{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:05:36Z","timestamp":1788260736184,"version":"build-2803163510"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["DRF66_08"],"award-info":[{"award-number":["DRF66_08"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["DRF66_08"],"award-info":[{"award-number":["DRF66_08"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010724","name":"Health Systems Research Institute","doi-asserted-by":"publisher","award":["66-101, 66-122"],"award-info":[{"award-number":["66-101, 66-122"]}],"id":[{"id":"10.13039\/501100010724","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010724","name":"Health Systems Research Institute","doi-asserted-by":"publisher","award":["66-101, 66-122"],"award-info":[{"award-number":["66-101, 66-122"]}],"id":[{"id":"10.13039\/501100010724","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["N42A650229"],"award-info":[{"award-number":["N42A650229"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017170","name":"Thailand Science Research and Innovation","doi-asserted-by":"publisher","award":["HEA663200060"],"award-info":[{"award-number":["HEA663200060"]}],"id":[{"id":"10.13039\/501100017170","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>Skeletal dysplasia (SD) comprises more than 450 separate disorders. We hypothesized that their dental features would be distinctive and investigated the tooth characteristics of four patients with different SDs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material and methods<\/jats:title>\n                <jats:p>Four SD patients with molecularly confirmed diagnoses, Pt-1 acromicric dysplasia, Pt-2 hypophosphatasia and hypochondroplasia, Pt-3 cleidocranial dysplasia, and Pt-4 achondroplasia, were recruited. A tooth from each patient was evaluated for mineral density (micro-computerized tomography), surface roughness (surface profilometer), microhardness, mineral contents (energy-dispersive X-ray), and ultrastructure (scanning electron microscopy and histology), and compared with three tooth-type matched controls.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Pt-1 and Pt-3 had several unerupted teeth. Pt-2 had an intact-root-exfoliated tooth at 2\u00a0years old. The lingual surfaces of the patients\u2019 teeth were significantly smoother, while their buccal surfaces were rougher, than controls, except for Pt-1\u2019s buccal surface. The patients\u2019 teeth exhibited deep grooves around the enamel prisms and rough intertubular dentin. Pt-3 demonstrated a flat dentinoenamel junction and Pt-2 had an enlarged pulp, barely detectable cementum layer, and ill-defined cemento-dentinal junction. Reduced microhardnesses in enamel, dentin, and both layers were observed in Pt-3, Pt-4, and Pt-1, respectively. Pt-1 showed reduced Ca\/P ratio in dentin, while both enamel and dentin of Pt-2 and Pt-3 showed reduced Ca\/P ratio.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Each SD has distinctive dental characteristics with changes in surface roughness, ultrastructure, and mineral composition of dental hard tissues.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>In this era of precision dentistry, identifying the specific potential dental problems for each patient with SD would help personalize dental management guidelines.