{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:48:50Z","timestamp":1791892130194,"version":"4.3.4"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"DOI":"10.1007\/s00784-023-05447-8","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T02:02:37Z","timestamp":1703728957000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy of injectable platelet-rich fibrin on clinical and biochemical parameters in non-surgical periodontal treatment: a split-mouth randomized controlled trial"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5362-4146","authenticated-orcid":false,"given":"Gizem","family":"Torumtay Cin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5939-4783","authenticated-orcid":false,"given":"Aysan","family":"Lektemur Alpan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9325-3757","authenticated-orcid":false,"given":"\u00d6zge","family":"\u00c7evik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,28]]},"reference":[{"key":"5447_CR1","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1111\/j.1600-051X.2009.01408.x","volume":"36","author":"A Savage","year":"2009","unstructured":"Savage A, Eaton KA, Moles DR, Needleman I (2009) A systematic review of definitions of periodontitis and methods that have been used to identify this disease. J Clin Periodontol 36:458\u2013467. https:\/\/doi.org\/10.1111\/j.1600-051X.2009.01408.x","journal-title":"J Clin Periodontol"},{"issue":"60","key":"5447_CR2","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1111\/j.1600-0757.2011.00429.x","volume":"2000","author":"J Slots","year":"2012","unstructured":"Slots J (2012) Low-cost periodontal. Periodontology 2000(60):110\u2013137. https:\/\/doi.org\/10.1111\/j.1600-0757.2011.00429.x","journal-title":"Periodontology"},{"key":"5447_CR3","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1002\/JPER.20-0713","volume":"92","author":"E Ozcan","year":"2021","unstructured":"Ozcan E, Saygun I, Kantarci A, Ozarslanturk S, Serdar MA, Ozgurtas T (2021) The effects of a novel non-invasive application of platelet-rich fibrin on periodontal clinical parameters and gingival crevicular fluid transforming growth factor-beta and collagen-1 levels: a randomized, controlled, clinical study. J Periodontol 92:1252\u20131261. https:\/\/doi.org\/10.1002\/JPER.20-0713","journal-title":"J Periodontol"},{"key":"5447_CR4","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1111\/prd.12008","volume":"62","author":"LJ Heitz-Mayfield","year":"2013","unstructured":"Heitz-Mayfield LJ, Lang NP (2013) Surgical and nonsurgical periodontal therapy. Learned and unlearned concepts. Periodontol 2000 62:218\u2013231. https:\/\/doi.org\/10.1111\/prd.12008","journal-title":"Periodontol 2000"},{"key":"5447_CR5","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1186\/s13148-020-00982-7","volume":"12","author":"KT Jurdzi\u0144ski","year":"2020","unstructured":"Jurdzi\u0144ski KT, Potempa J, Grabiec AM (2020) Epigenetic regulation of inflammation in periodontitis: cellular mechanisms and therapeutic potential. Clin Epigenet 12:186. https:\/\/doi.org\/10.1186\/s13148-020-00982-7","journal-title":"Clin Epigenet"},{"key":"5447_CR6","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41368-019-0064-z","volume":"11","author":"W Pan","year":"2019","unstructured":"Pan W, Wang Q, Chen Q (2019) The cytokine network involved in the host immune response to periodontitis. Int J Oral Sci 11:30. https:\/\/doi.org\/10.1038\/s41368-019-0064-z","journal-title":"Int J Oral Sci"},{"key":"5447_CR7","doi-asserted-by":"publisher","first-page":"847","DOI":"10.3892\/etm.2013.1222","volume":"6","author":"MK Noh","year":"2013","unstructured":"Noh MK, Jung M, Kim SH, Lee SR, Park KH, Kim DH, Kim HH, Park YG (2013) Assessment of IL-6, IL-8 and TNF-alpha levels in the gingival