{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:26:16Z","timestamp":1790223976215,"version":"4.1.0"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"DOI":"10.1007\/s00784-022-04848-5","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T12:03:29Z","timestamp":1672747409000},"page":"2735-2746","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Comparison of hyaluronic acid, hypochlorous acid, and flurbiprofen on postoperative morbidity in palatal donor area: a randomized controlled clinical trial"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5939-4783","authenticated-orcid":false,"given":"Aysan Lektemur","family":"Alpan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5362-4146","authenticated-orcid":false,"given":"Gizem Torumtay","family":"Cin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"4848_CR1","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1034\/j.1600-0757.2001.027001072.x","volume":"27","author":"PM Camargo","year":"2001","unstructured":"Camargo PM, Melnick PR, Kenney EB (2001) The use of free gingival grafts for aesthetic purposes. Periodontol 2000 27:72\u201396. https:\/\/doi.org\/10.1034\/j.1600-0757.2001.027001072.x","journal-title":"Periodontol 2000"},{"key":"4848_CR2","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1902\/jop.1978.49.8.403","volume":"49","author":"A Farnoush","year":"1978","unstructured":"Farnoush A (1978) Techniques for the protection and coverage of the donor sites in free soft tissue grafts. J Periodontol 49:403\u2013405. https:\/\/doi.org\/10.1902\/jop.1978.49.8.403","journal-title":"J Periodontol"},{"key":"4848_CR3","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/jcpe.12357","volume":"42","author":"R Burkhardt","year":"2015","unstructured":"Burkhardt R, Hammerle CH, Lang NP, Research Group on Oral Soft Tissue B, Wound H (2015) Self-reported pain perception of patients after mucosal graft harvesting in the palatal area. J Clin Periodontol 42:281\u20137. https:\/\/doi.org\/10.1111\/jcpe.12357","journal-title":"J Clin Periodontol"},{"key":"4848_CR4","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1902\/jop.2006.050296","volume":"77","author":"TJ Griffin","year":"2006","unstructured":"Griffin TJ, Cheung WS, Zavras AI, Damoulis PD (2006) Postoperative complications following gingival augmentation procedures. J Periodontol 77:2070\u20132079. https:\/\/doi.org\/10.1902\/jop.2006.050296","journal-title":"J Periodontol"},{"key":"4848_CR5","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1111\/jcpe.12404","volume":"42","author":"HG Keceli","year":"2015","unstructured":"Keceli HG, Aylikci BU, Koseoglu S, Dolgun A (2015) Evaluation of palatal donor site haemostasis and wound healing after free gingival graft surgery. J Clin Periodontol 42:582\u2013589. https:\/\/doi.org\/10.1111\/jcpe.12404","journal-title":"J Clin Periodontol"},{"key":"4848_CR6","doi-asserted-by":"publisher","first-page":"539","DOI":"10.11607\/prd.5035","volume":"41","author":"A Roccuzzo","year":"2021","unstructured":"Roccuzzo A, Imber JC, Bosshardt D, Salvi GE, Sculean A (2021) Development of bone exostosis following the use of a free gingival graft: a 30-year case report and literature review. Int J Periodont Restor Dent 41:539\u2013545. https:\/\/doi.org\/10.11607\/prd.5035","journal-title":"Int J Periodont Restor Dent"},{"key":"4848_CR7","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1186\/s12903-021-01541-z","volume":"21","author":"N Yussif","year":"2021","unstructured":"Yussif N, Wagih R, Selim K (2021) Propylene mesh versus acrylic resin stent for palatal wound protection following free gingival graft harvesting: a short-term pilot randomized clinical trial. BMC Oral Health 21:208. https:\/\/doi.org\/10.1186\/s12903-021-01541-z","journal-title":"BMC Oral Health"},{"key":"4848_CR8","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1080\/00016357.2016.1219045","volume":"74","author":"G Ustaoglu","year":"2016","unstructured":"Ustaoglu G, Ercan E, Tunali M (2016) The role of titanium-prepared platelet-rich