{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:43:18Z","timestamp":1791614598217,"version":"4.3.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"DOI":"10.1007\/s00784-022-04585-9","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T07:05:12Z","timestamp":1655708712000},"page":"817-826","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of N-acetylcysteine (NAC) and calcium hydroxide intracanal medications in primary endodontic infection: a randomized clinical trial"],"prefix":"10.1007","volume":"27","author":[{"given":"Frederico C.","family":"Martinho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna J. M.","family":"Corazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayana D.","family":"Khoury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban I. F.","family":"Orozco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassia C.","family":"Toia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe P.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia C.","family":"Valera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,20]]},"reference":[{"key":"4585_CR1","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1016\/j.joen.2021.04.026","volume":"47","author":"FC Martinho","year":"2021","unstructured":"Martinho FC, Leite FRM, Arruda-Vasconcelos R et al (2021) Influence of bacterial profiles in cytokine and clinical features of endodontic disease. J Endod 47:1265\u20131271. https:\/\/doi.org\/10.1016\/j.joen.2021.04.026","journal-title":"J Endod"},{"key":"4585_CR2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190469","volume":"13","author":"IN R\u00f4\u00e7as","year":"2018","unstructured":"R\u00f4\u00e7as IN, Siqueira JF (2018) Frequency and levels of candidate endodontic pathogens in acute apical abscesses as compared to asymptomatic apical periodontitis. PLoS ONE 13:e0190469. https:\/\/doi.org\/10.1371\/journal.pone.0190469","journal-title":"PLoS ONE"},{"key":"4585_CR3","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.joen.2015.01.031","volume":"41","author":"NS Ferreira","year":"2015","unstructured":"Ferreira NS, Martinho FC, Cardoso FGR et al (2015) Microbiological profile resistant to different intracanal medications in primary endodontic infections. J Endod 41:824\u2013830. https:\/\/doi.org\/10.1016\/j.joen.2015.01.031","journal-title":"J Endod"},{"key":"4585_CR4","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.joen.2008.02.004","volume":"34","author":"LM Sassone","year":"2008","unstructured":"Sassone LM, Fidel RA, Faveri M et al (2008) A microbiological profile of symptomatic teeth with primary endodontic infections. J Endod 34:541\u2013545. https:\/\/doi.org\/10.1016\/j.joen.2008.02.004","journal-title":"J Endod"},{"key":"4585_CR5","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1016\/j.joen.2017.03.032","volume":"43","author":"D Cavalli","year":"2017","unstructured":"Cavalli D, Toia CC, Flores Orozco EI et al (2017) Effectiveness in the removal of endotoxins and microbiological profile in primary endodontic infections using 3 different instrumentation systems: a randomized clinical study. J Endod 43:1237\u20131245. https:\/\/doi.org\/10.1016\/j.joen.2017.03.032","journal-title":"J Endod"},{"key":"4585_CR6","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.joen.2020.10.004","volume":"47","author":"FGR Cardoso","year":"2021","unstructured":"Cardoso FGR, Valera MC, Khoury RD, Martinho FC (2021) Resolution of nasal sinus tract after endodontic therapy: a case report with microbial analysis. J Endod 47:327\u2013334. https:\/\/doi.org\/10.1016\/j.joen.2020.10.004","journal-title":"J Endod"},{"key":"4585_CR7","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.joen.2013.10.022","volume":"40","author":"FC Martinho","year":"2014","unstructured":"Martinho FC, Leite FRM, Chiesa WMM et al (2014) Signaling pathways activation by primary endodontic infectious contents and production of inflammatory mediators. J Endod 40:484\u2013489. https:\/\/doi.org\/10.1016\/j.joen.2013.10.022","journal-title":"J