{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T13:18:06Z","timestamp":1774271886423,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"DOI":"10.1007\/s00784-023-05210-z","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T18:15:57Z","timestamp":1692728157000},"page":"5969-5975","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Analgesic effect of a lidocaine-ropivacaine mixture for extraction of impacted mandibular third molars: a randomized controlled trial"],"prefix":"10.1007","volume":"27","author":[{"given":"Tomoharu","family":"Hemmi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Sasahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyuki","family":"Yusa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehito","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuyoshi","family":"Iino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"key":"5210_CR1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/0266-4356(95)90083-7","volume":"33","author":"V Lopes","year":"1995","unstructured":"Lopes V, Mumenya R, Feinmann C, Harris M (1995) Third molar surgery: an audit of the indications for surgery, post-operative complaints and patient satisfaction. Br J Oral Maxillofac Surg 33:33\u201335. https:\/\/doi.org\/10.1016\/0266-4356(95)90083-7","journal-title":"Br J Oral Maxillofac Surg"},{"key":"5210_CR2","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/sj.bdj.4809930","volume":"194","author":"C McGrath","year":"2003","unstructured":"McGrath C, Comfort MB, Lo EC, Luo Y (2003) Changes in life quality following third molar surgery\u2014the immediate postoperative period. Br Dent J 194:265\u2013268. https:\/\/doi.org\/10.1038\/sj.bdj.4809930. (discussion 1)","journal-title":"Br Dent J"},{"key":"5210_CR3","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1016\/j.ijom.2020.04.016","volume":"49","author":"O Camps-Font","year":"2020","unstructured":"Camps-Font O, Figueiredo R, Sanchez-Torres A et al (2020) Which is the most suitable local anaesthetic when inferior nerve blocks are used for impacted mandibular third molar extraction? A network meta-analysis. Int J Oral Maxillofac Surg 49:1497\u20131507. https:\/\/doi.org\/10.1016\/j.ijom.2020.04.016","journal-title":"Int J Oral Maxillofac Surg"},{"key":"5210_CR4","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1053\/joms.2002.34409","volume":"60","author":"M Ernberg","year":"2002","unstructured":"Ernberg M, Kopp S (2002) Ropivacaine for dental anesthesia: a dose-finding study. J Oral Maxillofac Surg 60:1004\u20131010. https:\/\/doi.org\/10.1053\/joms.2002.34409. (discussion 10-11)","journal-title":"J Oral Maxillofac Surg"},{"key":"5210_CR5","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s10006-019-00779-w","volume":"23","author":"KV Reddy","year":"2019","unstructured":"Reddy KV, Jadhav A, Bhola N, Mishra A, Dakshinkar P (2019) Is 0.75% ropivacaine more efficacious than 2% lignocaine with 1:80,000 epinephrine for IANB in surgical extraction of impacted lower third molar? Oral Maxillofac Surg 23:225\u2013231. https:\/\/doi.org\/10.1007\/s10006-019-00779-w","journal-title":"Oral Maxillofac Surg"},{"key":"5210_CR6","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.bjoms.2015.02.021","volume":"53","author":"A Budharapu","year":"2015","unstructured":"Budharapu A, Sinha R, Uppada UK, Subramanya Kumar AV (2015) Ropivacaine: a new local anaesthetic agent in maxillofacial surgery. Br J Oral Maxillofac Surg 53:451\u2013454. https:\/\/doi.org\/10.1016\/j.bjoms.2015.02.021","journal-title":"Br J Oral Maxillofac Surg"},{"key":"5210_CR7","doi-asserted-by":"publisher","first-page":"3781","DOI":"10.1007\/s00784-020-03490-3","volume":"24","author":"F Yang","year":"2020","unstructured":"Yang F, Gao Y, Zhang L et al (2020) Local anaesthesia for surgical extraction of mandibular third molars: a systematic review and network meta-analysis. Clin Oral Investig 24:3781\u20133800. https:\/\/doi.org\/10.1007\/s00784-020-03490-3","journal-title":"Clin Oral Investig"},{"key":"5210_CR8","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1213\/ane.0b013e31819237f8","volume":"108","author":"P Cuvillon","year":"2009","unstructured":"Cuvillon P, Nouvellon E, Ripart J et al (2009) A comparison of the pharmacodynamics and pharmacokinetics of bupivacaine, ropivacaine (with epinephrine) and their equal volume mixtures with lidocaine used for femoral and sciatic nerve blocks: a double-blind randomized study. Anesth Analg 108:641\u2013649. https:\/\/doi.org\/10.1213\/ane.0b013e31819237f8","journal-title":"Anesth Analg"},{"key":"5210_CR9","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1213\/ANE.0b013e318265ba9a","volume":"112","author":"J Gadsden","year":"2011","unstructured":"Gadsden J, Hadzic A, Gandhi K et al (2011) The effect of mixing 1.5% mepivacaine and 0.5% bupivacaine on duration of analgesia and latency of block onset in ultrasound-guided interscalene block. Anesth Analg 112:471\u2013476. https:\/\/doi.org\/10.1213\/ANE.0b013e318265ba9a","journal-title":"Anesth Analg"},{"key":"5210_CR10","unstructured":"World Medical Association (2013) WMA Declaretion of Helsinki: ethical principles for medical research involving human subjects. Adopted by the 18th\u00a0WMA General Assembly, Helsinki, Finland, June 1964, and amended by the: 29th\u00a0WMA General Assembly, Tokyo, Japan, October 1975 35th\u00a0WMA General Assembly, Venice, Italy, October 1983 41st\u00a0WMA General Assembly, Hong Kong, September 1989 48th\u00a0WMA General Assembly, Somerset West, Republic of South Africa, October 1996 52nd\u00a0WMA General Assembly, Edinburgh, Scotland, October 2000 53th\u00a0WMA General Assembly, Washington 2002 (Note of Clarification on paragraph 29 added) 55th\u00a0WMA General Assembly, Tokyo 2004 (Note of Clarification on Paragraph 30 added) 59th\u00a0WMA General Assembly, Seoul, October 2008 64th\u00a0WMA General Assembly, Fortaleza, Brazil, October 2013. Accessed 18 Jun 2023."},{"key":"5210_CR11","first-page":"125","volume":"47","author":"Y Takasugi","year":"2000","unstructured":"Takasugi Y, Furuya H, Moriya K, Okamoto Y (2000) Clinical evaluation of inferior alveolar nerve block by injection into the pterygomandibular space anterior to the mandibular foramen. Anesth Prog 47:125\u2013129","journal-title":"Anesth Prog"},{"key":"5210_CR12","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.oooo.2020.09.010","volume":"131","author":"KS Amorim","year":"2021","unstructured":"Amorim KS, Gercina AC, Ramiro FMS et al (2021) Can local anesthesia with ropivacaine provide postoperative analgesia in extraction of impacted mandibular third molars? A randomized clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol 131:512\u2013518. https:\/\/doi.org\/10.1016\/j.oooo.2020.09.010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"5210_CR13","doi-asserted-by":"publisher","first-page":"S132","DOI":"10.1016\/j.oooo.2011.09.021","volume":"114","author":"S Ozer","year":"2012","unstructured":"Ozer S, Yaltirik M, Kirli I, Yargic I (2012) A comparative evaluation of pain and anxiety levels in 2 different anesthesia techniques: locoregional anesthesia using conventional syringe versus intraosseous anesthesia using a computer-controlled system (Quicksleeper). Oral Surg Oral Med Oral Pathol Oral Radiol 114:S132\u2013S139. https:\/\/doi.org\/10.1016\/j.oooo.2011.09.021","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"5210_CR14","doi-asserted-by":"publisher","first-page":"356","DOI":"10.4103\/0259-1162.171445","volume":"10","author":"NK Jain","year":"2016","unstructured":"Jain NK, John RR (2016) Anesthetic efficacy of 4% articaine versus 2% lignocaine during the surgical removal of the third molar: a comparative prospective study. Anesth Essays Res 10:356\u2013361. https:\/\/doi.org\/10.4103\/0259-1162.171445","journal-title":"Anesth Essays Res"},{"key":"5210_CR15","doi-asserted-by":"publisher","first-page":"S600","DOI":"10.4103\/0975-7406.163564","volume":"7","author":"S Barath","year":"2015","unstructured":"Barath S, Triveni VS, Sai Sujai GV, Harikishan G (2015) Efficacy of 2% mepivacaine and 2% lignocaine in the surgical extraction of mesioangular angulated bilaterally impacted third molars: a double-blind, randomized, clinical trial. J Pharm Bioallied Sci 7:S600\u2013S606. https:\/\/doi.org\/10.4103\/0975-7406.163564","journal-title":"J Pharm Bioallied Sci"},{"key":"5210_CR16","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1007\/s00784-016-1831-2","volume":"21","author":"B Brkovic","year":"2017","unstructured":"Brkovic B, Andric M, Calasan D et al (2017) Efficacy and safety of 1% ropivacaine for