fibrin in palatal mucosal wound healing and histoconduction. Acta Odontol Scand 74:558\u2013564. https:\/\/doi.org\/10.1080\/00016357.2016.1219045","journal-title":"Acta Odontol Scand"},{"key":"4848_CR9","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1111\/j.1600-051X.2006.01033.x","volume":"34","author":"A Kozlovsky","year":"2007","unstructured":"Kozlovsky A, Artzi Z, Hirshberg A, Israeli-Tobias C, Reich L (2007) Effect of local antimicrobial agents on excisional palatal wound healing: a clinical and histomorphometric study in rats. J Clin Periodontol 34:164\u2013171. https:\/\/doi.org\/10.1111\/j.1600-051X.2006.01033.x","journal-title":"J Clin Periodontol"},{"key":"4848_CR10","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1111\/coa.13058","volume":"43","author":"B Turk","year":"2018","unstructured":"Turk B, Akpinar M, Erol ZN, Kaya KS, Unsal O, Coskun BU (2018) The effect of flurbiprofen oral spray and ibuprofen vs ibuprofen alone on postoperative tonsillectomy pain: an open, randomised, controlled trial. Clin Otolaryngol 43:835\u2013840. https:\/\/doi.org\/10.1111\/coa.13058","journal-title":"Clin Otolaryngol"},{"key":"4848_CR11","doi-asserted-by":"publisher","first-page":"21","DOI":"10.23736\/S0375-9393.18.12703-9","volume":"85","author":"T Muderris","year":"2019","unstructured":"Muderris T, Tezcan G, Sancak M, Gul F, Ugur G (2019) Oral flurbiprofen spray for postoperative sore throat and hoarseness: a prospective, randomized, double-blind, placebo-controlled study. Minerva Anestesiol 85:21\u201327. https:\/\/doi.org\/10.23736\/S0375-9393.18.12703-9","journal-title":"Minerva Anestesiol"},{"key":"4848_CR12","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1158\/0008-5472.CAN-17-0836","volume":"78","author":"A Ooki","year":"2018","unstructured":"Ooki A, Del Carmen Rodriguez Pena M, Marchionni L, Dinalankara W, Begum A, Hahn NM, VandenBussche CJ, Rasheed ZA, Mao S, Netto GJ, Sidransky D, Hoque MO (2018) YAP1 and COX2 coordinately regulate urothelial cancer stem-like cells. Cancer Res 78:168\u2013181. https:\/\/doi.org\/10.1158\/0008-5472.CAN-17-0836","journal-title":"Cancer Res"},{"key":"4848_CR13","doi-asserted-by":"publisher","unstructured":"Aich A, Wang C, Chowdhury A, Ronsor C, Pacheu-Grau D, Richter-Dennerlein R, Dennerlein S, Rehling P (2018) COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis. Elife 7. https:\/\/doi.org\/10.7554\/eLife.32572","DOI":"10.7554\/eLife.32572"},{"key":"4848_CR14","doi-asserted-by":"publisher","first-page":"16469","DOI":"10.4238\/2015.December.9.18","volume":"14","author":"WW Jiang","year":"2015","unstructured":"Jiang WW, Wang QH, Peng P, Liao YJ, Duan HX, Xu M, Li Y, Zhang PB (2015) Effects of flurbiprofen axetil on postoperative serum IL-2 and IL-6 levels in patients with colorectal cancer. Genet Mol Res 14:16469\u201316475. https:\/\/doi.org\/10.4238\/2015.December.9.18","journal-title":"Genet Mol Res"},{"key":"4848_CR15","doi-asserted-by":"publisher","first-page":"132","DOI":"10.3892\/ol.2020.11993","volume":"20","author":"X Wang","year":"2020","unstructured":"Wang X, Ye X, Zhang Y, Ji F (2020) Flurbiprofen suppresses the inflammation, proliferation, invasion and migration of colorectal cancer cells via COX2. Oncol Lett 20:132. https:\/\/doi.org\/10.3892\/ol.2020.11993","journal-title":"Oncol Lett"},{"key":"4848_CR16","first-page":"e6","volume":"6","author":"MC Robson","year":"2007","unstructured":"Robson MC, Payne WG, Ko F, Mentis M, Donati G, Shafii SM, Culverhouse S, Wang L, Khosrovi B, Najafi R, Cooper DM, Bassiri M (2007) Hypochlorous acid as a potential wound care agent: part II. stabilized hypochlorous acid: its role in decreasing tissue bacterial bioburden and overcoming the inhibition of infection on wound healing. J Burns Wounds 6:e6","journal-title":"J Burns Wounds"},{"key":"4848_CR17","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1111\/jocd.13280","volume":"19","author":"MH Gold","year":"2020","unstructured":"Gold MH, Andriessen A, Bhatia AC, Bitter P Jr, Chilukuri S, Cohen JL, Robb CW (2020) Topical stabilized hypochlorous acid: the future gold standard for wound care and scar management in dermatologic and plastic surgery procedures. J Cosmet Dermatol 19:270\u2013277. https:\/\/doi.org\/10.1111\/jocd.13280","journal-title":"J Cosmet Dermatol"},{"key":"4848_CR18","first-page":"e5","volume":"6","author":"L Wang","year":"2007","unstructured":"Wang L, Bassiri M, Najafi R, Najafi K, Yang J, Khosrovi B, Hwong W, Barati E, Belisle B, Celeri C, Robson MC (2007) Hypochlorous acid as a potential wound care agent: part I. Stabilized hypochlorous acid: a component of the inorganic armamentarium of innate immunity. J Burns Wounds 6:e5","journal-title":"J Burns Wounds"},{"key":"4848_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2020.116364","volume":"241","author":"MFP Graca","year":"2020","unstructured":"Graca MFP, Miguel SP, Cabral CSD, Correia IJ (2020) Hyaluronic acid-based wound dressings: a review. Carbohydr Polym 241:116364. https:\/\/doi.org\/10.1016\/j.carbpol.2020.116364","journal-title":"Carbohydr Polym"},{"key":"4848_CR20","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.jcms.2014.01.041","volume":"42","author":"ZK Gencer","year":"2014","unstructured":"Gencer ZK, Ozkiris M, Okur A, Korkmaz M, Saydam L (2014) A comparative study on the impact of intra-articular injections of hyaluronic acid, tenoxicam and betametazon on the relief of temporomandibular joint disorder complaints. J Craniomaxillofac Surg 42:1117\u20131121. https:\/\/doi.org\/10.1016\/j.jcms.2014.01.041","journal-title":"J Craniomaxillofac Surg"},{"key":"4848_CR21","first-page":"129","volume":"54","author":"M Prosdocimi","year":"2012","unstructured":"Prosdocimi M, Bevilacqua C (2012) Exogenous hyaluronic acid and wound healing: an updated vision. Panminerva Med 54:129\u2013135","journal-title":"Panminerva Med"},{"key":"4848_CR22","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/j.1524-475X.2012.00777.x","volume":"20","author":"J Voigt","year":"2012","unstructured":"Voigt J, Driver VR (2012) Hyaluronic acid and wound healing. Wound Repair Regen 20:317\u2013331. https:\/\/doi.org\/10.1111\/j.1524-475X.2012.00777.x","journal-title":"Wound Repair Regen"},{"key":"4848_CR23","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/j.1524-475X.2012.00777.x","volume":"20","author":"J Voigt","year":"2012","unstructured":"Voigt J, Driver VR (2012) Hyaluronic acid derivatives and their healing effect on burns, epithelial surgical wounds, and chronic wounds: a systematic review and meta-analysis of randomized controlled trials. Wound Repair Regen 20:317\u2013331. https:\/\/doi.org\/10.1111\/j.1524-475X.2012.00777.x","journal-title":"Wound Repair Regen"},{"key":"4848_CR24","doi-asserted-by":"publisher","first-page":"53","DOI":"10.18433\/j3k89d","volume":"18","author":"MG Neuman","year":"2015","unstructured":"Neuman MG, Nanau RM, Oruna-Sanchez L, Coto G (2015) Hyaluronic acid and wound healing. J Pharm Pharm Sci 18:53\u201360. https:\/\/doi.org\/10.18433\/j3k89d","journal-title":"J Pharm Pharm Sci"},{"key":"4848_CR25","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/j.1742-481X.2012.00957.x","volume":"10","author":"P Humbert","year":"2013","unstructured":"Humbert P, Mikosinki J, Benchikhi H, Allaert FA (2013) Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 10:159\u2013166. https:\/\/doi.org\/10.1111\/j.1742-481X.2012.00957.x","journal-title":"Int Wound J"},{"key":"4848_CR26","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1902\/jop.2017.170105","volume":"89","author":"S Yildirim","year":"2018","unstructured":"Yildirim S, Ozener HO, Dogan B, Kuru B (2018) Effect of topically applied hyaluronic acid on pain and palatal epithelial wound healing: an examiner-masked, randomized, controlled clinical trial. J Periodontol 89:36\u201345. https:\/\/doi.org\/10.1902\/jop.2017.170105","journal-title":"J Periodontol"},{"key":"4848_CR27","doi-asserted-by":"publisher","first-page":"82","DOI":"10.2334\/josnusd.17-0423","volume":"61","author":"S Bergstrand","year":"2019","unstructured":"Bergstrand