{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:09:44Z","timestamp":1780758584633,"version":"3.54.1"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>Rheumatoid arthritis (RA) is a debilitating disease where numerous pro-inflammatory cytokines have a proven role in its pathology. These cytokines are also involved in the pathogenesis of apical periodontitis (AP) where they have a pro-inflammatory role and induce bone resorption. Patients with RA may therefore be more prone to develop pulpal-periapical pathology (PPP). This study systematically reviewed the existing literature evaluating the association between RA and PPP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>Studies including human participants with both RA and PPP were included. The search was performed in PubMed, Web of Science, and The Cochrane Library databases using keywords and Medical Subject Headings (MeSH) search terms. The risk of bias was assessed using Newcastle\u2013Ottawa Quality Assessment Scale. The following parameters were extracted and analyzed by the reviewers; author, journal, year, design of the study, diagnostic criteria for periapical pathology, the association between rheumatoid arthritis and periapical pathology, and the evidence level.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The search identified 142 records. Inclusion criteria were as follows; studies in the English language, including human participants only, including patients with RA and PPP, cohort studies, cross-sectional studies, clinical trials, and case\u2013control studies. According to the inclusion criteria, 5 studies were included in this systematic review. Three of the five studies reported significant association between RA and PPP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Existing evidence suggests there may be an association between RA and PPP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>Clinicians should be aware that RA patients can be more prone to develop PPP which may result in a reduced quality of life.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-023-05305-7","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T18:02:25Z","timestamp":1697133745000},"page":"7019-7028","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association between rheumatoid arthritis and pulpal-periapical pathology: a systematic review"],"prefix":"10.1007","volume":"27","author":[{"given":"Ertugrul","family":"Karata\u015f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayhan","family":"Kul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josette","family":"Camilleri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehra","family":"Yonel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,12]]},"reference":[{"key":"5305_CR1","unstructured":"World Health Organization (2017) Sugars and dental caries. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/sugars-and-dental-caries. Accessed 24 Feb 2023"},{"key":"5305_CR2","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/J.CDEN.2010.08.010","volume":"55","author":"DT Zero","year":"2011","unstructured":"Zero DT, Zandona AF, Vail MM, Spolnik KJ (2011) Dental caries and pulpal disease. Dent Clin North Am 55:29\u201346. https:\/\/doi.org\/10.1016\/J.CDEN.2010.08.010","journal-title":"Dent Clin North Am"},{"issue":"Suppl 3","key":"5305_CR3","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/IEJ.13688","volume":"55","author":"HF Duncan","year":"2022","unstructured":"Duncan HF (2022) Present status and future directions-vital pulp treatment and pulp preservation strategies. Int Endod J 55(Suppl 3):497\u2013511. https:\/\/doi.org\/10.1111\/IEJ.13688","journal-title":"Int Endod J"},{"key":"5305_CR4","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1111\/IEJ.13872","volume":"56","author":"A Jassal","year":"2023","unstructured":"Jassal A, Nawal RR, Yadav S et al (2023) Outcome of partial and full pulpotomy in cariously exposed mature molars with symptoms indicative of irreversible pulpitis: a randomized controlled trial. Int Endod J 