{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T03:44:26Z","timestamp":1775187866512,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T00:00:00Z","timestamp":1688774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T00:00:00Z","timestamp":1688774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Bern"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract\n<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>To histologically evaluate the effects of a novel human recombinant amelogenin (rAmelX) on periodontal wound healing \/ regeneration in recession-type defects.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>A total of 17 gingival recession-type defects were surgically created in the maxilla of three minipigs. The defects were randomly treated with a coronally advanced flap (CAF) and either rAmelX (test), or a CAF and placebo (control). At three months following reconstructive surgery, the animals were euthanized, and the healing outcomes histologically evaluated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The test group yielded statistically significantly (<jats:italic>p<\/jats:italic>\u2009=\u20090.047) greater formation of cementum with inserting collagen fibers compared with the control group (i.e., 4.38\u00a0mm\u2009\u00b1\u20090.36\u00a0mm vs. 3.48\u00a0mm\u2009\u00b1\u20091.13\u00a0mm). Bone formation measured 2.15\u00a0mm\u2009\u00b1\u20090.8\u00a0mm in the test group and 2.24\u00a0mm\u2009\u00b1\u20091.23\u00a0mm in the control group, respectively, without a statistically significant difference (<jats:italic>p<\/jats:italic>\u2009=\u20090.94).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The present data have provided for the first-time evidence for the potential of rAmelX to promote regeneration of periodontal ligament and root cementum in recession-type defects, thus warranting further preclinical and clinical testing.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>The present results set the basis for the potential clinical application of rAmelX in reconstructive periodontal surgery.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-023-05123-x","type":"journal-article","created":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T07:02:35Z","timestamp":1688799755000},"page":"5041-5048","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Histological evaluation following treatment of recession-type defects with coronally advanced flap and a novel human recombinant amelogenin"],"prefix":"10.1007","volume":"27","author":[{"given":"Tali","family":"Chackartchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter D.","family":"Bosshardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Claude","family":"Imber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"St\u00e4hli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagit","family":"Sacks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,7,8]]},"reference":[{"key":"5123_CR1","doi-asserted-by":"publisher","unstructured":"Wyrebek B, Gorska R, Gawron K, Gora MN, Gorski B, Plakwicz P (2021) Periodontal condition of mandibular incisors treated with modified Kazanjian vestibuloplasty compared to untreated sites: A prospective study. 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This study was conducted in accordance with the ARRIVE guidelines for preclinical animal studies and the Israeli National Council of Animal Experimentation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Tali Chackartchi: has no conflict of interest related to this study.Dieter D. Bosshardt: has no conflict of interest related to this study.Jean-Claude Imber: has no conflict of interest related to this study.Alexandra St\u00e4hli: has no conflict of interest related to this study.Hagit Sacks: is employed by Prudentix Ltd, Israel.Katalin Nagy: has no conflict of interest related to this study.Anton Sculean: has no conflict of interest related to this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}