{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:06:34Z","timestamp":1771628794309,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T00:00:00Z","timestamp":1671840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T00:00:00Z","timestamp":1671840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005788","name":"Medical University of Vienna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"crossref"}]},{"name":"MIS Implants Technologies"},{"DOI":"10.13039\/501100005788","name":"Medical University of Vienna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract\n<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>This study aimed to assess levels of biomarkers associated with inflammation and tissue destruction in peri-implant crevicular fluid (PICF) of implants provided with customized or standard healing abutments during early implant healing.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>Thirty implants were placed in 22 patients with partial posterior edentulism. Subsequently, test group implants (<jats:italic>n<\/jats:italic>=15) received one-piece titanium abutments that were fabricated using computer-aided design\/computer-aided manufacturing (CAD\/CAM). Control group implants (<jats:italic>n<\/jats:italic>=15) were provided with standard abutments. PICF collection and standardized periapical radiographs were carried out at suture removal one week later, following crown delivery after 3 months and at 6 months. Expression of C-reactive protein (CRP), interferon-\u03b3, tumor necrosis factor (TNF)-\u03b1, interleukin (IL)-1\u03b1, IL-1\u03b2, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12A, IL-17A, macrophage inflammatory protein (MIP)-1\u03b1, matrix metalloproteinase (MMP)-13, osteopontin, osteoactivin, Receptor Activator of NF-\u03baB (RANK), and TGF-\u03b2 were analyzed using a multiplex ELISA kit.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Both groups showed a significant decrease in protein expression of CRP, IL-1\u03b2, IL-6, IL-8, MIP-1\u03b1, osteopontin, osteoactivin, and TGF-\u03b2, while MMP-13 levels increased during the observation period. A rise in OPG and RANK levels was detected among customized abutments. Expression of CRP was higher, whereas IL-1\u03b2, IL-1\u03b1, and MIP-1\u03b1 were decreased in control compared to test group implants after 6 months. Marginal bone loss did not depend on abutment modality.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Both abutment types showed distinctive temporal expression of inflammatory biomarkers during 6 months following implant placement.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>ISRCTN98477184, registration date 18\/05\/2022<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>Customized healing abutments exert similar effects on inflammation during early implant healing compared to standard healing abutments.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-022-04826-x","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T05:16:52Z","timestamp":1671859012000},"page":"2621-2628","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of customized CAD\/CAM abutments on cytokine levels in peri-implant crevicular fluid during early implant healing: a pilot study"],"prefix":"10.1007","volume":"27","author":[{"given":"Christian","family":"Wehner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabor","family":"F\u00fcrst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Vaskovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleh","family":"Andrukhov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Vasak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Moritz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Rausch-Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,12,24]]},"reference":[{"issue":"Suppl 15","key":"4826_CR1","doi-asserted-by":"publisher","first-page":"S6","DOI":"10.1111\/jcpe.12206","volume":"41","author":"A Sculean","year":"2014","unstructured":"Sculean A, Gruber R, Bosshardt DD (2014) \u201cSoft tissue wound healing around teeth and dental implants,\u201d (in eng). 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