56:331\u2013344. https:\/\/doi.org\/10.1111\/IEJ.13872","journal-title":"Int Endod J"},{"key":"5305_CR5","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/J.1601-1546.2004.00098.X","volume":"8","author":"PV Abbott","year":"2004","unstructured":"Abbott PV (2004) Classification, diagnosis and clinical manifestations of apical periodontitis. Endod Top 8:36\u201354. https:\/\/doi.org\/10.1111\/J.1601-1546.2004.00098.X","journal-title":"Endod Top"},{"key":"5305_CR6","doi-asserted-by":"publisher","first-page":"23","DOI":"10.14744\/TEJ.2019.80299","volume":"4","author":"K Bane","year":"2019","unstructured":"Bane K, Ndiaye D, Seck A et al (2019) Apical periodontitis epidemiology: a population-based survey of students in Dakar, Senegal. Turkish Endod J 4:23\u201326. https:\/\/doi.org\/10.14744\/TEJ.2019.80299","journal-title":"Turkish Endod J"},{"key":"5305_CR7","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/AEJ.12220","volume":"44","author":"D Ricucci","year":"2018","unstructured":"Ricucci D, Loghin S, Siqueira JF (2018) Complicated untreated apical periodontitis causing paraesthesia: a case report. Aust Endod J 44:281\u2013285. https:\/\/doi.org\/10.1111\/AEJ.12220","journal-title":"Aust Endod J"},{"key":"5305_CR8","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1111\/IEJ.12567","volume":"49","author":"F Vidal","year":"2016","unstructured":"Vidal F, Fontes TV, Marques TVF, Gon\u00e7alves LS (2016) Association between apical periodontitis lesions and plasmatic levels of C-reactive protein, interleukin 6 and fibrinogen in hypertensive patients. Int Endod J 49:1107\u20131115. https:\/\/doi.org\/10.1111\/IEJ.12567","journal-title":"Int Endod J"},{"key":"5305_CR9","doi-asserted-by":"publisher","first-page":"931","DOI":"10.3390\/MEDICINA58070931","volume":"58","author":"SA Niazi","year":"2022","unstructured":"Niazi SA, Bakhsh A (2022) Association between endodontic infection, its treatment and systemic health: a narrative review. Medicina (B Aires) 58:931. https:\/\/doi.org\/10.3390\/MEDICINA58070931","journal-title":"Medicina (B Aires)"},{"key":"5305_CR10","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1159\/000500472","volume":"28","author":"SN Sisli","year":"2019","unstructured":"Sisli SN (2019) Evaluation of the relationship between type ii diabetes mellitus and the prevalence of apical periodontitis in root-filled teeth using cone beam computed tomography: an observational cross-sectional study. Med Princ Pract Int J Kuwait Univ Heal Sci Cent 28:533\u2013538. https:\/\/doi.org\/10.1159\/000500472","journal-title":"Med Princ Pract Int J Kuwait Univ Heal Sci Cent"},{"key":"5305_CR11","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1111\/IEJ.13253","volume":"53","author":"V Nagendrababu","year":"2020","unstructured":"Nagendrababu V, Segura-Egea JJ, Fouad AF et al (2020) Association between diabetes and the outcome of root canal treatment in adults: an umbrella review. Int Endod J 53:455\u2013466. https:\/\/doi.org\/10.1111\/IEJ.13253","journal-title":"Int Endod J"},{"key":"5305_CR12","doi-asserted-by":"publisher","first-page":"171","DOI":"10.17219\/dmp\/114463","volume":"57","author":"E Karata\u015f","year":"2020","unstructured":"Karata\u015f E, Kul A, Tepecik E (2020a) Association of ankylosing spondylitis with radiographically and clinically diagnosed apical periodontitis: A cross-sectional study. Dent Med Probl 57:171\u2013175. https:\/\/doi.org\/10.17219\/dmp\/114463","journal-title":"Dent Med Probl"},{"key":"5305_CR13","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1016\/j.joen.2016.03.011","volume":"42","author":"GK An","year":"2016","unstructured":"An GK, Morse DE, Kunin M et al (2016) Association of radiographically diagnosed apical periodontitis and cardiovascular disease: a hospital records-based study. J Endod 42:916\u2013920. https:\/\/doi.org\/10.1016\/j.joen.2016.03.011","journal-title":"J Endod"},{"key":"5305_CR14","doi-asserted-by":"publisher","first-page":"155","DOI":"10.14744\/EEJ.2019.52824","volume":"5","author":"E Karata\u015f","year":"2020","unstructured":"Karata\u015f E, Kul A, Tepecik E (2020b) Association