{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:44:54Z","timestamp":1791575094915,"version":"4.3.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Health Sciences"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Oral Invest"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the effects of wound healing using injectable platelet-rich fibrin (IPRF) after gingivectomy and gingivoplasty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      In this clinical study, 46 systemically healthy patients with chronic inflammatory gingival enlargement were randomly treated with gingivectomy-gingivoplasty + I-PRF (\n                      <jats:italic>n<\/jats:italic>\n                      =23) or gingivectomy-gingivoplasty alone (\n                      <jats:italic>n<\/jats:italic>\n                      =23). The primary outcome was to evaluate the effect of I-PRF on wound healing over a 3-week follow-up period. Samples collected from gingival crevicular fluid\u00a0(GCF) were processed using enzyme-linked immunosorbent assay\u00a0(EL\u0130SA) to measure VEGF and FGF-10 biomarkers. The surgical areas were stained with Mira-2 tone and evaluated in ImageJ. Wound healing was evaluated with Modified Manchester Scar (MMS) scale and Landry, Turnbull, and Howley (LTH) index.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>VEGF values of the control group at baseline, week 2, and week 3 were significantly higher than the test group. In weeks 2 and 3, FGF-10 values were found to be significantly higher in the control group than the test group. The amount of staining was found to be significantly higher in the control group than in the test group on days 3, 7, and 14. LTH values of the control group were significantly lower than the test group and MMS values were significantly higher than those of the test group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>I-PRF applications revealed positive effects on epithelial wound healing after gingivectomy and gingivoplasty operations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance<\/jats:title>\n                    <jats:p>Platelet concentrates such as I-PRF accelerate wound healing and contribute to the patient\u2019s comfort and quality of life. I-PRF application may have positive effects on wound healing after gingivectomy and gingivoplasty operations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00784-023-05477-2","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T19:02:30Z","timestamp":1704826950000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The effects of injectable platelet-rich fibrin application on wound healing following gingivectomy and gingivoplasty operations: single-blind, randomized controlled, prospective clinical study"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7682-2498","authenticated-orcid":false,"given":"\u015eeyma \u00c7ardakc\u0131","family":"Bahar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8256-4947","authenticated-orcid":false,"given":"Nebi Cans\u0131n","family":"Karakan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1840-2900","authenticated-orcid":false,"given":"Ayhan","family":"Vurmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"5477_CR1","volume-title":"Carranza\u2019s clinical periodontology. St. Louis","author":"MG Newman","year":"2018","unstructured":"Newman MG, Takei H, Klokkevold PR, Carranza FA (2018) Carranza\u2019s clinical periodontology. St. Louis, 13th edn. Elsevier, Missouri","edition":"13"},{"issue":"5","key":"5477_CR2","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1111\/iwj.13379","volume":"17","author":"B Kusakci-Seker","year":"2020","unstructured":"Kusakci-Seker B, Demirayak-Akdemir M (2020) The effect of non-thermal atmospheric pressure plasma application on wound healing after gingivectomy. Int Wound J 17(5):1376\u20131383. https:\/\/doi.org\/10.1111\/iwj.13379","journal-title":"Int Wound