Endod"},{"key":"4585_CR8","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1111\/iej.13261","volume":"53","author":"E Aveiro","year":"2020","unstructured":"Aveiro E, Chiarelli-Neto VM, de-Jesus-Soares A, et al (2020) Efficacy of reciprocating and ultrasonic activation of 6% sodium hypochlorite in the reduction of microbial content and virulence factors in teeth with primary endodontic infection. Int Endod J 53:604\u2013618. https:\/\/doi.org\/10.1111\/iej.13261","journal-title":"Int Endod J"},{"key":"4585_CR9","doi-asserted-by":"publisher","unstructured":"Orozco EIF, Toia CC, Cavalli D et al (2020) Effect of passive ultrasonic activation on microorganisms in primary root canal infection: a randomized clinical trial. J Appl Oral Sci 28.https:\/\/doi.org\/10.1590\/1678-7757-2019-0100","DOI":"10.1590\/1678-7757-2019-0100"},{"key":"4585_CR10","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.tripleo.2008.06.007","volume":"106","author":"JF Siqueira","year":"2008","unstructured":"Siqueira JF, R\u00f4\u00e7as IN, Riche FNSJ, Provenzano JC (2008) Clinical outcome of the endodontic treatment of teeth with apical periodontitis using an antimicrobial protocol. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:757\u2013762. https:\/\/doi.org\/10.1016\/j.tripleo.2008.06.007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"4585_CR11","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1111\/iej.12713","volume":"50","author":"DR Herrera","year":"2017","unstructured":"Herrera DR, Martinho FC, De-Jesus-Soares A et al (2017) Clinical efficacy of EDTA ultrasonic activation in the reduction of endotoxins and cultivable bacteria. Int Endod J 50:933\u2013940. https:\/\/doi.org\/10.1111\/iej.12713","journal-title":"Int Endod J"},{"key":"4585_CR12","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1111\/iej.12346","volume":"48","author":"ACS Marinho","year":"2015","unstructured":"Marinho ACS, Martinho FC, Gon\u00e7alves LM et al (2015) Does the Reciproc file remove root canal bacteria and endotoxins as effectively as multifile rotary systems? Int Endod J 48:542\u2013548. https:\/\/doi.org\/10.1111\/iej.12346","journal-title":"Int Endod J"},{"key":"4585_CR13","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.pdpdt.2017.06.005","volume":"19","author":"DGD Rabello","year":"2017","unstructured":"Rabello DGD, Corazza BJM, Ferreira LL et al (2017) Does supplemental photodynamic therapy optimize the disinfection of bacteria and endotoxins in one-visit and two-visit root canal therapy? A randomized clinical trial. Photodiagnosis Photodyn Ther 19:205\u2013211. https:\/\/doi.org\/10.1016\/j.pdpdt.2017.06.005","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"4585_CR14","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1038\/s41598-020-79300-3","volume":"11","author":"GG Nascimento","year":"2021","unstructured":"Nascimento GG, Rabello DGD, Corazza BJM et al (2021) Comparison of the effectiveness of single- and multiple-sessions disinfection protocols against endotoxins in root canal infections: systematic review and meta-analysis. Sci Rep 11:1226. https:\/\/doi.org\/10.1038\/s41598-020-79300-3","journal-title":"Sci Rep"},{"key":"4585_CR15","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s00784-017-2143-x","volume":"22","author":"FC Martinho","year":"2018","unstructured":"Martinho FC, Gomes CC, Nascimento GG et al (2018) Clinical comparison of the effectiveness of 7- and 14-day intracanal medications in root canal disinfection and inflammatory cytokines. Clin Oral Investig 22:523\u2013530. https:\/\/doi.org\/10.1007\/s00784-017-2143-x","journal-title":"Clin Oral Investig"},{"key":"4585_CR16","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.joen.2013.04.027","volume":"39","author":"ACC Xavier","year":"2013","unstructured":"Xavier ACC, Martinho FC, Chung A et al (2013) One-visit versus two-visit root canal treatment: effectiveness in the removal of endotoxins and cultivable bacteria. J Endod 39:959\u2013964. https:\/\/doi.org\/10.1016\/j.joen.2013.04.027","journal-title":"J Endod"},{"key":"4585_CR17","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1111\/j.1365-2591.2011.01886.x","volume":"44","author":"Z