{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:14:30Z","timestamp":1790824470599,"version":"4.1.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003065","name":"University of Vienna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003065","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background and objective<\/jats:title>\n                <jats:p>Agenesis of the maxillary lateral incisor occurs in up to 4% of all individuals and requires multidisciplinary treatment. Its developmental origins, however, are not fully understood. Earlier studies documented genetic factors contributing to agenesis but also an association with craniofacial morphology. In this study, we assessed\u00a0the association between maxillary morphology and lateral incisor agenesis by a geometric morphometric approach to disentangle the roles of developmental plasticity and genetic factors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>We quantified the maxillary alveolar ridge by 19 two-dimensional landmarks on cross-sectional images of 101 computed tomography scans. We compared the shape and size of the alveolar ridge across patients with unilateral or bilateral agenesis of maxillary lateral incisors and patients with extracted or in situ incisors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The maxillary alveolar ridge was clearly narrower in patients with agenesis or an extracted incisor compared to the control group, whereas the contralateral side of the unilateral agenesis had an intermediate width. Despite massive individual variation, the ventral curvature of the alveolar ridge was, on average, more pronounced in the bilateral agenesis group compared to unilateral agenesis and tooth extraction.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This suggests that pleiotropic genetic and epigenetic factors influence both tooth development and cranial growth, but an inappropriately sized or shaped alveolar process may also inhibit normal formation or development of the tooth bud, thus leading to dental agenesis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>Our results indicate that bilateral agenesis of the lateral incisor tends to be associated with a higher need of bone augmentation prior to implant placement than unilateral agenesis.\n<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-022-04690-9","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T06:03:31Z","timestamp":1661753011000},"page":"1063-1070","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Maxillary lateral incisor agenesis is associated with maxillary form: a geometric morphometric analysis"],"prefix":"10.1007","volume":"27","author":[{"given":"Michael","family":"Nemec","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Bertl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8279-7943","authenticated-orcid":false,"given":"Kristina","family":"Bertl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Gahleitner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Mitteroecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Jonke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"issue":"3","key":"4690_CR1","first-page":"199","volume":"39","author":"V Rakhshan","year":"2015","unstructured":"Rakhshan V (2015) Meta-analysis of observational studies on the most commonly missing permanent dentition (excluding the third molars) in non-syndromic dental patients or randomly-selected subjects, and the factors affecting the observed rates. J Clin Pediatr Dent 39(3):199\u2013207","journal-title":"J Clin Pediatr Dent"},{"issue":"3","key":"4690_CR2","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/j.1600-0528.2004.00158.x","volume":"32","author":"BJ Polder","year":"2004","unstructured":"Polder BJ et al (2004) A meta-analysis of the prevalence of dental agenesis of permanent teeth. Community Dent Oral Epidemiol 32(3):217\u2013226","journal-title":"Community Dent Oral Epidemiol"},{"issue":"1","key":"4690_CR3","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1093\/ejo\/cjq021","volume":"33","author":"M Behr","year":"2011","unstructured":"Behr M et al (2011) Survey of congenitally missing teeth in orthodontic patients in Eastern Bavaria. Eur J Orthod 33(1):32\u201336","journal-title":"Eur J Orthod"},{"issue":"4","key":"4690_CR4","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1002\/ajpa.1330180406","volume":"18","author":"ML Moss","year":"1960","unstructured":"Moss ML, Young RW (1960) A functional approach to craniology. Am J Phys Anthropol 18(4):281\u2013292","journal-title":"Am J Phys Anthropol"},{"issue":"3","key":"4690_CR5","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1902\/jop.1975.46.3.139","volume":"46","author":"GG