{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T15:45:52Z","timestamp":1724427952273},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Turku (UTU) including Turku University Central Hospital"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>The purposes of this study were to localize monocyte chemoattractant protein-1-induced protein-1 (MCPIP-1) and its suppressor mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT-1) in gingival tissues and to profile their protein expression levels in relation to the clinical inflammation, <jats:italic>Porphyromonas gingivalis<\/jats:italic> colonization, and interleukin (IL)-8 levels.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>Study samples were collected from two independent study populations: (1) Gingival tissues were collected from eight periodontally healthy individuals and eight periodontitis patients to localize MCPIP-1 and MALT-1 immunohistochemically, and (2) forty-one gingival tissue samples with marginal, mild, or moderate to severe inflammation were collected from 20 periodontitis patients to determine MCPIP-1 and MALT-1 levels using immunoblots, <jats:italic>P. gingivalis<\/jats:italic> levels with qPCR, <jats:italic>P. gingivalis<\/jats:italic> gingipain activities with fluorogenic substrates, and IL-8 levels with multiplex technique.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>MCPIP-1 was detectable in the epithelium and in connective tissue, being especially prominent around the blood vessel walls in healthy periodontal tissues. MALT-1 was observed at all layers of gingival epithelium and especially around the accumulated inflammatory cells in connective tissue. No difference in gingival tissue MCPIP-1 and MALT-1 levels was observed in relation to the severity of gingival inflammation. MALT-1 levels were elevated (<jats:italic>p<\/jats:italic> = 0.023) with the increase in tissue <jats:italic>P. gingivalis<\/jats:italic> levels, and there was an association between MALT-1 and IL-8 levels (<jats:italic>\u03b2<\/jats:italic> = 0.054, <jats:italic>p<\/jats:italic> = 0.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Interactions of MALT-1 levels with gingival tissue <jats:italic>P. gingivalis<\/jats:italic> counts and IL-8 levels suggest that activation of MALT-1 can take part in <jats:italic>P. gingivalis<\/jats:italic>-regulated host immune responses.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>Pharmacological targeting the crosstalk between immune response and MCPIP-1\/MALT-1 may have benefits in periodontal treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-023-05010-5","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T10:23:20Z","timestamp":1680517400000},"page":"2065-2074","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Localization and expression profiles of gingival monocyte chemoattractant protein-1-induced protein-1 (MCPIP-1) and mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT-1)"],"prefix":"10.1007","volume":"27","author":[{"given":"Lili","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yigit","family":"Firatli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samira","family":"Elmanfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mervi","family":"G\u00fcrsoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meltem","family":"\u00d6zdemir Kabalak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6khan","family":"Kasnak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pirkko","family":"Pussinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floris J.","family":"Bikker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feriha","family":"Caglayan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erhan","family":"Firatli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulvi Kahraman","family":"G\u00fcrsoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"key":"5010_CR1","doi-asserted-by":"publisher","unstructured":"Piboonprai K, Millius A, Shimoda M, Tanaka H, Akira S, Maeda K (2023) Breaking self-regulation of Regnase-1 promotes its own protein expression. Genes Cells. (Early online Feb 