J"},{"issue":"4","key":"5477_CR3","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1111\/j.2041-1626.2011.00072.x","volume":"2","author":"PV Patel","year":"2011","unstructured":"Patel PV, Kumar V, Kumar S, Gd V, Patel A (2011) Therapeutic effect of topical ozonated oil on the epithelial healing of palatal wound sites: a planimetrical and cytological study. J Investig Clin Dent 2(4):248\u2013258. https:\/\/doi.org\/10.1111\/j.2041-1626.2011.00072.x","journal-title":"J Investig Clin Dent"},{"key":"5477_CR4","volume-title":"Clinical periodontology and implant dentistry","year":"2015","unstructured":"Lang NP, Lindhe J (eds) (2015) Clinical periodontology and implant dentistry, 6th edn. Wiley and Blackwell Company","edition":"6"},{"issue":"2","key":"5477_CR5","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1902\/jop.2015.150198","volume":"87","author":"B Femminella","year":"2016","unstructured":"Femminella B, Iaconi MC, Di Tullio M et al (2016) Clinical comparison of platelet-rich fibrin and a gelatin sponge in the management of palatal wounds after epithelialized free gingival graft harvest: a randomized clinical trial. J Periodontol 87(2):103\u2013113. https:\/\/doi.org\/10.1902\/jop.2015.150198","journal-title":"J Periodontol"},{"issue":"7","key":"5477_CR6","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1007\/s10103-020-03037-8","volume":"35","author":"M\u00d6 Uslu","year":"2020","unstructured":"Uslu M\u00d6, Akg\u00fcl S (2020) Evaluation of the effects of photobiomodulation therapy and ozone applications after gingivectomy and gingivoplasty on postoperative pain and patients\u2019 oral health-related quality of life. Lasers Med Sci 35(7):1637\u20131647. https:\/\/doi.org\/10.1007\/s10103-020-03037-8","journal-title":"Lasers Med Sci"},{"issue":"2","key":"5477_CR7","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/0049-3848(83)90146-9","volume":"29","author":"TW Chow","year":"1983","unstructured":"Chow TW, McIntire LV, Peterson DM (1983) Importance of plasma fibronectin in determining PFP and PRP clot mechanical properties. Thromb Res 29(2):243\u2013248. https:\/\/doi.org\/10.1016\/0049-3848(83)90146-9","journal-title":"Thromb Res"},{"issue":"1","key":"5477_CR8","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s00068-017-0767-9","volume":"44","author":"J Choukroun","year":"2018","unstructured":"Choukroun J, Ghanaati S (2018) Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients\u2019 own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept. Eur J Trauma Emerg Surg 44(1):87\u201395. https:\/\/doi.org\/10.1007\/s00068-017-0767-9","journal-title":"Eur J Trauma Emerg Surg"},{"issue":"6","key":"5477_CR9","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1563\/aaid-joi-D-14-00138","volume":"40","author":"S Ghanaati","year":"2014","unstructured":"Ghanaati S, Booms P, Orlowska A (2014) Advanced platelet-rich fibrin: a new concept for cell-based tissue engineering by means of inflammatory cells. J Oral Implantol 40(6):679\u2013689. https:\/\/doi.org\/10.1563\/aaid-joi-D-14-00138","journal-title":"J Oral Implantol"},{"issue":"1","key":"5477_CR10","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1902\/jop.2016.160443","volume":"88","author":"M Fujioka-Kobayashi","year":"2017","unstructured":"Fujioka-Kobayashi M, Miron RJ, Hernandez M, Kandalam U, Zhang Y, Choukroun J (2017) Optimized platelet-rich fibrin with the low-speed concept: growth factor release, biocompatibility, and cellular response. J Periodontol 88(1):112\u2013121. https:\/\/doi.org\/10.1902\/jop.2016.160443","journal-title":"J Periodontol"},{"issue":"2","key":"5477_CR11","doi-asserted-by":"publisher","first-page":"27","DOI":"10.33204\/mucosa.707865","volume":"3","author":"ZB \u00d6zsa\u011f\u0131r","year":"2020","unstructured":"\u00d6zsa\u011f\u0131r ZB, Tunal\u0131 M (2020) Injectable platelet-rich fibrin: a new material in medicine and dentistry. Mucosa 