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-023-05194-w","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T11:02:55Z","timestamp":1691406175000},"page":"5827-5839","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dental characteristics of patients with four different types of skeletal dysplasias"],"prefix":"10.1007","volume":"27","author":[{"given":"Worasap","family":"Tantibhaedhyangkul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenjira","family":"Tantrapornpong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuttanun","family":"Yutchawit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanakorn","family":"Theerapanon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narin","family":"Intarak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sermporn","family":"Thaweesapphithak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thantrira","family":"Porntaveetus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vorasuk","family":"Shotelersuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"5194_CR1","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1097\/GIM.0b013e3181daae9b","volume":"12","author":"D Krakow","year":"2010","unstructured":"Krakow D, Rimoin DL (2010) The skeletal dysplasias. Genet Med 12:327\u2013341. https:\/\/doi.org\/10.1097\/GIM.0b013e3181daae9b","journal-title":"Genet Med"},{"key":"5194_CR2","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1600-0722.2006.00399.x","volume":"114","author":"S Camilleri","year":"2006","unstructured":"Camilleri S, McDonald F (2006) Runx2 and dental development. Eur J Oral Sci 114:361\u2013373. https:\/\/doi.org\/10.1111\/j.1600-0722.2006.00399.x","journal-title":"Eur J Oral Sci"},{"key":"5194_CR3","doi-asserted-by":"publisher","first-page":"e20220028","DOI":"10.1590\/1678-7757-2022-0028","volume":"30","author":"S Thaweesapphithak","year":"2022","unstructured":"Thaweesapphithak S, Saengsin J, Kamolvisit W et al (2022) Cleidocranial dysplasia and novel RUNX2 variants: dental, craniofacial, and osseous manifestations. J Appl Oral Sci 30:e20220028. https:\/\/doi.org\/10.1590\/1678-7757-2022-0028","journal-title":"J Appl Oral Sci"},{"key":"5194_CR4","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1002\/mgg3.96","volume":"2","author":"Y Xue","year":"2014","unstructured":"Xue Y, Sun A, Mekikian PB et al (2014) FGFR3 mutation frequency in 324 cases from the International Skeletal Dysplasia Registry. Mol Genet Genomic Med 2:497\u2013503. https:\/\/doi.org\/10.1002\/mgg3.96","journal-title":"Mol Genet Genomic Med"},{"key":"5194_CR5","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.sdentj.2010.07.001","volume":"22","author":"A Al-Saleem","year":"2010","unstructured":"Al-Saleem A, Al-Jobair A (2010) Achondroplasia: craniofacial manifestations and considerations in dental management. Saudi Dent J 22:195\u2013199. https:\/\/doi.org\/10.1016\/j.sdentj.2010.07.001","journal-title":"Saudi Dent J"},{"key":"5194_CR6","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1093\/ejo\/cjab056","volume":"44","author":"TM Choi","year":"2022","unstructured":"Choi TM, Kramer GJC, Goos JAC et al (2022) Evaluation of dental maturity in Muenke syndrome, Saethre-Chotzen syndrome, and TCF12-related craniosynostosis. Eur J Orthod 44:287\u2013293. https:\/\/doi.org\/10.1093\/ejo\/cjab056","journal-title":"Eur J Orthod"},{"key":"5194_CR7","doi-asserted-by":"publisher","first-page":"3038","DOI":"10.1093\/hmg\/ddv053","volume":"24","author":"M Huckert","year":"2015","unstructured":"Huckert M, Stoetzel C, Morkmued S et al (2015) Mutations in the latent TGF-beta binding protein 3 (LTBP3) gene cause brachyolmia with amelogenesis imperfecta. Hum Mol Genet 24:3038\u20133049. https:\/\/doi.org\/10.1093\/hmg\/ddv053","journal-title":"Hum Mol Genet"},{"key":"5194_CR8","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1177\/154405910508401110","volume":"84","author":"T van den Bos","year":"2005","unstructured":"van den Bos T, Handoko G, Niehof A et al (2005) Cementum and dentin in hypophosphatasia. J Dent Res 84:1021\u20131025. https:\/\/doi.org\/10.1177\/154405910508401110","journal-title":"J Dent