Mohammadi","year":"2011","unstructured":"Mohammadi Z, Dummer PMH (2011) Properties and applications of calcium hydroxide in endodontics and dental traumatology. Int Endod J 44:697\u2013730","journal-title":"Int Endod J"},{"key":"4585_CR18","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1046\/j.1365-2591.2002.00504.x","volume":"35","author":"M Evans","year":"2002","unstructured":"Evans M, Davies JK, Sundqvist G, Figdor D (2002) Mechanisms involved in the resistance of Enterococcus faecalis to calcium hydroxide. Int Endod J 35:221\u2013228. https:\/\/doi.org\/10.1046\/j.1365-2591.2002.00504.x","journal-title":"Int Endod J"},{"key":"4585_CR19","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1111\/j.1399-302x.2004.00174.x","volume":"19","author":"K Nakajo","year":"2004","unstructured":"Nakajo K, Nakazawa F, Iwaku M, Hoshino E (2004) Alkali-resistant bacteria in root canal systems. Oral Microbiol Immunol 19:390\u2013394. https:\/\/doi.org\/10.1111\/j.1399-302x.2004.00174.x","journal-title":"Oral Microbiol Immunol"},{"key":"4585_CR20","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/S0099-2399(06)81199-4","volume":"19","author":"KE Safavi","year":"1993","unstructured":"Safavi KE, Nichols FC (1993) Effect of calcium hydroxide on bacterial lipopolysaccharide. J Endod 19:76\u201378. https:\/\/doi.org\/10.1016\/S0099-2399(06)81199-4","journal-title":"J Endod"},{"key":"4585_CR21","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1111\/iej.12199","volume":"47","author":"EK Sir\u00e9n","year":"2014","unstructured":"Sir\u00e9n EK, Kerosuo E, Lavonius E et al (2014) Ca(OH) 2 application modes: in vitro alkalinity and clinical effect on bacteria. Int Endod J 47:628\u2013638. https:\/\/doi.org\/10.1111\/iej.12199","journal-title":"Int Endod J"},{"key":"4585_CR22","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/j.1365-2591.2008.01540.x","volume":"42","author":"Z Mohammadi","year":"2009","unstructured":"Mohammadi Z, Abbott PV (2009) The properties and applications of chlorhexidine in endodontics. Int Endod J 42:288\u2013302. https:\/\/doi.org\/10.1111\/j.1365-2591.2008.01540.x","journal-title":"Int Endod J"},{"key":"4585_CR23","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1097\/00004770-200209000-00002","volume":"28","author":"I Portenier","year":"2002","unstructured":"Portenier I, Haapasalo H, Orstavik D et al (2002) Inactivation of the antibacterial activity of iodine potassium iodide and chlorhexidine digluconate against Enterococcus faecalis by dentin, dentin matrix, type-I collagen, and heat-killed microbial whole cells. J Endod 28:634\u2013637. https:\/\/doi.org\/10.1097\/00004770-200209000-00002","journal-title":"J Endod"},{"key":"4585_CR24","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.joen.2009.09.017","volume":"36","author":"LE Ch\u00e1vez de Paz","year":"2010","unstructured":"Ch\u00e1vez de Paz LE, Bergenholtz G, Svens\u00e4ter G (2010) The effects of antimicrobials on endodontic biofilm bacteria. J Endod 36:70\u201377. https:\/\/doi.org\/10.1016\/j.joen.2009.09.017","journal-title":"J Endod"},{"key":"4585_CR25","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1097\/01.DON.0000133157.60731.3F","volume":"31","author":"C de Souza","year":"2005","unstructured":"de Souza C, Teles R, Souto R et al (2005) Endodontic therapy associated with calcium hydroxide as an intracanal dressing: microbiologic evaluation by the checkerboard DNA-DNA hybridization technique. J Endod 31:79\u201383. https:\/\/doi.org\/10.1097\/01.DON.0000133157.60731.3F","journal-title":"J Endod"},{"key":"4585_CR26","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/j.joen.2010.11.003","volume":"37","author":"IN R\u00f4\u00e7as","year":"2011","unstructured":"R\u00f4\u00e7as IN, Siqueira JF (2011) In vivo antimicrobial effects of endodontic treatment procedures as assessed by molecular microbiologic techniques. J Endod 37:304\u2013310. https:\/\/doi.org\/10.1016\/j.joen.2010.11.003","journal-title":"J