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The eligibility criteria were clinical studies reporting patients rehabilitated with zirconia implants. The cumulative survival rate (CSR) of implants was calculated. A meta-analysis for marginal bone loss (MBL) under different follow-up times and a meta-regression assessing the relationship between mean MBL and follow-up were done.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty-five studies were included (4017 implants, 2083 patients). Seven studies had follow-up longer than 60\u00a0months. 172 implants failed, after a mean of 12.0\u2009\u00b1\u200916.1\u00a0months (min\u2013max 0.3\u201386.0), of which 47 early failures, and 26 due to implant fracture, the majority in narrow-diameter implants. The 10-year CSR was 95.1%. Implants with coronal part prepared by drills presented statistically significant lower survival than non-prepared implants (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Two-piece implants presented lower survival than one-piece implants (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017). Implants discontinued from the market presented lower survival than the commercially available ones (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The difference in survival was not significant between implants in maxilla and mandible (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.637). The mean MBL fluctuated between 0.632 and 2.060\u00a0mm over long periods of observation (up until 132\u00a0months). There was an estimated MBL increase of 0.005\u00a0mm per additional month of follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Zirconia implants present high 10-year CSR and short-term low MBL.<\/jats:p>\n                    <jats:p>The review was registered in PROSPERO (CRD42022342055).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>The clinical outcomes observed for zirconia dental implants are very promising, although these have not yet been extensively studied as titanium alloy implants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-023-05401-8","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T23:34:16Z","timestamp":1703288056000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Clinical outcomes of zirconia implants: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"28","author":[{"given":"Parvin","family":"Mohseni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Soufi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Ramos","family":"Chrcanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,23]]},"reference":[{"key":"5401_CR1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/1746-160x-4-30","volume":"4","author":"R Depprich","year":"2008","unstructured":"Depprich R, Zipprich H, Ommerborn M, Naujoks C, Wiesmann HP, Kiattavorncharoen S, Lauer HC, Meyer U, K\u00fcbler NR, Handschel J (2008) Osseointegration of zirconia implants compared with titanium: an in vivo study. 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