between rheumatoid arthritis and apical periodontitis: a cross-sectional study. Eur Endod J 5:155\u2013158. https:\/\/doi.org\/10.14744\/EEJ.2019.52824","journal-title":"Eur Endod J"},{"key":"5305_CR15","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1002\/1529-0131(200012)43:12<2619::AID-ANR1>3.0.CO;2-V","volume":"43","author":"PP Tak","year":"2000","unstructured":"Tak PP, Bresnihan B (2000) The pathogenesis and prevention of joint damage in rheumatoid arthritis: advances from synovial biopsy and tissue analysis. Arthritis Rheum 43:2619\u20132633. https:\/\/doi.org\/10.1002\/1529-0131(200012)43:12%3c2619::AID-ANR1%3e3.0.CO;2-V","journal-title":"Arthritis Rheum"},{"key":"5305_CR16","doi-asserted-by":"publisher","first-page":"v3","DOI":"10.1093\/RHEUMATOLOGY\/KES113","volume":"51","author":"E Choy","year":"2012","unstructured":"Choy E (2012) Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis. Rheumatology 51:v3\u2013v11. https:\/\/doi.org\/10.1093\/RHEUMATOLOGY\/KES113","journal-title":"Rheumatology"},{"key":"5305_CR17","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.1002\/ART.10623","volume":"46","author":"EHS Choy","year":"2002","unstructured":"Choy EHS, Isenberg DA, Garrood T et al (2002) Therapeutic benefit of blocking interleukin-6 activity with an anti\u2013interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial. Arthritis Rheum 46:3143\u20133150. https:\/\/doi.org\/10.1002\/ART.10623","journal-title":"Arthritis Rheum"},{"key":"5305_CR18","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1097\/NOR.0000000000000610","volume":"38","author":"SB Srivastava","year":"2019","unstructured":"Srivastava SB, Fluegel N, Mansukhani RP (2019) Pharmacologic management of rheumatoid arthritis. Orthop Nurs 38:390\u2013395. https:\/\/doi.org\/10.1097\/NOR.0000000000000610","journal-title":"Orthop Nurs"},{"key":"5305_CR19","unstructured":"Morovic-Vergles J (2003) [Pathophysiology of rheumatoid arthritis] - PubMed. In: Pathophysiol. Rheum. arthritis. https:\/\/pubmed.ncbi.nlm.nih.gov\/15098367\/. Accessed 25 Sep 2023"},{"key":"5305_CR20","unstructured":"Gibofsky A (2014) Epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis: A Synopsis. Am J Manag Care 20(7):S128\u2013S135"},{"key":"5305_CR21","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1002\/ART.1780130606","volume":"13","author":"K Lund-Olesen","year":"1970","unstructured":"Lund-Olesen K (1970) Oxygen tension in synovial fluids. Arthritis Rheum 13:769\u2013776. https:\/\/doi.org\/10.1002\/ART.1780130606","journal-title":"Arthritis Rheum"},{"key":"5305_CR22","doi-asserted-by":"publisher","unstructured":"McInnes IB, Schett G (2011) The Pathogenesis of rheumatoid arthritis 365:2205\u20132219.\u00a0https:\/\/doi.org\/10.1056\/NEJMRA1004965","DOI":"10.1056\/NEJMRA1004965"},{"key":"5305_CR23","doi-asserted-by":"publisher","unstructured":"Ara\u00fajo VMA, Melo IM, Lima V (2015) Relationship between periodontitis and rheumatoid arthritis: Review of the literature. Mediators Inflamm 2015. https:\/\/doi.org\/10.1155\/2015\/259074","DOI":"10.1155\/2015\/259074"},{"key":"5305_CR24","doi-asserted-by":"publisher","first-page":"22","DOI":"10.4103\/0972-124X.94599","volume":"16","author":"SB Ranade","year":"2012","unstructured":"Ranade SB, Doiphode S (2012) Is there a relationship between periodontitis and rheumatoid arthritis? J Indian Soc Periodontol 16:22. https:\/\/doi.org\/10.4103\/0972-124X.94599","journal-title":"J Indian Soc Periodontol"},{"key":"5305_CR25","doi-asserted-by":"publisher","first-page":"e980","DOI":"10.4317\/JCED.57562","volume":"13","author":"S Varshney","year":"2021","unstructured":"Varshney S, Sharma M, Kapoor S, Siddharth M (2021) Association between rheumatoid arthritis and periodontitis in an adult population \u2013 a cross sectional study. J Clin Exp Dent 13:e980. https:\/\/doi.org\/10.4317\/JCED.57562","journal-title":"J Clin Exp Dent"},{"key":"5305_CR26","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/AR3106","volume":"12","author":"J Detert","year":"2010","unstructured":"Detert J, Pischon N, Burmester GR, Buttgereit