tissue of patients with periodontitis. Exp Ther Med 6:847\u2013851. https:\/\/doi.org\/10.3892\/etm.2013.1222","journal-title":"Exp Ther Med"},{"key":"5447_CR8","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1034\/j.1600-0757.2003.03106.x","volume":"31","author":"VJ Uitto","year":"2000","unstructured":"Uitto VJ (2000) Overall CM and McCulloch C (2003) Proteolytic host cell enzymes in gingival crevice fluid. Periodontology 31:77\u2013104. https:\/\/doi.org\/10.1034\/j.1600-0757.2003.03106.x","journal-title":"Periodontology"},{"key":"5447_CR9","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/j.1601-0825.2008.01491.x","volume":"15","author":"MF Bastos","year":"2009","unstructured":"Bastos MF, Lima JA, Vieira PM, Mestnik MJ, Faveri M, Duarte PM (2009) TNF-alpha and IL-4 levels in generalized aggressive periodontitis subjects. Oral Dis 15:82\u201387. https:\/\/doi.org\/10.1111\/j.1601-0825.2008.01491.x","journal-title":"Oral Dis"},{"key":"5447_CR10","doi-asserted-by":"publisher","first-page":"e32427","DOI":"10.5812\/hepatmon.32427","volume":"16","author":"B Moudi","year":"2016","unstructured":"Moudi B, Heidari Z, Mahmoudzadeh-Sagheb H, Hashemi M, Metanat M, Khosravi S, Farrokh P (2016) Association between IL-10 gene promoter polymorphisms (-592 A\/C, -819 T\/C, -1082 A\/G) and susceptibility to HBV infection in an Iranian population. Hepat Mon 16:e32427. https:\/\/doi.org\/10.5812\/hepatmon.32427","journal-title":"Hepat Mon"},{"key":"5447_CR11","doi-asserted-by":"publisher","first-page":"6131","DOI":"10.1038\/ncomms7131","volume":"6","author":"B Li","year":"2015","unstructured":"Li B, Gurung P, Malireddi RKS, Vogel P, Kanneganti T-D, Geiger TL (2015) IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis. Nat Commun 6:6131. https:\/\/doi.org\/10.1038\/ncomms7131","journal-title":"Nat Commun"},{"key":"5447_CR12","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12950-021-00281-9","volume":"18","author":"B Ren","year":"2021","unstructured":"Ren B, Feng Q, He S, Li Y, Fan J, Chai G, Liu L, Liu H, Yang C, Wang Y, Liu H, Liu H, Song Y (2021) VEGF as a potential molecular target in periodontitis: a meta-analysis and microarray data validation. J Inflamm 18:18. https:\/\/doi.org\/10.1186\/s12950-021-00281-9","journal-title":"J Inflamm"},{"key":"5447_CR13","first-page":"7922","volume":"8","author":"E Borie","year":"2015","unstructured":"Borie E, Olivi DG, Orsi IA, Garlet K, Weber B, Beltran V, Fuentes R (2015) Platelet-rich fibrin application in dentistry: a literature review. Int J Clin Exp Med 8:7922\u20137929","journal-title":"Int J Clin Exp Med"},{"key":"5447_CR14","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s00068-017-0767-9","volume":"44","author":"J Choukroun","year":"2018","unstructured":"Choukroun J, Ghanaati S (2018) Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients' own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept. Eur J Trauma Emerg Surg 44:87\u201395. https:\/\/doi.org\/10.1007\/s00068-017-0767-9","journal-title":"Eur J Trauma Emerg Surg"},{"key":"5447_CR15","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s10006-020-00899-8","volume":"25","author":"S Jasmine","year":"2021","unstructured":"Jasmine S, Thangavelu A, Krishnamoorthy R, Alshuniaber MA, Alshatwi AA (2021) Cytokine expression pattern and protein-protein interaction network analysis of leucocyte rich platelet rich fibrin and injectable form of platelet rich fibrin. Oral Maxillofac Surg 25:223\u2013229. https:\/\/doi.org\/10.1007\/s10006-020-00899-8","journal-title":"Oral Maxillofac Surg"},{"key":"5447_CR16","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1563\/aaid-joi-D-17-00231","volume":"45","author":"L Lei","year":"2019","unstructured":"Lei L, Yu Y, Ke T, Sun W, Chen L (2019) The application of three-dimensional