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Prevalence of orofacial clefts in general, orofacial clefts as manifestation of a syndrome, sex distribution, and prevalence of different cleft types was evaluated and associated with the need for corrective surgery, family history, pregnancy complications, and comorbidities.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The prevalence of orofacial clefts for Goettingen in Lower Saxony was 1:890. 231 patients were male and 173 were female. CLP was most common (39.1%) followed by CP (34.7%), CL (14.4%), CLA (9.9%), and facial clefts (2%). The left side was more frequently affected and unilateral cleft forms occurred more often than bilateral ones. Almost 10% of the population displayed syndromic CL\/P. 10.9% of all patients had a positive family history regarding CL\/P, predominantly from the maternal side. Pregnancy abnormalities were found in 11.4%, most often in the form of preterm birth. Comorbidities, especially of the cardiovascular system, were found in 30.2% of the sample. 2.2% of patients treated according to the University Medical Center Goettingen protocol corrective surgery was performed in form of a velopharyngoplasty or residual hole closure.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The epidemiological and clinical profile of the study population resembled the expected distributions in Western populations. The large number of syndromic CL\/P and associated comorbidities supports the need for specialized cleft centers and interdisciplinary cleft care.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-023-05187-9","type":"journal-article","created":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T11:01:36Z","timestamp":1691233296000},"page":"5661-5670","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Epidemiological and clinical evaluation of patients with a cleft in lower saxony Germany: a mono-center analysis"],"prefix":"10.1007","volume":"27","author":[{"given":"Kauffmann","family":"Philipp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quast","family":"Anja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schminke","family":"Boris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kolle","family":"Johanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfer","family":"Susanne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stepniewski","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meyer-Marcotty","family":"Philipp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schliephake","family":"Henning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,5]]},"reference":[{"issue":"1","key":"5187_CR1","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1597\/1545-1569_1998_035_0040_ioclap_2.3.co_2","volume":"35","author":"C Hagberg","year":"1998","unstructured":"Hagberg C, Larson O (1998) Incidence of cleft lip and palate and risks of additional malformations. 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