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Periodontitis was classified according to the CDC-AAP case definition. Inflammation, immune-activation, and immunosenescence markers were assessed, microbiological analyses were performed, and oral care routines and HIV characteristics were noted.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>From our group of PLWH, 42.5% and 57.5% suffered from moderate and severe periodontitis, respectively. Oral care habits did not differ between PLWH with moderate and severe periodontitis. Bacterial subgingival plaque loads were higher, and <jats:italic>Porphyromonas gingivalis<\/jats:italic> was more prevalent in PLWH with severe periodontitis than with moderate periodontitis (53% vs 7%, respectively). Mean C-reactive protein levels [CRP, 1.6\u00a0mg\/L versus 0.8\u00a0mg\/L, <jats:italic>p<\/jats:italic>\u2009=\u20090.020] and percentages of senescent CD28-CD57\u2009+\u2009CD8\u2009+\u2009T-cells in peripheral blood [16.5 versus 8.9, <jats:italic>p<\/jats:italic>\u2009=\u20090.035] were higher with severe periodontitis. Infection duration, CD4 count, CD4\/CD8 ratio and type of antiretroviral therapy did not differ between both groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Periodontitis severity is related to increased prevalence of <jats:italic>Porphyromonas gingivalis<\/jats:italic>, elevated CRP levels, and higher frequencies of circulating CD8\u2009+\u2009senescent cells in PLWH.\n<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-022-04758-6","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T01:23:46Z","timestamp":1667265826000},"page":"1255-1263","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Immune markers and microbial factors are related with periodontitis severity in people with HIV"],"prefix":"10.1007","volume":"27","author":[{"given":"Hester","family":"Groenewegen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantina","family":"Delli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjan","family":"Vissink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik K. 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