printing model and platelet-rich fibrin technology in guided tissue regeneration surgery for severe bone defects. J Oral Implantol 45:35\u201343. https:\/\/doi.org\/10.1563\/aaid-joi-D-17-00231","journal-title":"J Oral Implantol"},{"key":"5447_CR17","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1177\/0885328220914407","volume":"35","author":"S Kyyak","year":"2020","unstructured":"Kyyak S, Blatt S, Pabst A, Thiem D, Al-Nawas B, Kammerer PW (2020) Combination of an allogenic and a xenogenic bone substitute material with injectable platelet-rich fibrin - a comparative in vitro study. J Biomater Appl 35:83\u201396. https:\/\/doi.org\/10.1177\/0885328220914407","journal-title":"J Biomater Appl"},{"key":"5447_CR18","doi-asserted-by":"publisher","first-page":"e28647","DOI":"10.7759\/cureus.28647","volume":"14","author":"M Gollapudi","year":"2022","unstructured":"Gollapudi M, Bajaj P, Oza RR (2022) Injectable platelet-rich fibrin - a revolution in periodontal regeneration. Cureus 14:e28647. https:\/\/doi.org\/10.7759\/cureus.28647","journal-title":"Cureus"},{"key":"5447_CR19","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.actbio.2018.05.021","volume":"75","author":"RJ Miron","year":"2018","unstructured":"Miron RJ, Zhang Y (2018) Autologous liquid platelet rich fibrin: a novel drug delivery system. Acta Biomaterialia 75:35\u201351. https:\/\/doi.org\/10.1016\/j.actbio.2018.05.021","journal-title":"Acta Biomaterialia"},{"key":"5447_CR20","doi-asserted-by":"publisher","first-page":"112557","DOI":"10.1016\/j.msec.2021.112557","volume":"134","author":"N Farshidfar","year":"2022","unstructured":"Farshidfar N, Amiri MA, Jafarpour D, Hamedani S, Niknezhad SV, Tayebi L (2022) The feasibility of injectable PRF (I-PRF) for bone tissue engineering and its application in oral and maxillofacial reconstruction: From bench to chairside. Biomater Adv 134:112557. https:\/\/doi.org\/10.1016\/j.msec.2021.112557","journal-title":"Biomater Adv"},{"key":"5447_CR21","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1007\/s10856-017-5992-6","volume":"28","author":"S Wend","year":"2017","unstructured":"Wend S, Kubesch A, Orlowska A, Al-Maawi S, Zender N, Dias A, Miron RJ, Sader R, Booms P, Kirkpatrick CJ, Choukroun J, Ghanaati S (2017) Reduction of the relative centrifugal force influences cell number and growth factor release within injectable PRF-based matrices. J Mater Sci: Mater Med 28:188. https:\/\/doi.org\/10.1007\/s10856-017-5992-6","journal-title":"J Mater Sci: Mater Med"},{"key":"5447_CR22","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1007\/s00784-017-2063-9","volume":"21","author":"RJ Miron","year":"2017","unstructured":"Miron RJ, Fujioka-Kobayashi M, Hernandez M, Kandalam U, Zhang Y, Ghanaati S, Choukroun J (2017) Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry? Clin Oral Investig 21:2619\u20132627. https:\/\/doi.org\/10.1007\/s00784-017-2063-9","journal-title":"Clin Oral Investig"},{"key":"5447_CR23","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1002\/jbm.a.36792","volume":"108","author":"J Zhang","year":"2020","unstructured":"Zhang J, Yin C, Zhao Q, Zhao Z, Wang J, Miron RJ, Zhang Y (2020) Anti-inflammation effects of injectable platelet-rich fibrin via macrophages and dendritic cells. J Biomed Mater Res A 108:61\u201368. https:\/\/doi.org\/10.1002\/jbm.a.36792","journal-title":"J Biomed Mater Res A"},{"key":"5447_CR24","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.mam.2017.07.005","volume":"58","author":"B Wu","year":"2017","unstructured":"Wu B, Mottola G, Schaller M, Upchurch GR Jr, Conte MS (2017) Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications. Mol Aspects Med 58:72\u201382. https:\/\/doi.org\/10.1016\/j.mam.2017.07.005","journal-title":"Mol Aspects