{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T00:40:55Z","timestamp":1792975255758,"version":"4.5.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T00:00:00Z","timestamp":1660176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T00:00:00Z","timestamp":1660176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"DOI":"10.1007\/s00784-022-04649-w","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T23:02:19Z","timestamp":1660172539000},"page":"6941-6960","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Effect of preemptive photobiomodulation associated with nimesulide on the postsurgical outcomes, oxidative stress, and quality of life after third molar surgery: a randomized, split-mouth, controlled clinical trial"],"prefix":"10.1007","volume":"26","author":[{"given":"Edson Luiz","family":"Cetira Filho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1513-9027","authenticated-orcid":false,"given":"Paulo Goberl\u00e2nio Barros","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deysi Viviana Tenazoa","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Choquenaira-Quispe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Rafael Alves Santana","family":"Ces\u00e1rio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisele","family":"de Sousa Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan Vieira Costa","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a Silvia Walter","family":"de Aguiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Said Goncalves","family":"da Cruz Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Wildson Gurgel","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,11]]},"reference":[{"key":"4649_CR1","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1016\/j.ijom.2015.06.012","volume":"44","author":"FWG Costa","year":"2015","unstructured":"Costa FWG, Soares ECS, Esses DFS, Silva PGB, Bezerra TP, Scarparo HC, Ribeiro TR, Fonteles CSR (2015) A split-mouth, randomized, triple-blind, placebo-controlled study to analyze the pre-emptive effect of etoricoxib 120 mg on inflammatory events following removal of unerupted mandibular third molars. Int J Oral Maxillofac Surg 44:1166\u20131174. https:\/\/doi.org\/10.1016\/j.ijom.2015.06.012","journal-title":"Int J Oral Maxillofac Surg"},{"key":"4649_CR2","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/j.ijom.2014.10.026","volume":"44","author":"EC Pouchain","year":"2015","unstructured":"Pouchain EC, Costa FWG, Bezerra TP, Soares ECS (2015) Comparative efficacy of nimesulide and ketoprofen on inflammatory events in third molar surgery: a split-mouth, prospective, randomized, double-blind study. Int J Oral Maxillofac Surg 44:876\u2013884. https:\/\/doi.org\/10.1016\/j.ijom.2014.10.026","journal-title":"Int J Oral Maxillofac Surg"},{"key":"4649_CR3","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1016\/j.ijom.2017.05.007","volume":"46","author":"AFM Albuquerque","year":"2017","unstructured":"Albuquerque AFM, Fonteles CSR, Do Val DR, Chaves HV, Bezerra MM, Pereira KMA, Silva PGB, De Lima BB, Soares ECS, Ribeiro TR, Costa FWG (2017) Effect of pre-emptive analgesia on clinical parameters and tissue levels of TNF-a and IL-1b in third molar surgery: a triple-blind, randomized, placebo-controlled study. Int J Oral Maxillofac Surg 46:1615\u20131625. https:\/\/doi.org\/10.1016\/j.ijom.2017.05.007","journal-title":"Int J Oral Maxillofac Surg"},{"key":"4649_CR4","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.ijom.2005.08.008","volume":"35","author":"M Colorado-Bonnin","year":"2006","unstructured":"Colorado-Bonnin M, Valmaseda-Castell\u00f3n E, Berini-Ayt\u00e9s L, Gay-Escoda C (2006) Quality of life following lower third molar removal. Int J Oral Maxillofac Surg 35:343\u2013347. https:\/\/doi.org\/10.1016\/j.ijom.2005.08.008","journal-title":"Int J Oral Maxillofac