{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T17:15:42Z","timestamp":1778260542802,"version":"3.51.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["ACTA 2014-7468"],"award-info":[{"award-number":["ACTA 2014-7468"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["ACTA 2014-7468"],"award-info":[{"award-number":["ACTA 2014-7468"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["ACTA 2014-7468"],"award-info":[{"award-number":["ACTA 2014-7468"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["ACTA 2014-7468"],"award-info":[{"award-number":["ACTA 2014-7468"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["ACTA 2014-7468"],"award-info":[{"award-number":["ACTA 2014-7468"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["ACTA 2014-7468"],"award-info":[{"award-number":["ACTA 2014-7468"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>Haematopoietic cell transplantation (HCT) preceded by a conditioning regimen is an established treatment option for (non)malignant haematologic disorders. We aim to describe the development of hyposalivation over time in HCT recipients, and determine risk indicators.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>A multi-centre prospective longitudinal observational study was conducted. Unstimulated (UWS) and stimulated (SWS) whole saliva was collected before HCT, early post-HCT, and after 3, 6, 12, and 18\u00a0months. The effect of type of transplantation (allogeneic vs autologous) and intensity (full vs reduced) of the conditioning regimen on hyposalivation (UWS\u2009&lt;\u20090.2\u00a0mL\/min; SWS\u2009&lt;\u20090.7\u00a0mL\/min) was explored.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 125 HCT recipients were included. More than half of the patients had hyposalivation early post-HCT; a quarter still had hyposalivation after 12\u00a0months. The conditioning intensity was a risk indicator in the development of hyposalivation of both UWS (OR: 3.9, 95% CI: 1.6\u201310.6) and SWS (OR: 8.2, 95% CI: 2.9\u201324.6). After 3 and 12\u00a0months, this effect was not statistically significant anymore.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Hyposalivation affects the majority of patients early post-HCT. The conditioning intensity and the type of transplantation were significant risk indicators in the development of hyposalivation. The number of prescribed medications, total body irradiation as part of the conditioning regimen and oral mucosal graft-versus-host disease did not influence hyposalivation significantly.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>Because of the high prevalence of hyposalivation, HCT recipients will have an increased risk of oral complications. It might be reasonable to plan additional check-ups in the dental practice and consider additional preventive strategies.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-023-05327-1","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T19:01:33Z","timestamp":1697655693000},"page":"7369-7381","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The effect of conditioning regimen and prescribed medications on hyposalivation in haematopoietic cell transplantation (HCT) patients: an 18-month prospective longitudinal study"],"prefix":"10.1007","volume":"27","author":[{"given":"Marjolein S.","family":"Bulthuis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucky L. A.","family":"van Gennip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renske Z.