postoperative analgesia after lower third molar surgery: a prospective, randomized, double-blinded clinical study. Clin Oral Investig 21:779\u2013785. https:\/\/doi.org\/10.1007\/s00784-016-1831-2","journal-title":"Clin Oral Investig"},{"key":"5210_CR17","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/s0300-9785(86)80131-4","volume":"15","author":"K Danielsson","year":"1986","unstructured":"Danielsson K, Evers H, Holmlund A, Kjellman O, Nordenram A, Persson NE (1986) Long-acting local anaesthetics in oral surgery. Clinical evaluation of bupivacaine and etidocaine for mandibular nerve block. Int J Oral Maxillofac Surg 15:119\u2013126. https:\/\/doi.org\/10.1016\/s0300-9785(86)80131-4","journal-title":"Int J Oral Maxillofac Surg"},{"key":"5210_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/ANA.0000000000000149","volume":"28","author":"T Chaki","year":"2016","unstructured":"Chaki T, Sugino S, Janicki PK et al (2016) Efficacy and safety of a lidocaine and ropivacaine mixture for scalp nerve block and local infiltration anesthesia in patients undergoing awake craniotomy. J Neurosurg Anesthesiol 28:1\u20135. https:\/\/doi.org\/10.1097\/ANA.0000000000000149","journal-title":"J Neurosurg Anesthesiol"},{"key":"5210_CR19","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1080\/2000656X.2020.1720999","volume":"54","author":"P Bobik","year":"2020","unstructured":"Bobik P, Kosel J, \u015awirydo P, Ta\u0142a\u0142aj M, Czaban I, Radziwon W (2020) Comparison of the pharmacological properties of 0.375% bupivacaine with epinephrine, 0.5% ropivacaine and a mixture of bupivacaine with epinephrine and lignocaine\u2014a randomized prospective study. J Plast Surg Hand Surg 54:156\u2013160. https:\/\/doi.org\/10.1080\/2000656X.2020.1720999","journal-title":"J Plast Surg Hand Surg"},{"key":"5210_CR20","doi-asserted-by":"publisher","first-page":"498","DOI":"10.4103\/joacp.JOACP_341_18","volume":"35","author":"VR Moolagani","year":"2019","unstructured":"Moolagani VR, Burla SR, Neethipudi BR, Upadhyayula SM, Bikkina A, Arepalli NR (2019) Ropivacaine plus lidocaine versus bupivacaine plus lidocaine for peribulbar block in cataract surgery: a prospective, randomized, double-blind, single-center, comparative clinical study. J Anaesthesiol Clin Pharmacol 35:498\u2013503. https:\/\/doi.org\/10.4103\/joacp.JOACP_341_18","journal-title":"J Anaesthesiol Clin Pharmacol"},{"key":"5210_CR21","first-page":"59","volume":"71","author":"HA McLure","year":"2005","unstructured":"McLure HA, Rubin AP (2005) Review of local anaesthetic agents. Minerva Anestesiol 71:59\u201374","journal-title":"Minerva Anestesiol"},{"key":"5210_CR22","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1016\/j.joms.2019.04.021","volume":"77","author":"S Tsukimoto","year":"2019","unstructured":"Tsukimoto S, Takasugi Y, Aoki R, Kimura M, Konishi T (2019) Inferior alveolar nerve block using the anterior technique to anesthetize buccal nerve and improve anesthesia success rates for third molar extraction: a randomized controlled trial and magnetic resonance imaging evaluation. J Oral Maxillofac Surg 77:2004\u20132016. https:\/\/doi.org\/10.1016\/j.joms.2019.04.021","journal-title":"J Oral Maxillofac Surg"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-023-05210-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-023-05210-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-023-05210-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T08:13:51Z","timestamp":1696666431000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-023-05210-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,22]]},"references-count":22,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["5210"],"URL":"https:\/\/doi.org\/10.1007\/s00784-023-05210-z","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,22]]},"assertion":[{"value":"23 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The medical ethics committee of Okitama Public General Hospital approved this clinical study (approval no. 234\u20131), which was registered with the University Hospital Medical Information Network (No. UMIN000044315) on June 1, 2021. The study was carried out at the outpatient department of Oral and Maxillofacial Surgery of Okitama Public General Hospital.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}