Surg"},{"key":"4649_CR5","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1016\/j.joms.2019.02.044","volume":"77","author":"S Liu","year":"2019","unstructured":"Liu S, Zhao H, Weng Y, Zhao H, Ma C (2019) Oral Bromelain for the control of facial swelling, trismus, and pain after mandibular third molar surgery: a systematic review and meta-analysis. J Oral Maxillofac Surg 77:1566\u20131574. https:\/\/doi.org\/10.1016\/j.joms.2019.02.044","journal-title":"J Oral Maxillofac Surg"},{"key":"4649_CR6","unstructured":"Forbes JA (1991) Oral surgery. In: M.E. Max, R.K. Portenoy, E.M. Laska, eds. Advances in pain research and therapy. The design of analgesic clinical trials. New York: Raven Press cap. 18, p. 347"},{"key":"4649_CR7","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1213\/01.ane.0000063827.97392.5e","volume":"97","author":"M Averbuch","year":"2003","unstructured":"Averbuch M, Katzper M (2003) Severity of baseline pain and degree of analgesia in the third molar post-extraction dental pain model. Anesth Analg 97:163\u2013167. https:\/\/doi.org\/10.1213\/01.ane.0000063827.97392.5e","journal-title":"Anesth Analg"},{"key":"4649_CR8","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.clinthera.2012.01.004","volume":"34","author":"K Saito","year":"2012","unstructured":"Saito K, Kaneko A, Machii K, Ohta H, Ohkura M, Suzuki M (2012) Efficacy and safety of additional 200-mg dose of celecoxib in adult patients with postoperative pain following extraction of impacted third mandibular molar: a multicenter, randomized, double-blind, placebo-controlled, phase II study in Japan. Clin Ther 34:314\u2013328. https:\/\/doi.org\/10.1016\/j.clinthera.2012.01.004","journal-title":"Clin Ther"},{"key":"4649_CR9","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.jcms.2020.01.016","volume":"48","author":"EL Cetira Filho","year":"2020","unstructured":"Cetira Filho EL, Carvalho FSR, Barros Silva PG, Barbosa DAF, Pereira KMA, Ribeiro TR, Costa FWG (2020) Preemptive use of oral nonsteroidal anti-inflammatory drugs for the relief of inflammatory events after surgical removal of lower third molars: A systematic review with meta-analysis of placebo-controlled randomized clinical trials. J Craniomaxillofac Surg 48:293\u2013307. https:\/\/doi.org\/10.1016\/j.jcms.2020.01.016","journal-title":"J Craniomaxillofac Surg"},{"key":"4649_CR10","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1590\/S1415-52732010000400013","volume":"23","author":"KBF Barbosa","year":"2010","unstructured":"Barbosa KBF, Costa NMB, Alfenas RCC, de Paula SO, Minim VPR, Bressan J (2010) Estresse oxidativo: conceito, implica\u00e7\u00f5es e fatores modulat\u00f3rios. Ver Nutr 23:629\u2013643. https:\/\/doi.org\/10.1590\/S1415-52732010000400013","journal-title":"Ver Nutr"},{"key":"4649_CR11","doi-asserted-by":"publisher","first-page":"3820","DOI":"10.3892\/etm.2018.5921","volume":"15","author":"M Koparal","year":"2018","unstructured":"Koparal M, Kucuk AO, Alan H, Asutay F, Avci M (2018) Effects of low-level laser therapy following surgical extraction of the lower third molar with objective measurement of swelling using a three-dimensional system. Exp Ther Med 15:3820\u20133826. https:\/\/doi.org\/10.3892\/etm.2018.5921","journal-title":"Exp Ther Med"},{"key":"4649_CR12","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1089\/pho.2011.3199","volume":"30","author":"W Lim","year":"2012","unstructured":"Lim W, Kim J, Lim C, Kim S, Jeon S, Karna S, Cho M, Choi H, Kim O (2012) Effect of 635 nm light-emitting diode irradiation on intracellular superoxide anion scavenging independent of the cellular enzymatic antioxidant system. Photomed Laser Surg 30:451\u2013459. https:\/\/doi.org\/10.1089\/pho.2011.3199","journal-title":"Photomed Laser Surg"},{"key":"4649_CR13","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.4103\/njcp.njcp_38_18","volume":"21","author":"F Asutay","year":"2018","unstructured":"Asutay F, Ozcan-Kucuk