F (2010) The association between rheumatoid arthritis and periodontal disease. Arthritis Res Ther 12:218. https:\/\/doi.org\/10.1186\/AR3106","journal-title":"Arthritis Res Ther"},{"key":"5305_CR27","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1007\/BF00918681","volume":"11","author":"J Th\u00e9","year":"1991","unstructured":"Th\u00e9 J, Ebersole JL (1991) Rheumatoid factor (RF) distribution in periodontal disease. J Clin Immunol 11:132\u2013142. https:\/\/doi.org\/10.1007\/BF00918681","journal-title":"J Clin Immunol"},{"key":"5305_CR28","doi-asserted-by":"publisher","first-page":"3248","DOI":"10.1128\/IAI.67.7.3248-3256.1999","volume":"67","author":"WT McGraw","year":"1999","unstructured":"McGraw WT, Potempa J, Farley D, Travis J (1999) Purification, Characterization, and sequence analysis of a potential virulence factor from porphyromonas gingivalis, peptidylarginine deiminase. Infect Immun 67:3248. https:\/\/doi.org\/10.1128\/IAI.67.7.3248-3256.1999","journal-title":"Infect Immun"},{"key":"5305_CR29","doi-asserted-by":"publisher","unstructured":"Bingham Iii CO, Moni M Periodontal disease and rheumatoid arthritis: the evidence accumulates for complex pathobiologic interactions. https:\/\/doi.org\/10.1097\/BOR.0b013e32835fb8ec","DOI":"10.1097\/BOR.0b013e32835fb8ec"},{"key":"5305_CR30","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/S10753-004-6641-Z","volume":"28","author":"ED Rosenstein","year":"2004","unstructured":"Rosenstein ED, Greenwald RA, Kushner LJ, Weissmann G (2004) Hypothesis: the humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis. Inflammation 28:311\u2013318. https:\/\/doi.org\/10.1007\/S10753-004-6641-Z","journal-title":"Inflammation"},{"key":"5305_CR31","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/J.1600-0757.1994.TB00020.X","volume":"5","author":"AD Haffajee","year":"1994","unstructured":"Haffajee AD, Socransky SS (1994) Microbial etiological agents of destructive periodontal diseases. Periodontol 2000 5:78\u2013111. https:\/\/doi.org\/10.1111\/J.1600-0757.1994.TB00020.X","journal-title":"Periodontol 2000"},{"key":"5305_CR32","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1007\/978-1-4615-0171-8_11","volume":"520","author":"E Lubberts","year":"2013","unstructured":"Lubberts E, van den Berg WB (2013) Cytokines in the pathogenesis of rheumatoid arthritis and collagen-induced arthritis. Adv Exp Med Biol 520:194\u2013202","journal-title":"Adv Exp Med Biol"},{"key":"5305_CR33","doi-asserted-by":"publisher","first-page":"e0260254","DOI":"10.1371\/JOURNAL.PONE.0260254","volume":"16","author":"H Matsumoto","year":"2021","unstructured":"Matsumoto H, Fujita Y, Asano T et al (2021) Association between inflammatory cytokines and immune-checkpoint molecule in rheumatoid arthritis. PLoS ONE 16:e0260254. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0260254","journal-title":"PLoS ONE"},{"key":"5305_CR34","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1111\/IEJ.12196","volume":"47","author":"MM Azuma","year":"2014","unstructured":"Azuma MM, Samuel RO, Gomes-Filho JE et al (2014) The role of IL-6 on apical periodontitis: a systematic review. Int Endod J 47:615\u2013621. https:\/\/doi.org\/10.1111\/IEJ.12196","journal-title":"Int Endod J"},{"key":"5305_CR35","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/J.JOEN.2013.10.036","volume":"40","author":"IJ M\u00e1rton","year":"2014","unstructured":"M\u00e1rton IJ, Kiss C (2014) Overlapping protective and destructive regulatory pathways in apical periodontitis. J Endod 40:155\u2013163. https:\/\/doi.org\/10.1016\/J.JOEN.2013.10.036","journal-title":"J Endod"},{"key":"5305_CR36","doi-asserted-by":"publisher","unstructured":"Tazawa K, Presse MMA, Furusho H, et al (2022) Revisiting the role of IL-1 signaling in the development of apical periodontitis. Front Dent Med 3. https:\/\/doi.org\/10.3389\/FDMED.2022.985558","DOI":"10.3389\/FDMED.2022.985558"},{"key":"5305_CR37","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/J.JOEN.2022.02.008","volume":"48","author":"F Ideo","year":"2022","unstructured":"Ideo