Med"},{"key":"5447_CR25","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/j.1600-0757.2006.00157.x","volume":"41","author":"G Polimeni","year":"2006","unstructured":"Polimeni G, Xiropaidis AV, Wikesjo UM (2006) Biology and principles of periodontal wound healing\/regeneration. Periodontol 2000 41:30\u201347. https:\/\/doi.org\/10.1111\/j.1600-0757.2006.00157.x","journal-title":"Periodontol 2000"},{"key":"5447_CR26","doi-asserted-by":"publisher","first-page":"S126","DOI":"10.4103\/JPBS.JPBS_41_19","volume":"11","author":"SP Mohan","year":"2019","unstructured":"Mohan SP, Jaishangar N, Devy S, Narayanan A, Cherian D, Madhavan SS (2019) Platelet-rich plasma and platelet-rich fibrin in periodontal regeneration: a review. J Pharm Bioallied Sci 11:S126\u2013S130. https:\/\/doi.org\/10.4103\/JPBS.JPBS_41_19","journal-title":"J Pharm Bioallied Sci"},{"key":"5447_CR27","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1902\/jop.2017.160485","volume":"88","author":"T Arabaci","year":"2017","unstructured":"Arabaci T, Kose O, Albayrak M, Cicek Y, Kizildag A (2017) Advantages of autologous platelet-rich fibrin membrane on gingival crevicular fluid growth factor levels and periodontal healing: a randomized split-mouth clinical study. J Periodontol 88:771\u2013777. https:\/\/doi.org\/10.1902\/jop.2017.160485","journal-title":"J Periodontol"},{"key":"5447_CR28","doi-asserted-by":"publisher","first-page":"4744","DOI":"10.12659\/MSM.915142","volume":"25","author":"BS Izol","year":"2019","unstructured":"Izol BS, Uner DD (2019) A new approach for root surface biomodification using injectable platelet-rich fibrin (I-PRF). Med Sci Monit 25:4744\u20134750. https:\/\/doi.org\/10.12659\/MSM.915142","journal-title":"Med Sci Monit"},{"key":"5447_CR29","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/jcpe.13247","volume":"47","author":"ZB Ozsagir","year":"2020","unstructured":"Ozsagir ZB, Saglam E, Sen Yilmaz B, Choukroun J, Tunali M (2020) Injectable platelet-rich fibrin and microneedling for gingival augmentation in thin periodontal phenotype: a randomized controlled clinical trial. J Clin Periodontol 47:489\u2013499. https:\/\/doi.org\/10.1111\/jcpe.13247","journal-title":"J Clin Periodontol"},{"key":"5447_CR30","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1007\/s10266-020-00557-1","volume":"109","author":"HS Aydinyurt","year":"2021","unstructured":"Aydinyurt HS, Sancak T, Taskin C, Basbugan Y, Akinci L (2021) Effects of injectable platelet-rich fibrin in experimental periodontitis in rats. Odontology 109:422\u2013432. https:\/\/doi.org\/10.1007\/s10266-020-00557-1","journal-title":"Odontology"},{"key":"5447_CR31","doi-asserted-by":"publisher","first-page":"676","DOI":"10.3290\/j.qi.b1492019","volume":"52","author":"H Albonni","year":"2021","unstructured":"Albonni H, El Abdelah A, Al Hamwi M, Al Hamoui WB, Sawaf H (2021) Clinical effectiveness of a topical subgingival application of injectable platelet-rich fibrin as adjunctive therapy to scaling and root planing: a double-blind, split-mouth, randomized, prospective, comparative controlled trial. Quintessence Int 52:676\u2013685. https:\/\/doi.org\/10.3290\/j.qi.b1492019","journal-title":"Quintessence Int"},{"key":"5447_CR32","first-page":"455","volume":"59","author":"CS Melincovici","year":"2018","unstructured":"Melincovici CS, Bosca AB, Susman S, Marginean M, Mihu C, Istrate M, Moldovan IM, Roman AL, Mihu CM (2018) Vascular endothelial growth factor (VEGF) - key factor in normal and pathological angiogenesis. Rom J Morphol Embryol 59:455\u2013467","journal-title":"Rom J Morphol Embryol"},{"key":"5447_CR33","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1034\/j.1600-0765.2003.01646.x","volume":"38","author":"K Suthin","year":"2003","unstructured":"Suthin K, Matsushita K, Machigashira M, Tatsuyama S, Imamura