A, Alan H, Koparal M (2018) Three-dimensional evaluation of the effect of low-level laser therapy on facial swelling after lower third molar surgery: a randomized, placebo-controlled study. Niger J Clin Pract 21:1107\u20131113. https:\/\/doi.org\/10.4103\/njcp.njcp_38_18","journal-title":"Niger J Clin Pract"},{"key":"4649_CR14","doi-asserted-by":"publisher","unstructured":"Amaroli A, Ravera S, Baldini F, Benedicenti S, Panfoli I, Vergani L. Photobiomodulation with 808-nm diode laser light promotes wound healing of human endothelial cells through increased reactive oxygen species production stimulating mitochondrial oxidative phosphorylation. Lasers Med Sci 34: 495-504 https:\/\/doi.org\/10.1007\/s10103-018-2623-5","DOI":"10.1007\/s10103-018-2623-5"},{"key":"4649_CR15","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s10103-010-0837-2","volume":"26","author":"L Baratto","year":"2011","unstructured":"Baratto L, Calz\u00e0 L, Capra R, Gallamini M, Giardino L, Giuliani A, Lorenzini L, Traverso S (2011) Ultra-low-level laser therapy. Lasers Med Sci 26:103\u2013112. https:\/\/doi.org\/10.1007\/s10103-010-0837-2","journal-title":"Lasers Med Sci"},{"key":"4649_CR16","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1002\/art.22635","volume":"56","author":"S Kyrkanides","year":"2007","unstructured":"Kyrkanides S, Fiorentino PM, Miller JH, Gan Y, Lai Y, Shaftel SS, Puzas JE, Piancino MG, O\u2019Banion MK, Tallents RH (2007) Amelioration of pain and histopathologic joint abnormalities in the Col1-IL-1beta (XAT) mouse model of arthritis by intraarticular induction of mu-opioid receptor into the temporomandibular joint. Arthritis Rheum 56:2038\u20132048. https:\/\/doi.org\/10.1002\/art.22635","journal-title":"Arthritis Rheum"},{"key":"4649_CR17","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/j.archoralbio.2008.04.004","volume":"53","author":"R Vernal","year":"2008","unstructured":"Vernal R, Vel\u00e1squez E, Gamonal J, Garcia-Sanz JA, Silva A, Sanz M (2008) Expression of proinflammatory cytokines in osteoarthritis of the temporomandibular joint. Arch Oral Biol 53:910\u2013915. https:\/\/doi.org\/10.1016\/j.archoralbio.2008.04.004","journal-title":"Arch Oral Biol"},{"key":"4649_CR18","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s10753-011-9329-1","volume":"35","author":"TC Chicre-Alc\u00e2ntara","year":"2012","unstructured":"Chicre-Alc\u00e2ntara TC, Torres-Ch\u00e1vez KE, Fischer L, Clemente-Napimoga JT, Melo V, Parada CA, Tambeli CH (2012) Local kappa opioid receptor activation decreases temporomandibular joint inflammation. Inflammation 35:371\u2013376. https:\/\/doi.org\/10.1007\/s10753-011-9329-1","journal-title":"Inflammation"},{"key":"4649_CR19","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1002\/j.1532-2149.2012.00114.x","volume":"16","author":"MS Quinteiro","year":"2012","unstructured":"Quinteiro MS, Napimoga MH, Mesquita KP, Clemente-Napimoga JT (2012) The indirect antinociceptive mechanism of 15d-PGJ2 on rheumatoid arthritis-induced TMJ inflammatory pain in rats. Eur J Pain 16:1106\u20131115. https:\/\/doi.org\/10.1002\/j.1532-2149.2012.00114.x","journal-title":"Eur J Pain"},{"key":"4649_CR20","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1089\/ars.2015.6317","volume":"23","author":"J Frijhoff","year":"2015","unstructured":"Frijhoff J, Winyard PG, Zarkovic N, Davies SS, Stocker R, Cheng D, Knight AR, Taylor EL, Oettrich J, Ruskovska T, Gasparovic AC, Cuadrado A, Weber D, Poulsen HE, Grune T, Schmidt HHHW, Ghezzi P (2015) Clinical relevance of biomarkers of oxidative stress. Antioxid Redox Signal 23:1144\u20131170. https:\/\/doi.org\/10.1089\/ars.2015.6317","journal-title":"Antioxid Redox Signal"},{"key":"4649_CR21","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1089\/ars.2013.5643","volume":"20","author":"J Frijhoff","year":"2014","unstructured":"Frijhoff J, Dagnell M, Godfrey R, \u00d6stman