Res"},{"key":"5194_CR9","doi-asserted-by":"publisher","first-page":"115732","DOI":"10.1016\/j.bone.2020.115732","volume":"143","author":"K Kramer","year":"2021","unstructured":"Kramer K, Chavez MB, Tran AT et al (2021) Dental defects in the primary dentition associated with hypophosphatasia from biallelic ALPL mutations. Bone 143:115732. https:\/\/doi.org\/10.1016\/j.bone.2020.115732","journal-title":"Bone"},{"key":"5194_CR10","first-page":"101","volume":"36","author":"M Dard","year":"1993","unstructured":"Dard M (1993) Histology of alveolar bone and primary tooth roots in a case of cleidocranial dysplasia. Bull Group Int Rech Sci Stomatol Odontol 36:101\u2013107","journal-title":"Bull Group Int Rech Sci Stomatol Odontol"},{"key":"5194_CR11","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1111\/odi.13657","volume":"27","author":"N Intarak","year":"2021","unstructured":"Intarak N, Budsamongkol T, Theerapanon T et al (2021) Tooth ultrastructure of a novel COL1A2 mutation expanding its genotypic and phenotypic spectra. Oral Dis 27:1257\u20131267. https:\/\/doi.org\/10.1111\/odi.13657","journal-title":"Oral Dis"},{"key":"5194_CR12","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.gendis.2019.03.001","volume":"6","author":"T Budsamongkol","year":"2019","unstructured":"Budsamongkol T, Intarak N, Theerapanon T et al (2019) A novel mutation in COL1A2 leads to osteogenesis imperfecta\/Ehlers-Danlos overlap syndrome with brachydactyly. Genes Dis 6:138\u2013146. https:\/\/doi.org\/10.1016\/j.gendis.2019.03.001","journal-title":"Genes Dis"},{"key":"5194_CR13","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.jare.2019.10.006","volume":"21","author":"N Hemwong","year":"2020","unstructured":"Hemwong N, Phokaew C, Srichomthong C et al (2020) A patient with combined pituitary hormone deficiency and osteogenesis imperfecta associated with mutations in LHX4 and COL1A2. J Adv Res 21:121\u2013127. https:\/\/doi.org\/10.1016\/j.jare.2019.10.006","journal-title":"J Adv Res"},{"key":"5194_CR14","doi-asserted-by":"publisher","first-page":"103896","DOI":"10.1016\/j.ejmg.2020.103896","volume":"63","author":"W Udomchaiprasertkul","year":"2020","unstructured":"Udomchaiprasertkul W, Kuptanon C, Porntaveetus T et al (2020) A family with homozygous and heterozygous p.Gly337Ser mutations in COL1A2. Eur J Med Genet 63:103896. https:\/\/doi.org\/10.1016\/j.ejmg.2020.103896","journal-title":"Eur J Med Genet"},{"key":"5194_CR15","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1177\/00220345580370041301","volume":"37","author":"RG Craig","year":"1958","unstructured":"Craig RG, Peyton FA (1958) The micro-hardness of enamel and dentin. J Dent Res 37:661\u2013668. https:\/\/doi.org\/10.1177\/00220345580370041301","journal-title":"J Dent Res"},{"key":"5194_CR16","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1177\/00220345570360051401","volume":"36","author":"RC Caldwell","year":"1957","unstructured":"Caldwell RC, Muntz ML, Gilmore RW et al (1957) Microhardness studies of intact surface enamel. J Dent Res 36:732\u2013738. https:\/\/doi.org\/10.1177\/00220345570360051401","journal-title":"J Dent Res"},{"key":"5194_CR17","doi-asserted-by":"publisher","unstructured":"Pilar G-S, Reyes-Gasga J (2003) Microhardness and chemical composition of human tooth. Mater Res 6. https:\/\/doi.org\/10.1590\/S1516-14392003000300011","DOI":"10.1590\/S1516-14392003000300011"},{"key":"5194_CR18","doi-asserted-by":"publisher","unstructured":"Teutle-Coyotecatl B, Contreras-Bulnes R, Rodriguez-Vilchis LE et al (2022) Effect of surface roughness of deciduous and permanent tooth enamel on bacterial adhesion. Microorganisms 10. https:\/\/doi.org\/10.3390\/microorganisms10091701","DOI":"10.3390\/microorganisms10091701"},{"key":"5194_CR19","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1002\/jemt.20796","volume":"73","author":"MA