{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T11:06:54Z","timestamp":1784372814233,"version":"3.55.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"DOI":"10.1007\/s00784-023-05196-8","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T20:24:45Z","timestamp":1696019085000},"page":"5853-5863","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mechanical force application and inflammation induce osteoclastogenesis by independent pathways"],"prefix":"10.1007","volume":"27","author":[{"given":"Tali","family":"Chachartchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifat","family":"Itai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinat","family":"Tzach-Nahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Shapira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Polak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"5196_CR1","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/0002-9416(79)90024-1","volume":"76","author":"S Alstad","year":"1979","unstructured":"Alstad S, Zachrisson BU (1979) Longitudinal study of periodontal condition associated with orthodontic treatment in adolescents. Am J Orthod 76:277\u2013286","journal-title":"Am J Orthod"},{"key":"5196_CR2","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/0889-5406(89)90455-1","volume":"96","author":"RL Boyd","year":"1989","unstructured":"Boyd RL, Leggott PJ, Quinn RS, Eakle WS, Chambers D (1989) Periodontal implications of orthodontic treatment in adults with reduced or normal periodontal tissues versus those of adolescents. Am J Orthod Dentofac Orthop:Off Publ Am Assoc Orthod, Constituent Soc, Am Board Orthod 96:191\u2013198","journal-title":"Am J Orthod Dentofac Orthop:Off Publ Am Assoc Orthod, Constituent Soc, Am Board Orthod"},{"key":"5196_CR3","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/j.1600-051X.1998.tb02440.x","volume":"25","author":"MA Ong","year":"1998","unstructured":"Ong MA, Wang HL, Smith FN (1998) Interrelationship between periodontics and adult orthodontics. J Clin Periodontol 25:271\u2013277","journal-title":"J Clin Periodontol"},{"key":"5196_CR4","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1111\/j.1600-0765.2005.00809.x","volume":"40","author":"JA Garat","year":"2005","unstructured":"Garat JA, Gordillo ME, Ubios AM (2005) Bone response to different strength orthodontic forces in animals with periodontitis. J Periodontal Res 40:441\u2013445. https:\/\/doi.org\/10.1111\/j.1600-0765.2005.00809.x","journal-title":"J Periodontal Res"},{"key":"5196_CR5","first-page":"184","volume":"10","author":"TF Geraci","year":"1990","unstructured":"Geraci TF, Nevins M, Crossetti HW, Drizen K, Ruben MP (1990) Reattachment of the periodontium after tooth movement into an osseous defect in a monkey. 1. Int J Periodontics Restorative Dent 10:184\u2013197","journal-title":"Int J Periodontics Restorative Dent"},{"key":"5196_CR6","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1111\/j.1365-2842.2010.02068.x","volume":"37","author":"N Gkantidis","year":"2010","unstructured":"Gkantidis N, Christou P, Topouzelis N (2010) The orthodontic-periodontic interrelationship in integrated treatment challenges: a systematic review. J Oral Rehabil 37:377\u2013390. https:\/\/doi.org\/10.1111\/j.1365-2842.2010.02068.x","journal-title":"J Oral Rehabil"},{"key":"5196_CR7","first-page":"31","volume":"20","author":"S Re","year":"2000","unstructured":"Re S, Corrente G, Abundo R, Cardaropoli D (2000) Orthodontic treatment in periodontally compromised patients: 12-year report. Int J Periodontics Restorative Dent 20:31\u201339","journal-title":"Int J Periodontics Restorative Dent"},{"key":"5196_CR8","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1002\/cre2.28","volume":"2","author":"E Zasciurinskiene","year":"2016","unstructured":"Zasciurinskiene E, Lindsten R, Slotte C, Bjerklin K (2016) Orthodontic treatment in periodontitis-susceptible subjects: a systematic literature review. Clin Exp Dental Res 2:162\u2013173. https:\/\/doi.org\/10.1002\/cre2.28","journal-title":"Clin Exp Dental