Nordquist","year":"1975","unstructured":"Nordquist GG, McNeill RW (1975) Orthodontic vs restorative treatment of the congenitally absent lateral incisor\u2013long term periodontal and occlusal evaluation. J Periodontol 46(3):139\u201343","journal-title":"J Periodontol"},{"issue":"6","key":"4690_CR6","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1093\/ejo\/22.6.697","volume":"22","author":"S Robertsson","year":"2000","unstructured":"Robertsson S, Mohlin B (2000) The congenitally missing upper lateral incisor A retrospective study of orthodontic space closure versus restorative treatment. Eur J Orthod 22(6):697\u2013710","journal-title":"Eur J Orthod"},{"issue":"4","key":"4690_CR7","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/j.1708-8240.2005.tb00116.x","volume":"17","author":"GA Kinzer","year":"2005","unstructured":"Kinzer GA, Kokich VO Jr (2005) Managing congenitally missing lateral incisors Part III: single-tooth implants. J Esthet Restor Dent 17(4):202\u201310","journal-title":"J Esthet Restor Dent"},{"issue":"2","key":"4690_CR8","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/j.1708-8240.2005.tb00089.x","volume":"17","author":"GA Kinzer","year":"2005","unstructured":"Kinzer GA, Kokich VO Jr (2005) Managing congenitally missing lateral incisors Part II: tooth-supported restorations. J Esthet Restor Dent 17(2):76\u201384","journal-title":"J Esthet Restor Dent"},{"issue":"1","key":"4690_CR9","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/j.1708-8240.2005.tb00076.x","volume":"17","author":"VO Kokich Jr","year":"2005","unstructured":"Kokich VO Jr, Kinzer GA (2005) Managing congenitally missing lateral incisors Part I: Canine substitution. J Esthet Restor Dent 17(1):5\u201310","journal-title":"J Esthet Restor Dent"},{"issue":"8","key":"4690_CR10","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1016\/j.jcms.2017.03.023","volume":"45","author":"GD Strbac","year":"2017","unstructured":"Strbac GD et al (2017) Survival rate of autotransplanted teeth after 5 years - a retrospective cohort study. J Craniomaxillofac Surg 45(8):1143\u20131149","journal-title":"J Craniomaxillofac Surg"},{"issue":"2","key":"4690_CR11","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1111\/cid.12249","volume":"18","author":"J Cosyn","year":"2016","unstructured":"Cosyn J, Cleymaet R, De Bruyn H (2016) Predictors of alveolar process remodeling following ridge preservation in high-risk patients. Clin Implant Dent Relat Res 18(2):226\u2013233","journal-title":"Clin Implant Dent Relat Res"},{"issue":"2","key":"4690_CR12","first-page":"98","volume":"50","author":"S Kurihara","year":"1980","unstructured":"Kurihara S, Enlow DH, Rangel RD (1980) Remodeling reversals in anterior parts of the human mandible and maxilla. Angle Orthod 50(2):98\u2013106","journal-title":"Angle Orthod"},{"issue":"2","key":"4690_CR13","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/joa.13002","volume":"235","author":"A Schuh","year":"2019","unstructured":"Schuh A et al (2019) Ontogeny of the human maxilla: a study of intra-population variability combining surface bone histology and geometric morphometrics. J Anat 235(2):233\u2013245","journal-title":"J Anat"},{"issue":"9","key":"4690_CR14","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1111\/clr.12915","volume":"28","author":"K Bertl","year":"2017","unstructured":"Bertl K et al (2017) A wide mesio-distal gap in sites of congenitally missing maxillary lateral incisors is related to a thin alveolar ridge. Clin Oral Implants Res 28(9):1038\u20131045","journal-title":"Clin Oral Implants Res"},{"issue":"1\u20132","key":"4690_CR15","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0925-4773(99)00095-7","volume":"85","author":"L Sarkar","year":"1999","unstructured":"Sarkar L, Sharpe PT (1999) Expression of Wnt signalling pathway genes during tooth development. Mech Dev 85(1\u20132):197\u2013200","journal-title":"Mech Dev"},{"issue":"4","key":"4690_CR16","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/ng0494-348","volume":"6","author":"I Satokata","year":"1994","unstructured":"Satokata I, Maa R (1994) Msx1 deficient mice exhibit cleft palate and abnormalities of cra. Nat Genet 6(4):348\u201356","journal-title":"Nat Genet"},{"issue":"13","key":"4690_CR17","doi-asserted-by":"publisher","first-page":"2911","DOI":"10.1242\/dev.126.13.2911","volume":"126","author":"RN D'Souza","year":"1999","unstructured":"D\u2019Souza RN et al (1999) Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice. Development 126(13):2911\u20132920","journal-title":"Development"},{"key":"4690_CR18","doi-asserted-by":"crossref","unstructured":"Rodrigues, A.S., et