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewald M.","family":"Bronkhorst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexa M. G. A.","family":"Laheij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith E.","family":"Raber-Durlacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik R.","family":"Rozema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inger","family":"von B\u00fcltzingsl\u00f6wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole M. A.","family":"Blijlevens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Charlotte D. N. J. M.","family":"Huysmans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie J. M.","family":"van Leeuwen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"issue":"17","key":"5327_CR1","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1056\/NEJMra052638","volume":"354","author":"EA Copelan","year":"2006","unstructured":"Copelan EA (2006) Hematopoietic stem-cell transplantation. N Engl J Med 354(17):1813\u20131826. https:\/\/doi.org\/10.1056\/NEJMra052638","journal-title":"N Engl J Med"},{"issue":"6","key":"5327_CR2","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1038\/bmt.2016.18","volume":"51","author":"D Niederwieser","year":"2016","unstructured":"Niederwieser D, Baldomero H, Szer J, Gratwohl M, Aljurf M, Atsuta Y, Bouzas LF, Confer D, Greinix H, Horowitz M, Iida M, Lipton J, Mohty M, Novitzky N, Nunez J, Passweg J, Pasquini MC, Kodera Y, Apperley J, Seber A, Gratwohl A (2016) Hematopoietic stem cell transplantation activity worldwide in 2012 and a SWOT analysis of the Worldwide Network for Blood and Marrow Transplantation Group including the global survey. Bone Marrow Transplant 51(6):778\u2013785. https:\/\/doi.org\/10.1038\/bmt.2016.18","journal-title":"Bone Marrow Transplant"},{"issue":"12","key":"5327_CR3","doi-asserted-by":"publisher","first-page":"2716","DOI":"10.3324\/haematol.2019.245688","volume":"105","author":"N Granot","year":"2020","unstructured":"Granot N, Storb R (2020) History of hematopoietic cell transplantation: challenges and progress. Haematologica 105(12):2716\u20132729. https:\/\/doi.org\/10.3324\/haematol.2019.245688","journal-title":"Haematologica"},{"issue":"9","key":"5327_CR4","doi-asserted-by":"publisher","first-page":"E17","DOI":"10.1038\/sj.bdj.2009.977","volume":"207","author":"HS Brand","year":"2009","unstructured":"Brand HS, Bots CP, Raber-Durlacher JE (2009) Xerostomia and chronic oral complications among patients treated with haematopoietic stem cell transplantation. Br Dent J 207(9):E17. https:\/\/doi.org\/10.1038\/sj.bdj.2009.977. (discussion 428-429)","journal-title":"Br Dent J"},{"issue":"2","key":"5327_CR5","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/bmt.2011.63","volume":"47","author":"KM Hull","year":"2012","unstructured":"Hull KM, Kerridge I, Schifter M (2012) Long-term oral complications of allogeneic haematopoietic SCT. Bone Marrow Transplant 47(2):265\u2013270. https:\/\/doi.org\/10.1038\/bmt.2011.63","journal-title":"Bone Marrow Transplant"},{"issue":"9","key":"5327_CR6","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1111\/joor.12664","volume":"45","author":"AML Pedersen","year":"2018","unstructured":"Pedersen AML, Sorensen CE, Proctor GB, Carpenter GH, Ekstrom J (2018) Salivary secretion in health and disease. J Oral Rehabil 45(9):730\u2013746. https:\/\/doi.org\/10.1111\/joor.12664","journal-title":"J Oral Rehabil"},{"issue":"Suppl 1","key":"5327_CR7","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.jdent.2018.08.010","volume":"80","author":"AM Lynge Pedersen","year":"2019","unstructured":"Lynge Pedersen AM, Belstrom D (2019) The role of natural salivary defences in maintaining a healthy oral microbiota. J Dent 80(Suppl 1):S3\u2013S12. https:\/\/doi.org\/10.1016\/j.jdent.2018.08.010","journal-title":"J Dent"},{"issue":"9","key":"5327_CR8","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.1007\/s00520-015-2613-0","volume":"23","author":"CC Boer","year":"2015","unstructured":"Boer CC, Correa ME, Tenuta LM, Souza CA, Vigorito AC (2015) Post-allogeneic Hematopoietic Stem Cell Transplantation (HSCT) changes in inorganic salivary