Res"},{"key":"5196_CR9","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1111\/j.1600-051X.1977.tb01900.x","volume":"4","author":"I Ericsson","year":"1977","unstructured":"Ericsson I, Thilander B, Lindhe J, Okamoto H (1977) The effect of orthodontic tilting movements on the periodontal tissues of infected and non-infected dentitions in dogs. J Clin Periodontol 4:278\u2013293","journal-title":"J Clin Periodontol"},{"key":"5196_CR10","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/0889-5406(93)70011-C","volume":"103","author":"JL Wennstrom","year":"1993","unstructured":"Wennstrom JL, Stokland BL, Nyman S, Thilander B (1993) Periodontal tissue response to orthodontic movement of teeth with infrabony pockets. Am J Orthod Dentofac Orthop: Off Publ Am Assoc Orthod, Constituent Soc, Am Board Orthod 103:313\u2013319. https:\/\/doi.org\/10.1016\/0889-5406(93)70011-C","journal-title":"Am J Orthod Dentofac Orthop: Off Publ Am Assoc Orthod, Constituent Soc, Am Board Orthod"},{"key":"5196_CR11","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.ajodo.2014.09.022","volume":"147","author":"Y Ishihara","year":"2015","unstructured":"Ishihara Y, Tomikawa K, Deguchi T, Honjo T, Suzuki K, Kono T, Kuboki T, Kamioka H, Takashiba S, Yamashiro T (2015) Interdisciplinary orthodontic treatment for a patient with generalized aggressive periodontitis: assessment of IgG antibodies to identify type of periodontitis and correct timing of treatment. Am J Orthod Dentofac Orthop: Off Publ Am Assoc Orthod, Constituent Soc, Am Board Orthod 147:766\u2013780. https:\/\/doi.org\/10.1016\/j.ajodo.2014.09.022","journal-title":"Am J Orthod Dentofac Orthop: Off Publ Am Assoc Orthod, Constituent Soc, Am Board Orthod"},{"key":"5196_CR12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S1073-8746(97)80037-0","volume":"3","author":"DP Mathews","year":"1997","unstructured":"Mathews DP, Kokich VG (1997) Managing treatment for the orthodontic patient with periodontal problems. Sem Orthod 3:21\u201338","journal-title":"Sem Orthod"},{"key":"5196_CR13","first-page":"249","volume":"26","author":"A Maddi","year":"2013","unstructured":"Maddi A, Scannapieco FA (2013) Oral biofilms, oral and periodontal infections, and systemic disease. Am J Dent 26:249\u2013254","journal-title":"Am J Dent"},{"key":"5196_CR14","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1093\/ejo\/cjl001","volume":"28","author":"MC Meikle","year":"2006","unstructured":"Meikle MC (2006) The tissue, cellular, and molecular regulation of orthodontic tooth movement: 100 years after Carl Sandstedt. Eur J Orthod 28:221\u2013240. https:\/\/doi.org\/10.1093\/ejo\/cjl001","journal-title":"Eur J Orthod"},{"key":"5196_CR15","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.3109\/00016357.2012.749515","volume":"71","author":"H Hazan-Molina","year":"2013","unstructured":"Hazan-Molina H, Levin L, Einy S, Aizenbud D (2013) Aggressive periodontitis diagnosed during or before orthodontic treatment. Acta Odontol Scand 71:1023\u20131031. https:\/\/doi.org\/10.3109\/00016357.2012.749515","journal-title":"Acta Odontol Scand"},{"key":"5196_CR16","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.aanat.2016.10.004","volume":"210","author":"C Kirschneck","year":"2017","unstructured":"Kirschneck C, Fanghanel J, Wahlmann U, Wolf M, Roldan JC, Proff P (2017) Interactive effects of periodontitis and orthodontic tooth movement on dental root resorption, tooth movement velocity and alveolar bone loss in a rat model. Ann Anat= Anatomischer Anzeiger\u202f: Off Organ Anatomische Gesellschaft 210:32\u201343. https:\/\/doi.org\/10.1016\/j.aanat.2016.10.004","journal-title":"Ann Anat= Anatomischer Anzeiger : Off Organ Anatomische Gesellschaft"},{"key":"5196_CR17","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1111\/jre.12439","volume":"52","author":"J Shi","year":"2017","unstructured":"Shi J, Liu Z, Kawai T, Zhou Y, Han X (2017) Antibiotic administration alleviates the aggravating effect of orthodontic force on ligature-induced experimental periodontitis bone loss in mice. J