al. (2019) Is dental agenesis associated with craniofacial morphology pattern? A systematic review and meta-analysis. Eur J Orthod","DOI":"10.1093\/ejo\/cjz087"},{"issue":"1","key":"4690_CR19","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s40510-018-0238-9","volume":"19","author":"Y Takahashi","year":"2018","unstructured":"Takahashi Y et al (2018) Examination of craniofacial morphology in Japanese patients with congenitally missing teeth: a cross-sectional study. Prog Orthod 19(1):38","journal-title":"Prog Orthod"},{"issue":"4","key":"4690_CR20","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/ijos.2016.41","volume":"8","author":"MH Bertl","year":"2016","unstructured":"Bertl MH et al (2016) Second premolar agenesis is associated with mandibular form: a geometric morphometric analysis of mandibular cross-sections. Int J Oral Sci 8(4):254\u2013260","journal-title":"Int J Oral Sci"},{"issue":"6","key":"4690_CR21","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1007\/s00056-017-0109-x","volume":"78","author":"Y Huang","year":"2017","unstructured":"Huang Y et al (2017) Obeservations on association between third molar agenesis and craniofacial morphology. J Orofac Orthop 78(6):504\u2013510","journal-title":"J Orofac Orthop"},{"issue":"4","key":"4690_CR22","first-page":"332","volume":"5","author":"T Takeshima","year":"2004","unstructured":"Takeshima T et al (2004) Relationship between formation and eruption of permanent mandibular buccal dentition and vertical height of the mandibular body: longitudinal study of Japanese boys from 4 to 9 years of age. World J Orthod 5(4):332\u2013338","journal-title":"World J Orthod"},{"issue":"1","key":"4690_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1600-0714.2008.00699.x","volume":"38","author":"PJ De Coster","year":"2009","unstructured":"De Coster PJ et al (2009) Dental agenesis: genetic and clinical perspectives. J Oral Pathol Med 38(1):1\u201317","journal-title":"J Oral Pathol Med"},{"issue":"7014","key":"4690_CR24","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/nature02927","volume":"432","author":"AT Kangas","year":"2004","unstructured":"Kangas AT et al (2004) Nonindependence of mammalian dental characters. Nature 432(7014):211\u2013214","journal-title":"Nature"},{"issue":"7161","key":"4690_CR25","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/nature06153","volume":"449","author":"KD Kavanagh","year":"2007","unstructured":"Kavanagh KD, Evans AR, Jernvall J (2007) Predicting evolutionary patterns of mammalian teeth from development. Nature 449(7161):427\u2013432","journal-title":"Nature"},{"key":"4690_CR26","first-page":"246135","volume":"2011","author":"YH Kim","year":"2011","unstructured":"Kim YH (2011) Investigation of hypodontia as clinically related dental anomaly: prevalence and characteristics. ISRN Dent 2011:246135","journal-title":"ISRN Dent"},{"key":"4690_CR27","unstructured":"Schwindler, D.R., Primate dentition: an introduction to the teeth of non-human primates 2008: Cambridge University Press."},{"issue":"4","key":"4690_CR28","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.ajodo.2005.06.027","volume":"131","author":"AT Altug-Atac","year":"2007","unstructured":"Altug-Atac AT, Erdem D (2007) Prevalence and distribution of dental anomalies in orthodontic patients. Am J Orthod Dentofacial Orthop 131(4):510\u2013514","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"1","key":"4690_CR29","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.ajodo.2005.08.040","volume":"132","author":"E Jonke","year":"2007","unstructured":"Jonke E et al (2007) Secular trends in the facial skull from the 19th century to the present, analyzed with geometric morphometrics. Am J Orthod Dentofacial Orthop 132(1):63\u201370","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"4690_CR30","doi-asserted-by":"crossref","unstructured":"Ungar, P.S., Evolution\u2019s bite: a story of teeth, diet, and human origins. 2017: Princeton University Press.","DOI":"10.1515\/9781400884759"},{"issue":"3","key":"4690_CR31","first-page":"337","volume":"74","author":"TS Kajii","year":"2004","unstructured":"Kajii TS et al (2004) Agenesis of third molar germs depends on sagittal maxillary jaw dimensions in orthodontic patients in Japan. Angle Orthod 74(3):337\u2013342","journal-title":"Angle Orthod"},{"key":"4690_CR32","first-page":"304","volume":"4","author":"MG Moghadam","year":"2018","unstructured":"Moghadam MG, Etemadi F, Akbari N (2018) The relationship between agenesis of third molar and craniofacial morphology in orthodontic patients. J Int Soc Prev Community Dent 4:304\u2013308","journal-title":"J Int Soc Prev Community