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Clinical attachment level (CAL)\u2013gain (primary outcome), PD-reduction, gingival recession depth (GRD), full-mouth bleeding scores (FMBS), full-mouth plaque scores (FMPS), radiographic linear defect depth (RLDD), and radiographic bone fill (secondary-outcomes) were examined over 9\u00a0months post-surgically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Low-speed PRF\u2009+\u2009OFD and OFD demonstrated significant intra-group CAL-gain and PD- and RLDD-reduction at 3, 6, and 9\u00a0months (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Low-speed PRF\u2009+\u2009OFD exhibited a significant CAL-gain of 3.36\u2009\u00b1\u20091.12\u00a0mm at 6\u00a0months (2.36\u2009\u00b1\u20090.81\u00a0mm for the control group;<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), and a significantly greater PD-reduction of 3.36\u2009\u00b1\u20091.12\u00a0mm at 3\u00a0months, of 3.64\u2009\u00b1\u20091.12\u00a0mm at 6\u00a0months and of 3.73\u2009\u00b1\u20091.19\u00a0mm at 9\u00a0months (2.00\u2009\u00b1\u20090.89\u00a0mm, 2.09\u2009\u00b1\u20091.04\u00a0mm, and 2.18\u2009\u00b1\u20091.17\u00a0mm in the control group respectively;<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). No significant differences were notable regarding GRD, FMPS, FMBS, RLDD, or bone fill between both groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Within the current clinical trial\u2019s limitations, the use of low-speed PRF in conjunction with OFD improved CAL and PD post-surgically, and could provide a cost-effective modality to augment surgical periodontal therapy of intra-osseous defects of stage-III periodontitis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical relevance<\/jats:title><jats:p>Low-speed PRF could provide a cost-effective modality to improve clinical attachment gain and periodontal probing depth reduction with open flap debridement approaches.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00784-022-04627-2","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T14:03:58Z","timestamp":1658757838000},"page":"6671-6680","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Clinical and radiographic evaluation of low-speed platelet-rich fibrin (PRF) for the treatment of intra-osseous defects of stage-III periodontitis patients: a randomized controlled clinical trial"],"prefix":"10.1007","volume":"26","author":[{"given":"Yasser Ali","family":"Abdulrahman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal Mohamed","family":"Hosny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Elfana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6261-3609","authenticated-orcid":false,"given":"Karim Mohamed","family":"Fawzy El-Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"issue":"1","key":"4627_CR1","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1111\/prd.12008","volume":"62","author":"LJ Heitz-Mayfield","year":"2000","unstructured":"Heitz-Mayfield LJ, Lang NP (2000) (2013) Surgical and nonsurgical periodontal therapy. 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