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CZS is usually diagnosed postpartum by evident\/apparent neural development problems. Although there are some reports of craniofacial\/dentition development in CZS, several clinical oral aspects are still unknown. This study describes some structural and functional characteristics of facial and cranial growth and deciduous dentition in CZS-affected children.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material and methods<\/jats:title>\n                <jats:p>Some cranial, facial and dental characteristics were determined in 14 children with CZS aged 3\u20135\u00a0years and compared them against 12 apparently healthy children paired by age and gender.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Fourteen CZS cases presented microcephaly, maxillary prognathism, altered facial thirds, asymmetric pupillary line, bruxism (<jats:italic>p<\/jats:italic>\u2009=\u20090.006), deep and anterior open bite and distal step decidual molar relationship (<jats:italic>p<\/jats:italic>\u2009=\u20090.031). CZS children cannot feed by themselves and most cannot walk and have not develop coordinated and intelligible language according to their chronological age. In contrast, controls presented normal skull features, have autonomous locomotion skills, speak intelligible language, feed by themselves, presented a harmonic intermaxillary relationship and have symmetrical facial thirds.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Microcephaly, dysphagia, bruxism, mandibular retrognathia, altered facial proportions and malocclusion are the main craniofacial and oral features at CZS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>The complications of CZS including those related with the face and the oral cavity are still being identified. This study revealed some cranial, facial and oral features in children affected by CSZ. Interdisciplinary rehabilitation protocols must address these syndromic features that could improve children and parents living conditions.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-023-05137-5","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T07:02:15Z","timestamp":1691996535000},"page":"5181-5188","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Craniofacial and dental features in children aged 3\u20135\u00a0years with congenital Zika syndrome"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9110-3010","authenticated-orcid":false,"given":"Catalina","family":"D\u00edaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4261-306X","authenticated-orcid":false,"given":"Natalia","family":"Arag\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3066-5938","authenticated-orcid":false,"given":"Eduardo","family":"Lopez-Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9532-4056","authenticated-orcid":false,"given":"Maria Cristina","family":"Arango","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5422-5905","authenticated-orcid":false,"given":"Diana","family":"D\u00e1valos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0848-659X","authenticated-orcid":false,"given":"Adolfo","family":"Contreras-Rengifo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,14]]},"reference":[{"key":"5137_CR1","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1007\/s15010-016-0935-6","volume":"44","author":"M Atif","year":"2016","unstructured":"Atif M, Azeem M, Sarwar MR, Bashir A (2016) Zika virus disease: a current review of the literature. 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The authors complied with Helsinki\u2019s ethical guidelines for investigation with humans, and procedures were performed with parental written consent and within the authorization of the institutional review board (number 010\u20132018) from Universidad del Valle.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics and consent to participate"}},{"value":"We have read and understood the Clinical Oral Investigations publishing policy and submit this manuscript in accordance with this policy.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publishing policy"}},{"value":"The results\/data\/figures in this manuscript have not been published elsewhere, nor are they under consideration (from you or one of your contributing authors) by another publisher.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Dual publication"}},{"value":"The corresponding author has read the Springer journal policies on author responsibilities (opens in a new window) and submits this manuscript in accordance with those policies.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authorship"}},{"value":"All clinical material is owned by the authors, and\/or no further permissions are required.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Third party material"}},{"value":"The authors declare no competing interests.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}