S, Ingstad HK, Moystad A, Bjornland T (2019) Long-term effectiveness of arthrocentesis with and without hyaluronic acid injection for treatment of temporomandibular joint osteoarthritis. J Oral Sci 61:82\u201388. https:\/\/doi.org\/10.2334\/josnusd.17-0423","journal-title":"J Oral Sci"},{"key":"4848_CR28","doi-asserted-by":"publisher","first-page":"4507","DOI":"10.1007\/s00784-020-03763-x","volume":"25","author":"V Iturriaga","year":"2021","unstructured":"Iturriaga V, Vasquez B, Bornhardt T, Del Sol M (2021) Effects of low and high molecular weight hyaluronic acid on the osteoarthritic temporomandibular joint in rabbit. Clin Oral Investig 25:4507\u20134518. https:\/\/doi.org\/10.1007\/s00784-020-03763-x","journal-title":"Clin Oral Investig"},{"key":"4848_CR29","first-page":"192","volume":"49","author":"B G\u00fcnayd\u0131n","year":"2021","unstructured":"G\u00fcnayd\u0131n B (2021) ASA Fiziksel Durum S\u0131n\u0131fland\u0131rma Sistemi: ASA Physical Status Classification System. Turk J Anaesthesiol Reanim 49:192\u2013193","journal-title":"Turk J Anaesthesiol Reanim"},{"key":"4848_CR30","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1111\/j.1600-051X.2005.00814.x","volume":"32","author":"A Guerrero","year":"2005","unstructured":"Guerrero A, Griffiths GS, Nibali L, Suvan J, Moles DR, Laurell L, Tonetti MS (2005) Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial. J Clin Periodontol 32:1096\u20131107. https:\/\/doi.org\/10.1111\/j.1600-051X.2005.00814.x","journal-title":"J Clin Periodontol"},{"key":"4848_CR31","volume-title":"Effectiveness of benzydamine HC1 in the treatment of periodontal post-surgical patients","author":"RG Landry","year":"1985","unstructured":"Landry RG (1985) Effectiveness of benzydamine HC1 in the treatment of periodontal post-surgical patients. Faculty of Dentistry, University of Toronto"},{"key":"4848_CR32","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s00784-019-02934-9","volume":"24","author":"A Lektemur Alpan","year":"2020","unstructured":"Lektemur Alpan A, Torumtay Cin G (2020) PRF improves wound healing and postoperative discomfort after harvesting subepithelial connective tissue graft from palate: a randomized controlled trial. Clin Oral Investig 24:425\u2013436. https:\/\/doi.org\/10.1007\/s00784-019-02934-9","journal-title":"Clin Oral Investig"},{"key":"4848_CR33","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1002\/jper.17-0381","volume":"89","author":"SC Isler","year":"2018","unstructured":"Isler SC, Eraydin N, Akkale H, Ozdemir B (2018) Oral flurbiprofen spray for mucosal graft harvesting at the palatal area: a randomized placebo-controlled study. J Periodontol 89:1174\u20131183. https:\/\/doi.org\/10.1002\/jper.17-0381","journal-title":"J Periodontol"},{"key":"4848_CR34","doi-asserted-by":"publisher","first-page":"12S","DOI":"10.1097\/01.prs.0000225430.42531.c2","volume":"117","author":"G Broughton 2nd","year":"2006","unstructured":"Broughton G 2nd, Janis JE, Attinger CE (2006) The basic science of wound healing. Plast Reconstr Surg 117:12S-34S. https:\/\/doi.org\/10.1097\/01.prs.0000225430.42531.c2","journal-title":"Plast Reconstr Surg"},{"key":"4848_CR35","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1177\/147323000903700531","volume":"37","author":"T Velnar","year":"2009","unstructured":"Velnar T, Bailey T, Smrkolj V (2009) The wound healing process: an overview of the cellular and molecular mechanisms. J Int Med Res 37:1528\u20131542. https:\/\/doi.org\/10.1177\/147323000903700531","journal-title":"J Int Med Res"},{"key":"4848_CR36","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1111\/wrr.12214","volume":"22","author":"KL Aya","year":"2014","unstructured":"Aya KL, Stern R (2014) Hyaluronan in wound healing: rediscovering a major player. Wound Repair Regen 22:579\u2013593. https:\/\/doi.org\/10.1111\/wrr.12214","journal-title":"Wound Repair Regen"},{"key":"4848_CR37","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/j.1742-481X.2012.01057.x","volume":"11","author":"JS