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The primary outcome variable was the number of sites with probing pocket depth\u2009\u2265\u20095\u00a0mm and BOP. Treatment method, tooth type, smoking status, and gender were evaluated using a multivariate multilevel logistic regression model.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>After 6\u00a0months, the percentage of sites with PD\u2009\u2265\u20095\u00a0mm and BOP that healed (MINST\u2009=\u200975.5%; control group\u2009=\u200974.1%; <jats:italic>p<\/jats:italic>\u2009=\u20090.98), and the median number of persisting sites (MINST: 6.5, control group: 7.0; <jats:italic>p<\/jats:italic>\u2009=\u20090.925) were similar in both groups. In the test and control groups, respectively, median probing pocket depths (2.0\u00a0mm vs. 2.1\u00a0mm) and clinical attachment level (1.7\u00a0mm vs. 2.0\u00a0mm) changed significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) but similarly. Significantly less gingival recession occurred in the MINST group\u2019s deep molar pockets compared to the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.037). Men (OR\u2009=\u20090.52, <jats:italic>p<\/jats:italic>\u2009=\u20090.014) and non-molars (OR\u2009=\u20093.84, <jats:italic>p<\/jats:italic> 0.001) had altered odds for healing of sites with PD\u2009\u2265\u20095\u00a0mm and BOP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>MINST reduces gingival recession associated with molar teeth, although it performs similarly to traditional non-surgical therapy in treating stage III periodontitis with predominately horizontal-type defects.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>MINST performs similarly to non-surgical periodontal therapy in stage III periodontitis with predominantly suprabony defects.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>Clinicaltrials.gov (NCT04036513) on June 29, 2019.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-023-04994-4","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T11:52:19Z","timestamp":1680609139000},"page":"2075-2087","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Minimally invasive non-surgical therapy (MINST) in stage III periodontitis patients: 6-month results of a split-mouth, randomised controlled clinical trial"],"prefix":"10.1007","volume":"27","author":[{"given":"Alja Cmok","family":"Ku\u010di\u010d","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rok","family":"Ga\u0161per\u0161i\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,4]]},"reference":[{"key":"4994_CR1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/jcpe.13290","volume":"47","author":"M Sanz","year":"2020","unstructured":"Sanz M, Herrera D, Kebschull M et al (2020) Treatment of stage I-III periodontitis\u2014the EFP S3 level clinical practice guideline. 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The study protocol was reviewed by the National Medical Ethics Committee (No. 0120\u2013595\/2018\/4) of the Republic of Slovenia. It was also registered at Clinicaltrials.gov (NCT04036513).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}