T, Torii M, Izumi Y (2003) Enhanced expression of vascular endothelial growth factor by periodontal pathogens in gingival fibroblasts. J Periodontal Res 38:90\u201396. https:\/\/doi.org\/10.1034\/j.1600-0765.2003.01646.x","journal-title":"J Periodontal Res"},{"key":"5447_CR34","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1034\/j.1600-0714.2000.291004.x","volume":"29","author":"CC Chapple","year":"2000","unstructured":"Chapple CC, Kumar RK, Hunter N (2000) Vascular remodelling in chronic inflammatory periodontal disease. J Oral Pathol Med 29:500\u2013506. https:\/\/doi.org\/10.1034\/j.1600-0714.2000.291004.x","journal-title":"J Oral Pathol Med"},{"key":"5447_CR35","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1902\/jop.2003.74.2.181","volume":"74","author":"F Unlu","year":"2003","unstructured":"Unlu F, Guneri PG, Hekimgil M, Yesilbek B, Boyacioglu H (2003) Expression of vascular endothelial growth factor in human periodontal tissues: comparison of healthy and diabetic patients. J Periodontol 74:181\u2013187. https:\/\/doi.org\/10.1902\/jop.2003.74.2.181","journal-title":"J Periodontol"},{"key":"5447_CR36","doi-asserted-by":"publisher","unstructured":"Fernandez-Medina T, Vaquette C, Ivanovski S (2019) Systematic comparison of the effect of four clinical-grade platelet rich hemoderivatives on osteoblast behaviour. Int J Mol Sci 20. https:\/\/doi.org\/10.3390\/ijms20246243","DOI":"10.3390\/ijms20246243"},{"key":"5447_CR37","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1002\/term.2475","volume":"12","author":"E Dohle","year":"2018","unstructured":"Dohle E, El Bagdadi K, Sader R, Choukroun J, James Kirkpatrick C, Ghanaati S (2018) Platelet-rich fibrin-based matrices to improve angiogenesis in an in vitro co-culture model for bone tissue engineering. J Tissue Eng Regen Med 12:598\u2013610. https:\/\/doi.org\/10.1002\/term.2475","journal-title":"J Tissue Eng Regen Med"},{"key":"5447_CR38","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1007\/s11914-017-0358-z","volume":"15","author":"B Zhao","year":"2017","unstructured":"Zhao B (2017) TNF and bone remodeling. Curr Osteoporos Rep 15:126\u2013134. https:\/\/doi.org\/10.1007\/s11914-017-0358-z","journal-title":"Curr Osteoporos Rep"},{"key":"5447_CR39","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1111\/jre.12131","volume":"49","author":"R Fujihara","year":"2014","unstructured":"Fujihara R, Usui M, Yamamoto G, Nishii K, Tsukamoto Y, Okamatsu Y, Sato T, Asou Y, Nakashima K, Yamamoto M (2014) Tumor necrosis factor-alpha enhances RANKL expression in gingival epithelial cells via protein kinase A signaling. J Periodontal Res 49:508\u2013517. https:\/\/doi.org\/10.1111\/jre.12131","journal-title":"J Periodontal Res"},{"key":"5447_CR40","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3389\/fimmu.2014.00048","volume":"5","author":"B Osta","year":"2014","unstructured":"Osta B, Benedetti G, Miossec P (2014) Classical and paradoxical effects of TNF-alpha on bone homeostasis. Front Immunol 5:48. https:\/\/doi.org\/10.3389\/fimmu.2014.00048","journal-title":"Front Immunol"},{"key":"5447_CR41","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1111\/jre.12339","volume":"51","author":"K Algate","year":"2016","unstructured":"Algate K, Haynes DR, Bartold PM, Crotti TN, Cantley MD (2016) The effects of tumour necrosis factor-alpha on bone cells involved in periodontal alveolar bone loss; osteoclasts, osteoblasts and osteocytes. J Periodontal Res 51:549\u2013566. https:\/\/doi.org\/10.1111\/jre.12339","journal-title":"J Periodontal Res"},{"key":"5447_CR42","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1038\/ni.1791","volume":"10","author":"M Murai","year":"2009","unstructured":"Murai M, Turovskaya O, Kim G, Madan R, Karp CL, Cheroutre H, Kronenberg M (2009) Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat Immunol 10:1178\u20131184. https:\/\/doi.org\/10.1038\/ni.1791","journal-title":"Nat Immunol"},{"key":"5447_CR43","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.4049\/jimmunol.0804165","volume":"183","author":"KH Park-Min","year":"2009","unstructured":"Park-Min KH, Ji JD, Antoniv T, Reid AC, Silver RB, Humphrey MB, Nakamura M, Ivashkiv LB (2009) IL-10 suppresses calcium-mediated costimulation of receptor activator NF-kappa B signaling during human osteoclast differentiation by inhibiting TREM-2 expression. J Immunol 183:2444\u20132455. https:\/\/doi.org\/10.4049\/jimmunol.0804165","journal-title":"J Immunol"},{"key":"5447_CR44","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","volume":"19","author":"KW Moore","year":"2001","unstructured":"Moore KW, de Waal MR, Coffman RL, O\u2019Garra A (2001) Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19:683\u2013765. https:\/\/doi.org\/10.1146\/annurev.immunol.19.1.683","journal-title":"Annu Rev Immunol"},{"key":"5447_CR45","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/j.1365-2249.2006.03318.x","volume":"148","author":"CW Ernst","year":"2007","unstructured":"Ernst CW, Lee JE, Nakanishi T, Karimbux NY, Rezende TM, Stashenko P, Seki M, Taubman MA, Kawai T (2007) Diminished forkhead box P3\/CD25 double-positive T regulatory cells are associated with the increased nuclear factor-kappaB ligand (RANKL+) T cells in bone resorption lesion of periodontal disease. Clin Exp Immunol 148:271\u2013280. https:\/\/doi.org\/10.1111\/j.1365-2249.2006.03318.x","journal-title":"Clin Exp Immunol"},{"key":"5447_CR46","first-page":"34","volume":"15","author":"S Maheshwari","year":"2021","unstructured":"Maheshwari S, Grover V, Gupta J, Kumar N, Jain A (2021) Effect of non-surgical periodontal therapy on the serum and crevicular fluid interleukin-10 levels in chronic periodontitis - a systematic review and meta-analysis. Int J Health Sci (Qassim) 15:34\u201346","journal-title":"Int J Health Sci (Qassim)"},{"key":"5447_CR47","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.jdent.2004.04.003","volume":"32","author":"P Goutoudi","year":"2004","unstructured":"Goutoudi P, Diza E, Arvanitidou M (2004) Effect of periodontal therapy on crevicular fluid interleukin-1beta and interleukin-10 levels in chronic periodontitis. J Dent 32:511\u2013520. https:\/\/doi.org\/10.1016\/j.jdent.2004.04.003","journal-title":"J Dent"},{"key":"5447_CR48","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1007\/s00784-018-2555-2","volume":"23","author":"HA Varela","year":"2019","unstructured":"Varela HA, Souza JCM, Nascimento RM, Araujo RF Jr, Vasconcelos RC, Cavalcante RS, Guedes PM, Araujo AA (2019) Injectable platelet rich fibrin: cell content, morphological, and protein characterization. Clin Oral Investig 23:1309\u20131318. https:\/\/doi.org\/10.1007\/s00784-018-2555-2","journal-title":"Clin Oral Investig"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-023-05447-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-023-05447-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-023-05447-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T03:10:49Z","timestamp":1707361849000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-023-05447-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,28]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["5447"],"URL":"https:\/\/doi.org\/10.1007\/s00784-023-05447-8","relation":{},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,28]]},"assertion":[{"value":"25 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Permission was obtained from the Ethics Committee of Pamukkale University <b>(<\/b>22.02.2022\/04) for the study protocol.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"46"}}