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The aim of this study is to evaluate the gingival crevicular fluid (GCF) IL-39 levels in periodontal diseases and health and to correlate them to GCF levels of IL-1\u03b2 and periostin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Sixty-six adult patients were included in the study. The study design was comprised of three groups, each containing 22 individuals: the periodontally healthy (PH), gingivitis (G), and periodontitis (P) groups. The clinical periodontal parameters were recorded and GCF samples were collected from the participants. GCF interleukin (IL)-39, IL-1\u03b2, and periostin levels were examined using the enzyme-linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      GCF IL\u20111\u03b2, periostin, and IL-39 levels were higher in the P and G groups than in the PH group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Positive correlations were detected between all GCF biochemical parameters and clinical periodontal parameters (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In the multivariate generalized linear regression analysis, the P (\u03b2\u2009=\u200937.6, 95% CI\u2009=\u200922.9\u201352.4) and G (\u03b2\u2009=\u200928.4, 95% CI\u2009=\u200915.8\u201341) groups were associated with GCF IL-39 levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IL-39 levels were elevated in the presence of periodontal disease paralleling the increase in IL\u20111\u03b2 and periostin levels. IL-39 may have a role in the periodontal inflammation process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Statement of clinical relevance<\/jats:title>\n                    <jats:p>IL-39, a new cytokine from the IL-12 family, can be a possible predictor marker of periodontal diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-022-04681-w","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T01:02:50Z","timestamp":1660957370000},"page":"7209-7218","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Evaluation of IL-23p19\/Ebi3 (IL-39) gingival crevicular fluid levels in periodontal health, gingivitis, and periodontitis"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6180-9776","authenticated-orcid":false,"given":"Aysegul","family":"Sari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6854-2197","authenticated-orcid":false,"given":"Serdar","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7750-5010","authenticated-orcid":false,"given":"Luigi","family":"Nibali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4121-2494","authenticated-orcid":false,"given":"Serhat","family":"Koseoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,20]]},"reference":[{"key":"4681_CR1","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/prd.12371","volume":"86","author":"G Hajishengallis","year":"2021","unstructured":"Hajishengallis G, Lamont RJ (2021) Polymicrobial communities in periodontal disease: their quasi-organismal nature and dialogue with the host. 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