A (2014) Regulation of protein tyrosine phosphatase oxidation in cell adhesion and migration. Antioxid Redox Signal 20:1994\u20132010. https:\/\/doi.org\/10.1089\/ars.2013.5643","journal-title":"Antioxid Redox Signal"},{"key":"4649_CR22","doi-asserted-by":"publisher","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","volume":"24","author":"M Schieber","year":"2014","unstructured":"Schieber M, Chandel NS (2014) ROS function in redox signaling and oxidative stress. Curr Biol 24:R453\u2013R462. https:\/\/doi.org\/10.1016\/j.cub.2014.03.034","journal-title":"Curr Biol"},{"key":"4649_CR23","doi-asserted-by":"publisher","first-page":"e467","DOI":"10.4317\/medoral.21398","volume":"22","author":"M Petrini","year":"2017","unstructured":"Petrini M, Ferrante M, Trentini P, Perfetti G, Spoto G (2017) Effect of pre-operatory low-level laser therapy on pain, swelling, and trismus associated with third-molar surgery. Med Oral Patol Oral Cir Bucal 22:e467\u2013e472. https:\/\/doi.org\/10.4317\/medoral.21398","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"4649_CR24","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.ijom.2015.10.023","volume":"45","author":"A Landucci","year":"2016","unstructured":"Landucci A, Wosny AC, Uetanabaro LC, Moro A, Araujo MR (2016) Efficacy of a single dose of low-level laser therapy in reducing pain, swelling, and trismus following third molar extraction surgery. Int J Oral Maxillofac Surg 45:392\u2013398. https:\/\/doi.org\/10.1016\/j.ijom.2015.10.023","journal-title":"Int J Oral Maxillofac Surg"},{"key":"4649_CR25","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s10103-002-8267-4","volume":"17","author":"A G\u00fcr","year":"2002","unstructured":"G\u00fcr A, Karako\u00e7 M, Nas K, Cevik R, Sara\u00e7 J, Demir E (2002) Efficacy of low power laser therapy in fibromyalgia: a single-blind, placebo-controlled trial. Lasers Med Sci 17:57\u201361. https:\/\/doi.org\/10.1007\/s10103-002-8267-4","journal-title":"Lasers Med Sci"},{"key":"4649_CR26","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1186\/1745-6215-13-221","volume":"13","author":"PTC De Carvalho","year":"2012","unstructured":"De Carvalho PTC, Leal Junior ECP, Alves ACA, Rambo CSM, Sampaio LMM, Oliveira CS, Albertini R, Oliveira LVF (2012) Effect of low-level laser therapy on pain, quality of life and sleep in patients with fibromyalgia: study protocol for a double-blinded randomized controlled trial. Trials 13:221. https:\/\/doi.org\/10.1186\/1745-6215-13-221","journal-title":"Trials"},{"key":"4649_CR27","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s10103-014-1654-9","volume":"30","author":"YL Hsieh","year":"2015","unstructured":"Hsieh YL, Hong CZ, Chou LW, Yang SA, Yang CC (2015) Fluence-dependent effects of low-level laser therapy in myofascial trigger spots on modulation of biochemicals associated with pain in a rabbit model. Lasers Med Sci 30:209\u2013216. https:\/\/doi.org\/10.1007\/s10103-014-1654-9","journal-title":"Lasers Med Sci"},{"key":"4649_CR28","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1002\/lsm.20371","volume":"38","author":"CF Rizzi","year":"2006","unstructured":"Rizzi CF, Mauriz JL, Corr\u00eaa DSF, Moreira AJ, Zettler CG, Filippin LI, Marroni NP, Gonz\u00e1lez-Gallego J (2006) Effects of low-level laser therapy (LLLT) on the nuclear factor (NF)-kappaB signaling pathway in traumatized muscle. Lasers Surg Med 38:704\u2013713. https:\/\/doi.org\/10.1002\/lsm.20371","journal-title":"Lasers Surg Med"},{"key":"4649_CR29","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.3390\/ijerph18052593","volume":"18","author":"L Fiorillo","year":"2021","unstructured":"Fiorillo L, Meto A, Cicci\u00f9 F, De Stefano R (2021) An eventual SARS-CoV-2 infection prevention protocol in the medical setting and dental office. Int J Environ Res Public Health 18:2593. https:\/\/doi.org\/10.3390\/ijerph18052593","journal-title":"Int