3(2):27\u201333. https:\/\/doi.org\/10.33204\/mucosa.707865","journal-title":"Mucosa"},{"issue":"4","key":"5477_CR12","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.jobcr.2020.08.016","volume":"10","author":"AM Elsherbini","year":"2020","unstructured":"Elsherbini AM, Ezzat SK (2020) Effect of melatonin versus injectable platelet-rich fibrin on critical wound healing in submandibular salivary glands of diabetic rats. J Oral Biol Craniofac Res 10(4):592\u2013596. https:\/\/doi.org\/10.1016\/j.jobcr.2020.08.016","journal-title":"J Oral Biol Craniofac Res"},{"issue":"2","key":"5477_CR13","doi-asserted-by":"publisher","first-page":"331","DOI":"10.3390\/ijms18020331","volume":"18","author":"X Wang","year":"2017","unstructured":"Wang X, Zhang Y, Choukroun J, Ghanaati S, Miron RJ (2017) Behavior of gingival fibroblasts on titanium implant surfaces in combination with either injectable- PRF or PRP. Int J Mol Sci 18(2):331. https:\/\/doi.org\/10.3390\/ijms18020331","journal-title":"Int J Mol Sci"},{"key":"5477_CR14","doi-asserted-by":"publisher","first-page":"112557","DOI":"10.1016\/j.msec.2021.112557","volume":"134","author":"N Farshidfar","year":"2022","unstructured":"Farshidfar N, Amiri MA, Jafarpour D, Hamedani S, Niknezhad SV, Tayebi L (2022) The feasibility of injectable PRF (i-PRF) for bone tissue engineering and its application in oral and maxillofacial reconstruction: from bench to chairside. Biomater Adv 134:112557. https:\/\/doi.org\/10.1016\/j.msec.2021.112557","journal-title":"Biomater Adv"},{"issue":"3","key":"5477_CR15","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1007\/s00784-018-2555-2","volume":"23","author":"H Almeida Varela","year":"2019","unstructured":"Almeida Varela H, Souza JCM, Nascimento RM et al (2019) Injectable platelet rich fibrin: cell content, morphological, and protein characterization. Clin Oral Investig 23(3):1309\u20131318. https:\/\/doi.org\/10.1007\/s00784-018-2555-2","journal-title":"Clin Oral Investig"},{"issue":"12","key":"5477_CR16","doi-asserted-by":"publisher","first-page":"4549","DOI":"10.1007\/s00784-020-03320-6","volume":"24","author":"M K\u0131z\u0131ltoprak","year":"2020","unstructured":"K\u0131z\u0131ltoprak M, Uslu M\u00d6 (2020) (2020) Comparison of the effects of injectable platelet-rich fibrin and autologous fibrin glue applications on palatal wound healing: a randomized controlled clinical trial. Clin Oral Investig 24(12):4549\u20134561. https:\/\/doi.org\/10.1007\/s00784-020-03320-6","journal-title":"Clin Oral Investig"},{"issue":"4","key":"5477_CR17","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3290\/j.qi.b2449819","volume":"53","author":"E Bozkurt","year":"2022","unstructured":"Bozkurt E, Uslu M\u00d6 (2022) Evaluation of the effects of platelet-rich fibrin, concentrated growth factors, and autologous fibrin glue application on wound healing following gingivectomy and gingivoplasty operations: a randomized controlled clinical trial. Quintessence Int 53(4):328\u2013341. https:\/\/doi.org\/10.3290\/j.qi.b2449819","journal-title":"Quintessence Int"},{"key":"5477_CR18","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1902\/jop.2001.72.5.605","volume":"72","author":"J Miranda","year":"2001","unstructured":"Miranda J, Brunet L, Roset P, Berini L, Farre\u00b4 M, Mendieta C (2001) Prevalence and risk of gingival enlargement in patients treated with nifedipine. J Periodontol 72:605\u2013611. https:\/\/doi.org\/10.1902\/jop.2001.72.5.605","journal-title":"J Periodontol"},{"key":"5477_CR19","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1902\/jop.1992.63.5.453","volume":"63","author":"CS Miller","year":"1992","unstructured":"Miller CS, Damm DD (1992) Incidence of verapamil-induced gingival hyperplasia in a dental population. J Periodontol 63:453\u2013456. https:\/\/doi.org\/10.1902\/jop.1992.63.5.453","journal-title":"J Periodontol"},{"issue":"7","key":"5477_CR20","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1111\/jcpe.12750","volume":"44","author":"F