Periodontal Res 52:725\u2013733. https:\/\/doi.org\/10.1111\/jre.12439","journal-title":"J Periodontal Res"},{"key":"5196_CR18","doi-asserted-by":"publisher","first-page":"325","DOI":"10.2174\/1568010054022015","volume":"4","author":"Y Tanaka","year":"2005","unstructured":"Tanaka Y, Nakayamada S, Okada Y (2005) Osteoblasts and osteoclasts in bone remodeling and inflammation. Curr Drug Targets Inflamm Allergy 4:325\u2013328","journal-title":"Curr Drug Targets Inflamm Allergy"},{"key":"5196_CR19","doi-asserted-by":"publisher","first-page":"987","DOI":"10.2353\/ajpath.2006.060180","volume":"169","author":"T Kawai","year":"2006","unstructured":"Kawai T, Matsuyama T, Hosokawa Y, Makihira S, Seki M, Karimbux NY, Goncalves RB, Valverde P, Dibart S, Li YP, Miranda LA, Ernst CW, Izumi Y, Taubman MA (2006) B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease. Am J Pathol 169:987\u2013998. https:\/\/doi.org\/10.2353\/ajpath.2006.060180","journal-title":"Am J Pathol"},{"key":"5196_CR20","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1177\/00220345010800030801","volume":"80","author":"H Kanzaki","year":"2001","unstructured":"Kanzaki H, Chiba M, Shimizu Y, Mitani H (2001) Dual regulation of osteoclast differentiation by periodontal ligament cells through RANKL stimulation and OPG inhibition. J Dent Res 80:887\u2013891. https:\/\/doi.org\/10.1177\/00220345010800030801","journal-title":"J Dent Res"},{"key":"5196_CR21","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.cytogfr.2013.06.001","volume":"24","author":"M Baud'huin","year":"2013","unstructured":"Baud\u2019huin M, Duplomb L, Teletchea S, Lamoureux F, Ruiz-Velasco C, Maillasson M, Redini F, Heymann MF, Heymann D (2013) Osteoprotegerin: multiple partners for multiple functions. Cytokine Growth Factor Rev 24:401\u2013409. https:\/\/doi.org\/10.1016\/j.cytogfr.2013.06.001","journal-title":"Cytokine Growth Factor Rev"},{"key":"5196_CR22","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1002\/cncr.11134","volume":"97","author":"EM Sordillo","year":"2003","unstructured":"Sordillo EM, Pearse RN (2003) RANK-Fc: a therapeutic antagonist for RANK-L in myeloma. Cancer 97:802\u2013812. https:\/\/doi.org\/10.1002\/cncr.11134","journal-title":"Cancer"},{"key":"5196_CR23","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1111\/jre.12584","volume":"53","author":"CL Ferreira","year":"2018","unstructured":"Ferreira CL, Nunes CMM, Bernardo DV, Pedroso JF, Longo M, Santamaria M Jr, Santamaria MP, Jardini MAN (2018) Effect of orthodontic force associated with cigarette smoke inhalation in healthy and diseased periodontium. A histometric and immunohistochemistry analysis in rats. J Periodontal Res 53:924\u2013931. https:\/\/doi.org\/10.1111\/jre.12584","journal-title":"J Periodontal Res"},{"key":"5196_CR24","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.lfs.2013.05.015","volume":"93","author":"Y Wang","year":"2013","unstructured":"Wang Y, Wang H, Ye Q, Ye J, Xu C, Lin L, Deng H, Hu R (2013) Co-regulation of LPS and tensile strain downregulating osteogenicity via c-fos expression. Life Sci 93:38\u201343. https:\/\/doi.org\/10.1016\/j.lfs.2013.05.015","journal-title":"Life Sci"},{"key":"5196_CR25","doi-asserted-by":"publisher","first-page":"666","DOI":"10.3892\/mmr.2017.6644","volume":"16","author":"C Sun","year":"2017","unstructured":"Sun C, Liu F, Cen S, Chen L, Wang Y, Sun H, Deng H, Hu R (2017) Tensile strength suppresses the osteogenesis of periodontal ligament cells in inflammatory microenvironments. Mol Med Rep 16:666\u2013672. https:\/\/doi.org\/10.3892\/mmr.2017.6644","journal-title":"Mol Med Rep"},{"key":"5196_CR26","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1186\/s12903-021-01761-3","volume":"21","author":"A Schroder","year":"2021","unstructured":"Schroder A, Stumpf J, Paddenberg E, Neubert P, Schatz V, Kostler J, Jantsch J, Deschner J, Proff P, Kirschneck C (2021) Effects of mechanical strain on periodontal ligament fibroblasts in presence of Aggregatibacter actinomycetemcomitans lysate. BMC Oral Health 