J Environ Res Public Health"},{"key":"4649_CR30","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.ijom.2017.07.013","volume":"47","author":"RWF De Carvalho","year":"2018","unstructured":"De Carvalho RWF, Vasconcelos BC (2018) Pernambuco index: predictability of the complexity of surgery for impacted lower third molars. Int J Oral Maxillofac Surg 47:234\u2013240. https:\/\/doi.org\/10.1016\/j.ijom.2017.07.013","journal-title":"Int J Oral Maxillofac Surg"},{"key":"4649_CR31","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.ijom.2016.10.011","volume":"46","author":"JC Barbalho","year":"2017","unstructured":"Barbalho JC, Vasconcellos RJH, De Morais HH, Santos LAM, Almeida RAC, R\u00eabelo HL, Lucena EE, De Ara\u00fajo SQ (2017) Effects of co-administered dexamethasone and nimesulide on pain, swelling, and trismus following third molar surgery: a randomized, triple-blind, controlled clinical trial. Int J Oral Maxillofac Surg 46:236\u2013242. https:\/\/doi.org\/10.1016\/j.ijom.2016.10.011","journal-title":"Int J Oral Maxillofac Surg"},{"key":"4649_CR32","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1186\/1745-6215-14-373","volume":"14","author":"SO Sierra","year":"2013","unstructured":"Sierra SO, Deana AM, Ferrari RAM, Albarello PM, Bussadori SK, Fernandes KPS (2013) Effect of low-level laser therapy on the post-surgical inflammatory process after third molar removal: study protocol for a double-blind randomized controlled trial. Trials 14:373. https:\/\/doi.org\/10.1186\/1745-6215-14-373","journal-title":"Trials"},{"key":"4649_CR33","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1089\/pho.2016.4252","volume":"35","author":"SA Kahraman","year":"2017","unstructured":"Kahraman SA, Cetiner S, Strauss RA (2017) The effects of transcutaneous and intraoral low-level laser therapy after extraction of lower third molars: a randomized single blind, placebo controlled dual-center study. Photomed Laser Surg 35:401\u2013407. https:\/\/doi.org\/10.1089\/pho.2016.4252","journal-title":"Photomed Laser Surg"},{"key":"4649_CR34","doi-asserted-by":"publisher","first-page":"42","DOI":"10.15171\/jlms.2017.08","volume":"8","author":"S Raiesian","year":"2017","unstructured":"Raiesian S, Khani M, Khiabani K, Hemmati E, Pouretezad M (2017) Assessment of low-level laser therapy effects after extraction of impacted lower third molar surgery. J Lasers Med Sci 8:42\u201345. https:\/\/doi.org\/10.15171\/jlms.2017.08","journal-title":"J Lasers Med Sci"},{"key":"4649_CR35","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1590\/s0102-86502014000600004","volume":"29","author":"RB Melo","year":"2014","unstructured":"Melo RB, Guimar\u00e3es SB, Silva PGB, Ori\u00e1 RB, Melo JUS, Vasconcelos PRL (2014) Antiperoxidative properties of oil mixes of high ratio Omega-9:Omega-6 and low ratio Omega-6:Omega-3 after molar extraction in rats. Acta Cir Bras 29:371\u2013375. https:\/\/doi.org\/10.1590\/s0102-86502014000600004","journal-title":"Acta Cir Bras"},{"key":"4649_CR36","first-page":"695","volume-title":"Tiezt Textbook of Clinical Chemistry","author":"CA Burtis","year":"1986","unstructured":"Burtis CA, Ashwood ER (1986) Tiezt Textbook of Clinical Chemistry, 4th edn. WB Saunders Company, Philadelphia, pp 695\u2013700","edition":"4"},{"key":"4649_CR37","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1016\/j.joms.2006.03.052","volume":"64","author":"DA Shugars","year":"2006","unstructured":"Shugars DA, Gentile MA, Ahmad N, Stravropoulos MF, Slade GD, Phillpis C, Conrad SM, Fleuchaus PT, White Junior RP (2006) Assessment of oral health-related quality of life before and after third molar surgery. J Oral Maxillofac Surg 64:1721\u20131730. https:\/\/doi.org\/10.1016\/j.joms.2006.03.052","journal-title":"J Oral Maxillofac Surg"},{"key":"4649_CR38","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1053\/joms.2003.50106","volume":"61","author":"RP