Cairo","year":"2017","unstructured":"Cairo F, Barbato L, Tonelli P, Batalocco G, Pagavino G, Nieri M (2017) Xenogeneic collagen matrix versus connective tissue graft for buccal soft tissue augmentation at implant site. A randomized, controlled clinical trial. J Clin Periodontol 44(7):769\u2013776. https:\/\/doi.org\/10.1111\/jcpe.12750","journal-title":"J Clin Periodontol"},{"issue":"9","key":"5477_CR21","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/j.1600-0757.1995.tb00055.x","volume":"1995","author":"L Flores-de-Jacoby","year":"1995","unstructured":"Flores-de-Jacoby L, Mengel R (1995) Conventional surgical procedures. Periodontol 1995(9):38\u201354. https:\/\/doi.org\/10.1111\/j.1600-0757.1995.tb00055.x","journal-title":"Periodontol"},{"issue":"6","key":"5477_CR22","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1902\/jop.1967.38.6.610","volume":"38","author":"H L\u00f6e","year":"1967","unstructured":"L\u00f6e H (1967) The gingival index, the plaque index and the retention index systems. J Periodontol 38(6):610\u2013616. https:\/\/doi.org\/10.1902\/jop.1967.38.6.610","journal-title":"J Periodontol"},{"issue":"4","key":"5477_CR23","first-page":"229","volume":"25","author":"J Ainamo","year":"1975","unstructured":"Ainamo J, Bay I (1975) Problems and proposals for recording gingivitis and plaque. Int Dent J 25(4):229\u2013235","journal-title":"Int Dent J"},{"issue":"1","key":"5477_CR24","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1080\/09537104.2017.1293807","volume":"29","author":"X Wang","year":"2018","unstructured":"Wang X, Zhang Y, Choukroun J, Ghanaati S, Miron RJ (2018) Effects of an injectable platelet-rich fibrin on osteoblast behavior and bone tissue formation in comparison to platelet-rich plasma. Platelets 29(1):48\u201355. https:\/\/doi.org\/10.1080\/09537104.2017.1293807","journal-title":"Platelets"},{"issue":"5","key":"5477_CR25","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1093\/ejo\/cjs053","volume":"35","author":"C Canavarro","year":"2013","unstructured":"Canavarro C, Teles RP, Capelli J\u00fanior J (2013) Matrix metalloproteinases-1, -2, -3, -7, -8, -12, and -13 in gingival crevicular fluid during orthodontic tooth movement: a longitudinal randomized split-mouth study. Eur J Orthod 35(5):652\u2013658. https:\/\/doi.org\/10.1093\/ejo\/cjs053","journal-title":"Eur J Orthod"},{"issue":"3","key":"5477_CR26","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1111\/j.1600-051X.2007.01194.x","volume":"35","author":"O \u00d6zcelik","year":"2008","unstructured":"\u00d6zcelik O, Cenk Haytac M, Kunin A, Seydaoglu G (2008) Improved wound healing by low level laser irradiation after gingivectomy operations: a controlled clinical pilot study. J Clin Periodontol 35(3):250\u2013254. https:\/\/doi.org\/10.1111\/j.1600-051X.2007.01194.x","journal-title":"J Clin Periodontol"},{"issue":"8","key":"5477_CR27","doi-asserted-by":"publisher","first-page":"721","DOI":"10.7150\/ijms.1972","volume":"14","author":"R Pippi","year":"2017","unstructured":"Pippi R (2017) Post-surgical clinical monitoring of soft tissue wound healing in periodontal and implant surgery. Int J Med Sci 14(8):721\u2013728. https:\/\/doi.org\/10.7150\/ijms.1972","journal-title":"Int J Med Sci"},{"issue":"6","key":"5477_CR28","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.1097\/00006534-199811000-00022","volume":"102","author":"E Beausang","year":"1998","unstructured":"Beausang E, Floyd H, Dunn KW, Orton CI, Ferguson MWJ (1998) A new quantitative scale for clinical scar assessment. Plast Reconstr Surg 102(6):1954\u20131961. https:\/\/doi.org\/10.1097\/00006534-199811000-00022","journal-title":"Plast Reconstr Surg"},{"issue":"12","key":"5477_CR29","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1111\/j.1553-2712.2001.tb01132.x","volume":"8","author":"PE Bijur","year":"2001","unstructured":"Bijur PE, Silver W, John GE (2001) Reliability of the Visual Analog Scale for measurement of