u2013164. https:\/\/doi.org\/10.1111\/j.1600-051X.2006.00892.x","journal-title":"J Clin Periodontol"},{"issue":"2","key":"4479_CR24","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.aca.2010.08.011","volume":"677","author":"IM Di Gangi","year":"2010","unstructured":"Di Gangi IM, Chiandetti L, Gucciardi A, Moret V, Naturale M, Giordano G (2010) Simultaneous quantitative determination of N(G), N(G)-dimethyl-L-arginine or asymmetric dimethylarginine and related pathway\u2019s metabolites in biological fluids by ultrahigh-performance liquid chromatography\/electrospray ionization-tandem mass spectrometry. Anal Chim Acta 677(2):140\u2013148. https:\/\/doi.org\/10.1016\/j.aca.2010.08.011","journal-title":"Anal Chim Acta"},{"issue":"7","key":"4479_CR25","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1111\/iej.12196","volume":"47","author":"MM Azuma","year":"2014","unstructured":"Azuma MM, Jamuel RO, Gomes-Filho JE, Dezan-Junior E, Cintra LTA (2014) The role IL-6 on apical periodontitis: a systematic review. Int Endod J 47(7):615\u2013621. https:\/\/doi.org\/10.1111\/iej.12196","journal-title":"Int Endod J"},{"issue":"22","key":"4479_CR26","doi-asserted-by":"publisher","first-page":"3579","DOI":"10.2174\/13816128113196660748","volume":"20","author":"S Karbach","year":"2014","unstructured":"Karbach S, Wenzel P, Waisman A, Munzel T, Daiber A (2014) eNOS uncoupling in cardiovascular diseases\u2014the role of oxidative stress and inflammation. Curr Pharm Des 20(22):3579\u20133594. https:\/\/doi.org\/10.2174\/13816128113196660748","journal-title":"Curr Pharm Des"},{"issue":"6","key":"4479_CR27","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1172\/JCI21767","volume":"114","author":"KP Koh","year":"2004","unstructured":"Koh KP, Wang Y, Yi T, Shiao SL, Lorber MI, Sessa WC, Tellides G, Pober JS (2004) T cell-mediated vascular dysfunction of human allografts results from IFN-gamma dysregulation of NO synthase. J Clin Invest 114(6):846\u2013856. https:\/\/doi.org\/10.1172\/JCI21767","journal-title":"J Clin Invest"},{"issue":"1","key":"4479_CR28","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/s0008-6363(03)00296-7","volume":"59","author":"PF Lai","year":"2003","unstructured":"Lai PF, Mohamed F, Monge JC, Stewart DJ (2003) Down-regulation of eNOS mRNA expression by TNF alpha: identification and functional characterization of RNA-protein interactions in the 3\u2019UTR. Cardiovascular Res 59(1):160\u2013168. https:\/\/doi.org\/10.1016\/s0008-6363(03)00296-7","journal-title":"Cardiovascular Res"},{"issue":"2","key":"4479_CR29","doi-asserted-by":"publisher","first-page":"180","DOI":"10.2174\/1568026611313020007","volume":"13","author":"G Bouras","year":"2013","unstructured":"Bouras G, Deftereos S, Tousoulis D, Giannopoulos G, Chatzis G, Tsounis D, Cleman MW, Stefanadis C (2013) ADMA: a promising biomarker for cardiovascular disease? Curr Top Med Chem 13(2):180\u2013200. https:\/\/doi.org\/10.2174\/1568026611313020007","journal-title":"Curr Top Med Chem"},{"key":"4479_CR30","doi-asserted-by":"publisher","first-page":"4028353","DOI":"10.1155\/2016\/4028353","volume":"2016","author":"JH Kim","year":"2016","unstructured":"Kim JH, Yoo BC, Yang WS, Kim E, Hong S, Cho JY (2016) The role of protein arginine methyltransferases in inflammatory responses. Mediators Inflamm 2016:4028353. https:\/\/doi.org\/10.1155\/2016\/4028353","journal-title":"Mediators Inflamm"},{"key":"4479_CR31","doi-asserted-by":"publisher","first-page":"5965721","DOI":"10.1155\/2019\/5965721.eCollection","volume":"2019","author":"M Krzystek-Korpacka","year":"2019","unstructured":"Krzystek-Korpacka M, Wisniewski J, Fleszar FG, Bednarz-Misa