{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:15:15Z","timestamp":1788830115930,"version":"build-2803163510"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100018778","name":"Al-Azhar University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018778","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>We aimed to investigate prolactin (PRL) levels in gingival crevicular fluid (GCF), synovial fluid, and serum in patients suffering from moderately active rheumatoid arthritis (RA) with and without periodontitis (P). Further, to evaluate the effect of non-surgical periodontal treatment on these levels compared to controls.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>Eighty subjects were divided into 4 groups: group 1: 20 patients with RA\u2009+\u2009P, group 2: 20 periodontitis patients (systemically healthy), group 3: RA patients (periodontally healthy), and group 4: healthy controls. Patients with periodontitis received scaling and root planning (SRP). PRL was measured using enzyme\u2010linked immunosorbent assay.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>At baseline, in GCF of RA\u2009+\u2009P group showed the highest mean PRL levels, followed by P group whereas groups 3 and 4 showed a statistically less values than the first 2 groups. Serum values showed non-significant difference between the first three groups, although higher than healthy controls. SRP reduced GCF and serum levels of PRL in both P groups as well as synovial fluid PRL in group 1. SRP caused no change in DAS scores while reduced ESR values were observed in group 1 after treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Local GCF and synovial levels of PRL seem to be linked to the disease process of both periodontitis and rheumatoid arthritis than serum levels. SRP reduced these local levels.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>In patients with RA and CP, local PRL seems to play a role in the association between the two conditions; further, periodontal treatment is essential to improve periodontal condition in RA patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>Clinicaltrials.gov. Identifier: NCT04279691.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-023-04867-w","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T06:03:20Z","timestamp":1675145000000},"page":"2813-2821","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Local gingival crevicular fluid, synovial fluid, and circulating levels of prolactin hormone in patients with moderately active rheumatoid arthritis and stage III and IV periodontitis before and after non-surgical periodontal treatment\u2014a controlled trial"],"prefix":"10.1007","volume":"27","author":[{"given":"Naglaa Mohamed","family":"El-Wakeel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zienab Farid","family":"Shalaby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania Farouk","family":"Abdulmaguid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally Said Abd","family":"Elhamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olfat","family":"Shaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"4867_CR1","doi-asserted-by":"publisher","first-page":"620920","DOI":"10.3389\/fendo.2021.620920","volume":"12","author":"E Bertoldo","year":"2021","unstructured":"Bertoldo E, Adami G, Rossini M, Giollo A, Orsolini G, Viapiana O, Gatti D, Fassio A (2021) The emerging roles of endocrine hormones in different arthritic disorders. Front Endocrinol 12:620920. https:\/\/doi.org\/10.3389\/fendo.2021.620920","journal-title":"Front Endocrinol"},{"issue":"1","key":"4867_CR2","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/prd.12385","volume":"87","author":"J Gonz\u00e1lez-Febles","year":"2021","unstructured":"Gonz\u00e1lez-Febles J, Sanz M (2021) Periodontitis and rheumatoid arthritis: what have we learned about their connection and their treatment? Periodontology 2000 87(1):181\u2013203. https:\/\/doi.org\/10.1111\/prd.12385","journal-title":"Periodontology 2000"},{"issue":"1","key":"4867_CR3","doi-asserted-by":"publisher","first-page":"e011916","DOI":"10.1136\/bmjopen-2016-011916","volume":"7","author":"L \u00c4yr\u00e4v\u00e4inen","year":"2017","unstructured":"\u00c4yr\u00e4v\u00e4inen L, Leirisalo-Repo M, Kuuliala