acute pain. Acad Emerg Med 8(12):1153\u20131157. https:\/\/doi.org\/10.1111\/j.1553-2712.2001.tb01132.x","journal-title":"Acad Emerg Med"},{"issue":"39\u201348","key":"5477_CR30","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.clindermatol.2006.10.001","volume":"25","author":"AE Rivera","year":"2007","unstructured":"Rivera AE, Spencer JM (2007) Clinical aspects of full-thickness wound healing. Clin Dermatol 25(39\u201348):21. https:\/\/doi.org\/10.1016\/j.clindermatol.2006.10.001","journal-title":"Clin Dermatol"},{"key":"5477_CR31","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.mpsur.2007.11.005","volume":"26","author":"S Enoch","year":"2008","unstructured":"Enoch S, Leaper DJ (2008) Basic science of wound healing. Surgery (Oxford) 26:31\u201337. https:\/\/doi.org\/10.1016\/j.mpsur.2007.11.005","journal-title":"Surgery (Oxford)"},{"issue":"2","key":"5477_CR32","doi-asserted-by":"publisher","first-page":"150","DOI":"10.4103\/jisp.jisp_342_17","volume":"22","author":"K Debnath","year":"2018","unstructured":"Debnath K, Chatterjee A (2018) Clinical and histological evaluation on application of platelet concentrates on depigmented gingival epithelium. J Indian Soc Periodontol 22(2):150\u2013157. https:\/\/doi.org\/10.4103\/jisp.jisp_342_17","journal-title":"J Indian Soc Periodontol"},{"issue":"8","key":"5477_CR33","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1007\/s00784-017-2063-9","volume":"21","author":"RJ Miron","year":"2017","unstructured":"Miron RJ, Fujioka-Kobayashi M, Hernandez M et al (2017) Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry? Clin Oral Investig 21(8):2619\u20132627. https:\/\/doi.org\/10.1007\/s00784-017-2063-9","journal-title":"Clin Oral Investig"},{"key":"5477_CR34","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1007\/s00784-018-2555-2","volume":"23","author":"HA Varela","year":"2019","unstructured":"Varela HA, Souza JC, Nascimento RM et al (2019) Injectable platelet rich fibrin: cell content, morphological, and protein characterization. Clin Oral Investig 23:1309\u20131318. https:\/\/doi.org\/10.1007\/s00784-018-2555-2","journal-title":"Clin Oral Investig"},{"issue":"7","key":"5477_CR35","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1902\/jop.1998.69.7.791","volume":"69","author":"A Pilloni","year":"1998","unstructured":"Pilloni A, Camargo PM, Carere M, Carranza FA Jr (1998) Surgical treatment of cyclosporine A- and nifedipine-induced gingival enlargement: gingivectomy versus periodontal flap. J Periodontol 69(7):791\u2013797. https:\/\/doi.org\/10.1902\/jop.1998.69.7.791","journal-title":"J Periodontol"},{"issue":"1","key":"5477_CR36","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1093\/ejo\/cjz032","volume":"42","author":"R Lione","year":"2020","unstructured":"Lione R, Pavoni C, Noviello A et al (2020) Conventional versus laser gingivectomy in the management of gingival enlargement during orthodontic treatment: a randomized controlled trial. Eur J Orthod 42(1):78\u201385. https:\/\/doi.org\/10.1093\/ejo\/cjz032","journal-title":"Eur J Orthod"},{"key":"5477_CR37","first-page":"854","volume":"36","author":"X Chen","year":"2009","unstructured":"Chen X, Hu W, Wei W et al (2009) Effects of keratinocyte growth factor 2 (KGF-2) on keratinocyte growth, migration and on excisional wound healing. Prog Biochem Biophys 36:854\u2013862","journal-title":"Prog Biochem Biophys"},{"issue":"1","key":"5477_CR38","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1046\/j.1087-0024.2000.00009.x","volume":"5","author":"HD Beer","year":"2000","unstructured":"Beer HD, Gassmann MG, Munz B (2000) Expression and function of keratinocyte growth factor and activin in skin morphogenesis and cutaneous wound repair. J Investig Dermatol Symp Proc 5(1):34\u201339","journal-title":"J Investig Dermatol Symp Proc"},{"issue":"5","key":"5477_CR39","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1046\/j.1524-475x.2001.00347.x","volume":"9","author":"MC