23]. https:\/\/doi.org\/10.1111\/gtc.13018","DOI":"10.1111\/gtc.13018"},{"key":"5010_CR2","doi-asserted-by":"publisher","first-page":"727861","DOI":"10.3389\/fimmu.2021.727861","volume":"12","author":"Z Jin","year":"2021","unstructured":"Jin Z, Zheng E, Sareli C, Kolattukudy PE, Niu J (2021) Monocyte chemotactic protein-induced protein 1 (MCPIP-1): a key player of host defense and immune regulation. Front Immunol 12:727861. https:\/\/doi.org\/10.3389\/fimmu.2021.727861","journal-title":"Front Immunol"},{"issue":"19","key":"5010_CR3","doi-asserted-by":"publisher","first-page":"7183","DOI":"10.3390\/ijms21197183","volume":"21","author":"R Musson","year":"2020","unstructured":"Musson R, Szuka\u0142a W, Jura J (2020) MCPIP1 RNase and its multifaceted role. Int J Mol Sci 21(19):7183. https:\/\/doi.org\/10.3390\/ijms21197183","journal-title":"Int J Mol Sci"},{"issue":"9","key":"5010_CR4","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1161\/01.RES.0000220106.64661.71","volume":"98","author":"L Zhou","year":"2006","unstructured":"Zhou L, Azfer A, Niu J, Graham S, Choudhury M, Adamski FM, Younce C, Binkley PF, Kolattukudy PE (2006) Monocyte chemoattractant protein-1 induces a novel transcription factor that causes cardiac myocyte apoptosis and ventricular dysfunction. Circ Res 98(9):1177\u20131185. https:\/\/doi.org\/10.1161\/01.RES.0000220106.64661.71","journal-title":"Circ Res"},{"issue":"1","key":"5010_CR5","doi-asserted-by":"publisher","first-page":"7381","DOI":"10.1038\/s41598-018-25765-2","volume":"8","author":"M Wilamowski","year":"2018","unstructured":"Wilamowski M, Gorecki A, Dziedzicka-Wasylewska M, Jura J (2018) Substrate specificity of human MCPIP1 endoribonuclease. Sci Rep 8(1):7381. https:\/\/doi.org\/10.1038\/s41598-018-25765-2","journal-title":"Sci Rep"},{"issue":"6","key":"5010_CR6","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1159\/000448038","volume":"8","author":"E Dobosz","year":"2016","unstructured":"Dobosz E, Wilamowski M, Lech M, Bugara B, Jura J, Potempa J, Koziel J (2016) MCPIP-1, Alias Regnase-1, controls epithelial inflammation by posttranscriptional regulation of IL-8 production. J Innate Immun 8(6):564\u2013578. https:\/\/doi.org\/10.1159\/000448038","journal-title":"J Innate Immun"},{"issue":"7242","key":"5010_CR7","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1038\/nature07924","volume":"458","author":"K Matsushita","year":"2009","unstructured":"Matsushita K, Takeuchi O, Standley DM, Kumagai Y, Kawagoe T, Miyake T, Satoh T, Kato H, Tsujimura T, Nakamura H, Akira S (2009) Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature 458(7242):1185\u20131190. https:\/\/doi.org\/10.1038\/nature07924","journal-title":"Nature"},{"issue":"24","key":"5010_CR8","doi-asserted-by":"publisher","first-page":"7386","DOI":"10.1111\/j.1742-4658.2009.07452.x","volume":"276","author":"D Mizgalska","year":"2009","unstructured":"Mizgalska D, Wegrzyn P, Murzyn K, Kasza A, Koj A, Jura J, Jarzab B, Jura J (2009) Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1beta mRNA. FEBS J 276(24):7386\u20137399. https:\/\/doi.org\/10.1111\/j.1742-4658.2009.07452.x","journal-title":"FEBS J"},{"key":"5010_CR9","doi-asserted-by":"publisher","first-page":"17066","DOI":"10.1038\/sigtrans.2017.66","volume":"2","author":"Y Li","year":"2017","unstructured":"Li Y, Huang X, Huang S, He H, Lei T, Saaoud F, Yu XQ, Melnick A, Kumar A, Papasian CJ, Fan D, Fu M (2017) Central role of myeloid MCPIP1 in protecting against LPS-induced inflammation and lung injury. Signal Transduct Target Ther 2:17066. https:\/\/doi.org\/10.1038\/sigtrans.2017.66","journal-title":"Signal Transduct Target Ther"},{"issue":"5","key":"5010_CR10","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.cell.2013.04.034","volume":"153","author":"T Uehata","year":"2013","unstructured":"Uehata T, Iwasaki H, Vandenbon A, Matsushita K, Hernandez-Cuellar E, Kuniyoshi K, Satoh T, Mino T, Suzuki Y, Standley DM, Tsujimura T, Rakugi H, Isaka Y, Takeuchi O, Akira S (2013) Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation. Cell 