De Menezes Oliveira","year":"2010","unstructured":"De Menezes Oliveira MA, Torres CP, Gomes-Silva JM et al (2010) Microstructure and mineral composition of dental enamel of permanent and deciduous teeth. Microsc Res Tech 73:572\u2013577. https:\/\/doi.org\/10.1002\/jemt.20796","journal-title":"Microsc Res Tech"},{"key":"5194_CR20","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1007\/s00438-019-01547-x","volume":"294","author":"N Intarak","year":"2019","unstructured":"Intarak N, Theerapanon T, Thaweesapphithak S et al (2019) Genotype-phenotype correlation and expansion of orodental anomalies in LTBP3-related disorders. Mol Genet Genomics 294:773\u2013787. https:\/\/doi.org\/10.1007\/s00438-019-01547-x","journal-title":"Mol Genet Genomics"},{"key":"5194_CR21","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1002\/ajmg.a.38370","volume":"173","author":"T Porntaveetus","year":"2017","unstructured":"Porntaveetus T, Srichomthong C, Suphapeetiporn K et al (2017) Monoallelic FGFR3 and biallelic ALPL mutations in a Thai girl with hypochondroplasia and hypophosphatasia. Am J Med Genet A 173:2747\u20132752. https:\/\/doi.org\/10.1002\/ajmg.a.38370","journal-title":"Am J Med Genet A"},{"key":"5194_CR22","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1111\/cge.12812","volume":"90","author":"A Jaruga","year":"2016","unstructured":"Jaruga A, Hordyjewska E, Kandzierski G et al (2016) Cleidocranial dysplasia and RUNX2-clinical phenotype\u2013genotype correlation. Clin Genet 90:393\u2013402. https:\/\/doi.org\/10.1111\/cge.12812","journal-title":"Clin Genet"},{"key":"5194_CR23","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1086\/302622","volume":"65","author":"I Quack","year":"1999","unstructured":"Quack I, Vonderstrass B, Stock M et al (1999) Mutation analysis of core binding factor A1 in patients with cleidocranial dysplasia. Am J Hum Genet 65:1268\u20131278. https:\/\/doi.org\/10.1086\/302622","journal-title":"Am J Hum Genet"},{"key":"5194_CR24","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.1002\/ajmg.a.33021","volume":"149A","author":"MM Cohen Jr","year":"2009","unstructured":"Cohen MM Jr (2009) Perspectives on RUNX genes: an update. Am J Med Genet Part A 149A:2629\u20132646. https:\/\/doi.org\/10.1002\/ajmg.a.33021","journal-title":"Am J Med Genet Part A"},{"key":"5194_CR25","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1210\/edrv.21.1.0387","volume":"21","author":"Z Vajo","year":"2000","unstructured":"Vajo Z, Francomano CA, Wilkin DJ (2000) The molecular and genetic basis of fibroblast growth factor receptor 3 disorders: the achondroplasia family of skeletal dysplasias, Muenke craniosynostosis, and Crouzon syndrome with acanthosis nigricans*. Endocr Rev 21:23\u201339. https:\/\/doi.org\/10.1210\/edrv.21.1.0387","journal-title":"Endocr Rev"},{"key":"5194_CR26","doi-asserted-by":"publisher","first-page":"e46678","DOI":"10.1371\/journal.pone.0046678","volume":"7","author":"J Placone","year":"2012","unstructured":"Placone J, Hristova K (2012) Direct assessment of the effect of the Gly380Arg achondroplasia mutation on FGFR3 dimerization using quantitative imaging FRET. PLOS One 7:e46678. https:\/\/doi.org\/10.1371\/journal.pone.0046678","journal-title":"PLOS One"},{"key":"5194_CR27","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.matbio.2015.05.005","volume":"47","author":"IB Robertson","year":"2015","unstructured":"Robertson IB, Horiguchi M, Zilberberg L et al (2015) Latent TGF-\u03b2-binding proteins. Matrix Biol 47:44\u201353. https:\/\/doi.org\/10.1016\/j.matbio.2015.05.005","journal-title":"Matrix Biol"},{"key":"5194_CR28","doi-asserted-by":"publisher","first-page":"3038","DOI":"10.1093\/hmg\/ddv053","volume":"24","author":"M