21:405. https:\/\/doi.org\/10.1186\/s12903-021-01761-3","journal-title":"BMC Oral Health"},{"key":"5196_CR27","doi-asserted-by":"publisher","unstructured":"Rath-Deschner B, Nogueira AVB, Memmert S, Nokhbehsaim M, Augusto Cirelli J, Eick S, Miosge N, Kirschneck C, Kesting M, Deschner J, Jager A, Damanaki A (2021) Regulation of anti-apoptotic SOD2 and BIRC3 in periodontal cells and tissues. Int J Mol Sci 22. https:\/\/doi.org\/10.3390\/ijms22020591","DOI":"10.3390\/ijms22020591"},{"key":"5196_CR28","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s00784-021-03988-4","volume":"26","author":"B Rath-Deschner","year":"2022","unstructured":"Rath-Deschner B, Nogueira AVB, Beisel-Memmert S, Nokhbehsaim M, Eick S, Cirelli JA, Deschner J, Jager A, Damanaki A (2022) Interaction of periodontitis and orthodontic tooth movement-an in vitro and in vivo study. Clin Oral Investig 26:171\u2013181. https:\/\/doi.org\/10.1007\/s00784-021-03988-4","journal-title":"Clin Oral Investig"},{"key":"5196_CR29","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1007\/s00056-010-1031-7","volume":"71","author":"M Nokhbehsaim","year":"2010","unstructured":"Nokhbehsaim M, Deschner B, Winter J, Reimann S, Bourauel C, Jepsen S, Jager A, Deschner J (2010) Contribution of orthodontic load to inflammation-mediated periodontal destruction. J Orofac Orthop 71:390\u2013402. https:\/\/doi.org\/10.1007\/s00056-010-1031-7","journal-title":"J Orofac Orthop"},{"key":"5196_CR30","doi-asserted-by":"publisher","first-page":"425421","DOI":"10.1155\/2014\/425421","volume":"2014","author":"AV Nogueira","year":"2014","unstructured":"Nogueira AV, Nokhbehsaim M, Eick S, Bourauel C, Jager A, Jepsen S, Rossa C Jr, Deschner J, Cirelli JA (2014) Biomechanical loading modulates proinflammatory and bone resorptive mediators in bacterial-stimulated PDL cells. Mediators Inflamm 2014:425421. https:\/\/doi.org\/10.1155\/2014\/425421","journal-title":"Mediators Inflamm"},{"key":"5196_CR31","doi-asserted-by":"publisher","first-page":"11516","DOI":"10.1038\/s41598-017-11771-3","volume":"7","author":"R Tzach-Nahman","year":"2017","unstructured":"Tzach-Nahman R, Nashef R, Fleissig O, Palmon A, Shapira L, Wilensky A, Nussbaum G (2017) Oral fibroblasts modulate the macrophage response to bacterial challenge. Sci Rep 7:11516. https:\/\/doi.org\/10.1038\/s41598-017-11771-3","journal-title":"Sci Rep"},{"key":"5196_CR32","doi-asserted-by":"publisher","first-page":"2458","DOI":"10.1073\/pnas.75.5.2458","volume":"75","author":"SJ Collins","year":"1978","unstructured":"Collins SJ, Ruscetti FW, Gallagher RE, Gallo RC (1978) Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds. Proc Natl Acad Sci USA 75:2458\u20132462","journal-title":"Proc Natl Acad Sci USA"},{"key":"5196_CR33","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0531","author":"D Polak","year":"2018","unstructured":"Polak D, Shmueli A, Brenner T, Shapira L (2018) Oral infection with P. gingivalis exacerbates autoimmune encephalomyelitis. J Periodontol. https:\/\/doi.org\/10.1002\/JPER.17-0531","journal-title":"J Periodontol"},{"key":"5196_CR34","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/S0003-9969(97)00108-8","volume":"43","author":"M Redlich","year":"1998","unstructured":"Redlich M, Palmon A, Zaks B, Geremi E, Rayzman S, Shoshan S (1998) The effect of centrifugal force on the transcription levels of collagen type I and collagenase in cultured canine gingival fibroblasts. Arch Oral Biol 43:313\u2013316","journal-title":"Arch Oral Biol"},{"issue":"469","key":"5196_CR35","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.ajodo.2005.10.007","volume":"129","author":"V Krishnan","year":"2006","unstructured":"Krishnan V, Davidovitch Z (2006) Cellular, molecular, and tissue-level reactions to orthodontic force. Am J Orthod Dentofac Orthop: Off Publ Am Assoc Orthod, Constituent Soc, Am Board Orthod 129(469):e1-32. https:\/\/doi.org\/10.1016\/j.ajodo.2005.10.007","journal-title":"Am J Orthod Dentofac Orthop: Off Publ Am Assoc Orthod, Constituent Soc, Am Board