{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:02:34Z","timestamp":1789624954462,"version":"build-2803163510"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100018936","name":"Universit\u00e4tsklinikum Heidelberg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018936","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>To investigate oral health and oral health-related quality of life (OHRQoL) of patients under antiresorptive therapy (ART) during supportive periodontal care (SPC) considering history of medication-related osteonecrosis of the jaw (MRONJ).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>In this cross-sectional study, 100 patients (50 receiving ART (exposed) and 50 without ART (unexposed)) in regular SPC were enrolled for a clinical oral examination and the evaluation of OHRQoL using the OHIP-G14-questionnaire. History of MRONJ was assessed by anamnesis and reviewing patient records.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>There were no statistically significant group differences in age (exposed: 70.00\u2009\u00b1\u20099.07 versus unexposed: 71.02\u2009\u00b1\u20098.22\u00a0years), sex, distribution of systemic diseases and duration of SPC (on average 8.61\u2009\u00b1\u20095.73\u00a0years). Number of teeth (21.02\u2009\u00b1\u20095.84 versus 21.40\u2009\u00b1\u20095.42), DMFT (18.38\u2009\u00b1\u20093.85 versus 17.96\u2009\u00b1\u20094.08), probing pocket depth (2.31\u2009\u00b1\u20090.20 versus 2.38\u2009\u00b1\u20090.26), clinical attachment level (3.25\u2009\u00b1\u20090.76 versus 3.46\u2009\u00b1\u20090.58) and bleeding on probing (15.07\u2009\u00b1\u200911.53 versus 15.77\u2009\u00b1\u200913.08) were also not significantly different. The OHIP-G14 sum-score was significantly higher in exposed participants (6.10\u2009\u00b1\u20096.76 versus 3.62\u2009\u00b1\u20095.22, <jats:italic>p<\/jats:italic>\u2009=\u20090.043). History of MRONJ was prevalent in 8% of patients under ART. Periodontal\/peri-implant-related MRONJ were reported in three participants with cancer (n\u2009=\u20091 before and n\u2009=\u20092 after active periodontal therapy). History of MRONJ due to endodontic\/restorative reasons was reported in one patient with osteoporosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Patients under ART in SPC demonstrated similar clinical periodontal and dental status but lower OHRQoL compared to unexposed (not statistically significant). Patient awareness of the MRONJ-risk and appropriate preventive measures should be ensured.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>SPC in osteoporotic patients under ART appeared safe regarding MRONJ, but further investigations on the MRONJ-risk in patients with different risk-profiles are necessary.<\/jats:p>\n                <jats:p><jats:bold>Study registration<\/jats:bold>: clinicaltrials.gov (#NCT04192188).<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-023-05257-y","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T05:02:11Z","timestamp":1694754131000},"page":"6523-6536","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Oral health conditions in patients under antiresorptive therapy are comparable to unexposed during supportive periodontal care"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2181-3505","authenticated-orcid":false,"given":"Antonio","family":"Ciardo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlinde M.