Endod"},{"key":"4585_CR27","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.joen.2021.11.002","volume":"48","author":"R Arruda-Vasconcelos","year":"2022","unstructured":"Arruda-Vasconcelos R, Barbosa-Ribeiro M, Louzada LM et al (2022) Efficacy of 6% sodium hypochlorite on infectious content of teeth with symptomatic irreversible pulpitis. J Endod 48:179\u2013189. https:\/\/doi.org\/10.1016\/j.joen.2021.11.002","journal-title":"J Endod"},{"key":"4585_CR28","doi-asserted-by":"publisher","first-page":"4117","DOI":"10.1016\/j.bbagen.2013.04.016","volume":"1830","author":"Y Samuni","year":"2013","unstructured":"Samuni Y, Goldstein S, Dean OM, Berk M (2013) The chemistry and biological activities of N-acetylcysteine. Biochim Biophys Acta 1830:4117\u20134129. https:\/\/doi.org\/10.1016\/j.bbagen.2013.04.016","journal-title":"Biochim Biophys Acta"},{"key":"4585_CR29","doi-asserted-by":"publisher","unstructured":"Cacciatore I, Cornacchia C, Pinnen F et al (2010) Prodrug approach for increasing cellular glutathione levels. Molecules.https:\/\/doi.org\/10.3390\/molecules15031242","DOI":"10.3390\/molecules15031242"},{"key":"4585_CR30","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.archoralbio.2016.03.017","volume":"68","author":"SP Karapinar","year":"2016","unstructured":"Karapinar SP, Ulum YZA, Ozcelik B et al (2016) The effect of N-acetylcysteine and calcium hydroxide on TNF-\u03b1 and TGF-\u03b21 in lipopolysaccharide-activated macrophages. Arch Oral Biol 68:48\u201354. https:\/\/doi.org\/10.1016\/j.archoralbio.2016.03.017","journal-title":"Arch Oral Biol"},{"key":"4585_CR31","doi-asserted-by":"publisher","first-page":"967","DOI":"10.3390\/antiox10060967","volume":"10","author":"MC dos Ten\u00f3rio","year":"2021","unstructured":"dos Ten\u00f3rio MC, S, Graciliano NG, Moura FA, et al (2021) N-acetylcysteine (NAC): impacts on human health. Antioxidants 10:967. https:\/\/doi.org\/10.3390\/antiox10060967","journal-title":"Antioxidants"},{"key":"4585_CR32","doi-asserted-by":"publisher","first-page":"2942","DOI":"10.1111\/j.1440-1584.2011.01213.x","volume":"18","author":"S Dinicola","year":"2014","unstructured":"Dinicola S, De Grazia S, Carlomagno G, Pintucci JP (2014) N-acetylcysteine as powerful molecule to destroy bacterial biofilms. A systematic review. Eur Rev Med Pharmacol Sci 18:2942\u20132948. https:\/\/doi.org\/10.1111\/j.1440-1584.2011.01213.x","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"4585_CR33","doi-asserted-by":"publisher","first-page":"4814","DOI":"10.1128\/AEM.69.8.4814-4822.2003","volume":"69","author":"AC Olofsson","year":"2003","unstructured":"Olofsson AC, Hermansson M, Elwing H (2003) N-acetyl-L-cysteine affects growth, extracellular polysaccharide production, and bacterial biofilm formation on solid surfaces. Appl Environ Microbiol 69:4814\u20134822. https:\/\/doi.org\/10.1128\/AEM.69.8.4814-4822.2003","journal-title":"Appl Environ Microbiol"},{"key":"4585_CR34","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1007\/s12275-016-5534-9","volume":"54","author":"J-HH Moon","year":"2016","unstructured":"Moon J-HH, Choi Y-SS, Lee H-WW et al (2016) Antibacterial effects of N-acetylcysteine against endodontic pathogens. J Microbiol 54:322\u2013329. https:\/\/doi.org\/10.1007\/s12275-016-5534-9","journal-title":"J Microbiol"},{"key":"4585_CR35","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.bjm.2017.04.003","volume":"49","author":"YS Choi","year":"2018","unstructured":"Choi YS, Kim C, Moon JH, Lee JY (2018) Removal and killing of multispecies endodontic biofilms by N-acetylcysteine. Brazilian J Microbiol 49:184\u2013188. https:\/\/doi.org\/10.1016\/j.bjm.2017.04.003","journal-title":"Brazilian J Microbiol"},{"key":"4585_CR36","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-015-4500-2","author":"JH Moon","year":"2015","unstructured":"Moon JH, Jang EY, Shim KS, Lee JY (2015) In vitro effects of N-acetyl cysteine alone and in combination with antibiotics on Prevotella intermedia. J Microbiol. https:\/\/doi.org\/10.1007\/s12275-015-4500-2","journal-title":"J