A, Ahola K, Koivuniemi R, Meurman JH, Heikkinen AM (2017) Periodontitis in early and chronic rheumatoid arthritis: a prospective follow-up study in Finnish population. BMJ Open 7(1):e011916","journal-title":"BMJ Open"},{"key":"4867_CR4","doi-asserted-by":"publisher","first-page":"503754","DOI":"10.1155\/2013\/503754","volume":"2013","author":"A Di Benedetto","year":"2013","unstructured":"Di Benedetto A, Gigante I, Colucci S, Grano M (2013) Periodontal disease: linking the primary inflammation to bone loss. Clin Dev Immunol 2013:503754","journal-title":"Clin Dev Immunol"},{"issue":"1","key":"4867_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40496-014-0039-2","volume":"2","author":"T Kobayashi","year":"2015","unstructured":"Kobayashi T, Yoshie H (2015) Host responses in the link between periodontitis and rheumatoid arthritis. Curr Oral Health Rep 2(1):1\u20138","journal-title":"Curr Oral Health Rep"},{"issue":"1","key":"4867_CR6","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/prd.12300","volume":"83","author":"PM Bartold","year":"2020","unstructured":"Bartold PM, Lopez-Oliva I (2020) Periodontitis and rheumatoid arthritis: an update 2012\u20132017. Periodontology 2000 83(1):189\u2013212. https:\/\/doi.org\/10.1111\/prd.12300","journal-title":"Periodontology 2000"},{"issue":"1","key":"4867_CR7","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1111\/prd.12457","volume":"90","author":"F Pamuk","year":"2022","unstructured":"Pamuk F, Kantarci A (2022) Inflammation as a link between periodontal disease and obesity. Periodontology 2000 90(1):186\u2013196. https:\/\/doi.org\/10.1111\/prd.12457","journal-title":"Periodontology 2000"},{"issue":"1","key":"4867_CR8","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/prd.12432","volume":"89","author":"J Koziel","year":"2022","unstructured":"Koziel J, Potempa J (2022) Pros and cons of causative association between periodontitis and rheumatoid arthritis. Periodontology 2000 89(1):83. https:\/\/doi.org\/10.1111\/prd.12432","journal-title":"Periodontology 2000"},{"issue":"6","key":"4867_CR9","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/s41574-019-0194-6","volume":"15","author":"V Bernard","year":"2019","unstructured":"Bernard V, Young J, Binart N (2019) Prolactin - a pleiotropic factor in health and disease. Nat Rev Endocrinol 15(6):356\u2013365","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"4867_CR10","first-page":"29","volume":"22","author":"NM El-Wakeel","year":"2020","unstructured":"El-Wakeel NM, Shaker O, Amr EM (2020) Gingival crevicular fluid levels of prolactin hormone in periodontitis patients before and after treatment and in healthy controls. J Int Acad Periodontol 22(1):29\u201336","journal-title":"J Int Acad Periodontol"},{"issue":"6","key":"4867_CR11","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1111\/odi.13145","volume":"25","author":"PS Rahajoe","year":"2019","unstructured":"Rahajoe PS, Smit MJ, Kertia N, Westra J, Vissink A (2019) Cytokines in gingivocrevicular fluid of rheumatoid arthritis patients: a review of the literature. Oral Dis 25(6):1423\u20131434","journal-title":"Oral Dis"},{"key":"4867_CR12","doi-asserted-by":"publisher","first-page":"110350","DOI":"10.1016\/j.mehy.2020.110350","volume":"146","author":"N El-Wakeel","year":"2021","unstructured":"El-Wakeel N, Hazzaa H, Gawish AS (2021) Hypothesis: rheumatoid arthritis and periodontitis: a new possible link via prolactin hormone. Med Hypotheses 146:110350","journal-title":"Med Hypotheses"},{"issue":"2","key":"4867_CR13","doi-asserted-by":"publisher","first-page":"287","DOI":"10.2105\/ajph.56.2","volume":"56","author":"JH Abramson","year":"1966","unstructured":"Abramson JH (1966) The Cornell medical index as an epidemiological tool. Am J Public Health Nations Health 56(2):287\u2013298. https:\/\/doi.org\/10.2105\/ajph.56.2","journal-title":"Am J Public Health Nations Health"},{"issue":"9","key":"4867_CR14","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.1002\/art","volume":"52","author":"D Aletaha","year":"2005","unstructured":"Aletaha D, Ward MM, Machold KP, Nell VP, Stamm T, Smolen JS (2005) Remission and active disease in rheumatoid arthritis: defining criteria for disease activity states. Arthritis Rheum 