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinclair","family":"Awounvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ti-Sun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,15]]},"reference":[{"key":"5257_CR1","doi-asserted-by":"publisher","first-page":"Cd003188","DOI":"10.1002\/14651858.CD003188.pub4","volume":"12","author":"R Mhaskar","year":"2017","unstructured":"Mhaskar R, Kumar A, Miladinovic B, Djulbegovic B (2017) Bisphosphonates in multiple myeloma: an updated network meta-analysis. Cochrane Database Syst Rev 12:Cd003188. https:\/\/doi.org\/10.1002\/14651858.CD003188.pub4","journal-title":"Cochrane Database Syst Rev"},{"key":"5257_CR2","doi-asserted-by":"publisher","first-page":"3289","DOI":"10.1007\/s00198-016-3654-z","volume":"27","author":"J Zhou","year":"2016","unstructured":"Zhou J, Ma X, Wang T, Zhai S (2016) Comparative efficacy of bisphosphonates in short-term fracture prevention for primary osteoporosis: a systematic review with network meta-analyses. Osteoporos Int 27:3289\u20133300. https:\/\/doi.org\/10.1007\/s00198-016-3654-z","journal-title":"Osteoporos Int"},{"key":"5257_CR3","doi-asserted-by":"publisher","first-page":"Cd003474","DOI":"10.1002\/14651858.CD003474.pub4","volume":"10","author":"B O'Carrigan","year":"2017","unstructured":"O\u2019Carrigan B, Wong MH, Willson ML, Stockler MR, Pavlakis N, Goodwin A (2017) Bisphosphonates and other bone agents for breast cancer. Cochrane Database Syst Rev 10:Cd003474. https:\/\/doi.org\/10.1002\/14651858.CD003474.pub4","journal-title":"Cochrane Database Syst Rev"},{"key":"5257_CR4","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1200\/jco.2001.19.2.558","volume":"19","author":"P Major","year":"2001","unstructured":"Major P, Lortholary A, Hon J, Abdi E, Mills G, Menssen HD, Yunus F, Bell R, Body J, Quebe-Fehling E, Seaman J (2001) Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: a pooled analysis of two randomized, controlled clinical trials. J Clin Oncol 19:558\u2013567. https:\/\/doi.org\/10.1200\/jco.2001.19.2.558","journal-title":"J Clin Oncol"},{"key":"5257_CR5","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.bone.2010.11.020","volume":"48","author":"R Baron","year":"2011","unstructured":"Baron R, Ferrari S, Russell RG (2011) Denosumab and bisphosphonates: different mechanisms of action and effects. Bone 48:677\u2013692. https:\/\/doi.org\/10.1016\/j.bone.2010.11.020","journal-title":"Bone"},{"key":"5257_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-021-04261-4","author":"A Wick","year":"2021","unstructured":"Wick A, Bankosegger P, Otto S, Hohlweg-Majert B, Steiner T, Probst F, Ristow O, Pautke C (2021) Risk factors associated with onset of medication-related osteonecrosis of the jaw in patients treated with denosumab. Clin Oral Investig. https:\/\/doi.org\/10.1007\/s00784-021-04261-4","journal-title":"Clin Oral Investig"},{"key":"5257_CR7","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.oooo.2014.05.006","volume":"118","author":"F Hallmer","year":"2014","unstructured":"Hallmer F, Bj\u00f8rnland T, Nicklasson A, Becktor JP, Andersson G (2014) Osteonecrosis of the jaw in patients treated with oral and intravenous bisphosphonates: experience in Sweden. Oral Surg Oral Med Oral Pathol Oral Radiol 118:202\u2013208. https:\/\/doi.org\/10.1016\/j.oooo.2014.05.006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"5257_CR8","doi-asserted-by":"publisher","first-page":"116184","DOI":"10.1016\/j.bone.2021.116184","volume":"153","author":"JI Aguirre","year":"2021","unstructured":"Aguirre JI, Castillo EJ, Kimmel DB (2021) Preclinical models of medication-related osteonecrosis of the jaw (MRONJ). Bone 153:116184. https:\/\/doi.org\/10.1016\/j.bone.2021.116184","journal-title":"Bone"},{"key":"5257_CR9","unstructured":"Schiegnitz E, Al-Nawas B, Hoefert S, Otto S, Pautke C, Ristow O, Voss P and Gr\u00f6tz KA (2018) S3-guideline antiresorptive-associated necrosis of the jaw (AR-ONJ) (S3-Leitlinie Antiresorptiva-assoziierte Kiefernekrosen (AR-ONJ)) AWMF-Register-No. 007\u2013091"},{"key":"5257_CR10","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1634\/theoncologist.2010-0183","volume":"16","author":"RA Miksad","year":"2011","unstructured":"Miksad RA, Lai KC, Dodson TB, Woo SB, Treister NS, Akinyemi O, Bihrle M, Maytal G, August M, Gazelle GS, Swan JS (2011) Quality of life implications of bisphosphonate-associated osteonecrosis of the jaw. Oncologist 16:121\u2013132. https:\/\/doi.org\/10.1634\/theoncologist.2010-0183","journal-title":"Oncologist"},{"key":"5257_CR11","doi-asserted-by":"publisher","first-page":"e024376","DOI":"10.1136\/bmjopen-2018-024376","volume":"9","author":"A Sturrock","year":"2019","unstructured":"Sturrock A, Preshaw PM, Hayes C, Wilkes S (2019) Perceptions and attitudes of patients towards medication-related osteonecrosis of the jaw (MRONJ): a qualitative study in England. BMJ Open 9:e024376. https:\/\/doi.org\/10.1136\/bmjopen-2018-024376","journal-title":"BMJ Open"},{"key":"5257_CR12","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1111\/odi.12708","volume":"24","author":"K McGowan","year":"2018","unstructured":"McGowan K, McGowan T, Ivanovski S (2018) Risk factors for medication-related osteonecrosis of the jaws: A systematic review. Oral Dis 24:527\u2013536. https:\/\/doi.org\/10.1111\/odi.12708","journal-title":"Oral Dis"},{"key":"5257_CR13","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.oooo.2016.11.011","volume":"123","author":"F Hallmer","year":"2017","unstructured":"Hallmer F, Bj\u00f8rnland T, Andersson G, Becktor JP, Kristoffersen AK, Enersen M (2017) Bacterial diversity in medication-related osteonecrosis of the jaw. Oral Surg Oral Med Oral Pathol Oral Radiol 123:436\u2013444. https:\/\/doi.org\/10.1016\/j.oooo.2016.11.011","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"5257_CR14","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1080\/10428190802483778","volume":"49","author":"V Montefusco","year":"2008","unstructured":"Montefusco V, Gay F, Spina F, Miceli R, Maniezzo M, Teresa Ambrosini M, Farina L, Piva S, Palumbo A, Boccadoro M, Corradini P (2008) Antibiotic prophylaxis before dental procedures may reduce the incidence of osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates. Leuk Lymphoma 49:2156\u20132162. https:\/\/doi.org\/10.1080\/10428190802483778","journal-title":"Leuk Lymphoma"},{"key":"5257_CR15","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/j.joms.2013.01.006","volume":"71","author":"M Scoletta","year":"2013","unstructured":"Scoletta M, Arata V, Arduino PG, Lerda E, Chiecchio A, Gallesio G, Scully C, Mozzati M (2013) Tooth extractions in intravenous bisphosphonate-treated patients: a refined protocol. J Oral Maxillofac Surg 71:994\u2013999. https:\/\/doi.org\/10.1016\/j.joms.2013.01.006","journal-title":"J Oral Maxillofac Surg"},{"key":"5257_CR16","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1111\/jcpe.12882","volume":"45","author":"M Diniz-Freitas","year":"2018","unstructured":"Diniz-Freitas M, Fern\u00e1ndez-Feijoo J, Diz Dios P, Pousa X, Limeres J (2018) Denosumab-related osteonecrosis of the jaw following non-surgical periodontal therapy: A case report. J Clin Periodontol 45:570\u2013577. https:\/\/doi.org\/10.1111\/jcpe.12882","journal-title":"J Clin Periodontol"},{"key":"5257_CR17","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/s0140-6736(07)61602-x","volume":"370","author":"E von Elm","year":"2007","unstructured":"von Elm E, Altman DG, Egger M, Pocock SJ, G\u00f8tzsche PC, Vandenbroucke JP (2007) The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet (London, England) 