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CAL (primary outcome), periodontal probing depth (PPD), gingival recession depth (GRD), full-mouth plaque scores (FMPS), full-mouth bleeding scores (FMBS), radiographic linear defect depth (RLDD), and bone fill (secondary outcomes) were examined at baseline, 3, 6, and 9\u00a0months post-surgically.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      I-PRF\u2009+\u2009DFDBA and DFDBA independently demonstrated significant intragroup CAL-gain, PPD-, and RLDD-reduction at 3, 6, and 9\u00a0months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), with no significant intergroup differences observed (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). CAL-gain (mean\u2009\u00b1\u2009SD) of 2.40\u2009\u00b1\u20090.70\u00a0mm and 2.50\u2009\u00b1\u20090.85\u00a0mm and PPD-reduction of 3.50\u2009\u00b1\u20091.18\u00a0mm and 2.80\u2009\u00b1\u20090.42\u00a0mm were demonstrated for I-PRF\u2009+\u2009DFDBA and DFDBA at 9\u00a0months respectively. Both groups showed significant intragroup RLDD improvement, with a RLDD of 3.58\u2009\u00b1\u20090.66\u00a0mm and 3.89\u2009\u00b1\u20091.57\u00a0mm for I-PRF\u2009+\u2009DFDBA and DFDBA at 9\u00a0months respectively. Stepwise linear regression analysis revealed that baseline RLDD and bone fill at 9\u00a0months were significant predictors of CAL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Within the present study\u2019s limitations, DFDBA with or without I-PRF resulted in significant improvement in clinical and radiographic periodontal parameters in the surgical treatment of periodontal intrabony defects of stage-III periodontitis patients. Addition of I-PRF to DFDBA does not appear to significantly enhance the DFDBA\u2019s reparative\/regenerative outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>Within the current study\u2019s limitations, routinely adding I-PRF to DFDBA cannot be recommended to significantly improve DFDBA\u2019s treatment outcomes in intrabony defects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-023-04954-y","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T20:02:46Z","timestamp":1680292966000},"page":"3457-3467","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Injectable platelet-rich fibrin with demineralized freeze-dried bone allograft compared to demineralized freeze-dried bone allograft in intrabony defects of patients with stage-III periodontitis: a randomized controlled clinical trial"],"prefix":"10.1007","volume":"27","author":[{"given":"Mashaal Mohammed","family":"Alshoiby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim Mohamed","family":"Fawzy El-Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weam","family":"Elbattawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal Mohamed","family":"Hosny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,31]]},"reference":[{"issue":"Suppl 1","key":"4954_CR1","doi-asserted-by":"publisher","first-page":"S159","DOI":"10.1002\/jper.18-0006","volume":"89","author":"MS Tonetti","year":"2018","unstructured":"Tonetti MS, Greenwell H, Kornman KS (2018) Staging and grading of periodontitis: framework and proposal of a new classification and case definition. 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