52(9):2625\u20132636. https:\/\/doi.org\/10.1002\/art","journal-title":"Arthritis Rheum"},{"issue":"Suppl 20","key":"4867_CR15","first-page":"S1","volume":"45","author":"JG Caton","year":"2018","unstructured":"Caton JG, Armitage G, Berglundh T, Chapple I, Jepsen S, Kornman KS, Mealey BL, Papapanou PN, Sanz M, Tonetti MS (2018) A new classification scheme for periodontal and peri-implant diseases and conditions - introduction and key changes from the 1999 classification. J Clin Periodontol 45(Suppl 20):S1\u2013S8","journal-title":"J Clin Periodontol"},{"issue":"2","key":"4867_CR16","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1097\/BOR.0b013e32835cfc41","volume":"25","author":"JH Humphreys","year":"2013","unstructured":"Humphreys JH, Symmons DP (2013) Postpublication validation of the 2010 American College of Rheumatology\/European League Against Rheumatism classification criteria for rheumatoid arthritis: where do we stand? Curr Opin Rheumatol 25(2):157\u2013163","journal-title":"Curr Opin Rheumatol"},{"issue":"1","key":"4867_CR17","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1002\/art.1780380107","volume":"38","author":"ML Prevoo","year":"1995","unstructured":"Prevoo ML, van\u2019t Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL (1995) Modified disease activity scores that include twenty-eight-joint counts Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthr Rheum 38(1):44\u201348","journal-title":"Arthr Rheum"},{"issue":"5","key":"4867_CR18","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1002\/acr.21649","volume":"64","author":"J Anderson","year":"2012","unstructured":"Anderson J, Caplan L, Yazdany J, Robbins ML, Neogi T, Michaud K, Saag KG, O\u2019Dell JR, Kazi S (2012) Rheumatoid arthritis disease activity measures: American College of Rheumatology recommendations for use in clinical practice. Arthr Care Res 64(5):640\u2013647","journal-title":"Arthr Care Res"},{"key":"4867_CR19","doi-asserted-by":"publisher","first-page":"533","DOI":"10.3109\/00016356309011240","volume":"21","author":"H Loe","year":"1963","unstructured":"Loe H, Silness J (1963) Periodontal disease in pregnancy. I. Prevalence Severity Acta odontologica Scandinavica 21:533\u2013551. https:\/\/doi.org\/10.3109\/00016356309011240","journal-title":"Prevalence Severity Acta odontologica Scandinavica"},{"key":"4867_CR20","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3109\/00016356408993968","volume":"22","author":"J Silness","year":"1964","unstructured":"Silness J, Loe H (1964) Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condtion. Acta OdontologicaScandinavica 22:121\u2013135. https:\/\/doi.org\/10.3109\/00016356408993968","journal-title":"Acta OdontologicaScandinavica"},{"issue":"3","key":"4867_CR21","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1111\/jre.12425","volume":"52","author":"\u015e Kurgan","year":"2017","unstructured":"Kurgan \u015e, \u00d6nder C, Balc\u0131 N, Fento\u011flu \u00d6, Eser F, Balseven M et al (2017) Gingival crevicular fluid tissue\/blood vessel-type plasminogen activator and plasminogen activator inhibitor-2 levels in patients with rheumatoid arthritis: effects of nonsurgical periodontal therapy. J Periodontal Res 52(3):574\u2013581","journal-title":"J Periodontal Res"},{"issue":"8","key":"4867_CR22","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1111\/odi.12930","volume":"24","author":"L \u00c4yr\u00e4v\u00e4inen","year":"2018","unstructured":"\u00c4yr\u00e4v\u00e4inen L, Heikkinen AM, Kuuliala A, Ahola K, Koivuniemi R, Moilanen E et al (2018) Anti-rheumatic medication and salivary MMP-8, a biomarker for periodontal disease. Oral Dis 24(8):1562\u20131571","journal-title":"Oral Dis"},{"issue":"11","key":"4867_CR23","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1902\/jop.2000.71.11.1756","volume":"71","author":"FY Bozkurt","year":"2000","unstructured":"Bozkurt FY, Berker E, Akku\u015f S, Bulut S (2000) Relationship between interleukin-6 levels in gingival crevicular fluid and periodontal status in patients with rheumatoid arthritis and adult periodontitis. J Periodontol 71(11):1756\u20131760","journal-title":"J Periodontol"},{"issue":"8","key":"4867_CR24","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1902\/jop.2007.060520","volume":"78","author":"LA