Dent"},{"issue":"22","key":"4690_CR33","doi-asserted-by":"publisher","first-page":"4775","DOI":"10.1242\/dev.127.22.4775","volume":"127","author":"HR Dassule","year":"2000","unstructured":"Dassule HR et al (2000) Sonic hedgehog regulates growth and morphogenesis of the tooth. Development 127(22):4775\u20134785","journal-title":"Development"},{"issue":"19","key":"4690_CR34","doi-asserted-by":"publisher","first-page":"3487","DOI":"10.1242\/dev.085084","volume":"139","author":"J Jernvall","year":"2012","unstructured":"Jernvall J, Thesleff I (2012) Tooth shape formation and tooth renewal: evolving with the same signals. Development 139(19):3487\u20133497","journal-title":"Development"},{"key":"4690_CR35","doi-asserted-by":"crossref","unstructured":"Seppala, M., et al. (2017) Sonic hedgehog signaling and development of the dentition. J Dev Biol. 5(2)","DOI":"10.3390\/jdb5020006"},{"issue":"6","key":"4690_CR36","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/j.ajodo.2011.05.021","volume":"140","author":"M Celikoglu","year":"2011","unstructured":"Celikoglu M, Bayram M, Nur M (2011) Patterns of third-molar agenesis and associated dental anomalies in an orthodontic population. Am J Orthod Dentofacial Orthop 140(6):856\u2013860","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"4690_CR37","doi-asserted-by":"crossref","unstructured":"Garib, D.G., et al. (2010) Agenesis of maxillary lateral incisors and associated dental anomalies. Am J Orthod Dentofacial Orthop. 137(6):732.e1\u20136; discussion 732\u20133","DOI":"10.1016\/j.ajodo.2009.12.024"},{"issue":"3","key":"4690_CR38","first-page":"267","volume":"68","author":"T Baccetti","year":"1998","unstructured":"Baccetti T (1998) A controlled study of associated dental anomalies. Angle Orthod 68(3):267\u2013274","journal-title":"Angle Orthod"},{"issue":"2","key":"4690_CR39","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s11692-009-9055-x","volume":"36","author":"P Mitteroecker","year":"2009","unstructured":"Mitteroecker P, Gunz P (2009) Advances in geometric morphometrics. Evol Biol 36(2):235\u2013247","journal-title":"Evol Biol"},{"issue":"5","key":"4690_CR40","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.ajodo.2003.05.013","volume":"125","author":"DJ Halazonetis","year":"2004","unstructured":"Halazonetis DJ (2004) Morphometrics for cephalometric diagnosis. Am J Orthod Dentofacial Orthop 125(5):571\u2013581","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"4690_CR41","doi-asserted-by":"crossref","unstructured":"Bookstein, F.L. (2018) A course in morphometrics for biologists: geometry and statistics for studies of organismal form., ed. C.U. Press.,Cambridge, UK.","DOI":"10.1017\/9781108120418"},{"issue":"2","key":"4690_CR42","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1007\/s00330-002-1373-7","volume":"13","author":"A Gahleitner","year":"2003","unstructured":"Gahleitner A, Watzek G, Imhof H (2003) Dental CT: imaging technique, anatomy, and pathologic conditions of the jaws. Eur Radiol 13(2):366\u2013376","journal-title":"Eur Radiol"},{"issue":"1","key":"4690_CR43","first-page":"103","volume":"24","author":"P Gunz","year":"2013","unstructured":"Gunz P, Mitteroecker P (2013) Semilandmarks: a method for quantifying curves and surfaces. Hystrix, the Italian journal of mammalogy 24(1):103\u2013109","journal-title":"Hystrix, the Italian journal of mammalogy"},{"issue":"3","key":"4690_CR44","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S1361-8415(97)85012-8","volume":"1","author":"FL Bookstein","year":"1997","unstructured":"Bookstein FL (1997) Landmark methods for forms without landmarks: morphometrics of group differences in outline shape. Med Image Anal 1(3):225\u2013243","journal-title":"Med Image Anal"},{"issue":"1","key":"4690_CR45","first-page":"40","volume":"39","author":"FJ Rohlf","year":"1990","unstructured":"Rohlf FJ, Slice D (1990) Extensions of the Procrustes method for the optimal superimposition of landmarks. Syst Biol 39(1):40\u201359","journal-title":"Syst Biol"},{"issue":"1","key":"4690_CR46","first-page":"59","volume":"24","author":"P Mitteroecker","year":"2013","unstructured":"Mitteroecker P, Gunz P, Windhager S, Schaefer K (2013) A brief review of shape, form, and allometry in geometric morphometrics, with applications to human facial morphology. Hystrix 24(1):59\u201366","journal-title":"Hystrix"},{"key":"4690_CR47","doi-asserted-by":"crossref","unstructured":"Bookstein, F. (1991) Morphometric tools for landmark data: geometry and biology., ed. C.U. Press. Cambridge (UK).","DOI":"10.1017\/CBO9780511573064"},{"key":"4690_CR48","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1007\/s11692-011-9109-8","volume":"38","author":"P Mitteroecker","year":"2011","unstructured":"Mitteroecker P, Bookstein F (2011) Linear discrimination, ordination, and the visualization of selection gradients in modern morphometrics. Evol Biol 38:100\u2013114","journal-title":"Evol Biol"},{"key":"4690_CR49","doi-asserted-by":"crossref","unstructured":"Good, P., Permutation tests: a practical guide to resampling methods for testing hypotheses. 