White","year":"2003","unstructured":"White RP, Shugars DA, Shafer DM, Laskin DM, Buckley MJ, Phillips C (2003) Recovery after third molar surgery: clinical and health-related quality of life outcomes. J Oral Maxillofac Surg 61:535\u2013544. https:\/\/doi.org\/10.1053\/joms.2003.50106","journal-title":"J Oral Maxillofac Surg"},{"key":"4649_CR39","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0304-3959(88)90023-1","volume":"32","author":"RH Gracely","year":"1988","unstructured":"Gracely RH, Lota L, Walter DJ, Dubner R (1988) A multiple random staircase method of psychophysical pain assessment. Pain 32:55\u201363. https:\/\/doi.org\/10.1016\/0304-3959(88)90023-1","journal-title":"Pain"},{"key":"4649_CR40","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1002\/lsm.22488","volume":"48","author":"SO Sierra","year":"2016","unstructured":"Sierra SO, Deana AM, Bussadori SK, Mota ACC, Ferrari RAM, Vale KL, Fernandes KPS (2016) Choosing between intraoral or extraoral, red or infrared laser irradiation after impacted third molar extraction. Lasers Surg Med 48:511\u2013518. https:\/\/doi.org\/10.1002\/lsm.22488","journal-title":"Lasers Surg Med"},{"key":"4649_CR41","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1590\/s0102-86502005000800002","volume":"20","author":"B Hochman","year":"2005","unstructured":"Hochman B, Nahas FX, De Oliveira Filho RS, Ferreira LM (2005) Research designs. Acta Cir Bras 20:2\u20139. https:\/\/doi.org\/10.1590\/s0102-86502005000800002","journal-title":"Acta Cir Bras"},{"key":"4649_CR42","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s10006-010-0255-4","volume":"15","author":"FD Lustenberger","year":"2011","unstructured":"Lustenberger FD, Gr\u00e4tz KW, Mutzbauer TS (2011) Efficacy of ibuprofen versus lornoxicam after third molar surgery: a randomized, double-blind, crossover pilot study. Oral Maxillofac Surg 15:57\u201362. https:\/\/doi.org\/10.1007\/s10006-010-0255-4","journal-title":"Oral Maxillofac Surg"},{"key":"4649_CR43","doi-asserted-by":"publisher","first-page":"e108","DOI":"10.1097\/SCS.0b013e318231e1d5","volume":"23","author":"RL Avelar","year":"2012","unstructured":"Avelar RL, Primo BT, Vogt BF, Silva EDO, Antunes AA, Magalh\u00e3es MTC, Rocha A (2012) Effect of partially selective cyclooxygenase-2 inhibitor in the removal of third molars. J Craniofac Surg 23:e108\u2013e112. https:\/\/doi.org\/10.1097\/SCS.0b013e318231e1d5","journal-title":"J Craniofac Surg"},{"key":"4649_CR44","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.5272\/jimab.2017233.1697","volume":"23","author":"D Neychev","year":"2017","unstructured":"Neychev D, Chenchev I, Simitchiev K (2017) Analysis of postoperative pain after extraction of impacted mandibular third molars and administration of preemptive analgesia. J of IMAB 23:1697\u20131701. https:\/\/doi.org\/10.5272\/jimab.2017233.1697","journal-title":"J of IMAB"},{"key":"4649_CR45","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/BF00567117","volume":"8","author":"P Lokken","year":"1975","unstructured":"Lokken P, Olsen I, Bruaset I, Norman-Pedersen K (1975) Bilateral surgical removal of impacted lower third molar teeth as a model for drug evaluation: a test with ibuprofen. Eur J Clin Pharmacol 8:209\u2013216. https:\/\/doi.org\/10.1007\/BF00567117","journal-title":"Eur J Clin Pharmacol"},{"key":"4649_CR46","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.ijom.2010.02.019","volume":"39","author":"T Kaczmarzyk","year":"2010","unstructured":"Kaczmarzyk T, Wichlinski J, Stypulkowska J, Zaleska M, Woron J (2010) Preemptive effect of ketoprofen on postoperative pain following third molar surgery. A prospective, randomized, double-blinded clinical trial. Int J Oral Maxillofac Surg 39:647\u2013652. https:\/\/doi.org\/10.1016\/j.ijom.2010.02.019","journal-title":"Int J Oral Maxillofac Surg"},{"key":"4649_CR47","doi-asserted-by":"publisher","first-page":"e4","DOI":"10.1016\/j.tripleo.2006.02.024","volume":"102","author":"AB Markovi\u0107","year":"2006","unstructured":"Markovi\u0107 AB, Todorovi\u0107 L (2006) Postoperative analgesia after lower third molar surgery: contribution of the use of long-acting local anesthetics, low-power laser, and diclofenac. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:e4-8. https:\/\/doi.org\/10.1016\/j.tripleo.2006.02.024","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"4649_CR48","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1046\/j.1365-2125.2003.01779.x","volume":"55","author":"GA Bj\u00f8rnsson","year":"2003","unstructured":"Bj\u00f8rnsson GA, Haanaes HR, Skoglund LA (2003) A randomized, double-blind crossover trial of paracetamol 1000 mg four times daily vs ibuprofen 600 mg: effect on swelling and other postoperative events after third molar surgery. Br J Clin Pharmacol 55:405\u2013412. https:\/\/doi.org\/10.1046\/j.1365-2125.2003.01779.x","journal-title":"Br J Clin Pharmacol"},{"key":"4649_CR49","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/s0300-9785(84)80017-4","volume":"13","author":"RA Seymour","year":"1984","unstructured":"Seymour RA, Walton JG (1984) Pain control after third molar surgery. Int J Oral Surg 13:457\u2013485. https:\/\/doi.org\/10.1016\/s0300-9785(84)80017-4","journal-title":"Int J Oral Surg"},{"key":"4649_CR50","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1089\/pho.2006.24.158","volume":"24","author":"JM Bjordal","year":"2006","unstructured":"Bjordal JM, Johnson MI, Iversen V, Aimbire F, Lopes-Martins RAB (2006) Low-level laser therapy in acute pain: a systematic review of possible mechanisms of action and clinical effects in randomized placebo-controlled trials. Photomed Laser Surg 24:158\u2013168. https:\/\/doi.org\/10.1089\/pho.2006.24.158","journal-title":"Photomed Laser Surg"},{"key":"4649_CR51","first-page":"630","volume":"59","author":"R Koszowski","year":"2006","unstructured":"Koszowski R, Smieszek-Wilczewska J, Wiec G (2006) Comparison of analgetic effect of magnetic and laser stimulation before oral surgery procedures. Wiad Lek 59:630\u2013633","journal-title":"Wiad Lek"},{"key":"4649_CR52","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1089\/pho.2005.23.289","volume":"23","author":"FR Ihsan","year":"2005","unstructured":"Ihsan FR (2005) Low-level laser therapy accelerates collateral circulation and enhances microcirculation. Photomed Laser Surg 23:289\u2013294. https:\/\/doi.org\/10.1089\/pho.2005.23.289","journal-title":"Photomed Laser Surg"},{"key":"4649_CR53","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1016\/j.joms.2016.02.030","volume":"74","author":"M Eshghpour","year":"2016","unstructured":"Eshghpour M, Ahrari F, Takallu M (2016) Is low-level laser therapy effective in the management of pain and swelling after mandibular third molar surgery? J Oral Maxillofac Surg 74:1322. https:\/\/doi.org\/10.1016\/j.joms.2016.02.030","journal-title":"J Oral Maxillofac Surg"},{"key":"4649_CR54","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.ijom.2010.03.012","volume":"39","author":"SA De Menezes","year":"2010","unstructured":"De Menezes SA, Cury PR (2010) Efficacy of nimesulide versus meloxicam in the control of pain, swelling and trismus following extraction of impacted lower third molar. Int J Oral Maxillofac Surg 39:580\u2013584. https:\/\/doi.org\/10.1016\/j.ijom.2010.03.012","journal-title":"Int J Oral Maxillofac Surg"},{"key":"4649_CR55","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1007\/s00216-017-0814-8","volume":"410","author":"Z Wang","year":"2018","unstructured":"Wang Z, Fang Y, Rock D, Ma J (2018) Rapid screening and characterization of glutathione-trapped reactive metabolites using a polarity switch-based approach on a high-resolution quadrupole orbitrap mass spectrometer, Analytical and Bioanalytical. Chemistry 