Microbiol"},{"key":"4585_CR37","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.joen.2011.10.004","volume":"38","author":"SY Quah","year":"2012","unstructured":"Quah SY, Wu S, Lui JN et al (2012) N-acetylcysteine inhibits growth and eradicates biofilm of enterococcus faecalis. J Endod 38:81\u201385. https:\/\/doi.org\/10.1016\/j.joen.2011.10.004","journal-title":"J Endod"},{"key":"4585_CR38","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1111\/j.1399-302x.2004.00168.x","volume":"19","author":"SS Socransky","year":"2004","unstructured":"Socransky SS, Haffajee AD, Smith C et al (2004) Use of checkerboard DNA-DNA hybridization to study complex microbial ecosystems. Oral Microbiol Immunol 19:352\u2013362. https:\/\/doi.org\/10.1111\/j.1399-302x.2004.00168.x","journal-title":"Oral Microbiol Immunol"},{"key":"4585_CR39","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1111\/j.1600-9657.1998.tb00835.x","volume":"14","author":"S Lindskog","year":"2007","unstructured":"Lindskog S, Piercs AM, Blomi\u00f6f L (2007) Ghlorhexidine as a root canal medicament for treating inflammatory lesions in the periodontal space. Dent Traumatol 14:186\u2013190. https:\/\/doi.org\/10.1111\/j.1600-9657.1998.tb00835.x","journal-title":"Dent Traumatol"},{"key":"4585_CR40","doi-asserted-by":"publisher","unstructured":"Hasna AA, Khoury RD, Toia CC et al (2020) In vitro evaluation of the antimicrobial effect of N-acetylcysteine and photodynamic therapy on root canals infected with Enterococcus faecalis. Iran Endod J 15:236\u2013245. https:\/\/doi.org\/10.22037\/IEJ.V15I4.26865","DOI":"10.22037\/IEJ.V15I4.26865"},{"key":"4585_CR41","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1046\/j.1365-2591.1997.00092.x","volume":"30","author":"U Sj\u00f6gren","year":"2003","unstructured":"Sj\u00f6gren U, Figdor D, Persson S, Sundqvist G (2003) Influence of infection at the time of root filling on the outcome of endodontic treatment of teeth with apical periodontitis. Int Endod J 30:297\u2013306. https:\/\/doi.org\/10.1046\/j.1365-2591.1997.00092.x","journal-title":"Int Endod J"},{"key":"4585_CR42","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1097\/01.don.0000164856.27920.85","volume":"31","author":"T Waltimo","year":"2005","unstructured":"Waltimo T, Trope M, Haapasalo M, \u00d8rstavik D (2005) Clinical efficacy of treatment procedures in endodontic infection control and one year follow-up of periapical healing. J Endod 31:863\u2013866. https:\/\/doi.org\/10.1097\/01.don.0000164856.27920.85","journal-title":"J Endod"},{"key":"4585_CR43","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/j.joen.2019.05.021","volume":"45","author":"H Zandi","year":"2019","unstructured":"Zandi H, Petronijevic N, Mdala I et al (2019) Outcome of endodontic retreatment using 2 root canal irrigants and influence of infection on healing as determined by a molecular method: a randomized clinical trial. J Endod 45:1089-1098.e5. https:\/\/doi.org\/10.1016\/j.joen.2019.05.021","journal-title":"J Endod"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-022-04585-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-022-04585-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-022-04585-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T10:49:22Z","timestamp":1675162162000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-022-04585-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,20]]},"references-count":43,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["4585"],"URL":"https:\/\/doi.org\/10.1007\/s00784-022-04585-9","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,20]]},"assertion":[{"value":"5 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the local Institute Review Board (S\u00e3o Paulo State University (Unesp), Institute of Science and Technology, S\u00e3o Jos\u00e9 dos Campos, Brazil) (#2.651.035) 035 and registered with the Brazilian Clinical Trials Registry (ReBEC) (RBR-3xbnnn).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All individual participants included in the study signed an informed consent form.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}