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Ligature- and lipopolysaccharide-induced peri-implantitis lesions were established at 2 maxillary implants over a period of 16 weeks. Histological (e.g., apical extension and surface area of the inflammatory cell infiltrate\u2014aICT, ICT; defect length; defect width; CD68 positive cells) and bone micromorphometric (\u03bcCT) outcomes were assessed. The animal was defined as a statistical unit.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of <jats:italic>n<\/jats:italic> = 38 animals (Zo = 6, De = 6, Be = 8, Zo + Be = 6, De + Be = 5, Co = 7) were analyzed. ICT\u2019s were commonly marked by a positive CD68 antigen reactivity. Comparable median aICT (lowest\u2014Zo: 0.53 mm; highest\u2014Be: 1.22 mm), ICT (lowest\u2014De + Be: 0.00 mm<jats:sup>2<\/jats:sup>; highest\u2014Co: 0.49 mm<jats:sup>2<\/jats:sup>), defect length (lowest\u2014Zo: 0.90 mm; highest\u2014Co: 1.93 mm) and defect width (lowest\u2014De+Be: 1.27 mm; highest\u2014Be: 1.80 mm) values were noted in all test and control groups. Within an inner (diameter: 0.8 mm) cylindric volume of interest, the bone microstructure did not significantly differ between groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The present analysis did not reveal any marked effects of various antiresorptive\/ antiangiogenic medications on the extension of experimentally induced peri-implantitis lesions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>The extension of peri-implantitis lesions may not be facilitated by the antiresorptive and antiangiogenic medications investigated.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-023-04904-8","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T07:56:48Z","timestamp":1676620608000},"page":"3009-3019","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Influence of antiresorptive\/antiangiogenic therapy on the extension of experimentally induced peri-implantitis lesions"],"prefix":"10.1007","volume":"27","author":[{"given":"Frank","family":"Schwarz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanya","family":"Lukman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina Melissa","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Sarabhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Rauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kerberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ausra","family":"Ramanauskaite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Sader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Obreja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"issue":"Suppl 20","key":"4904_CR1","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1111\/jcpe.12954","volume":"45","author":"F Schwarz","year":"2018","unstructured":"Schwarz F, Derks J, Monje A, Wang HL (2018) Peri-implantitis. 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