370:1453\u20131457. https:\/\/doi.org\/10.1016\/s0140-6736(07)61602-x","journal-title":"Lancet (London, England)"},{"issue":"Suppl 1","key":"5257_CR18","doi-asserted-by":"publisher","first-page":"S173","DOI":"10.1002\/jper.17-0721","volume":"89","author":"PN Papapanou","year":"2018","unstructured":"Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, Flemmig TF, Garcia R, Giannobile WV, Graziani F, Greenwell H, Herrera D, Kao RT, Kebschull M, Kinane DF, Kirkwood KL, Kocher T, Kornman KS, Kumar PS, Loos BG, Machtei E, Meng H, Mombelli A, Needleman I, Offenbacher S, Seymour GJ, Teles R, Tonetti MS (2018) Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol 89(Suppl 1):S173-s182. https:\/\/doi.org\/10.1002\/jper.17-0721","journal-title":"J Periodontol"},{"key":"5257_CR19","unstructured":"Ramseier CA and Lang NP (1999) Periodontal care. A learning program for quality assurance in periodontology (Die Parodontalbetreuung. Ein Lernprogramm zur Qualit\u00e4tssicherung in der Parodontologie) (CD-ROM). Quintessenz Verlag,\u00a0Berlin, Germany"},{"key":"5257_CR20","first-page":"229","volume":"25","author":"J Ainamo","year":"1975","unstructured":"Ainamo J, Bay I (1975) Problems and proposals for recording gingivitis and plaque. Int Dent J 25:229\u2013235","journal-title":"Int Dent J"},{"key":"5257_CR21","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1902\/jop.1972.43.1.38","volume":"43","author":"TJ O'Leary","year":"1972","unstructured":"O\u2019Leary TJ, Drake RB, Naylor JE (1972) The plaque control record. J Periodontol 43:38. https:\/\/doi.org\/10.1902\/jop.1972.43.1.38","journal-title":"J Periodontol"},{"key":"5257_CR22","first-page":"11","volume":"10","author":"J Lindhe","year":"1977","unstructured":"Lindhe J, Nyman S (1977) The role of occlusion in periodontal disease and the biological rationale for splinting in treatment of periodontitis. Oral Sci Rev 10:11\u201343","journal-title":"Oral Sci Rev"},{"key":"5257_CR23","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/j.1600-051x.1975.tb01734.x","volume":"2","author":"SE Hamp","year":"1975","unstructured":"Hamp SE, Nyman S, Lindhe J (1975) Periodontal treatment of multirooted teeth. Results after 5 years. J Clin Periodontol 2:126\u2013135. https:\/\/doi.org\/10.1111\/j.1600-051x.1975.tb01734.x","journal-title":"J Clin Periodontol"},{"key":"5257_CR24","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.joms.2022.02.008","volume":"80","author":"SL Ruggiero","year":"2022","unstructured":"Ruggiero SL, Dodson TB, Aghaloo T, Carlson ER, Ward BB, Kademani D (2022) American association of oral and maxillofacial surgeons\u2019 position paper on medication-related osteonecrosis of the jaws-2022 update. J Oral Maxillofac Surg 80:920\u2013943. https:\/\/doi.org\/10.1016\/j.joms.2022.02.008","journal-title":"J Oral Maxillofac Surg"},{"key":"5257_CR25","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/j.1600-0528.2006.00279.x","volume":"34","author":"MT John","year":"2006","unstructured":"John MT, Miglioretti DL, LeResche L, Koepsell TD, Hujoel P, Micheelis W (2006) German short forms of the oral health impact profile. Commun Dent Oral Epidemiol 34:277\u2013288. https:\/\/doi.org\/10.1111\/j.1600-0528.2006.00279.x","journal-title":"Commun Dent Oral Epidemiol"},{"key":"5257_CR26","doi-asserted-by":"publisher","first-page":"535","DOI":"10.3290\/j.jad.a37360","volume":"18","author":"D Wolff","year":"2016","unstructured":"Wolff D, Coupek M, Erber R, Krueger T, Krisam J, Staehle HJ, Frese C (2016) Effect of aqueous storage on original and repair bond strength and residual monomer release of fiberreinforced composites. J Adhes Dent 18:535\u2013543. https:\/\/doi.org\/10.3290\/j.jad.a37360","journal-title":"J