Huckert","year":"2015","unstructured":"Huckert M, Stoetzel C, Morkmued S et al (2015) Mutations in the latent TGF-beta binding protein 3 (LTBP3) gene cause brachyolmia with amelogenesis imperfecta. Hum Mol Genet 24:3038\u20133049. https:\/\/doi.org\/10.1093\/hmg\/ddv053","journal-title":"Hum Mol Genet"},{"key":"5194_CR29","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/eos.12328","volume":"125","author":"S Morkmued","year":"2017","unstructured":"Morkmued S, Hemmerle J, Mathieu E et al (2017) Enamel and dental anomalies in latent-transforming growth factor beta-binding protein 3 mutant mice. Eur J Oral Sci 125:8\u201317. https:\/\/doi.org\/10.1111\/eos.12328","journal-title":"Eur J Oral Sci"},{"key":"5194_CR30","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/bs.ctdb.2018.11.020","volume":"133","author":"DM Ornitz","year":"2019","unstructured":"Ornitz DM, Marie PJ (2019) Chapter eight - fibroblast growth factors in skeletal development. Curr Top Dev Biol 133:195\u2013234. https:\/\/doi.org\/10.1016\/bs.ctdb.2018.11.020","journal-title":"Curr Top Dev Biol"},{"key":"5194_CR31","doi-asserted-by":"publisher","first-page":"132","DOI":"10.7150\/ijms.61798","volume":"19","author":"W Guo","year":"2022","unstructured":"Guo W, Lin X, Zhang R et al (2022) Spatiotemporal expression patterns of critical genes involved in FGF signaling during morphogenesis and odontogenesis of deciduous molars in miniature pigs. Int J Med Sci 19:132\u2013141. https:\/\/doi.org\/10.7150\/ijms.61798","journal-title":"Int J Med Sci"},{"key":"5194_CR32","unstructured":"Bober M, Bellus GA, Nikkel SM, Tiller GE (2020) Hypochondroplasia. In: GeneReviews\u00ae. Adam MP, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A (eds) University of Washington, Seattle (WA)"},{"key":"5194_CR33","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1034\/j.1600-0722.2000.108003189.x","volume":"108","author":"JC Hu","year":"2000","unstructured":"Hu JC, Plaetke R, Mornet E et al (2000) Characterization of a family with dominant hypophosphatasia. Eur J Oral Sci 108:189\u2013194. https:\/\/doi.org\/10.1034\/j.1600-0722.2000.108003189.x","journal-title":"Eur J Oral Sci"},{"key":"5194_CR34","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/nrendo.2016.14","volume":"12","author":"MP Whyte","year":"2016","unstructured":"Whyte MP (2016) Hypophosphatasia \u2014 aetiology, nosology, pathogenesis, diagnosis and treatment. Nat Rev Endocrinol 12:233\u2013246. https:\/\/doi.org\/10.1038\/nrendo.2016.14","journal-title":"Nat Rev Endocrinol"},{"key":"5194_CR35","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1177\/00220345990780060501","volume":"78","author":"W Beertsen","year":"1999","unstructured":"Beertsen W, VandenBos T, Everts V (1999) Root development in mice lacking functional tissue non-specific alkaline phosphatase gene: inhibition of acellular cementum formation. J Dent Res 78:1221\u20131229. https:\/\/doi.org\/10.1177\/00220345990780060501","journal-title":"J Dent Res"},{"key":"5194_CR36","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1750-1172-4-6","volume":"4","author":"A Reibel","year":"2009","unstructured":"Reibel A, Maniere MC, Clauss F et al (2009) Orodental phenotype and genotype findings in all subtypes of hypophosphatasia. Orphanet J Rare Dis 4:6. https:\/\/doi.org\/10.1186\/1750-1172-4-6","journal-title":"Orphanet J Rare Dis"},{"key":"5194_CR37","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1002\/jbmr.1767","volume":"28","author":"BL Foster","year":"2013","unstructured":"Foster BL, Nagatomo KJ, Tso HW et al (2013) Tooth root dentin mineralization defects in a mouse model of hypophosphatasia. J Bone Miner Res 28:271\u2013282. https:\/\/doi.org\/10.1002\/jbmr.1767","journal-title":"J