153(5):1036\u20131049. https:\/\/doi.org\/10.1016\/j.cell.2013.04.034","journal-title":"Cell"},{"issue":"17","key":"5010_CR11","doi-asserted-by":"publisher","first-page":"3286","DOI":"10.1111\/febs.13325","volume":"282","author":"IS Afonina","year":"2015","unstructured":"Afonina IS, Elton L, Carpentier I, Beyaert R (2015) MALT1--a universal soldier: multiple strategies to ensure NF-\u03baB activation and target gene expression. FEBS J 282(17):3286\u20133297. https:\/\/doi.org\/10.1111\/febs.13325","journal-title":"FEBS J"},{"issue":"3","key":"5010_CR12","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s00018-015-2059-z","volume":"73","author":"M Jaworski","year":"2016","unstructured":"Jaworski M, Thome M (2016) The paracaspase MALT1: biological function and potential for therapeutic inhibition. Cell Mol Life Sci 73(3):459\u2013473. https:\/\/doi.org\/10.1007\/s00018-015-2059-z","journal-title":"Cell Mol Life Sci"},{"issue":"11","key":"5010_CR13","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1038\/ni.3008","volume":"15","author":"KM Jeltsch","year":"2014","unstructured":"Jeltsch KM, Hu D, Brenner S, Z\u00f6ller J et al (2014) Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation. Nat Immun 15(11):1079\u20131089. https:\/\/doi.org\/10.1038\/ni.3008","journal-title":"Nat Immun"},{"issue":"1","key":"5010_CR14","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/prd.12377","volume":"86","author":"S Joseph","year":"2021","unstructured":"Joseph S, Curtis MA (2021) Microbial transitions from health to disease. Periodontol 2000 86(1):201\u2013209. https:\/\/doi.org\/10.1111\/prd.12377","journal-title":"Periodontol 2000"},{"key":"5010_CR15","doi-asserted-by":"publisher","unstructured":"Belibasakis GN, Belstr\u00f8m D, Eick S, Gursoy UK, Johansson A, K\u00f6n\u00f6nen E (2023) Periodontal microbiology and microbial etiology of periodontal diseases: historical concepts and contemporary perspectives. Periodontol 2000 [Early online Jan 20]. https:\/\/doi.org\/10.1111\/prd.12473","DOI":"10.1111\/prd.12473"},{"issue":"3","key":"5010_CR16","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/nri2918","volume":"11","author":"G Hajishengallis","year":"2011","unstructured":"Hajishengallis G, Lambris JD (2011) Microbial manipulation of receptor crosstalk in innate immunity. Nat Rev Immunol 11(3):187\u2013200. https:\/\/doi.org\/10.1038\/nri2918","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"5010_CR17","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1002\/JPER.22-0093","volume":"94","author":"Y Firatli","year":"2022","unstructured":"Firatli Y, Firatli E, Loimaranta V, Elmanfi S, G\u00fcrsoy UK (2022) Regulation of gingival keratinocyte monocyte chemoattractant protein-1-induced protein (MCPIP)-1 and mucosa-associated lymphoid tissue lymphoma translocation protein (MALT)-1 expressions by periodontal bacteria, lipopolysaccharide, and interleukin-1\u03b2. J Periodontol 94(1):130\u2013140. https:\/\/doi.org\/10.1002\/JPER.22-0093","journal-title":"J Periodontol"},{"issue":"3","key":"5010_CR18","doi-asserted-by":"publisher","first-page":"e0050221","DOI":"10.1128\/mBio.00502-21","volume":"12","author":"A Gasiorek","year":"2021","unstructured":"Gasiorek A, Dobosz E, Potempa B, Ciaston I, Wilamowski M, Oruba Z, Lamont RJ, Jura J, Potempa J, Koziel J (2021) Subversion of lipopolysaccharide signaling in gingival keratinocytes via MCPIP-1 degradation as a novel pathogenic strategy of inflammophilic pathobionts. mBio 12(3):e0050221. https:\/\/doi.org\/10.1128\/mBio.00502-21","journal-title":"mBio"},{"issue":"Suppl 1","key":"5010_CR19","doi-asserted-by":"publisher","first-page":"S173","DOI":"10.1002\/JPER.17-0721","volume":"89","author":"PN Papapanou","year":"2018","unstructured":"Papapanou PN, Sanz M, Buduneli N et al (2018) Periodontitis: consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions. J Periodontol 89(Suppl 1):S173\u2013S182. https:\/\/doi.org\/10.1002\/JPER.17-0721","journal-title":"J Periodontol"},{"issue":"Suppl 1","key":"5010_CR20","doi-asserted-by":"publisher","first-page":"S9","DOI":"10.1002\/JPER.16-0517","volume":"89","author":"NP Lang","year":"2018","unstructured":"Lang NP, Bartold PM (2018) Periodontal health. J Periodontol 