410:1595\u20131606. https:\/\/doi.org\/10.1007\/s00216-017-0814-8","journal-title":"Chemistry"},{"key":"4649_CR56","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.lfs.2018.11.014","volume":"1","author":"K Pravalika","year":"2019","unstructured":"Pravalika K, Sarmah D, Kaur H, Vats K, Saraf J, Wanve M, Kalia K, Borah A, Yavagal DR, Dave KR, Bhattacharya P (2019) Trigonelline therapy confers neuroprotection by reduced glutathione mediated myeloperoxidase expression in animal model of ischemic stroke. Life Sci 1:49\u201358. https:\/\/doi.org\/10.1016\/j.lfs.2018.11.014","journal-title":"Life Sci"},{"key":"4649_CR57","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1074\/jbc.R700051200","volume":"283","author":"IA Blair","year":"2008","unstructured":"Blair IA (2008) DNA adducts with lipid peroxidation products. J Biol Chem 283:15545\u201315549. https:\/\/doi.org\/10.1074\/jbc.R700051200","journal-title":"J Biol Chem"},{"key":"4649_CR58","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.ijom.2013.11.006","volume":"43","author":"HO Kazancioglu","year":"2014","unstructured":"Kazancioglu HO, Kurklu E, Ezirganli S (2014) Effects of ozone therapy on pain, swelling, and trismus following third molar surgery. Int J Oral Maxillofac Surg 43:644\u2013648. https:\/\/doi.org\/10.1016\/j.ijom.2013.11.006","journal-title":"Int J Oral Maxillofac Surg"},{"key":"4649_CR59","doi-asserted-by":"publisher","first-page":"e346","DOI":"10.1016\/j.jcms.2012.01.018","volume":"40","author":"FA Da Costa Ara\u00fajo","year":"2012","unstructured":"Da Costa Ara\u00fajo FA, Santos TS, De Morais HHA, Laureano Filho JR, Silva EDO, Vasconcellos RJH (2012) Comparative analysis of preemptive analgesic effect of tramadol chlorhydrate and nimesulide following third molar surgery. J Craniomaxillofac Surg 40:e346\u2013e349. https:\/\/doi.org\/10.1016\/j.jcms.2012.01.018","journal-title":"J Craniomaxillofac Surg"},{"key":"4649_CR60","first-page":"596","volume":"72","author":"MA Maci\u00f3","year":"2002","unstructured":"Maci\u00f3 MA, Carvajal A, Vera E (2002) Hepatotoxicity associated with nimesulide: data from the Spanish pharmacovigilance system. Clin Pharmacol Ther 72:596\u2013597","journal-title":"Clin Pharmacol Ther"},{"key":"4649_CR61","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1089\/pho.2016.4101","volume":"34","author":"CN Eroglu","year":"2016","unstructured":"Eroglu CN, Tunc SK (2016) Effectiveness of single session of low-level laser therapy with a 940 nm wavelength diode laser on pain, swelling, and trismus after impacted third molar surgery. Photomed Laser Surg 34:406\u2013410. https:\/\/doi.org\/10.1089\/pho.2016.4101","journal-title":"Photomed Laser Surg"},{"key":"4649_CR62","first-page":"118","volume":"95","author":"C Richard","year":"2008","unstructured":"Richard C (2008) Principles and practice of clinical trial medicine. Periods, Sequences, and Trial Design 95:118","journal-title":"Periods, Sequences, and Trial Design"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-022-04649-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-022-04649-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-022-04649-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T12:29:32Z","timestamp":1744201772000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-022-04649-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,11]]},"references-count":62,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["4649"],"URL":"https:\/\/doi.org\/10.1007\/s00784-022-04649-w","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,11]]},"assertion":[{"value":"28 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Approval by the Ethics Committee, under protocol number 3,358,496.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All patients signed the consent form and agreed to participate in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}