Bone Miner Res"},{"key":"5194_CR38","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1007\/s00441-014-2106-3","volume":"361","author":"MJ Tomlinson","year":"2015","unstructured":"Tomlinson MJ, Dennis C, Yang XB et al (2015) Tissue non-specific alkaline phosphatase production by human dental pulp stromal cells is enhanced by high density cell culture. Cell Tissue Res 361:529\u2013540. https:\/\/doi.org\/10.1007\/s00441-014-2106-3","journal-title":"Cell Tissue Res"},{"key":"5194_CR39","doi-asserted-by":"publisher","first-page":"112026","DOI":"10.1016\/j.yexcr.2020.112026","volume":"392","author":"H Melms","year":"2020","unstructured":"Melms H, Herrmann M, F\u00f6rstner K et al (2020) Novel molecular cues for dental defects in hypophosphatasia. Exp Cell Res 392:112026. https:\/\/doi.org\/10.1016\/j.yexcr.2020.112026","journal-title":"Exp Cell Res"},{"key":"5194_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2021.12.006","author":"M-C Chang","year":"2021","unstructured":"Chang M-C, Chen N-Y, Chen J-H et al (2021) bFGF stimulated plasminogen activation factors, but inhibited alkaline phosphatase and SPARC in stem cells from apical papilla: involvement of MEK\/ERK, TAK1 and p38 signaling. J Adv Res. https:\/\/doi.org\/10.1016\/j.jare.2021.12.006","journal-title":"J Adv Res"},{"key":"5194_CR41","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1186\/s13287-018-1093-9","volume":"9","author":"N Nowwarote","year":"2018","unstructured":"Nowwarote N, Sukarawan W, Pavasant P et al (2018) Basic fibroblast growth factor regulates phosphate\/pyrophosphate regulatory genes in stem cells isolated from human exfoliated deciduous teeth. Stem Cell Res Ther 9:345\u2013345. https:\/\/doi.org\/10.1186\/s13287-018-1093-9","journal-title":"Stem Cell Res Ther"},{"key":"5194_CR42","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1083\/jcb.149.6.1297","volume":"149","author":"A Mansukhani","year":"2000","unstructured":"Mansukhani A, Bellosta P, Sahni M et al (2000) Signaling by fibroblast growth factors (FGF) and fibroblast growth factor receptor 2 (FGFR2)-activating mutations blocks mineralization and induces apoptosis in osteoblasts. J Cell Biol 149:1297\u20131308. https:\/\/doi.org\/10.1083\/jcb.149.6.1297","journal-title":"J Cell Biol"},{"key":"5194_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jcb.10276","volume":"87","author":"T Komori","year":"2002","unstructured":"Komori T (2002) Runx2, a multifunctional transcription factor in skeletal development. J Cell Biochem 87:1\u20138. https:\/\/doi.org\/10.1002\/jcb.10276","journal-title":"J Cell Biochem"},{"key":"5194_CR44","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1177\/0022034509342873","volume":"88","author":"S Chen","year":"2009","unstructured":"Chen S, Gluhak-Heinrich J, Wang YH et al (2009) Runx2, osx, and dspp in tooth development. J Dent Res 88:904\u2013909. https:\/\/doi.org\/10.1177\/0022034509342873","journal-title":"J Dent Res"},{"key":"5194_CR45","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1002\/jcb.22875","volume":"111","author":"D Xuan","year":"2010","unstructured":"Xuan D, Sun X, Yan Y et al (2010) Effect of cleidocranial dysplasia-related novel mutation of RUNX2 on characteristics of dental pulp cells and tooth development. J Cell Biochem 111:1473\u20131481. https:\/\/doi.org\/10.1002\/jcb.22875","journal-title":"J Cell Biochem"},{"key":"5194_CR46","doi-asserted-by":"publisher","first-page":"9594","DOI":"10.1038\/s41598-018-27873-5","volume":"8","author":"Q Chu","year":"2018","unstructured":"Chu Q, Gao Y, Gao X et al (2018) Ablation of Runx2 in ameloblasts suppresses enamel maturation in tooth development. Sci Rep 8:9594. https:\/\/doi.org\/10.1038\/s41598-018-27873-5","journal-title":"Sci