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A further 4\u00a0weeks later, the first molar was moved into the reconstructed maxilla. Microfocus computed tomography (\u03bcCT) was performed six times (T0\u2013T5) to assess the tooth movement and root resorption. After 8\u00a0weeks, the affected reconstructed jaw was resected for histopathological investigation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Total distances reached ranged from 0.82\u2009\u00b1\u20090.72\u00a0mm (\u03b2-TCP\/HA) to 0.67\u2009\u00b1\u20090.27\u00a0mm (autograft). The resorption was particularly determined at the mesiobuccal root. Descriptive tooth movement slowed and root resorption increased slightly. However, neither the radiological changes during tooth movement (\u00b5CT T1 vs. \u00b5CT T5: autograft 1.85\u2009\u00b1\u20090.39 mm<jats:sup>3<\/jats:sup> vs. 2.38\u2009\u00b1\u20090.35 mm<jats:sup>3<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u20090.30; human xenograft 1.75\u2009\u00b1\u20090.45 mm<jats:sup>3<\/jats:sup> vs. 2.17\u2009\u00b1\u20090.26 mm<jats:sup>3<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u20090.54; \u03b2-TCP\/HA: 1.52\u2009\u00b1\u20090.42 mm<jats:sup>3<\/jats:sup> vs. 1.88\u2009\u00b1\u20090.41 mm<jats:sup>3<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u20090.60) nor the histological differences after tooth movement (human xenograft: 0.078\u2009\u00b1\u20090.05 mm<jats:sup>2<\/jats:sup>; \u03b2-TCP\/HA: 0.067\u2009\u00b1\u20090.049 mm<jats:sup>2<\/jats:sup>; autograft: 0.048\u2009\u00b1\u20090.015 mm<jats:sup>2<\/jats:sup>) were statistically significant.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The autografts, human xenografts or synthetic bone substitute used for cleft repair seem to have a similar effect on the subsequent orthodontic tooth movement and the associated root resorptions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>Development of root resorptions seems to have a secondary role in choosing a suitable grafting material for cleft repair.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-022-04537-3","type":"journal-article","created":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T15:03:02Z","timestamp":1652540582000},"page":"5809-5821","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Development of root resorption during orthodontic tooth movement after cleft repair using different grafting materials in rats"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7023-991X","authenticated-orcid":false,"given":"Stephan Christian","family":"M\u00f6hlhenrich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian","family":"Kniha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzanna","family":"Magnuska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachin","family":"Chhatwani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benita","family":"Hermanns-Sachweh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Gremse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"H\u00f6lzle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gholamreza","family":"Danesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Modabber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,14]]},"reference":[{"key":"4537_CR1","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1097\/00001665-200311000-00005","volume":"14","author":"AK Bajaj","year":"2003","unstructured":"Bajaj AK, Wongworawat AA, Punjabi A (2003) Management of alveolar clefts. 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The study protocol conforms to the ARRIVE Guidelines and with the Guide for the Care and Use of Laboratory Animals. All applicable international, national, and\/or institutional guidelines for the care and use of animals were followed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}