F, Niazi S, Mezzena S et al (2022) Prevalence of apical periodontitis in patients with autoimmune diseases under immunomodulators: a retrospective cohort study. J Endod 48:722\u2013729. https:\/\/doi.org\/10.1016\/J.JOEN.2022.02.008","journal-title":"J Endod"},{"key":"5305_CR38","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/J.JOEN.2017.02.015","volume":"43","author":"P Jalali","year":"2017","unstructured":"Jalali P, Glickman GN, Schneiderman ED, Schweitzer JL (2017) Prevalence of periapical rarefying osteitis in patients with rheumatoid arthritis. J Endod 43:1093\u20131096. https:\/\/doi.org\/10.1016\/J.JOEN.2017.02.015","journal-title":"J Endod"},{"key":"5305_CR39","doi-asserted-by":"publisher","unstructured":"Guerrero-Giron\u00e9s J, Ros-Valverde A, Pecci-Lloret MP et al (2021) Association between pulpal-periapical pathology and autoimmune diseases: a systematic review. J Clin Med 10. https:\/\/doi.org\/10.3390\/JCM10214886","DOI":"10.3390\/JCM10214886"},{"key":"5305_CR40","first-page":"469","volume":"34","author":"J Simard","year":"2007","unstructured":"Simard J, Mittleman M (2007) Prevalent rheumatoid arthritis and diabetes among NHANES III participants aged 60 and older. J Rheumatol 34:469\u2013473","journal-title":"J Rheumatol"},{"key":"5305_CR41","first-page":"856","volume":"19","author":"M Hakala","year":"1992","unstructured":"Hakala M, Ilonen J, Reijonen H et al (1992) No association between rheumatoid arthritis and insulin dependent diabetes mellitus: an epidemiologic and immunogenetic study. J Rheumatol 19:856\u2013858","journal-title":"J Rheumatol"},{"key":"5305_CR42","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/2046-4053-4-1\/TABLES\/4","volume":"20","author":"D Moher","year":"2016","unstructured":"Moher D, Shamseer L, Clarke M et al (2016) Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Rev Esp Nutr Humana y Diet 20:148\u2013160. https:\/\/doi.org\/10.1186\/2046-4053-4-1\/TABLES\/4","journal-title":"Rev Esp Nutr Humana y Diet"},{"key":"5305_CR43","doi-asserted-by":"publisher","unstructured":"Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372. https:\/\/doi.org\/10.1136\/BMJ.N71","DOI":"10.1136\/BMJ.N71"},{"key":"5305_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2458-13-154\/COMMENTS","volume":"13","author":"R Herzog","year":"2013","unstructured":"Herzog R, \u00c1lvarez-Pasquin MJ, D\u00edaz C et al (2013) Are healthcare workers intentions to vaccinate related to their knowledge, beliefs and attitudes? A systematic review. BMC Public Health 13:1\u201317. https:\/\/doi.org\/10.1186\/1471-2458-13-154\/COMMENTS","journal-title":"BMC Public Health"},{"key":"5305_CR45","first-page":"211","volume":"34","author":"I Rotstein","year":"2021","unstructured":"Rotstein I, Katz J (2021) Prevalence of periapical abscesses in patients with rheumatoid arthritis. A cross sectional study. Am J Dent 34:211\u2013214","journal-title":"Am J Dent"},{"key":"5305_CR46","doi-asserted-by":"publisher","first-page":"956072","DOI":"10.3389\/froh.2022.956072","volume":"3","author":"P Heikkil\u00e4","year":"2022","unstructured":"Heikkil\u00e4 P, Niskanen L, But A et al (2022) Oral health associated with incident diabetes but not other chronic diseases: a register-based cohort study. Front oral Heal 3:956072. https:\/\/doi.org\/10.3389\/froh.2022.956072","journal-title":"Front oral Heal"},{"key":"5305_CR47","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3109\/03009747509165440","volume":"4","author":"M Malmstr\u00f6m","year":"1975","unstructured":"Malmstr\u00f6m M, Jokinen EJ (1975) Free rheumatoid factor in dental periapical lesions and gingivae of patients with rheumatoid disease. Scand J Rheumatol 4:121\u2013124. https:\/\/doi.org\/10.3109\/03009747509165440","journal-title":"Scand J Rheumatol"},{"key":"5305_CR48","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3109\/03009747509165253","volume":"4","author":"M Malmstr\u00f6m","year":"1975","unstructured":"Malmstr\u00f6m M, Natvig JB (1975) IgG rheumatoid factor in dental periapical lesions of patients with rheumatoid disease. Scand