Adhes Dent"},{"key":"5257_CR27","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1111\/j.1600-051X.2008.01245.x","volume":"35","author":"G Matuliene","year":"2008","unstructured":"Matuliene G, Pjetursson BE, Salvi GE, Schmidlin K, Br\u00e4gger U, Zwahlen M, Lang NP (2008) Influence of residual pockets on progression of periodontitis and tooth loss: results after 11 years of maintenance. J Clin Periodontol 35:685\u2013695. https:\/\/doi.org\/10.1111\/j.1600-051X.2008.01245.x","journal-title":"J Clin Periodontol"},{"issue":"Suppl 22","key":"5257_CR28","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/jcpe.13240","volume":"47","author":"CA Ramseier","year":"2020","unstructured":"Ramseier CA, Woelber JP, Kitzmann J, Detzen L, Carra MC, Bouchard P (2020) Impact of risk factor control interventions for smoking cessation and promotion of healthy lifestyles in patients with periodontitis: A systematic review. J Clin Periodontol 47(Suppl 22):90\u2013106. https:\/\/doi.org\/10.1111\/jcpe.13240","journal-title":"J Clin Periodontol"},{"key":"5257_CR29","unstructured":"Jordan AR and Micheelis W (2016) Fifth German Oral Health Study (F\u00fcnfte Deutsche Mundgesundheitsstudie (DMS IV)). Deutscher Zahn\u00e4rzte Verlag D\u00c4V K\u00f6ln"},{"key":"5257_CR30","doi-asserted-by":"publisher","unstructured":"Campos LA, Peltom\u00e4ki T, Mar\u00f4co J and Campos J (2021) Use of oral health impact profile-14 (OHIP-14) in different contexts. What is being measured? Int J Environ Res Public Health 18. https:\/\/doi.org\/10.3390\/ijerph182413412","DOI":"10.3390\/ijerph182413412"},{"key":"5257_CR31","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1080\/00016357.2018.1483528","volume":"76","author":"SK Sonnenschein","year":"2018","unstructured":"Sonnenschein SK, Betzler C, Kohnen R, Krisam J, Kim TS (2018) Oral health-related quality of life in patients under supportive periodontal therapy. Acta Odontol Scand 76:572\u2013579. https:\/\/doi.org\/10.1080\/00016357.2018.1483528","journal-title":"Acta Odontol Scand"},{"key":"5257_CR32","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1111\/jcpe.13324","volume":"47","author":"C Graetz","year":"2020","unstructured":"Graetz C, Schwalbach M, Seidel M, Geiken A, Schwendicke F (2020) Oral health-related quality of life impacts are low 27 years after periodontal therapy. J Clin Periodontol 47:952\u2013961. https:\/\/doi.org\/10.1111\/jcpe.13324","journal-title":"J Clin Periodontol"},{"key":"5257_CR33","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1177\/0022034514552491","volume":"93","author":"NJ Kassebaum","year":"2014","unstructured":"Kassebaum NJ, Bernab\u00e9 E, Dahiya M, Bhandari B, Murray CJ, Marcenes W (2014) Global burden of severe periodontitis in 1990\u20132010: a systematic review and meta-regression. J Dent Res 93:1045\u20131053. https:\/\/doi.org\/10.1177\/0022034514552491","journal-title":"J Dent Res"},{"key":"5257_CR34","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1111\/odi.13160","volume":"25","author":"M Schiodt","year":"2019","unstructured":"Schiodt M, Otto S, Fedele S, Bedogni A, Nicolatou-Galitis O, Guggenberger R, Herlofson BB, Ristow O, Kofod T (2019) Workshop of European task force on medication-related osteonecrosis of the jaw-current challenges. Oral Dis 25:1815\u20131821. https:\/\/doi.org\/10.1111\/odi.13160","journal-title":"Oral Dis"},{"key":"5257_CR35","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/jop.12963","volume":"49","author":"AI Lorenzo-Pouso","year":"2020","unstructured":"Lorenzo-Pouso AI, P\u00e9rez-Say\u00e1ns M, Chamorro-Petronacci C, G\u00e1ndara-Vila P, L\u00f3pez-Jornet P, Carballo J, Garc\u00eda-Garc\u00eda