89(Suppl 1):S9\u2013S16. https:\/\/doi.org\/10.1002\/JPER.16-0517","journal-title":"J Periodontol"},{"issue":"3","key":"5010_CR21","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/jcpe.13227","volume":"47","author":"M \u00d6zdemir","year":"2020","unstructured":"\u00d6zdemir M, Caglayan F, Bikker FJ, Pussinen P, K\u00f6n\u00f6nen E, Yamalik N, G\u00fcrsoy M, Fteita D, Nazmi K, G\u00fcnc\u00fc GN, Pieti\u00e4inen M, Tolvanen M, G\u00fcrsoy UK (2020) Gingival tissue human beta-defensin levels in relation to infection and inflammation. J Clin Periodontol 47(3):309\u2013318. https:\/\/doi.org\/10.1111\/jcpe.13227","journal-title":"J Clin Periodontol"},{"issue":"4","key":"5010_CR22","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1177\/1753425908101920","volume":"15","author":"K Hyv\u00e4rinen","year":"2009","unstructured":"Hyv\u00e4rinen K, Laitinen S, Paju S, Hakala A, Suominen-Taipale L, Skurnik M, K\u00f6n\u00f6nen E, Pussinen PJ (2009) Detection and quantification of five major periodontal pathogens by single copy gene-based real-time PCR. Innate Immun 15(4):195\u2013204. https:\/\/doi.org\/10.1177\/1753425908101920","journal-title":"Innate Immun"},{"key":"5010_CR23","doi-asserted-by":"publisher","first-page":"910531","DOI":"10.3389\/fbinf.2022.910531","volume":"2","author":"K Nakai","year":"2002","unstructured":"Nakai K, Wei L (2002) Recent advances in the prediction of subcellular localization of proteins and related topics. Front Bioinform 2:910531. https:\/\/doi.org\/10.3389\/fbinf.2022.910531","journal-title":"Front Bioinform"},{"key":"5010_CR24","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3389\/fmicb.2016.00053","volume":"7","author":"KY How","year":"2016","unstructured":"How KY, Song KP, Chan KG (2016) Porphyromonas gingivalis: an overview of periodontopathic pathogen below the gum line. Front Microbiol 7:53. https:\/\/doi.org\/10.3389\/fmicb.2016.00053","journal-title":"Front Microbiol"},{"issue":"5","key":"5010_CR25","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.immuni.2011.05.006","volume":"34","author":"T Kawai","year":"2011","unstructured":"Kawai T, Akira S (2011) Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34(5):637\u2013650. https:\/\/doi.org\/10.1016\/j.immuni.2011.05.006","journal-title":"Immunity"},{"issue":"12","key":"5010_CR26","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1038\/ni.2137","volume":"12","author":"H Iwasaki","year":"2011","unstructured":"Iwasaki H, Takeuchi O, Teraguchi S, Matsushita K, Uehata T, Kuniyoshi K, Satoh T, Saitoh T, Matsushita M, Standley DM, Akira S (2011) The I\u03baB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1. Nat Immunol 12(12):1167\u20131175. https:\/\/doi.org\/10.1038\/ni.2137","journal-title":"Nat Immunol"},{"issue":"10","key":"5010_CR27","doi-asserted-by":"publisher","first-page":"6337","DOI":"10.1074\/jbc.M707861200","volume":"283","author":"J Liang","year":"2008","unstructured":"Liang J, Wang J, Azfer A, Song W, Tromp G, Kolattukudy PE, Fu M (2008) A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. J Biol Chem 283(10):6337\u20136346. https:\/\/doi.org\/10.1074\/jbc.M707861200","journal-title":"J Biol Chem"},{"issue":"1","key":"5010_CR28","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1159\/000339826","volume":"5","author":"E Blazusiak","year":"2013","unstructured":"Blazusiak E, Florczyk D, Jura J, Potempa J, Koziel J (2013) Differential regulation by Toll-like receptor agonists reveals that MCPIP1 is the potent regulator of innate immunity in bacterial and viral infections. J Innate Immun 5(1):15\u201323. https:\/\/doi.org\/10.1159\/000339826","journal-title":"J Innate Immun"},{"issue":"7","key":"5010_CR29","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.4049\/jimmunol.2101184","volume":"209","author":"M Wadowska","year":"2022","unstructured":"Wadowska M, Dobosz E, Golda A, Bryzek D, Lech M, Fu M, Koziel J (2022) MCP-induced protein 1 participates in macrophage-dependent endotoxin tolerance. J Immunol 209(7):1348\u20131358. https:\/\/doi.org\/10.4049\/jimmunol.2101184","journal-title":"J