Frenkel","year":"2014","unstructured":"Frenkel JS (2014) The role of hyaluronan in wound healing. Int Wound J 11:159\u2013163. https:\/\/doi.org\/10.1111\/j.1742-481X.2012.01057.x","journal-title":"Int Wound J"},{"key":"4848_CR38","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.jdermsci.2014.11.001","volume":"76","author":"A Kasuya","year":"2014","unstructured":"Kasuya A, Tokura Y (2014) Attempts to accelerate wound healing. J Dermatol Sci 76:169\u2013172. https:\/\/doi.org\/10.1016\/j.jdermsci.2014.11.001","journal-title":"J Dermatol Sci"},{"key":"4848_CR39","first-page":"78","volume":"28","author":"M Litwiniuk","year":"2016","unstructured":"Litwiniuk M, Krejner A, Speyrer MS, Gauto AR, Grzela T (2016) Hyaluronic acid in inflammation and tissue regeneration. Wounds 28:78\u201388","journal-title":"Wounds"},{"key":"4848_CR40","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1097\/prs.0000000000005504","volume":"143","author":"RF Chen","year":"2019","unstructured":"Chen RF, Wang CT, Chen YH, Chien CM, Lin SD, Lai CS, Wang CJ, Kuo YR (2019) Hyaluronic acid-povidone-iodine compound facilitates diabetic wound healing in a streptozotocin-induced diabetes rodent model. Plast Reconstr Surg 143:1371\u20131382. https:\/\/doi.org\/10.1097\/prs.0000000000005504","journal-title":"Plast Reconstr Surg"},{"key":"4848_CR41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088479","volume":"9","author":"C Tolg","year":"2014","unstructured":"Tolg C, Telmer P, Turley E (2014) Specific sizes of hyaluronan oligosaccharides stimulate fibroblast migration and excisional wound repair. PLoS ONE 9:e88479. https:\/\/doi.org\/10.1371\/journal.pone.0088479","journal-title":"PLoS ONE"},{"key":"4848_CR42","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1080\/10520295.2020.1832255","volume":"96","author":"MM Taskan","year":"2021","unstructured":"Taskan MM, Balci Yuce H, Karatas O, Gevrek F, Isiker Kara G, Celt M, Sirma Taskan E (2021) Hyaluronic acid with antioxidants improve wound healing in rats. Biotechnol Histochem 96:536\u2013545. https:\/\/doi.org\/10.1080\/10520295.2020.1832255","journal-title":"Biotechnol Histochem"},{"key":"4848_CR43","doi-asserted-by":"publisher","first-page":"e2221","DOI":"10.1097\/GOX.0000000000002221","volume":"7","author":"E Nyman","year":"2019","unstructured":"Nyman E, Henricson J, Ghafouri B, Anderson CD, Kratz G (2019) Hyaluronic acid accelerates re-epithelialization and alters protein expression in a human wound model. Plast Reconstr Surg Glob Open 7:e2221\u2013e2221. https:\/\/doi.org\/10.1097\/GOX.0000000000002221","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"4848_CR44","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1007\/s00784-021-04197-9","volume":"26","author":"S Khalil","year":"2022","unstructured":"Khalil S, Habashneh RA, Alomari S, Alzoubi M (2022) Local application of hyaluronic acid in conjunction with free gingival graft: a randomized clinical trial. Clin Oral Invest 26:2165\u20132174. https:\/\/doi.org\/10.1007\/s00784-021-04197-9","journal-title":"Clin Oral Invest"},{"key":"4848_CR45","doi-asserted-by":"publisher","first-page":"2548665","DOI":"10.1155\/2021\/2548665","volume":"2021","author":"A Hassan","year":"2021","unstructured":"Hassan A, Ahmed E, Ghalwash D, Elarab AE (2021) Clinical comparison of MEBO and hyaluronic acid gel in the management of pain after free gingival graft harvesting: a randomized clinical trial. Int J Dent 2021:2548665\u20132548665. https:\/\/doi.org\/10.1155\/2021\/2548665","journal-title":"Int J Dent"},{"key":"4848_CR46","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1053\/joca.1998.0207","volume":"7","author":"K Takahashi","year":"1999","unstructured":"Takahashi K, Goomer RS, Harwood F, Kubo T, Hirasawa Y, Amiel D (1999) The effects of hyaluronan on matrix metalloproteinase-3 (MMP-3), interleukin-1beta(IL-1beta), and tissue inhibitor of metalloproteinase-1 (TIMP-1) gene expression during the development of osteoarthritis. Osteoarthritis Cartil 7:182\u2013190. https:\/\/doi.org\/10.1053\/joca.1998.0207","journal-title":"Osteoarthritis