components. Support Care Cancer 23(9):2561\u20132567. https:\/\/doi.org\/10.1007\/s00520-015-2613-0","journal-title":"Support Care Cancer"},{"issue":"6","key":"5327_CR9","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/0030-4220(92)90007-d","volume":"73","author":"LR Jones","year":"1992","unstructured":"Jones LR, Toth BB, Keene HJ (1992) Effects of total body irradiation on salivary gland function and caries-associated oral microflora in bone marrow transplant patients. Oral Surg Oral Med Oral Pathol 73(6):670\u2013676. https:\/\/doi.org\/10.1016\/0030-4220(92)90007-d","journal-title":"Oral Surg Oral Med Oral Pathol"},{"issue":"3","key":"5327_CR10","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1007\/s00520-019-04922-x","volume":"28","author":"MH Ferreira","year":"2020","unstructured":"Ferreira MH, Mello Bezinelli L, de Paula EF, Lopes RM, Pereira AZ, Hamerschlack N, Corr\u00eaa L (2020) Association of oral toxicity and taste changes during hematopoietic stem cell transplantation: a preliminary study. Support Care Cancer 28(3):1277\u20131287. https:\/\/doi.org\/10.1007\/s00520-019-04922-x","journal-title":"Support Care Cancer"},{"issue":"10","key":"5327_CR11","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1177\/0022034511414156","volume":"90","author":"M Laaksonen","year":"2011","unstructured":"Laaksonen M, Ramseier AM, Rov\u00f3 A, Jensen SB, Raber-Durlacher JE, Zitzmann NU, Waltimo T (2011) Longitudinal assessment of hematopoietic stem cell transplantation and hyposalivation. J Dent Res 90(10):1177\u20131182. https:\/\/doi.org\/10.1177\/0022034511414156","journal-title":"J Dent Res"},{"issue":"1","key":"5327_CR12","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00784-016-1760-0","volume":"21","author":"M Mauramo","year":"2017","unstructured":"Mauramo M, Rohde L, Ramseier AM, Rovo A, Waltimo T (2017) Determinants of stimulated salivary flow among haematopoietic stem cell transplantation recipients. Clin Oral Investig 21(1):121\u2013126. https:\/\/doi.org\/10.1007\/s00784-016-1760-0","journal-title":"Clin Oral Investig"},{"issue":"4","key":"5327_CR13","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/ejh.13283","volume":"103","author":"P Uutela","year":"2019","unstructured":"Uutela P, Passweg J, Halter J, Gerull S, Weiger R, Mauramo E, Waltimo T, Mauramo M (2019) Common oral diseases, hyposalivation and survival post-HSCT, a longitudinal study. Eur J Haematol 103(4):300\u2013306. https:\/\/doi.org\/10.1111\/ejh.13283","journal-title":"Eur J Haematol"},{"issue":"2","key":"5327_CR14","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/s1079-2104(05)80276-8","volume":"79","author":"G Chaushu","year":"1995","unstructured":"Chaushu G, Itzkovitz-Chaushu S, Yefenof E, Slavin S, Or R, Garfunkel AA (1995) A longitudinal follow-up of salivary secretion in bone marrow transplant patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 79(2):164\u2013169. https:\/\/doi.org\/10.1016\/s1079-2104(05)80276-8","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"5327_CR15","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14358","author":"LLA van Gennip","year":"2022","unstructured":"van Gennip LLA, Bulthuis MS, Blijlevens NMA, Huysmans M, van Leeuwen SJM, Thomas RZ (2022) Caries, periodontitis and tooth loss after haematopoietic stem cell transplantation: A systematic review. Oral Dis. https:\/\/doi.org\/10.1111\/odi.14358","journal-title":"Oral Dis"},{"issue":"10","key":"5327_CR16","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/sj.bmt.1705351","volume":"37","author":"FL Coracin","year":"2006","unstructured":"Coracin FL, Pizzigatti Correa ME, Camargo EE, Peterson DE, de Oliveira SA, Vigorito AC, Borba Oliveira G, de Brito Eid KA, Zulli R, De Souza CA (2006) Major salivary gland damage in allogeneic hematopoietic