{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:54Z","timestamp":1789084854813,"version":"build-2803163510"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"DOI":"10.1007\/s00784-023-05354-y","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T15:02:38Z","timestamp":1698332558000},"page":"7651-7662","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessment of cardiovascular alterations and catecholamines serum concentration after oral surgery in patients receiving local anesthetics with epinephrine: a randomized, blind, controlled clinical trial"],"prefix":"10.1007","volume":"27","author":[{"given":"Marcelo Leite Machado","family":"da Silveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ormuz Dumont","family":"da Concei\u00e7\u00e3o Co\u00ealho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano Rocha","family":"Germano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,26]]},"reference":[{"key":"5354_CR1","volume-title":"Manual de anestesia local","author":"SF Malamed","year":"2005","unstructured":"Malamed SF (2005) Manual de anestesia local, 5th edn. Elsevier, Rio de Janeiro","edition":"5"},{"key":"5354_CR2","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/0030-4220(88)90310-6","volume":"66","author":"JG Meechan","year":"1988","unstructured":"Meechan JG, Rawlins MD (1988) The effects of two different dental local anesthetic solutions on plasma potassium levels during third molar surgery. Oral Surg Oral Med Oral Pathol 66:650\u2013653","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"5354_CR3","doi-asserted-by":"publisher","first-page":"623","DOI":"10.14219\/jada.archive.1983.0307","volume":"107","author":"JT Jastak","year":"1983","unstructured":"Jastak JT, Yagiela JA (1983) Vasoconstrictors and local anesthesia: a review and rationale for use. J Am Dent Assoc 107:623\u2013630","journal-title":"J Am Dent Assoc"},{"key":"5354_CR4","doi-asserted-by":"publisher","first-page":"41","DOI":"10.14219\/jada.archive.1982.0114","volume":"104","author":"AG Tolas","year":"1982","unstructured":"Tolas AG, Pflug AE, Halter JB (1982) Arterial plasma epinephrine concentrations and hemodynamic responses after dental injection of local anesthetic with epinephrine. J Am Dent Assoc 104:41\u201343","journal-title":"J Am Dent Assoc"},{"key":"5354_CR5","volume-title":"Tratado de Fisiologia M\u00e9dica","author":"AC Guyton","year":"2017","unstructured":"Guyton AC, Hall EJ (2017) Tratado de Fisiologia M\u00e9dica, 13th edn. Elsevier, Rio de Janeiro","edition":"13"},{"key":"5354_CR6","doi-asserted-by":"publisher","first-page":"639","DOI":"10.14219\/jada.archive.1986.0245","volume":"113","author":"AL Hasse","year":"1986","unstructured":"Hasse AL, Heng MK, Garrett NR (1986) Blood pressure and electrocardiographic response to dental treatment with use of local anesthesia. J Am Dent Assoc 113:639\u2013642","journal-title":"J Am Dent Assoc"},{"key":"5354_CR7","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/0278-2391(91)90059-U","volume":"49","author":"E Knoll-K\u00f6hler","year":"1991","unstructured":"Knoll-K\u00f6hler E, Kn\u00f6ller M, Brandt K, Becker J (1991) Cardiohemodynamic and serum catecholamine response to surgical removal of impacted mandibular third molars under local anesthesia: a randomized double-blind parallel group and crossover study. J Oral Maxillofac Surg 49:957\u2013962","journal-title":"J Oral Maxillofac Surg"},{"key":"5354_CR8","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1902\/jop.1990.61.9.553","volume":"61","author":"RE Davenport","year":"1990","unstructured":"Davenport RE, Porcelli RJ, Iacono VJ, Bonura CF, Mallis GI, Baer PN (1990) Effects of anesthetics containing epinephrine on catecholamine levels during periodontal surgery. J Periodontol 61:553\u2013558","journal-title":"J Periodontol"},{"key":"5354_CR9","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.tripleo.2005.01.005","volume":"100","author":"AM Viana","year":"2005","unstructured":"Viana AM, Campos AC, Morlin MT, Chin VK (2005) Plasma catecholamine concentrations and hemodynamic responses to vasoconstrictor during conventional or Gow-Gates mandibular anesthesia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:415\u2013419","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"5354_CR10","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1067\/moe.2001.118903","volume":"92","author":"H Niwa","year":"2001","unstructured":"Niwa H, Sugimura M, Satoh Y, Tanimoto A (2001) Cardiovascular response to epinephrine-containing local anesthesia in patients with cardiovascular disease. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 92:610\u2013616","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"5354_CR11","unstructured":"Doyle DJ, Goyal A, Bansal P, Garmon EH (2022) American Society of Anesthesiologists Classification. StatPearls, Treasure Island"},{"key":"5354_CR12","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1210\/jcem-69-3-546","volume":"69","author":"ES Troullos","year":"1989","unstructured":"Troullos ES, Hargreaves KM, Goldstein DS, Stull R, Dionne RA (1989) Epinephrine suppresses stress-induced increases in plasma immunoreactive beta-endorphin in humans. J Clin Endocrinol Metab 69:546\u2013551","journal-title":"J Clin Endocrinol Metab"},{"key":"5354_CR13","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1291\/hypres.24.209","volume":"24","author":"Y Nakamura","year":"2001","unstructured":"Nakamura Y, Matsumura K, Miura K, Kurokawa H, Abe I, Takata Y (2001) Cardiovascular and sympathetic responses to dental surgery with local anesthesia. Hypertens Res 24:209\u2013214","journal-title":"Hypertens Res"},{"key":"5354_CR14","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.14219\/jada.archive.2006.0092","volume":"137","author":"EV Hersh","year":"2006","unstructured":"Hersh EV, Giannakopoulos H, Levin LM, Secreto S, Moore PA, Peterson C et al (2006) The pharmacokinetics and cardiovascular effects of high-dose articaine with 1:100,000 and 1:200,000 epinephrine. J Am Dent Assoc 137:1562\u20131571","journal-title":"J Am Dent Assoc"},{"key":"5354_CR15","first-page":"6","volume":"18","author":"M Lipp","year":"1993","unstructured":"Lipp M, Dick W, Daubl\u00e4nder M, Fuder H, Stanton-Hicks M (1993) Exogenous and endogenous plasma levels of epinephrine during dental treatment under local anesthesia. Reg Anesth 18:6\u201312","journal-title":"Reg Anesth"},{"key":"5354_CR16","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1213\/00000539-198407000-00003","volume":"63","author":"RA Dionne","year":"1984","unstructured":"Dionne RA, Goldstein DS, Wirdzek PR (1984) Effects of diazepam premedication and epinephrine-containing local anesthetic on cardiovascular and plasma catecholamine responses to oral surgery. Anesth Analg 63:640\u2013646","journal-title":"Anesth Analg"},{"key":"5354_CR17","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1177\/00220345890680060801","volume":"68","author":"E Knoll-K\u00f6hler","year":"1989","unstructured":"Knoll-K\u00f6hler E, Frie A, Becker J, Ohlendorf D (1989) Changes in plasma epinephrine concentration after dental infiltration anesthesia with different doses of epinephrine. J Dent Res 68:1098\u20131101","journal-title":"J Dent Res"},{"key":"5354_CR18","doi-asserted-by":"publisher","first-page":"117","DOI":"10.5455\/medarh.2015.117-122","volume":"69","author":"ZB Agani","year":"2015","unstructured":"Agani ZB, Benedetti A, Krasniqi VH, Ahmedi J, Sejfija Z, Loxha MP et al (2015) Cortisol level and hemodynamic changes during tooth extraction at hypertensive and normotensive patients. Med Arch 69:117\u2013122","journal-title":"Med Arch"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-023-05354-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-023-05354-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-023-05354-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T04:36:20Z","timestamp":1702355780000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-023-05354-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,26]]},"references-count":18,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["5354"],"URL":"https:\/\/doi.org\/10.1007\/s00784-023-05354-y","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,26]]},"assertion":[{"value":"14 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This is a randomized controlled trial approved by the Federal University of Rio Grande do Norte (UFRN) Research Ethics Committee, registered under CAAE 43783614.6.00005292. This study was registered publicly on the Brazilian Registry of Clinical Trials (REBEC) with identification code RBR-96wmytm. All procedures performed involving human participants were in accordance with the ethical standards of the Institutional Research Committee and the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}