Cartil"},{"key":"4848_CR47","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1016\/j.joca.2006.05.009","volume":"14","author":"CT Wang","year":"2006","unstructured":"Wang CT, Lin YT, Chiang BL, Lin YH, Hou SM (2006) High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis. Osteoarthritis Cartil 14:1237\u20131247. https:\/\/doi.org\/10.1016\/j.joca.2006.05.009","journal-title":"Osteoarthritis Cartil"},{"key":"4848_CR48","doi-asserted-by":"publisher","unstructured":"Campo GM, Avenoso A, Nastasi G, Micali A, Prestipino V, Vaccaro M, D\u2019Ascola A, Calatroni , Campo S (2011) Hyaluronan reduces inflammation in experimental arthritis by modulating TLR-2 and TLR-4 cartilage expression. Biochim Biophysica Acta (BBA) Mol Basis Dis 1812:1170\u20131181. https:\/\/doi.org\/10.1016\/j.bbadis.2011.06.006","DOI":"10.1016\/j.bbadis.2011.06.006"},{"key":"4848_CR49","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1111\/j.1471-4159.2012.07789.x","volume":"122","author":"JW Austin","year":"2012","unstructured":"Austin JW, Gilchrist C, Fehlings MG (2012) High molecular weight hyaluronan reduces lipopolysaccharide mediated microglial activation. J Neurochem 122:344\u2013355. https:\/\/doi.org\/10.1111\/j.1471-4159.2012.07789.x","journal-title":"J Neurochem"},{"key":"4848_CR50","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1016\/j.joms.2020.06.029","volume":"78","author":"MS Block","year":"2020","unstructured":"Block MS, Rowan BG (2020) Hypochlorous acid: a review. J Oral Maxillofac Surg 78:1461\u20131466. https:\/\/doi.org\/10.1016\/j.joms.2020.06.029","journal-title":"J Oral Maxillofac Surg"},{"key":"4848_CR51","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1111\/jam.15284","volume":"132","author":"N Hatanaka","year":"2022","unstructured":"Hatanaka N, Yasugi M, Sato T, Mukamoto M, Yamasaki S (2022) Hypochlorous acid solution is a potent antiviral agent against SARS-CoV-2. J Appl Microbiol 132:1496\u20131502. https:\/\/doi.org\/10.1111\/jam.15284","journal-title":"J Appl Microbiol"},{"issue":"Pt 1","key":"4848_CR52","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1042\/bj3070057","volume":"307","author":"MC Vissers","year":"1995","unstructured":"Vissers MC, Winterbourn CC (1995) Oxidation of intracellular glutathione after exposure of human red blood cells to hypochlorous acid. Biochem J 307(Pt 1):57\u201362. https:\/\/doi.org\/10.1042\/bj3070057","journal-title":"Biochem J"},{"key":"4848_CR53","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.12968\/jowc.2020.29.Sup10a.S4","volume":"29","author":"D Joachim","year":"2020","unstructured":"Joachim D (2020) Wound cleansing: benefits of hypochlorous acid. J Wound Care 29:S4\u2013S8. https:\/\/doi.org\/10.12968\/jowc.2020.29.Sup10a.S4","journal-title":"J Wound Care"},{"key":"4848_CR54","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/jac\/dky432","volume":"74","author":"A-L Severing","year":"2018","unstructured":"Severing A-L, Rembe J-D, Koester V, Stuermer EK (2018) Safety and efficacy profiles of different commercial sodium hypochlorite\/hypochlorous acid solutions (NaClO\/HClO): antimicrobial efficacy, cytotoxic impact and physicochemical parameters in vitro. J Antimicrob Chemother 74:365\u2013372. https:\/\/doi.org\/10.1093\/jac\/dky432","journal-title":"J Antimicrob Chemother"},{"key":"4848_CR55","first-page":"S2","volume":"61","author":"DG Armstrong","year":"2015","unstructured":"Armstrong DG, Bohn G, Glat P, Kavros SJ, Kirsner R, Snyder R, Tettelbach W (2015) Expert recommendations for the use of hypochlorous solution: science and clinical application. Ostomy Wound Manag 61:S2-s19","journal-title":"Ostomy Wound Manag"},{"key":"4848_CR56","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1111\/j.1365-2133.2004.05845.x","volume":"150","author":"R Moseley","year":"2004","unstructured":"Moseley R, Stewart JE, Stephens P, Waddington RJ, Thomas DW (2004) Extracellular matrix metabolites as potential biomarkers of disease activity in wound fluid: lessons