Orthod"},{"key":"5196_CR36","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1080\/15384101.2018.1426415","volume":"17","author":"RM Babes","year":"2018","unstructured":"Babes RM, Tofolean IT, Sandu RG, Baran OE, Cosoreanu V, Ilie MT, Duta AI, Ceausescu MC, Ciucur PM, Costache S, Ganea C, Baran I (2018) Simple discrimination of sub-cycling cells by propidium iodide flow cytometric assay in Jurkat cell samples with extensive DNA fragmentation. Cell Cycle 17:766\u2013779. https:\/\/doi.org\/10.1080\/15384101.2018.1426415","journal-title":"Cell Cycle"},{"key":"5196_CR37","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1100\/2011\/761768","volume":"11","author":"SHZ Ariffin","year":"2011","unstructured":"Ariffin SHZ, Yamamoto Z, Abidin LZZ, Wahab RMA, Ariffin ZZ (2011) Cellular and molecular changes in orthodontic tooth movement. TheScientificWorldJournal 11:1788\u2013803. https:\/\/doi.org\/10.1100\/2011\/761768","journal-title":"TheScientificWorldJournal"},{"key":"5196_CR38","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1017\/erm.2013.8","volume":"15","author":"T Yucel-Lindberg","year":"2013","unstructured":"Yucel-Lindberg T, Bage T (2013) Inflammatory mediators in the pathogenesis of periodontitis. Expert Rev Mol Med 15:e7. https:\/\/doi.org\/10.1017\/erm.2013.8","journal-title":"Expert Rev Mol Med"},{"key":"5196_CR39","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1359\/jbmr.2002.17.2.210","volume":"17","author":"H Kanzaki","year":"2002","unstructured":"Kanzaki H, Chiba M, Shimizu Y, Mitani H (2002) Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activator of nuclear factor kappaB ligand up-regulation via prostaglandin E2 synthesis. J Bone Miner Res: Off J Am Soc Bone Miner Res 17:210\u2013220. https:\/\/doi.org\/10.1359\/jbmr.2002.17.2.210","journal-title":"J Bone Miner Res: Off J Am Soc Bone Miner Res"},{"key":"5196_CR40","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1601-6343.2009.01444.x","volume":"12","author":"M Yamaguchi","year":"2009","unstructured":"Yamaguchi M (2009) RANK\/RANKL\/OPG during orthodontic tooth movement. Orthod Craniofac Res 12:113\u2013119. https:\/\/doi.org\/10.1111\/j.1601-6343.2009.01444.x","journal-title":"Orthod Craniofac Res"},{"key":"5196_CR41","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1093\/intimm\/dxr077","volume":"23","author":"T Mori","year":"2011","unstructured":"Mori T, Miyamoto T, Yoshida H, Asakawa M, Kawasumi M, Kobayashi T, Morioka H, Chiba K, Toyama Y, Yoshimura A (2011) IL-1beta and TNFalpha-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis. Int Immunol 23:701\u2013712. https:\/\/doi.org\/10.1093\/intimm\/dxr077","journal-title":"Int Immunol"},{"key":"5196_CR42","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1006\/bbrc.2000.3379","volume":"275","author":"T Nakashima","year":"2000","unstructured":"Nakashima T, Kobayashi Y, Yamasaki S, Kawakami A, Eguchi K, Sasaki H, Sakai H (2000) Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotropic factors and cytokines. Biochem Biophys Res Commun 275:768\u2013775. https:\/\/doi.org\/10.1006\/bbrc.2000.3379","journal-title":"Biochem Biophys Res Commun"},{"key":"5196_CR43","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/j.1600-0757.2010.00347.x","volume":"53","author":"PM Bartold","year":"2000","unstructured":"Bartold PM (2000) Cantley MD and Haynes DR (2010) Mechanisms and control of pathologic bone loss in periodontitis. Periodontol 53:55\u201369. https:\/\/doi.org\/10.1111\/j.1600-0757.2010.00347.x","journal-title":"Periodontol"},{"key":"5196_CR44","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1111\/j.1365-2249.2005.02937.x","volume":"142","author":"D Hormdee","year":"2005","unstructured":"Hormdee D, Nagasawa T, Kiji M, Yashiro R, Kobayashi H, Koshy G, Noguchi K, Nitta H, Ishikawa I (2005) Protein kinase-A-dependent osteoprotegerin production on interleukin-1 stimulation in human gingival fibroblasts is distinct from periodontal ligament fibroblasts. Clin Exp Immunol 142:490\u2013497. https:\/\/doi.org\/10.1111\/j.1365-2249.2005.02937.x","journal-title":"Clin Exp