Miranda","year":"2007","unstructured":"Miranda LA, Islab\u00e3o AG, Fischer RG, Figueredo CM, Oppermann RV, Gustafsson A (2007) Decreased interleukin-1beta and elastase in the gingival crevicular fluid of individuals undergoing anti-inflammatory treatment for rheumatoid arthritis. J Periodontol 78(8):1612\u20131619","journal-title":"J Periodontol"},{"issue":"11","key":"4867_CR25","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1002\/JPER.17-0616","volume":"89","author":"D Ziebolz","year":"2018","unstructured":"Ziebolz D, Rupprecht A, Schmickler J, Bothmann L, Kr\u00e4mer J, Patschan D et al (2018) Association of different immunosuppressive medications with periodontal condition in patients with rheumatoid arthritis: results from a cross-sectional study. J Periodontol 89(11):1310\u20131317","journal-title":"J Periodontol"},{"key":"4867_CR26","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12337","author":"S Kurgan","year":"2015","unstructured":"Kurgan S, Fentoglu O, Onder C, Serdar M, Eser F, Tatakis DN, Gunhan M (2015) The effects of periodontal therapy on gingival crevicular fluid matrix metalloproteinase-8, interleukin-6 and prostaglandin E levels in patients with rheumatoid arthritis. J Periodontal Res. https:\/\/doi.org\/10.1111\/jre.12337","journal-title":"J Periodontal Res"},{"key":"4867_CR27","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.1007\/s00296-013-2781-5","volume":"33","author":"B Biyikoglu","year":"2013","unstructured":"Biyikoglu B, Buduneli N, Aksu K, Nalbantsoy A, Lappin DF, Evrenosoglu E, Kinane DF (2013) Periodontal therapy in chronic periodontitis lowers gingival crevicular fluid interleukin-1beta and DAS28 in rheumatoid arthritis patients. Rheumatol Int 33:2607\u20132616","journal-title":"Rheumatol Int"},{"issue":"1","key":"4867_CR28","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s00784-018-2420-3","volume":"23","author":"R Cosgarea","year":"2019","unstructured":"Cosgarea R, Tristiu R, Dumitru RB, Arweiler NB, Rednic S, Sirbu CI et al (2019) Effects of non-surgical periodontal therapy on periodontal laboratory and clinical data as well as on disease activity in patients with rheumatoid arthritis. Clin Oral Invest 23(1):141\u2013151","journal-title":"Clin Oral Invest"},{"issue":"4","key":"4867_CR29","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1111\/odi.12017","volume":"19","author":"K Erciyas","year":"2013","unstructured":"Erciyas K, Sezer U, Ust\u00fcn K, Pehlivan Y, Kisacik B, Senyurt SZ et al (2013) Effects of periodontal therapy on disease activity and systemic inflammation in rheumatoid arthritis patients. Oral Dis 19(4):394\u2013400","journal-title":"Oral Dis"},{"issue":"11","key":"4867_CR30","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/nrurol.2011.143","volume":"8","author":"V Goffin","year":"2011","unstructured":"Goffin V, Hoang DT, Bogorad RL, Nevalainen MT (2011) Prolactin regulation of the prostate gland: a female player in a male game. Nat Rev Urol 8(11):597\u2013607","journal-title":"Nat Rev Urol"},{"issue":"3","key":"4867_CR31","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1007\/s12020-019-02060-2","volume":"66","author":"Y Ozdemir","year":"2019","unstructured":"Ozdemir Y, Keceli HG, Helvaci N, Erbas T, Nohutcu RM (2019) The tendency of reduced periodontal destruction in acromegalic patients showing similar inflammatory status with periodontitis patients. Endocrine 66(3):622\u2013633","journal-title":"Endocrine"},{"issue":"3","key":"4867_CR32","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1189\/jlb.2A0317-115RR","volume":"102","author":"MW Tang","year":"2017","unstructured":"Tang MW, Garcia S, Malvar Fernandez B, Gerlag DM, Tak PP, Reedquist KA (2017) Rheumatoid arthritis and psoriatic arthritis synovial fluids stimulate prolactin production by macrophages. J Leukoc Biol 102(3):897\u2013904","journal-title":"J Leukoc Biol"},{"issue":"Suppl 1","key":"4867_CR33","doi-asserted-by":"publisher","first-page":"S173","DOI":"10.1002\/JPER.17-0721","volume":"89","author":"PN Papapanou","year":"2018","unstructured":"Papapanou PN, Sanz M, Buduneli N, Dietrich T et al (2018) Periodontitis: consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol 89(Suppl 1):S173\u2013S182","journal-title":"J