learned from other inflammatory diseases? Br J Dermatol 150:401\u2013413. https:\/\/doi.org\/10.1111\/j.1365-2133.2004.05845.x","journal-title":"Br J Dermatol"},{"key":"4848_CR57","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1042\/BJ20030715","volume":"376","author":"AA Woods","year":"2003","unstructured":"Woods AA, Davies MJ (2003) Fragmentation of extracellular matrix by hypochlorous acid. Biochem J 376:219\u2013227. https:\/\/doi.org\/10.1042\/BJ20030715","journal-title":"Biochem J"},{"key":"4848_CR58","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/S0891-5849(96)00619-3","volume":"23","author":"MCM Vissers","year":"1997","unstructured":"Vissers MCM, Thomas C (1997) Hypochlorous acid disrupts the adhesive properties of subendothelial matrix. Free Radic Biol Med 23:401\u2013411. https:\/\/doi.org\/10.1016\/S0891-5849(96)00619-3","journal-title":"Free Radic Biol Med"},{"key":"4848_CR59","doi-asserted-by":"publisher","first-page":"24","DOI":"10.25270\/wmp.2021.8.2431","volume":"67","author":"SC Davis","year":"2021","unstructured":"Davis SC, Gil J, Li J, Simms C, Valdes J, Solis M, Higa A (2021) Effect of mechanical debridement and irrigation with hypochlorous acid wound management solution on methicillin-resistant Staphylococcus aureus contamination and healing deep dermal wounds in a porcine model. Wound Manag Prev 67:24\u201331","journal-title":"Wound Manag Prev"},{"key":"4848_CR60","doi-asserted-by":"publisher","unstructured":"Burian EA, Sabah L, Kirketerp-M\u00f8ller K, Gundersen G, \u00c5gren MS (2022) Effect of stabilized hypochlorous acid on re-epithelialization and bacterial bioburden in acute wounds: a randomized controlled trial in healthy volunteers. Acta Dermato-Venereol 102:adv00727. https:\/\/doi.org\/10.2340\/actadv.v102.1624","DOI":"10.2340\/actadv.v102.1624"},{"key":"4848_CR61","first-page":"89","volume":"5","author":"MM Mekkawy","year":"2014","unstructured":"Mekkawy MM, Kamal A (2014) A randomized clinical trial: the efficacy of hypochlorous acid on septic traumatic wound. J Educ Pract 5:89\u2013100","journal-title":"J Educ Pract"},{"key":"4848_CR62","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1089\/wound.2012.0381","volume":"2","author":"G Zhao","year":"2013","unstructured":"Zhao G, Usui ML, Lippman SI, James GA, Stewart PS, Fleckman P, Olerud JE (2013) Biofilms and inflammation in chronic wounds. Adv Wound Care (New Rochelle) 2:389\u2013399. https:\/\/doi.org\/10.1089\/wound.2012.0381","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"4848_CR63","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1097\/won.0000000000000703","volume":"47","author":"T Goto","year":"2020","unstructured":"Goto T, Saligan LN (2020) Wound pain and wound healing biomarkers from wound exudate: a scoping review. J Wound Ostomy Continence Nurs 47:559\u2013568. https:\/\/doi.org\/10.1097\/won.0000000000000703","journal-title":"J Wound Ostomy Continence Nurs"},{"key":"4848_CR64","first-page":"36","volume":"11","author":"JQ Del Rosso","year":"2018","unstructured":"Del Rosso JQ, Bhatia N (2018) Status report on topical hypochlorous acid: clinical relevance of specific formulations, potential modes of action, and study outcomes. J Clin Aesthet Dermatol 11:36\u201339","journal-title":"J Clin Aesthet Dermatol"},{"key":"4848_CR65","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.intimp.2007.03.005","volume":"7","author":"J Medina-Tamayo","year":"2007","unstructured":"Medina-Tamayo J, S\u00e1nchez-Miranda E, Balleza-Tapia H, Ambriz X, Cid ME, Gonz\u00e1lez-Espinosa D, Guti\u00e9rrez AA, Gonz\u00e1lez-Espinosa C (2007) Super-oxidized solution inhibits IgE-antigen-induced degranulation and cytokine release in mast cells. Int Immunopharmacol 7:1013\u20131024. https:\/\/doi.org\/10.1016\/j.intimp.2007.03.005","journal-title":"Int Immunopharmacol"},{"key":"4848_CR66","doi-asserted-by":"publisher","first-page":"100","DOI":"10.2165\/00003088-199528020-00002","volume":"28","author":"NM Davies","year":"1995","unstructured":"Davies NM (1995) Clinical