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The primary outcome variable was reduction of probing depth (PD), while changes in clinical attachment level (CAL), bleeding on probing (BOP) and plaque index (PI) were secondary outcomes. The outcomes were assessed at baseline, at 3 and 6\u00a0months following therapy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>All patients completed the 6\u00a0months evaluation. At 6\u00a0months, the test group showed statistically significantly better results in terms of mean PD reduction (2.9\u2009\u00b1\u20090.4 vs 1.8\u2009\u00b1\u20090.6\u00a0mm, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Similarly, mean CAL gain was statistically higher in the test group compared to the control one (test: 2.6\u2009\u00b1\u20090.5 vs control: 1.6\u2009\u00b1\u20090.6\u00a0mm, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Mean BOP decreased from 81.8\u2009\u00b1\u200916.2% to 48.9\u2009\u00b1\u200914.5% in control (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and from 83.2\u2009\u00b1\u200915.5% to 17.6\u2009\u00b1\u200911.5% in test (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) groups with a statistically significant difference favouring the test group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Mean PI scores were reduced statistically significantly in both groups (from 38.8\u2009\u00b1\u200926% to 26.5\u2009\u00b1\u200920.5% in control (p\u2009=\u20090.039) and from 60.6\u2009\u00b1\u200910.9% to 12.7\u2009\u00b1\u20098.9% in test group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001)), with a statistically significant difference between the groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The number of moderate pockets (4\u20136\u00a0mm) were reduced from 1518 (41.2%) to 803 (22.6%) in the control and from 1803 (48.6%) to 234 (7.7%) in the test group with a statistically significant difference between the groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), while the number of deep pockets (\u2265\u20097\u00a0mm) changed from 277 (7.6%) to 35 (1.0%) in the control and from 298 (8.7%) to 4 (0.1%) in test group (<jats:italic>p<\/jats:italic>\u2009=\u20090.003).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Within their limits the present data indicate that: a) both treatments resulted in statistically significant improvements in all evaluated clinical parameters, and b) the adjunctive subgingival application of sodium hypochlorite\/amino acid and xHyA to SRP yielded statistically significantly higher improvements compared to SRP alone.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>The combination of sodium hypochlorite\/amino acid and xHyA gels to subgingival mechanical debridement appears to represent a valuable approach to additionally improve the outcomes of non-surgical periodontal treatment.<\/jats:p>\n                <jats:p>Clinical Trial Registration Number NCT04662216 (ClinicalTrials.gov).<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-023-05271-0","type":"journal-article","created":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T01:02:18Z","timestamp":1695430938000},"page":"6645-6656","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Clinical evaluation of sodium hypochlorite\/amino acids and cross-linked hyaluronic acid adjunctive to non-surgical periodontal treatment: a randomized controlled clinical trial"],"prefix":"10.1007","volume":"27","author":[{"given":"Egle","family":"Ramanauskaite","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vita","family":"Machiulskiene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Shirakata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urte Marija","family":"Dvyliene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Nedzelskiene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,23]]},"reference":[{"key":"5271_CR1","doi-asserted-by":"publisher","unstructured":"Belibasakis GN, Belstr\u00f8m D, Eick S, Gursoy UK, Johansson A, K\u00f6n\u00f6nen E (2023) Periodontal microbiology and microbial etiology of periodontal diseases: historical concepts and contemporary perspectives. 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