Rep"},{"key":"5194_CR47","first-page":"1204","volume":"69","author":"A Manoor","year":"2019","unstructured":"Manoor A, Moeen F, Mehmood M et al (2019) Correelation between micro-hardness and mineral content in the healthy tooth enamel of humans belonging to different age groups. PAFMJ 69:1204\u20131209","journal-title":"PAFMJ"},{"key":"5194_CR48","doi-asserted-by":"publisher","first-page":"S107","DOI":"10.1016\/S0925-4773(03)00101-1","volume":"119","author":"T Yamashiro","year":"2002","unstructured":"Yamashiro T, \u00c5berg T, Levanon D et al (2002) Expression of Runx1, -2 and -3 during tooth, palate and craniofacial bone development. Mech Dev 119:S107\u2013S110. https:\/\/doi.org\/10.1016\/S0925-4773(03)00101-1","journal-title":"Mech Dev"},{"key":"5194_CR49","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1387\/ijdb.150192ao","volume":"59","author":"K Kawasaki","year":"2015","unstructured":"Kawasaki K, Kawasaki M, Watanabe M et al (2015) Expression of Sox genes in tooth development. Int J Dev Biol 59:471\u2013478. https:\/\/doi.org\/10.1387\/ijdb.150192ao","journal-title":"Int J Dev Biol"},{"key":"5194_CR50","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1242\/dev.015081","volume":"135","author":"OD Klein","year":"2008","unstructured":"Klein OD, Lyons DB, Balooch G et al (2008) An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors. Development 135:377\u2013385. https:\/\/doi.org\/10.1242\/dev.015081","journal-title":"Development"},{"key":"5194_CR51","doi-asserted-by":"publisher","first-page":"5268342","DOI":"10.1155\/2019\/5268342","volume":"2019","author":"DE Betancourt","year":"2019","unstructured":"Betancourt DE, Baldion PA, Castellanos JE (2019) Resin-dentin bonding interface: mechanisms of degradation and strategies for stabilization of the hybrid layer. Int J Biomater 2019:5268342. https:\/\/doi.org\/10.1155\/2019\/5268342","journal-title":"Int J Biomater"},{"key":"5194_CR52","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s00784-018-2437-7","volume":"23","author":"T Porntaveetus","year":"2019","unstructured":"Porntaveetus T, Nowwarote N, Osathanon T et al (2019) Compromised alveolar bone cells in a patient with dentinogenesis imperfecta caused by DSPP mutation. Clin Oral Investig 23:303\u2013313. https:\/\/doi.org\/10.1007\/s00784-018-2437-7","journal-title":"Clin Oral Investig"},{"key":"5194_CR53","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1111\/odi.12801","volume":"24","author":"T Porntaveetus","year":"2018","unstructured":"Porntaveetus T, Osathanon T, Nowwarote N et al (2018) Dental properties, ultrastructure, and pulp cells associated with a novel DSPP mutation. Oral Dis 24:619\u2013627. https:\/\/doi.org\/10.1111\/odi.12801","journal-title":"Oral Dis"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-023-05194-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-023-05194-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-023-05194-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T08:11:49Z","timestamp":1696666309000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-023-05194-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,7]]},"references-count":53,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["5194"],"URL":"https:\/\/doi.org\/10.1007\/s00784-023-05194-w","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,7]]},"assertion":[{"value":"4 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was approved by the Research Ethics Committee (HREC-DCU 2020\u2013059), Faculty of Dentistry, Chulalongkorn University, and performed following the ethical principles of the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all participants in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}