A (2020) Association between periodontitis and medication-related osteonecrosis of the jaw: A systematic review and meta-analysis. J Oral Pathol Med 49:190\u2013200. https:\/\/doi.org\/10.1111\/jop.12963","journal-title":"J Oral Pathol Med"},{"key":"5257_CR36","doi-asserted-by":"publisher","first-page":"217","DOI":"10.2334\/josnusd.21-0016","volume":"63","author":"M Cabras","year":"2021","unstructured":"Cabras M, Gambino A, Broccoletti R, Sciascia S, Arduino PG (2021) Lack of evidence in reducing risk of MRONJ after teeth extractions with systemic antibiotics. J Oral Sci 63:217\u2013226. https:\/\/doi.org\/10.2334\/josnusd.21-0016","journal-title":"J Oral Sci"},{"key":"5257_CR37","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.joms.2009.03.050","volume":"68","author":"JC Lo","year":"2010","unstructured":"Lo JC, O\u2019Ryan FS, Gordon NP, Yang J, Hui RL, Martin D, Hutchinson M, Lathon PV, Sanchez G, Silver P, Chandra M, McCloskey CA, Staffa JA, Willy M, Selby JV, Go AS (2010) Prevalence of osteonecrosis of the jaw in patients with oral bisphosphonate exposure. J Oral Maxillofac Surg 68:243\u2013253. https:\/\/doi.org\/10.1016\/j.joms.2009.03.050","journal-title":"J Oral Maxillofac Surg"},{"key":"5257_CR38","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1746-160x-6-11","volume":"6","author":"C Walter","year":"2010","unstructured":"Walter C, Al-Nawas B, Frickhofen N, Gamm H, Beck J, Reinsch L, Blum C, Gr\u00f6tz KA, Wagner W (2010) Prevalence of bisphosphonate associated osteonecrosis of the jaws in multiple myeloma patients. Head Face Med 6:11. https:\/\/doi.org\/10.1186\/1746-160x-6-11","journal-title":"Head Face Med"},{"key":"5257_CR39","doi-asserted-by":"publisher","first-page":"5356","DOI":"10.1200\/jco.2009.21.9584","volume":"27","author":"K Vahtsevanos","year":"2009","unstructured":"Vahtsevanos K, Kyrgidis A, Verrou E, Katodritou E, Triaridis S, Andreadis CG, Boukovinas I, Koloutsos GE, Teleioudis Z, Kitikidou K, Paraskevopoulos P, Zervas K, Antoniades K (2009) Longitudinal cohort study of risk factors in cancer patients of bisphosphonate-related osteonecrosis of the jaw. J Clin Oncol 27:5356\u20135362. https:\/\/doi.org\/10.1200\/jco.2009.21.9584","journal-title":"J Clin Oncol"},{"key":"5257_CR40","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1007\/s12032-009-9195-y","volume":"27","author":"M Bonomi","year":"2010","unstructured":"Bonomi M, Nortilli R, Molino A, Sava T, Santo A, Caldara A, Cetto GL (2010) Renal toxicity and osteonecrosis of the jaw in cancer patients treated with bisphosphonates: a long-term retrospective analysis. Med Oncol 27:224\u2013229. https:\/\/doi.org\/10.1007\/s12032-009-9195-y","journal-title":"Med Oncol"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-023-05257-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-023-05257-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-023-05257-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T10:04:53Z","timestamp":1699351493000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-023-05257-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,15]]},"references-count":40,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["5257"],"URL":"https:\/\/doi.org\/10.1007\/s00784-023-05257-y","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,15]]},"assertion":[{"value":"14 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the ethics committee of the Medical Faculty of Heidelberg (# S-630\/2019) and is in accordance with the ethical standards of the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent to participate in the study and to publish was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}