pharmacokinetics of flurbiprofen and its enantiomers. Clin Pharmacokinet 28:100\u2013114. https:\/\/doi.org\/10.2165\/00003088-199528020-00002","journal-title":"Clin Pharmacokinet"},{"key":"4848_CR67","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1161\/ATVBAHA.110.207449","volume":"31","author":"E Ricciotti","year":"2011","unstructured":"Ricciotti E, FitzGerald GA (2011) Prostaglandins and inflammation. Arterioscler Thromb Vasc Biol 31:986\u20131000. https:\/\/doi.org\/10.1161\/ATVBAHA.110.207449","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"4848_CR68","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.jss.2014.12.026","volume":"194","author":"M Fairweather","year":"2015","unstructured":"Fairweather M, Heit YI, Buie J, Rosenberg LM, Briggs A, Orgill DP, Bertagnolli MM (2015) Celecoxib inhibits early cutaneous wound healing. J Surg Res 194:717\u2013724. https:\/\/doi.org\/10.1016\/j.jss.2014.12.026","journal-title":"J Surg Res"},{"key":"4848_CR69","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/j.1749-6632.1999.tb08726.x","volume":"889","author":"JL Masferrer","year":"1999","unstructured":"Masferrer JL, Koki A, Seibert K (1999) COX-2 inhibitors. A new class of antiangiogenic agents. Ann N Y Acad Sci 889:84\u201386. https:\/\/doi.org\/10.1111\/j.1749-6632.1999.tb08726.x","journal-title":"Ann N Y Acad Sci"},{"key":"4848_CR70","doi-asserted-by":"publisher","first-page":"3055","DOI":"10.1016\/s0024-3205(01)01412-6","volume":"69","author":"R Pai","year":"2001","unstructured":"Pai R, Szabo IL, Giap AQ, Kawanaka H, Tarnawski AS (2001) Nonsteroidal anti-inflammatory drugs inhibit re-epithelialization of wounded gastric monolayers by interfering with actin, Src, FAK, and tensin signaling. Life Sci 69:3055\u20133071. https:\/\/doi.org\/10.1016\/s0024-3205(01)01412-6","journal-title":"Life Sci"},{"key":"4848_CR71","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1111\/jcpe.12592","volume":"43","author":"I Keskiner","year":"2016","unstructured":"Keskiner I, Aydogdu A, Balli U, Kaleli AE (2016) Quantitative changes in palatal donor site thickness after free gingival graft harvesting: a pilot study. J Clin Periodontol 43:976\u2013984. https:\/\/doi.org\/10.1111\/jcpe.12592","journal-title":"J Clin Periodontol"},{"key":"4848_CR72","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1177\/0194599816637865","volume":"155","author":"T Muderris","year":"2016","unstructured":"Muderris T, Gul F, Yalciner G, Babademez MA, Bercin S, Kiris M (2016) Oral flurbiprofen spray for posttonsillectomy pain. Otolaryngol Head Neck Surg 155:166\u2013172. https:\/\/doi.org\/10.1177\/0194599816637865","journal-title":"Otolaryngol Head Neck Surg"},{"key":"4848_CR73","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1016\/j.ijom.2014.05.003","volume":"43","author":"M Koray","year":"2014","unstructured":"Koray M, Ofluoglu D, Onal EA, Ozgul M, Ersev H, Yaltirik M, Tanyeri H (2014) Efficacy of hyaluronic acid spray on swelling, pain, and trismus after surgical extraction of impacted mandibular third molars. Int J Oral Maxillofac Surg 43:1399\u20131403. https:\/\/doi.org\/10.1016\/j.ijom.2014.05.003","journal-title":"Int J Oral Maxillofac Surg"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-022-04848-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-022-04848-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-022-04848-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T14:49:23Z","timestamp":1744210163000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-022-04848-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,3]]},"references-count":73,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["4848"],"URL":"https:\/\/doi.org\/10.1007\/s00784-022-04848-5","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,3]]},"assertion":[{"value":"1 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Permission was obtained from the Ethics Committee of Pamukkale University (05.03.2019\/05) for the study protocol.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}