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The aim of the study was to investigate whether PRF is also a suitable bio-carrier for clindamycin (CLI).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>PRF membranes were produced from 36 patients receiving intravenous therapy with CLI (e.g. due to the diagnosis of an osteonecrosis of the jaw or infections). Concentrations of CLI in PRF membranes were measured with liquid chromatography-tandem mass spectrometry, and the antimicrobial effects were investigated in vitro in agar diffusion tests with fresh\u00a0PRF and PRF stored for 24\u00a0h. Storage was performed in an incubator at 36\u00a0\u00b0C to simulate the in-vivo situation.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The mean concentration of CLI in plasma was 1.0\u2009\u00b1\u20090.3\u00a0\u03bcg\/100\u00a0mg plasma; in resulting PRF membranes 0.7\u2009\u00b1\u20090.4\u00a0\u03bcg\/100\u00a0mg PRF. Agar diffusion tests were performed with <jats:italic>Staphylococcus aureus<\/jats:italic>, <jats:italic>Streptococcus pneumoniae<\/jats:italic>, <jats:italic>Streptococcus mitis<\/jats:italic>, <jats:italic>Porphyromonas gingivalis,\u00a0<\/jats:italic>and <jats:italic>Fusobacterium nucleatum<\/jats:italic>. Mean inhibition zones, in mm, for fresh PRF were 17.3, 12.2, 18.8, 17.1, 25.8 and 18.1, 12.7, 19.2, 17.3, and 26.3 for stored PRF, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The results demonstrate that PRF is a suitable bio-carrier for CLI when administered systemically to patients. The concentration in PRF generated from patients after infusion of 600\u00a0mg CLI dose suffices to target clinically relevant bacteria.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>Using PRF as a carrier for local antibiotic application can prevent infections in oral and maxillofacial surgery. Within the study limitations, the findings could expand the scope of PRF application by adding CLI as a new antibiotic to the spectrum of PRF therapy.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-024-05532-6","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T20:02:06Z","timestamp":1707854526000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Antimicrobial effects of clindamycin-loaded platelet-rich fibrin (PRF)"],"prefix":"10.1007","volume":"28","author":[{"given":"Anton","family":"Straub","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Stapf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Utz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Vollmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Flesch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"K\u00fcbler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Scherf-Clavel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi\u00ean-Tr\u00ed","family":"L\u00e2m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"issue":"8","key":"5532_CR1","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1007\/s00784-017-2063-9","volume":"21","author":"RJ Miron","year":"2017","unstructured":"Miron RJ, Fujioka-Kobayashi M, Hernandez M et al (2017) Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry? 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