progenitor cell transplantation assessed by scintigraphic methods. Bone Marrow Transplant 37(10):955\u2013959. https:\/\/doi.org\/10.1038\/sj.bmt.1705351","journal-title":"Bone Marrow Transplant"},{"issue":"2","key":"5327_CR17","first-page":"75","volume":"26","author":"J Blomgren","year":"2002","unstructured":"Blomgren J, Jansson S, Rodjer S, Birkhed D (2002) Secretion rate from minor salivary glands in patients with malignant haematological diseases receiving chemotherapy\u2013a pilot study. Swed Dent J 26(2):75\u201380","journal-title":"Swed Dent J"},{"issue":"4","key":"5327_CR18","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/bmt.2009.237","volume":"45","author":"CC Boer","year":"2010","unstructured":"Boer CC, Correa ME, Miranda EC, de Souza CA (2010) Taste disorders and oral evaluation in patients undergoing allogeneic hematopoietic SCT. Bone Marrow Transplant 45(4):705\u2013711. https:\/\/doi.org\/10.1038\/bmt.2009.237","journal-title":"Bone Marrow Transplant"},{"issue":"3","key":"5327_CR19","first-page":"167","volume":"6","author":"RM Nagler","year":"2004","unstructured":"Nagler RM, Nagler A (2004) Salivary gland involvement in graft-versus-host disease: the underlying mechanism and implicated treatment. Isr Med Assoc J 6(3):167\u2013172","journal-title":"Isr Med Assoc J"},{"issue":"3","key":"5327_CR20","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1080\/07357900600634013","volume":"24","author":"R Nagler","year":"2006","unstructured":"Nagler R, Barness-Hadar L, Lieba M, Nagler A (2006) Salivary antioxidant capacity in graft versus host disease. Cancer Invest 24(3):269\u2013277. https:\/\/doi.org\/10.1080\/07357900600634013","journal-title":"Cancer Invest"},{"issue":"1","key":"5327_CR21","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1081\/cnv-120016401","volume":"21","author":"RM Nagler","year":"2003","unstructured":"Nagler RM, Nagler A (2003) Sialometrical and sialochemical analysis of patients with chronic graft-versus-host disease\u2013a prolonged study. Cancer Invest 21(1):34\u201340. https:\/\/doi.org\/10.1081\/cnv-120016401","journal-title":"Cancer Invest"},{"issue":"10","key":"5327_CR22","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1016\/j.bbmt.2010.03.023","volume":"16","author":"MM Imanguli","year":"2010","unstructured":"Imanguli MM, Atkinson JC, Mitchell SA, Avila DN, Bishop RJ, Cowen EW, Datiles MB, Hakim FT, Kleiner DE, Krumlauf MC, Pavletic SZ (2010) Salivary gland involvement in chronic graft-versus-host disease: prevalence, clinical significance, and recommendations for evaluation. Biol Blood Marrow Transplant 16(10):1362\u20131369. https:\/\/doi.org\/10.1016\/j.bbmt.2010.03.023","journal-title":"Biol Blood Marrow Transplant"},{"issue":"4","key":"5327_CR23","doi-asserted-by":"publisher","first-page":"e103","DOI":"10.2196\/resprot.8982","volume":"7","author":"MT Brennan","year":"2018","unstructured":"Brennan MT, Hass\u00e9us B, Hovan AJ, Raber-Durlacher JE, Blijlevens NM, Huysmans MC, Garming Legert K, Johansson JE, Moore CG, von B\u00fcltzingsl\u00f6wen I (2018) Impact of oral side effects from conditioning therapy before hematopoietic stem cell transplantation: protocol for a multicenter study. JMIR Res Protoc 7(4):e103. https:\/\/doi.org\/10.2196\/resprot.8982","journal-title":"JMIR Res Protoc"},{"key":"5327_CR24","first-page":"35S","volume":"139","author":"M Navazesh","year":"2008","unstructured":"Navazesh M, Kumar SKS (2008) Measuring salivary flow, Challenges and opportunities. JADA 139:35S-40S","journal-title":"JADA"},{"issue":"4","key":"5327_CR25","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/0030-4220(88)90268-X","volume":"66","author":"LM Screebny","year":"1988","unstructured":"Screebny LM (1988) Xerostomia. Part I: Relationship to other oral symptoms and salivary gland