Immunol"},{"issue":"2","key":"5010_CR30","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1002\/eji.201344202","volume":"44","author":"G Hajishengallis","year":"2014","unstructured":"Hajishengallis G, Lamont RJ (2014) Breaking bad: manipulation of the host response by Porphyromonas gingivalis. Eur J Immunol 44(2):328\u2013338. https:\/\/doi.org\/10.1002\/eji.201344202","journal-title":"Eur J Immunol"},{"issue":"3","key":"5010_CR31","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1128\/IAI.69.3.1364-1372.2001","volume":"69","author":"GT Huang","year":"2001","unstructured":"Huang GT, Kim D, Lee JK, Kuramitsu HK, Haake SK (2001) Interleukin-8 and intercellular adhesion molecule 1 regulation in oral epithelial cells by selected periodontal bacteria: multiple effects of Porphyromonas gingivalis via antagonistic mechanisms. Infect Immun 69(3):1364\u20131372. https:\/\/doi.org\/10.1128\/IAI.69.3.1364-1372.2001","journal-title":"Infect Immun"},{"issue":"1","key":"5010_CR32","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1128\/IAI.01139-07","volume":"76","author":"S Onishi","year":"2008","unstructured":"Onishi S, Honma K, Liang S, Stathopoulou P, Kinane D, Hajishengallis G, Sharma A (2008) Toll-like receptor 2-mediated interleukin-8 expression in gingival epithelial cells by the Tannerella forsythia leucine-rich repeat protein BspA. Infect Immun 76(1):198\u2013205. https:\/\/doi.org\/10.1128\/IAI.01139-07","journal-title":"Infect Immun"},{"issue":"1","key":"5010_CR33","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/prd.12374","volume":"86","author":"RP Darveau","year":"2021","unstructured":"Darveau RP, Curtis MA (2021) Oral biofilms revisited: a novel host tissue of bacteriological origin. Periodontol 2000 86(1):8\u201313. https:\/\/doi.org\/10.1111\/prd.12374","journal-title":"Periodontol 2000"},{"issue":"1","key":"5010_CR34","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/prd.12361","volume":"86","author":"NS Jakubovics","year":"2021","unstructured":"Jakubovics NS, Goodman SD, Mashburn-Warren L, Stafford GP, Cieplik F (2021) The dental plaque biofilm matrix. Periodontol 2000 86(1):32\u201356. https:\/\/doi.org\/10.1111\/prd.12361","journal-title":"Periodontol 2000"},{"issue":"1","key":"5010_CR35","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/prd.12371","volume":"86","author":"G Hajishengallis","year":"2021","unstructured":"Hajishengallis G, Lamont RJ (2021) Polymicrobial communities in periodontal disease: their quasi-organismal nature and dialogue with the host. Periodontol 2000 86(1):210\u2013230. https:\/\/doi.org\/10.1111\/prd.12371","journal-title":"Periodontol 2000"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-023-05010-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-023-05010-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-023-05010-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T10:13:26Z","timestamp":1683195206000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-023-05010-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,3]]},"references-count":35,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["5010"],"URL":"https:\/\/doi.org\/10.1007\/s00784-023-05010-5","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,3]]},"assertion":[{"value":"18 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Due to the nature of the study, the current project got ethical permissions from two independent committees:1) For the samples that are collected for immunoblot analysis: The Ethical Committee of Hacettepe University reviewed and approved the study protocol (No: GO 17\/786-34). All participants gave written informed consent, and the study was conducted in accordance with the Helsinki Declaration of 1975, as revised in 2013.2) For the samples that are collected for immunohistochemical analysis: The study protocol was approved by the University of Istanbul\u2019s Faculty of Dentistry\u2019s Ethics Committee in accordance with the Helsinki Declaration (2017\/41), and the study was conducted in accordance with the Helsinki Declaration of 1975, as revised in 2013. All participants gave written informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}