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In contrast, the dental proportion of antibiotic prescriptions compared to all antibiotic prescriptions in Germany increased from 9.1 to 13.6%. Aminopenicillins enhanced their share from 35.6 to 49.4%, while clindamycin prescriptions declined from 37.8 to 23.4%. The proportion of ibuprofen prescriptions significantly increased from 60.4% in 2012 to 79.0% in 2021.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Since 2013, the most frequently prescribed antibiotic by German dentists has been amoxicillin reaching nearly half of all dental antibiotic prescriptions in 2021. Simultaneously, the proportion of clindamycin has steadily decreased, but the level is still high compared to international data. During the past decade, ibuprofen as a first-line analgesic in German dentistry was continuously gaining in importance.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>Aminopenicillins have the best risk\u2013benefit balance in dentistry, but the use of antibiotics generally must be limited only to cases of severe infections or compromised patients. Pre-existing diseases or permanent medications should always be considered when choosing an analgesic.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-024-05497-6","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T05:03:10Z","timestamp":1705467790000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Facts and trends in dental antibiotic and analgesic prescriptions in Germany, 2012\u20132021"],"prefix":"10.1007","volume":"28","author":[{"given":"Helena","family":"Albrecht","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eik","family":"Schiegnitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Halling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"issue":"3\u20134","key":"5497_CR1","doi-asserted-by":"publisher","first-page":"518","DOI":"10.3109\/00016357.2012.696694","volume":"71","author":"G Cachovan","year":"2013","unstructured":"Cachovan G et al (2013) Odontogenic infections: an 8-year epidemiologic analysis in a dental emergency outpatient care unit. 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