Immunol"},{"key":"5196_CR45","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1902\/jop.1976.47.8.435","volume":"47","author":"JV Soames","year":"1976","unstructured":"Soames JV, Entwisle DN, Davies RM (1976) The progression of gingivitis to periodontitis in the beagle dog: a histological and morphometric investigation. J Periodontol 47:435\u2013439. https:\/\/doi.org\/10.1902\/jop.1976.47.8.435","journal-title":"J Periodontol"},{"key":"5196_CR46","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1902\/jop.2012.120510","volume":"84","author":"AV Boas Nogueira","year":"2013","unstructured":"Boas Nogueira AV, Chaves de Souza JA, Kim YJ, Damiao de Sousa-Neto M, Chan Cirelli C, Cirelli JA (2013) Orthodontic force increases interleukin-1beta and tumor necrosis factor-alpha expression and alveolar bone loss in periodontitis. J Periodontol 84:1319\u20131326. https:\/\/doi.org\/10.1902\/jop.2012.120510","journal-title":"J Periodontol"},{"key":"5196_CR47","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0022-3913(97)70234-8","volume":"77","author":"S Koka","year":"1997","unstructured":"Koka S, Reinhardt RA (1997) Periodontal pathogen-related stimulation indicates unique phenotype of primary cultured human fibroblasts from gingiva and periodontal ligament: implications for oral health disease. J Prosthet Dent 77:191\u2013196","journal-title":"J Prosthet Dent"},{"key":"5196_CR48","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1084\/jem.191.2.275","volume":"191","author":"K Kobayashi","year":"2000","unstructured":"Kobayashi K, Takahashi N, Jimi E, Udagawa N, Takami M, Kotake S, Nakagawa N, Kinosaki M, Yamaguchi K, Shima N, Yasuda H, Morinaga T, Higashio K, Martin TJ, Suda T (2000) Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF\/RANKL-RANK interaction. J Exp Med 191:275\u2013286. https:\/\/doi.org\/10.1084\/jem.191.2.275","journal-title":"J Exp Med"},{"key":"5196_CR49","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1172\/JCI15687","volume":"110","author":"MN Weitzmann","year":"2002","unstructured":"Weitzmann MN, Roggia C, Toraldo G, Weitzmann L, Pacifici R (2002) Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency. J Clin Invest 110:1643\u20131650. https:\/\/doi.org\/10.1172\/JCI15687","journal-title":"J Clin Invest"},{"key":"5196_CR50","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/16852","volume":"397","author":"YY Kong","year":"1999","unstructured":"Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM (1999) OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397:315\u2013323. https:\/\/doi.org\/10.1038\/16852","journal-title":"Nature"},{"key":"5196_CR51","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3389\/fendo.2015.00052","volume":"6","author":"GL Galea","year":"2015","unstructured":"Galea GL, Hannuna S, Meakin LB, Delisser PJ, Lanyon LE, Price JS (2015) Quantification of alterations in cortical bone geometry using site specificity software in mouse models of aging and the responses to ovariectomy and altered loading. Front Endocrinol (Lausanne) 6:52. https:\/\/doi.org\/10.3389\/fendo.2015.00052","journal-title":"Front Endocrinol (Lausanne)"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-023-05196-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-023-05196-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-023-05196-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T08:17:43Z","timestamp":1696666663000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-023-05196-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,29]]},"references-count":51,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["5196"],"URL":"https:\/\/doi.org\/10.1007\/s00784-023-05196-8","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,29]]},"assertion":[{"value":"28 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Experiments involving human tissues were conducted according to the approval of the Helsinki committee of the Hadassah\u2014Hebrew University Medical Center (approval number HMO-12\u2013144-08).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}