J Rheumatol 4:177\u2013185. https:\/\/doi.org\/10.3109\/03009747509165253","journal-title":"Scand J Rheumatol"},{"key":"5305_CR49","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/J.CELL.2014.04.007","volume":"157","author":"M Lamkanfi","year":"2014","unstructured":"Lamkanfi M, Dixit VM (2014) Mechanisms and functions of inflammasomes. Cell 157:1013\u20131022. https:\/\/doi.org\/10.1016\/J.CELL.2014.04.007","journal-title":"Cell"},{"key":"5305_CR50","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/JOIM.12395","volume":"278","author":"L Wang","year":"2015","unstructured":"Wang L, Wang F-S, Gershwin ME (2015) Human autoimmune diseases: a comprehensive update. J Intern Med 278:369\u2013395. https:\/\/doi.org\/10.1111\/JOIM.12395","journal-title":"J Intern Med"},{"key":"5305_CR51","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1159\/000418552","volume":"57","author":"JP Isbister","year":"1990","unstructured":"Isbister JP (1990) The risk\/benefit equation for therapeutic plasma exchange. Curr Stud Hematol Blood Transfus 57:10\u201330. https:\/\/doi.org\/10.1159\/000418552","journal-title":"Curr Stud Hematol Blood Transfus"},{"key":"5305_CR52","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/J.JOEN.2015.12.015","volume":"42","author":"K Leonardi Dutra","year":"2016","unstructured":"Leonardi Dutra K, Haas L, Porporatti AL et al (2016) Diagnostic accuracy of cone-beam computed tomography and conventional radiography on apical periodontitis: a systematic review and meta-analysis. J Endod 42:356\u2013364. https:\/\/doi.org\/10.1016\/J.JOEN.2015.12.015","journal-title":"J Endod"},{"key":"5305_CR53","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0099-2399(82)80212-4","volume":"8","author":"IB Bender","year":"1982","unstructured":"Bender IB (1982) Factors influencing the radiographic appearance of bony lesions. J Endod 8:161\u2013170. https:\/\/doi.org\/10.1016\/S0099-2399(82)80212-4","journal-title":"J Endod"},{"key":"5305_CR54","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1097\/00004770-200311000-00006","volume":"29","author":"IB Bender","year":"2003","unstructured":"Bender IB, Seltzer S (2003) Roentgenographic and direct observation of experimental lesions in bone: II. 1961. J Endod 29:707\u2013712. https:\/\/doi.org\/10.1097\/00004770-200311000-00006","journal-title":"J Endod"},{"key":"5305_CR55","unstructured":"Glickman GN, Schweitzer JN (2013) Endodontic diagnosis. Colleagues Excell Endod 1:1\u20136"},{"key":"5305_CR56","first-page":"123","volume-title":"Abd-Elsayed A","author":"AS Hess","year":"2019","unstructured":"Hess AS, Abd-Elsayed A (2019) Observational studies: uses and limitations bt - pain: a review guide. In: International S (ed) Abd-Elsayed A. Publishing, Cham, pp 123\u2013125"},{"key":"5305_CR57","doi-asserted-by":"publisher","first-page":"100","DOI":"10.31083\/J.RCM2303100\/2153-8174-23-3-100.PDF","volume":"23","author":"R Noites","year":"2022","unstructured":"Noites R, Teixeira M, Cavero-Redondo I et al (2022) Apical Periodontitis and cardiovascular disease in adults: a systematic review with meta-analysis. Rev Cardiovasc Med 23:100. https:\/\/doi.org\/10.31083\/J.RCM2303100\/2153-8174-23-3-100.PDF","journal-title":"Rev Cardiovasc Med"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-023-05305-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-023-05305-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-023-05305-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T04:33:35Z","timestamp":1702355615000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-023-05305-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,12]]},"references-count":57,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["5305"],"URL":"https:\/\/doi.org\/10.1007\/s00784-023-05305-7","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,12]]},"assertion":[{"value":"18 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 October 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study does not involve human participants or animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}