I, Bronowicka-Szyde\u0142ko A, Gacka M, Mas\u0142owski L, K\u0119dzior K, Witkiewicz W (2019) Gamian A (2019) Metabolites of the NO pathway are altered and indicative of reduced NO and arginine bioavailability in patients with cardiometabolic diseases complicated with chronic wounds of lower extremities: targeted metabolomics approach. Oxid Med Cell Longev 2019:5965721. https:\/\/doi.org\/10.1155\/2019\/5965721.eCollection","journal-title":"Oxid Med Cell Longev"},{"key":"4479_CR32","doi-asserted-by":"publisher","first-page":"114","DOI":"10.4274\/meandros.galenos.2018.58661","volume":"20","author":"M Kar\u015f\u0131yaka-Hendek","year":"2019","unstructured":"Kar\u015f\u0131yaka-Hendek M, Olgun E, K\u0131sa \u00dc (2019) Effect of initial periodontal treatment on cardiovascular risk markers in patients with severe chronic periodontitis. Meandros Med Dent J 20:114\u2013120. https:\/\/doi.org\/10.4274\/meandros.galenos.2018.58661","journal-title":"Meandros Med Dent J"},{"key":"4479_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12933-017-0656-x","volume":"17","author":"D Tsikas","year":"2018","unstructured":"Tsikas D, Bollenbach A, Hanff E, Arinc Kayacelebi A (2018) Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and homoarginine (hArg): the ADMA. SDMA and hArg paradoxes Cardiovasc Diabetol 17:1. https:\/\/doi.org\/10.1186\/s12933-017-0656-x","journal-title":"SDMA and hArg paradoxes Cardiovasc Diabetol"},{"issue":"50","key":"4479_CR34","doi-asserted-by":"publisher","first-page":"31213","DOI":"10.1074\/jbc.272.50.31213","volume":"272","author":"KK McDonald","year":"1997","unstructured":"McDonald KK, Zharikov S, Block ER, Kilberg MS (1997) A caveolar complex between the cationic amino acid transport I and endothelial nitric oxide synthase may explain the arginine paradox. J Biol Chem 272(50):31213\u201331216. https:\/\/doi.org\/10.1074\/jbc.272.50.31213","journal-title":"J Biol Chem"},{"issue":"4787","key":"4479_CR35","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1126\/science.2432665","volume":"235","author":"JB Hibbs Jr","year":"1987","unstructured":"Hibbs JB Jr, Taintor RR, Vavrin Z (1987) Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite. Science 235(4787):473\u2013476. https:\/\/doi.org\/10.1126\/science.2432665","journal-title":"Science"},{"issue":"13","key":"4479_CR36","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1161\/CIRCULATIONAHA.113.005924","volume":"128","author":"T Michel","year":"2013","unstructured":"Michel T (2013) R is for arginine: metabolism of arginine takes off again, in new directions. Circulation 128(13):1400\u20131404. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.113.005924","journal-title":"Circulation"},{"issue":"11","key":"4479_CR37","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1253\/circj.cj-08-0240","volume":"72","author":"P Valtonen","year":"2008","unstructured":"Valtonen P, Laitinen T, Lyyra-Laitinen T, Raitakari OT, Juonala M, Viikari JSA, Heiskanen N, Vanninen E, Punnonen K, Heinonen S (2008) Serum L-homoarginine is elevated during normal pregnancy and is related to flow-mediated vasodilatation. Circ J 72(11):1879\u20131884. https:\/\/doi.org\/10.1253\/circj.cj-08-0240","journal-title":"Circ J"},{"issue":"1","key":"4479_CR38","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/j.1600-051x.1996.tb00502.x","volume":"23","author":"A Gustafsson","year":"1996","unstructured":"Gustafsson A, Asman B (1996) Increased release of free oxygen radicals from peripheral neutrophils in adult periodontitis after fc delta-receptor stimulation. J Clin Periodontol 23(1):38\u201344. https:\/\/doi.org\/10.1111\/j.1600-051x.1996.tb00502.x","journal-title":"J Clin