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Ligature-induced peri-implantitis lesions were established at 2 maxillary implants over 16 weeks. Afterward, animals were randomly treated either with open flap debridement (OFD) or reconstructive therapy (RT). Treatment procedures were followed by a 12-week healing period. The histological outcomes included residual defect length (DL); defect width (DW) at the bone crest (BC-DW); 25%, 50%, and 75% of the DL; and areas of inflammatory cell infiltrate (ICT). When present, areas of bone sequester (BS) were assessed considering the animal as a statistical unit.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 21 animals were analyzed (Zo: RT = 3, OFD = 1; De: RT = 3, OFD = 2; Be: OFD = 1; Zo + Be: RT = 2, OFD = 2; Co: RT = 3, OFD = 2). Implant loss rates were comparable among the experimental groups. Except for the 25% and 75% DW values that were significantly higher in the Zo + Be group compared to the Co group (<jats:italic>p<\/jats:italic> = 0.04 and <jats:italic>p<\/jats:italic> = 0.03, respectively), no significant differences were found among the experimental groups for the DL (lowest\u2014Be: 0.56 mm; highest\u2014Co: 1.05 mm), BC-DW (lowest\u2014De: 0.86 mm, highest\u2014Co: 1.07 mm), 50% DW (lowest\u2014De: 0.86 mm; highest\u2014Be + Zo: 1.29 mm), and ICT (lowest\u2014Be: 0.56 mm<jats:sup>2<\/jats:sup>; highest\u2014Be + Zo: 1.65 mm<jats:sup>2<\/jats:sup>). All groups, except for the Zo and Be following RT, showed presence of BS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The present findings did not reveal a marked effect of various antiresorptive\/antiangiogenic medications on the resolution of experimentally induced peri-implantitis lesions, regardless of the surgical approach employed (OFD and RT).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>Resolution of peri-implantitis lesions may not be affected by the investigated antiresorptive\/antiangiogenic medications.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-023-05275-w","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T18:01:38Z","timestamp":1696269698000},"page":"6657-6666","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Influence of antiresorptive\/antiangiogenic therapy on the surgical treatment outcomes of experimentally induced peri-implantitis lesions"],"prefix":"10.1007","volume":"27","author":[{"given":"Ausra","family":"Ramanauskaite","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Obreja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanya","family":"Borchert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iulia","family":"Dahmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,2]]},"reference":[{"issue":"Suppl 20","key":"5275_CR1","doi-asserted-by":"publisher","first-page":"S286","DOI":"10.1111\/jcpe.12957","volume":"45","author":"T Berglundh","year":"2018","unstructured":"Berglundh T, Armitage G, Araujo MG et al (2018) Peri-implant diseases and conditions: consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. 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