2nd edition. ed, ed. S.S.i.S. Springer. 2000, New York.","DOI":"10.1007\/978-1-4757-3235-1_3"},{"key":"4690_CR50","first-page":"233","volume-title":"Handbook of microscopic anatomy","author":"HE Schroeder","year":"1986","unstructured":"Schroeder HE (1986) (1986) The periodontium. Handbook of microscopic anatomy. Springer, Berlin, Germany, pp 233\u2013246"},{"issue":"6","key":"4690_CR51","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/j.ajodo.2013.08.017","volume":"144","author":"F Uribe","year":"2013","unstructured":"Uribe F et al (2013) Cone-beam computed tomography evaluation of alveolar ridge width and height changes after orthodontic space opening in patients with congenitally missing maxillary lateral incisors. Am J Orthod Dentofacial Orthop 144(6):848\u2013859","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"1","key":"4690_CR52","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1093\/ejo\/cjr072","volume":"35","author":"F Uribe","year":"2013","unstructured":"Uribe F et al (2013) Alveolar ridge width and height changes after orthodontic space opening in patients congenitally missing maxillary lateral incisors. Eur J Orthod 35(1):87\u201392","journal-title":"Eur J Orthod"},{"issue":"2","key":"4690_CR53","doi-asserted-by":"publisher","first-page":"266","DOI":"10.14219\/jada.archive.1978.0054","volume":"96","author":"LW Graber","year":"1978","unstructured":"Graber LW (1978) Congenital absence of teeth: a review with emphasis on inheritance patterns. J Am Dent Assoc 96(2):266\u2013275","journal-title":"J Am Dent Assoc"},{"issue":"5","key":"4690_CR54","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0003-9969(84)90163-8","volume":"29","author":"AH Brook","year":"1984","unstructured":"Brook AH (1984) A unifying aetiological explanation for anomalies of human tooth number and size. Arch Oral Biol 29(5):373\u2013378","journal-title":"Arch Oral Biol"},{"issue":"5","key":"4690_CR55","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1093\/ejo\/cji022","volume":"27","author":"K Al-Nimri","year":"2005","unstructured":"Al-Nimri K, Gharaibeh T (2005) Space conditions and dental and occlusal features in patients with palatally impacted maxillary canines: an aetiological study. Eur J Orthod 27(5):461\u2013465","journal-title":"Eur J Orthod"},{"issue":"5","key":"4690_CR56","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1177\/0022034514523986","volume":"93","author":"M Alves-Ferreira","year":"2014","unstructured":"Alves-Ferreira M et al (2014) Identification of genetic risk factors for maxillary lateral incisor agenesis. J Dent Res 93(5):452\u2013458","journal-title":"J Dent Res"},{"issue":"1","key":"4690_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1708-8208.2012.00450.x","volume":"16","author":"KR Morjaria","year":"2014","unstructured":"Morjaria KR, Wilson R, Palmer RM (2014) Bone healing after tooth extraction with or without an intervention: a systematic review of randomized controlled trials. Clin Implant Dent Relat Res 16(1):1\u201320","journal-title":"Clin Implant Dent Relat Res"},{"issue":"4","key":"4690_CR58","first-page":"313","volume":"23","author":"L Schropp","year":"2003","unstructured":"Schropp L et al (2003) Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study. Int J Periodontics Restorative Dent 23(4):313\u2013323","journal-title":"Int J Periodontics Restorative Dent"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-022-04690-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-022-04690-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-022-04690-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T10:05:56Z","timestamp":1677924356000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-022-04690-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,29]]},"references-count":58,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["4690"],"URL":"https:\/\/doi.org\/10.1007\/s00784-022-04690-9","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,29]]},"assertion":[{"value":"15 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the ethics committee of the Medical University of Vienna, Austria (2005\/2012). The ethics approval of the present retrospective study did not require collecting any type of consent of the participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}