hypofunction. Oral Surg Oral Med Oral Pathol 66(4):451\u2013458","journal-title":"Oral Surg Oral Med Oral Pathol"},{"issue":"1","key":"5327_CR26","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/bmt.2013.137","volume":"49","author":"CW Bassim","year":"2014","unstructured":"Bassim CW, Fassil H, Mays JW, Edwards D, Baird K, Steinberg SM, Williams KM, Cowen EW, Mitchell SA, Cole K, Taylor T, Avila D, Zhang D, Pulanic D, Grkovic L, Fowler D, Gress RE, Pavletic SZ (2014) Validation of the National Institutes of Health chronic GVHD Oral mucosal score using component-specific measures. Bone Marrow Transplant 49(1):116\u2013121. https:\/\/doi.org\/10.1038\/bmt.2013.137","journal-title":"Bone Marrow Transplant"},{"issue":"7 Suppl","key":"5327_CR27","doi-asserted-by":"publisher","first-page":"45s","DOI":"10.1177\/0022034512450881","volume":"91","author":"H Fassil","year":"2012","unstructured":"Fassil H, Bassim CW, Mays J, Edwards D, Baird K, Steinberg SM, Williams KM, Cowen EW, Mitchell SA, Hakim FT, Taylor T, Avila D, Zhang D, Grkovic L, Datiles M, Gress RE, Pavletic SZ (2012) Oral chronic graft-vs-host disease characterization using the NIH scale. J Dent Res 91(7 Suppl):45s\u201351s","journal-title":"J Dent Res"},{"issue":"12","key":"5327_CR28","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1016\/j.bbmt.2009.07.004","volume":"15","author":"A Bacigalupo","year":"2009","unstructured":"Bacigalupo A, Ballen K, Rizzo D, Giralt S, Lazarus H, Ho V, Apperley J, Slavin S, Pasquini M, Sandmaier BM, Barrett J, Blaise D, Lowski R, Horowitz M (2009) Defining the intensity of conditioning regimens: working definitions. Biol Blood Marrow Transplant 15(12):1628\u20131633. https:\/\/doi.org\/10.1016\/j.bbmt.2009.07.004","journal-title":"Biol Blood Marrow Transplant"},{"issue":"2","key":"5327_CR29","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.tripleo.2008.04.003","volume":"106","author":"SB Jensen","year":"2008","unstructured":"Jensen SB, Mouridsen HT, Bergmann OJ, Reibel J, Brunner N, Nauntofte B (2008) Oral mucosal lesions, microbial changes, and taste disturbances induced by adjuvant chemotherapy in breast cancer patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106(2):217\u2013226. https:\/\/doi.org\/10.1016\/j.tripleo.2008.04.003","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"25","key":"5327_CR30","doi-asserted-by":"publisher","first-page":"2825","DOI":"10.1200\/JCO.21.01208","volume":"39","author":"V Mercadante","year":"2021","unstructured":"Mercadante V, Jensen SB, Smith DK, Bohlke K, Bauman J, Brennan MT, Coppes RP, Jessen N, Malhotra NK, Murphy B, Rosenthal DI, Vissink A, Wu J, Saunders DP, Peterson DE (2021) Salivary Gland hypofunction and\/or xerostomia induced by nonsurgical cancer therapies: ISOO\/MASCC\/ASCO Guideline. J Clin Oncol 39(25):2825\u20132843. https:\/\/doi.org\/10.1200\/JCO.21.01208","journal-title":"J Clin Oncol"},{"key":"5327_CR31","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/j.1749-6632.1993.tb18377.x","volume":"694","author":"M Slavik","year":"1993","unstructured":"Slavik M, Wu J, Riley C (1993) Salivary excretion of anticancer drugs. Ann N Y Acad Sci 694:319\u2013321. https:\/\/doi.org\/10.1111\/j.1749-6632.1993.tb18377.x","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"5327_CR32","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1177\/0022034515570942","volume":"94","author":"CW Bassim","year":"2015","unstructured":"Bassim CW, Fassil H, Mays JW, Edwards D, Baird K, Steinberg SM, Cowen EW, Naik H, Datiles M, Stratton P, Gress RE, Pavletic SZ (2015) Oral disease profiles in chronic graft versus host disease. J Dent Res 94(4):547\u2013554. https:\/\/doi.org\/10.1177\/0022034515570942","journal-title":"J Dent Res"},{"issue":"1","key":"5327_CR33","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s40368-022-00761-3","volume":"24","author":"AR