Robson","year":"2001","unstructured":"Robson MC, Phillips TJ, Falanga V et al (2001) (2001) Randomized trial of topically applied repifermin (recombinant human keratinocyte growth factor-2) to accelerate wound healing in venous ulcers. Wound Repair Regen 9(5):347\u2013352. https:\/\/doi.org\/10.1046\/j.1524-475x.2001.00347.x","journal-title":"Wound Repair Regen"},{"issue":"11","key":"5477_CR40","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1097\/ICO.0000000000002134","volume":"38","author":"J Cai","year":"2019","unstructured":"Cai J, Zhou Q, Wang Z, Guo R, Yang R, Yang X, Li W, Ahmad N, Chen Q, Hui Q, Wang X (2019) Comparative analysis of KGF-2 and bFGF in prevention of excessive wound healing and scar formation in a corneal alkali burn model. Cornea 38(11):1430\u20131437. https:\/\/doi.org\/10.1097\/ICO.0000000000002134","journal-title":"Cornea"},{"issue":"2","key":"5477_CR41","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1177\/1534734603256626","volume":"2","author":"DO Bates","year":"2003","unstructured":"Bates DO, Jones ROP (2003) The role of vascular endothelial growth factor in wound healing. Int J Low Extrem Wounds 2(2):107\u2013120. https:\/\/doi.org\/10.1177\/1534734603256626","journal-title":"Int J Low Extrem Wounds"},{"issue":"10","key":"5477_CR42","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1089\/wound.2013.0517","volume":"3","author":"KE Johnson","year":"2014","unstructured":"Johnson KE, Wilgus TA (2014) Vascular endothelial growth factor and angiogenesis in the regulation of cutaneous wound repair. Adv Wound Care (New Rochelle) 3(10):647\u2013661. https:\/\/doi.org\/10.1089\/wound.2013.0517","journal-title":"Adv Wound Care (New Rochelle)"},{"issue":"12","key":"5477_CR43","doi-asserted-by":"publisher","first-page":"6526","DOI":"10.3390\/ijms23126526","volume":"23","author":"EA Burian","year":"2022","unstructured":"Burian EA, Sabah L, Karlsmark T et al (2022) Cytokines and venous leg ulcer healing\u2014a systematic review. Int J Mol Sci 23(12):6526. https:\/\/doi.org\/10.3390\/ijms23126526","journal-title":"Int J Mol Sci"},{"issue":"1","key":"5477_CR44","first-page":"34","volume":"2","author":"A Ojha","year":"2015","unstructured":"Ojha A, Srivastava V (2015) Gingival depigmentation with diode laser, electrosurgery and scalpel; a comparative report of 2 cases. TMU J Dent 2(1):34\u201337","journal-title":"TMU J Dent"},{"issue":"4","key":"5477_CR45","doi-asserted-by":"publisher","first-page":"447","DOI":"10.4103\/ejd.ejd_76_17","volume":"11","author":"MK Samani","year":"2017","unstructured":"Samani MK, Saberi BV, Tabatabaei SMA, Moghadam MG (2017) The clinical evaluation of platelet-rich plasma on free gingival graft\u2019s donor site wound healing. Eur J Dent 11(4):447\u2013454. https:\/\/doi.org\/10.4103\/ejd.ejd_76_17","journal-title":"Eur J Dent"}],"container-title":["Clinical Oral Investigations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-023-05477-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00784-023-05477-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00784-023-05477-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:17:55Z","timestamp":1707092275000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00784-023-05477-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,10]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["5477"],"URL":"https:\/\/doi.org\/10.1007\/s00784-023-05477-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3107235\/v1","asserted-by":"object"}]},"ISSN":["1436-3771"],"issn-type":[{"value":"1436-3771","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,10]]},"assertion":[{"value":"25 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved for human subjects by the Ethical Committee of Afyonkarahisar Health Sciences University (permit number 2021\/338). Written informed consent was obtained from all study participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"85"}}