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Half of the teeth underwent thermomechanical loading including 240,000 occlusal load cycles and 534 thermal cycles (TML, 5\u00a0\u00b0C\/55\u00a0\u00b0C; 49\u00a0N, 1.7\u00a0Hz). With RBC left in one proximal box as DME, all teeth received MOD inlays, made from lithium disilicate (LDS) or a polymer-infiltrated ceramic network material (PICN). The restored teeth underwent TML including 1.2 million occlusal cyclic loadings and 2673 thermal cycles. The marginal quality was assessed at baseline and after both runs of TML. Load-to-fracture tests were performed. The statistical analysis comprised multiple linear regressions (<jats:italic>\u03b1<\/jats:italic>\u2009=\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Simulated aging of RBC restorations had no significant effect on the marginal quality at the interface between the RBC and the tooth and the RBC and the inlay (<jats:italic>p<\/jats:italic>\u2009\u2265\u20090.247). Across time points, higher percentages of non-continuous margin were observed between the inlay and the tooth than between the tooth and the RBC (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.039). The age of the DME did not significantly affect the fracture resistance (<jats:italic>p<\/jats:italic>\u2009\u2265\u20090.052).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Artificial aging of RBC restorations used for DME had no detrimental effect on the marginal quality and fracture resistance of LDS and PICN inlays.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>This laboratory study suggests that\u2014in select cases\u2014intact, direct RBC restorations not placed immediately before the delivery of an indirect restoration may be used for DME.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-022-04841-y","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T07:05:52Z","timestamp":1673247952000},"page":"2691-2703","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Quality of CAD-CAM inlays placed on aged resin-based composite restorations used as deep margin elevation: a laboratory study"],"prefix":"10.1007","volume":"27","author":[{"given":"Catherine E. 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Dent Mater 25:1213\u20131220. https:\/\/doi.org\/10.1016\/j.dental.2009.04.007","journal-title":"Dent Mater"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-022-04841-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-022-04841-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-022-04841-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T12:19:23Z","timestamp":1686658763000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-022-04841-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,9]]},"references-count":36,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["4841"],"URL":"https:\/\/doi.org\/10.1007\/s00784-022-04841-y","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,9]]},"assertion":[{"value":"3 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study complied with the regulatory requirements of the Swiss Human Research Act and Human Research Ordinance. The local ethics committee approved the use of irreversibly anonymized teeth from donors who provided informed consent to the use of their extracted tooth\/teeth for research purposes (EKNZ UBE-15\/111).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"No formal consent was required for this type of laboratory study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Julia Amato reports grants from the Swiss Dental Association (SSO), grants from the Freiwillige Akademische Gesellschaft Basel (FAG), non-financial support from Ivoclar, and non-financial support from VITA during the conduct of the study.Thomas Attin reports no competing financial and\/or non-financial interests in relation to the work described.Markus B. Blatz reports no competing financial and\/or non-financial interests in relation to the work described.Florin Eggmann reports grants from the Swiss Dental Association (SSO), grants from the Freiwillige Akademische Gesellschaft Basel (FAG), a scholarship from the Gottfried and Julia Bangerter-Rhyner Foundation, a scholarship from the Freiwillige Akademische Gesellschaft Basel (FAG), non-financial support from Ivoclar, and non-financial support from VITA during the conduct of the study.Gabriel Krastl reports no competing financial and\/or non-financial interests in relation to the work described.Catherine E. R. Theisen reports grants from the Swiss Dental Association (SSO), grants from the Freiwillige Akademische Gesellschaft Basel (FAG), non-financial support from Ivoclar, and non-financial support from VITA during the conduct of the study.Roland Weiger reports grants from the Swiss Dental Association (SSO), grants from the Freiwillige Akademische Gesellschaft Basel (FAG), non-financial support from Ivoclar, and non-financial support from VITA during the conduct of the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}