Mantelli","year":"2023","unstructured":"Mantelli AR, Kramer PF, Vitolo MR, Alves AC, Sarmento N, Feldens CA (2023) Clinical manifestations of tooth eruption in the first year of life and related risk factors in three regions of Brazil: multicenter birth cohort study. Eur Arch Paediatr Dent 24(1):63\u201373. https:\/\/doi.org\/10.1007\/s40368-022-00761-3","journal-title":"Eur Arch Paediatr Dent"},{"key":"5327_CR34","doi-asserted-by":"publisher","first-page":"114157","DOI":"10.1016\/j.physbeh.2023.114157","volume":"265","author":"Y Zhou","year":"2023","unstructured":"Zhou Y, Liu Y, Yang C, Chen H (2023) Reactivity to food cues in spicy food cravers: Physiological and behavioral responses. Physiol Behav 265:114157. https:\/\/doi.org\/10.1016\/j.physbeh.2023.114157","journal-title":"Physiol Behav"},{"issue":"2","key":"5327_CR35","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1113\/jphysiol.1975.sp010811","volume":"244","author":"C Dawes","year":"1975","unstructured":"Dawes C (1975) Circadian rhythms in the flow rate and composition of unstimulated and stimulated human submandibular saliva. J Physiol 244(2):535\u2013548. https:\/\/doi.org\/10.1113\/jphysiol.1975.sp010811","journal-title":"J Physiol"},{"issue":"10","key":"5327_CR36","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1038\/bmt.2008.387","volume":"43","author":"I Avivi","year":"2009","unstructured":"Avivi I, Avraham S, Koren-Michowitz M, Zuckerman T, Aviv A, Ofran Y, Benyamini N, Nagler A, Rowe JM, Nagler RM (2009) Oral integrity and salivary profile in myeloma patients undergoing high-dose therapy followed by autologous SCT. Bone Marrow Transplant 43(10):801\u2013806. https:\/\/doi.org\/10.1038\/bmt.2008.387","journal-title":"Bone Marrow Transplant"},{"issue":"6","key":"5327_CR37","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1590\/0103-6440201802302","volume":"29","author":"BA Agostini","year":"2018","unstructured":"Agostini BA, Cericato GO, Silveira ERD, Nascimento GG, Costa FDS, Thomson WM, Demarco FF (2018) How common is dry mouth? Systematic review and meta-regression analysis of prevalence estimates. Braz Dent J 29(6):606\u2013618. https:\/\/doi.org\/10.1590\/0103-6440201802302","journal-title":"Braz Dent J"},{"issue":"3","key":"5327_CR38","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1159\/000525599","volume":"56","author":"MS Bulthuis","year":"2022","unstructured":"Bulthuis MS, van Gennip LLA, Thomas RZ, Bronkhorst EM, Laheij A, Raber-Durlacher JE, Rozema FR, Brennan MT, von Bultzingslowen I, Blijlevens NMA, van Leeuwen SJM, Huysmans M (2022) Caries progression after haematopoietic stem cell transplantation and the role of hyposalivation. Caries Res 56(3):187\u2013196. https:\/\/doi.org\/10.1159\/000525599","journal-title":"Caries Res"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-023-05327-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-023-05327-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-023-05327-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T04:34:33Z","timestamp":1702355673000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-023-05327-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,18]]},"references-count":38,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["5327"],"URL":"https:\/\/doi.org\/10.1007\/s00784-023-05327-1","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,18]]},"assertion":[{"value":"30 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval was obtained (NL52117.018.15) and the study was conducted according to GCP guidelines and the World Medical Association Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Before participating, written informed consent was obtained from all patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}