{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:26:46Z","timestamp":1788956806321,"version":"build-2803163510"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Study objectives<\/jats:title>\n                <jats:p>To compare the effects of mandibular advancement device (MAD) therapy on upper airway dimensions between responders and non-responders with mild to moderate obstructive sleep apnea (OSA).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Thirty-one participants (21 men and 10 women) with a mean \u00b1 SD apnea-hypopnea index (AHI) of 16.6 \u00b1 6.7 events\/h, and aged 48.5 \u00b1 13.9 years, were included in this study. Polysomnographic recordings and cone beam computed tomography (CBCT) scans in supine position were performed for every participant at baseline and at 3-month follow-up with their MAD in situ. Responders were defined as having \u2265 50% reduction in baseline AHI with a residual AHI &lt; 10 events\/h. The primary outcome variable was the minimal cross-sectional area of the upper airway (CSAmin).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>No significant differences were found between responders (<jats:italic>n<\/jats:italic> = 15) and non-responders (<jats:italic>n<\/jats:italic> = 16) in age, gender distribution, body mass index, and neck circumference (<jats:italic>P<\/jats:italic> = 0.06\u20130.93), nor in AHI and CSAmin (<jats:italic>P<\/jats:italic> = 0.40 and 0.65, respectively) at baseline. The changes of the CSAmin with MAD in situ in the responder group were not significantly different compared to those in the non-responder group (<jats:italic>P<\/jats:italic> = 0.06).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Within the limitations of this study, we conclude that the changes of the upper airway dimensions induced by MADs are not significantly different between responders and non-responders with mild to moderate OSA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>ClinicalTrials.gov Identifier: NCT02724865. <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02724865\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02724865<\/jats:ext-link><\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-023-05186-w","type":"journal-article","created":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T11:02:40Z","timestamp":1692270160000},"page":"5649-5660","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of mandibular advancement devices on upper airway dimensions in obstructive sleep apnea: responders versus non-responders"],"prefix":"10.1007","volume":"27","author":[{"given":"Xiaoxin","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Lobbezoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boudewijn R. 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Written informed consent was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Xiaoxin Shi declares that she has no conflicts of interest. Frank Lobbezoo is a member of the Academic Advisory Boards for GrindCare and Oral Function of Sunstar Suisse S.A. and receives research grants from Sunstar Suisse S.A., SomnoMed, Vivisol, Health Holland, and Airway Management. Hui Chen declares that she has no conflicts of interest. Boudewijn R. A. M. Rosenm\u00f6ller declares that he has no conflicts of interest. Erwin Berkhout declares that he has no conflicts of interest. Jan de Lange declares that he has no conflicts of interest. Ghizlane Aarab is a member of the Academic Advisory Board for Oral Function of Sunstar Suisse S.A. and receives research grants from Sunstar Suisse S.A., SomnoMed, Vivisol, and Health Holland.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}