Periodontol"},{"issue":"4","key":"4479_CR39","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/8756-3282(94)90821-4","volume":"15","author":"LL Key Jr","year":"1994","unstructured":"Key LL Jr, Wolf WC, Gundberg CM, Ries WL (1994) Superoxide and bone resorption. Bone 15(4):431\u2013436. https:\/\/doi.org\/10.1016\/8756-3282(94)90821-4","journal-title":"Bone"},{"issue":"5","key":"4479_CR40","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1590\/s1807-59322009000500015","volume":"64","author":"MBP Landim","year":"2009","unstructured":"Landim MBP, Filho AC, Chagas CP (2009) Asymmetric dimethylarginine (ADMA) and endothelial dysfunction: implications for atherogenesis. Clinics 64(5):471\u2013478. https:\/\/doi.org\/10.1590\/s1807-59322009000500015","journal-title":"Clinics"},{"issue":"21","key":"4479_CR41","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1016\/j.ehj.2003.08.010","volume":"24","author":"RH B\u00f6ger","year":"2003","unstructured":"B\u00f6ger RH (2003) When the endothelium cannot say \u2018NO\u2019 anymore. ADMA, an endogenous inhibitor of NO synthase, promotes cardiovascular disease. Eur Heart J 24(21):1901\u20131902. https:\/\/doi.org\/10.1016\/j.ehj.2003.08.010","journal-title":"Eur Heart J"},{"issue":"1","key":"4479_CR42","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/s0008-6363(02)00617-x","volume":"57","author":"K Sydow","year":"2003","unstructured":"Sydow K, Schwedhelm E, Arakawa N, Bode-B\u00f6ger SM, Tsikas D, Hornig B, Fr\u00f6lich JC, B\u00f6ger RH (2003) ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins. Cardiovasc Res 57(1):244\u2013252. https:\/\/doi.org\/10.1016\/s0008-6363(02)00617-x","journal-title":"Cardiovasc Res"},{"issue":"10","key":"4479_CR43","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1161\/01.res.87.10.840","volume":"87","author":"H Cai","year":"2000","unstructured":"Cai H, Harrison DG (2000) Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87(10):840\u2013844. https:\/\/doi.org\/10.1161\/01.res.87.10.840","journal-title":"Circ Res"},{"issue":"4","key":"4479_CR44","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1093\/ajcn\/84.4.781","volume":"84","author":"C Antoniades","year":"2006","unstructured":"Antoniades C, Tousoulis D, Marinou K, Vasiliadou C, Tentolouris C, Bouras G, Pitsavos C, Stefanadis C (2006) Asymmetrical dimethylarginine regulates endothelial function in methionine-induced but not in chronic homocystinemia in humans: effect of oxidative stress and proinflammatory cytokines. Am J Clin Nutr 84(4):781\u2013788. https:\/\/doi.org\/10.1093\/ajcn\/84.4.781","journal-title":"Am J Clin Nutr"},{"issue":"37","key":"4479_CR45","doi-asserted-by":"publisher","first-page":"33995","DOI":"10.1074\/jbc.M108983200","volume":"277","author":"AJ Cardounel","year":"2002","unstructured":"Cardounel AJ, Zweier JL (2002) Endogenous methylarginines regulate neuronal nitric-oxide synthase and prevent excitotoxic injury. J Biol Chem 277(37):33995\u201334002. https:\/\/doi.org\/10.1074\/jbc.M108983200","journal-title":"J Biol Chem"},{"issue":"8793","key":"4479_CR46","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/0140-6736(92)90865-z","volume":"339","author":"P Vallance","year":"1992","unstructured":"Vallance P, Leone A, Calver A, Collier J, Moncada S (1992) Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339(8793):572\u2013576. https:\/\/doi.org\/10.1016\/0140-6736(92)90865-z","journal-title":"Lancet"},{"issue":"1","key":"4479_CR47","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1093\/intimm\/10.1.61","volume":"10","author":"R Ross","year":"1998","unstructured":"Ross R, Gillitzer C, Kleinz R, Schwing J, Kleinert H, F\u00f6rstermann