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In half of the animals (test group, <jats:italic>n<\/jats:italic>\u2009=\u200924 implants), the implants received ligatures around the implant-abutment connection. In the other half, no ligatures were placed (control group, <jats:italic>n<\/jats:italic>\u2009=\u200924 implants). Four weeks later, implants were extracted in a flapless approach and standard 3.3-mm diameter SLActive implants were placed into the same osteotomy site without any further drilling. Eight weeks after the second implantation, animals were sacrificed and analyzed in terms of implant survival.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>After 8\u00a0weeks of healing, 4 implants were lost in the control group and 14 in the test group. This corresponded to a 17.4% of early implant loss in the control group and 58.3% in the test. Most of the early failures occurred within the first 5\u00a0weeks of healing.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Implants placed in a pre-contaminated site present higher early loss than those placed in a non-contaminated site. This study represents a valid and robust preclinical model to study mechanisms and reduction of early implant loss as new technologies become available.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>Scientific rationale for the study: There is lack of animal models to study early implant loss. Thus, a proposal of a new model is presented. With the validation of this model, new technologies can be implemented to prevent early implant loss.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-022-04642-3","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T06:11:33Z","timestamp":1658988693000},"page":"6805-6815","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Development of a new preclinical model to study early implant loss: a validation study in the beagle dog"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1611-5884","authenticated-orcid":false,"given":"Antonio","family":"Li\u00f1ares","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul","family":"Verdeja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Pippenger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"L\u00f3pez-Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"issue":"Suppl","key":"4642_CR1","doi-asserted-by":"publisher","first-page":"308","DOI":"10.11607\/jomi.2014suppl.g5.2","volume":"29","author":"BE Pjetursson","year":"2014","unstructured":"Pjetursson BE, Asgeirsson AG, Zwahlen M, Sailer I (2014) Improvements in implant dentistry over the last decade: comparison of survival and complication rates in older and newer publications. 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Antonio Li\u00f1ares and Juan Blanco have been sponsored by Straumann AG for lecturing. Benjamin Pippenger is employed by Institut Straumann AG.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}