Periodontol"},{"key":"4867_CR34","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1159\/000452906","volume":"48","author":"W Savino","year":"2017","unstructured":"Savino W (2017) Prolactin: an immunomodulator in health and disease. Front Horm Res 48:69\u201375","journal-title":"Front Horm Res"},{"issue":"12","key":"4867_CR35","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1093\/rheumatology\/kew316","volume":"55","author":"MW Tang","year":"2016","unstructured":"Tang MW, Reedquist KA, Garcia S, Fernandez BM, Codullo V, Vieira-Sousa E et al (2016) The prolactin receptor is expressed in rheumatoid arthritis and psoriatic arthritis synovial tissue and contributes to macrophage activation. Rheumatology (Oxford) 55(12):2248\u20132259","journal-title":"Rheumatology (Oxford)"},{"issue":"9","key":"4867_CR36","first-page":"1890","volume":"26","author":"H Nagafuchi","year":"1999","unstructured":"Nagafuchi H, Suzuki N, Kaneko A, Asai T, Sakane T (1999) Prolactin locally produced by synovium infiltrating T lymphocytes induces excessive synovial cell functions in patients with rheumatoid arthritis. J Rheumatol 26(9):1890\u20131900","journal-title":"J Rheumatol"},{"issue":"3","key":"4867_CR37","first-page":"292","volume":"23","author":"J Rovensky","year":"2005","unstructured":"Rovensky J, Kvetnansky R, Radikova Z, Imrich R, Greguska O, Vigas M, Macho L (2005) Hormone concentrations in synovial fluid of patients with rheumatoid arthritis. Clin Exp Rheumatol 23(3):292\u2013296","journal-title":"Clin Exp Rheumatol"},{"issue":"6","key":"4867_CR38","doi-asserted-by":"publisher","first-page":"272","DOI":"10.3390\/medicina56060272","volume":"56","author":"G Cecoro","year":"2020","unstructured":"Cecoro G, Annunziata M, Iuorio MT, Nastri L, Guida L (2020) Periodontitis, low-grade inflammation and systemic health: a scoping review. Medicina (Kaunas) 56(6):272","journal-title":"Medicina (Kaunas)"},{"issue":"1","key":"4867_CR39","first-page":"33","volume":"126","author":"F Figueroa","year":"1998","unstructured":"Figueroa F, Carri\u00f3n F, Mart\u00ednez ME, Rivero S, Mamani I, Gonz\u00e1lez G (1998) Effects of bromocriptine in patients with active rheumatoid arthritis. Rev Med Chil 126(1):33\u201341","journal-title":"Rev Med Chil"},{"issue":"6","key":"4867_CR40","first-page":"705","volume":"13","author":"C Jorgensen","year":"1995","unstructured":"Jorgensen C, Maziad H, Bologna C, Sany J (1995) Kinetics of prolactin release in rheumatoid arthritis. Clin Exp Rheumatol 13(6):705\u2013709","journal-title":"Clin Exp Rheumatol"},{"key":"4867_CR41","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1196\/annals.1398.044","volume":"1109","author":"H Orbach","year":"2007","unstructured":"Orbach H, Zandman-Goddard G, Amital H, Barak V, Szekanecz Z, Szucs G et al (2007) Novel biomarkers in autoimmune diseases: prolactin, ferritin, vitamin D, and TPA levels in autoimmune diseases. Ann N Y Acad Sci 1109:385\u2013400","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"4867_CR42","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.tem.2020.01.004","volume":"31","author":"Y Macotela","year":"2020","unstructured":"Macotela Y, Triebel J, Clapp C (2020) Time for a new perspective on prolactin in metabolism. Trends Endocrinol Metab 31(4):276\u2013286. https:\/\/doi.org\/10.1016\/j.tem.2020.01.004","journal-title":"Trends Endocrinol Metab"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-023-04867-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-023-04867-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-023-04867-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T12:22:02Z","timestamp":1686658922000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-023-04867-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,31]]},"references-count":42,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["4867"],"URL":"https:\/\/doi.org\/10.1007\/s00784-023-04867-w","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,31]]},"assertion":[{"value":"25 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All procedures performed were in accordance with the ethical institutional standards and with the Helsinki Declaration.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all study participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}