U, Reske-Kunz AB (1998) Involvement of NO in contact hypersensitivity. Int Immunol 10(1):61\u201390. https:\/\/doi.org\/10.1093\/intimm\/10.1.61","journal-title":"Int Immunol"},{"issue":"1","key":"4479_CR48","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/jre.12273","volume":"51","author":"QA Hussain","year":"2016","unstructured":"Hussain QA, McKay IJ, Gonzales-Marin C, Allaker RP (2016) Detection of adrenomedullin and nitric oxide in different forms of periodontal disease. J Periodontal Res 51(1):16\u201325. https:\/\/doi.org\/10.1111\/jre.12273","journal-title":"J Periodontal Res"},{"issue":"10","key":"4479_CR49","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1111\/jcpe.12145","volume":"40","author":"O Andrukhov","year":"2013","unstructured":"Andrukhov O, Haririan H, Bertl K, Rausch WD, Bantleon HP, Moritz A, Rausch-Fan X (2013) Nitric oxide production, systemic inflammation and lipid metabolism in periodontitis patients: possible gender aspect. J Clin Periodontol 40(10):916\u2013923. https:\/\/doi.org\/10.1111\/jcpe.12145","journal-title":"J Clin Periodontol"},{"issue":"6","key":"4479_CR50","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1007\/s00784-016-1984-z","volume":"21","author":"C \u00d6nder","year":"2017","unstructured":"\u00d6nder C, Kurgan \u015e, Alt\u0131ng\u00f6z SM, Ba\u011f\u0131\u015f N, Uyan\u0131k M, Serdar MA, Kantarc\u0131 A, G\u00fcnhan M (2017) Impact of non-surgical periodontal therapy on saliva and serum levels of markers of oxidative stress. Clin Oral Investig 21(6):1961\u20131969. https:\/\/doi.org\/10.1007\/s00784-016-1984-z","journal-title":"Clin Oral Investig"},{"issue":"3","key":"4479_CR51","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1111\/j.1574-695X.2007.00329.x","volume":"51","author":"P Tripathi","year":"2007","unstructured":"Tripathi P, Tripathi P, Kashyap L, Singh V (2007) The role of nitric oxide in inflammatory reactions. FEMS Immunol Med Microbiol 51(3):443\u2013452. https:\/\/doi.org\/10.1111\/j.1574-695X.2007.00329.x","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"3","key":"4479_CR52","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00392-017-1172-4","volume":"107","author":"IE Emrich","year":"2017","unstructured":"Emrich IE, Zawada AM, Martens- Lobenhoffer J, Fliser D, Wagenpfeil S, Heine GH, Bode-B\u00f6ger SM (2017) Symmetric dimethylarginine (SDMA) outperforms ADMA and other methylarginines as predictor of renal and cardiovascular outcome in non-dialysis chronic kidney disease. Clin Res Cardiol 107(3):201\u2013213. https:\/\/doi.org\/10.1007\/s00392-017-1172-4","journal-title":"Clin Res Cardiol"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-022-04479-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-022-04479-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-022-04479-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T06:14:54Z","timestamp":1657606494000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-022-04479-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,14]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["4479"],"URL":"https:\/\/doi.org\/10.1007\/s00784-022-04479-w","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,14]]},"assertion":[{"value":"28 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The present study was approved by the human subject\u2019s ethics board of Ankara University (No: 09\/01, on 24.07.2019) for use and access of human subjects in research and was performed according to the Helsinki Declaration.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All participants have given written consent before the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}