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Diminishing the microbial load within the root canal system is crucial for healing in endodontically treated teeth. The aim of this study was to evaluate the effect of 2780 nm Er,Cr:YSGG and 940 nm diode lasers on the eradication of microorganisms from single-rooted teeth with asymptomatic apical periodontitis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and Methods<\/jats:title>\n                <jats:p>Thirty participants conforming to the inclusion criteria were randomly divided into 3 groups according to the disinfection protocol used; Conventional group: 2.5% Sodium Hypochlorite (NaOCl) and 17% EDTA solution NaOCl\/EDTA, Dual laser group: 2780 nm Erbium, chromium: yttrium scandium-gallium-garnet (Er,Cr:YSGG) laser and 940 nm diode laser Er,CrYSGG\/Diode, and Combined group: 17% EDTA and 940 nm diode laser EDTA\/Diode. Bacterial samples were collected before and after intervention. The collected data were statistically analyzed using Friedman\u2019s test and Kruskal\u2013Wallis test (<jats:italic>P<\/jats:italic>\u2009\u2264\u2009<jats:italic>0.05<\/jats:italic>).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The results of the study showed that both dual laser Er,CrYSGG\/Diode and combined laser EDTA\/Diode groups showed significantly less mean Log10 CFU\/ml of aerobic and anaerobic bacterial counts than the conventional NaOCl\/EDTA group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In this study we evaluated in vivo the bactericidal efficacy of three disinfection protocols for endodontic treatment of single-rooted teeth with apical periodontitis. The results indicated that both dual laser Er,CrYSGG\/Diode and combined laser EDTA\/Diode groups provide superior bactericidal effect compared to the conventional NaOCl\/EDTA group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Clinical relevance<\/jats:title>\n                <jats:p>The integration of lasers into root canal disinfection protocols has demonstrated significant bacterial reduction which might promote healing and long-term success.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00784-024-05563-z","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T02:02:03Z","timestamp":1708912923000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The efficacy of 2780 nm Er,Cr;YSGG and 940 nm Diode Laser in root canal disinfection: A randomized clinical trial"],"prefix":"10.1007","volume":"28","author":[{"given":"Sara Zakaria","family":"Fahim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami Maher","family":"Ghali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A.","family":"Hashem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Medhat","family":"Farid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"5563_CR1","doi-asserted-by":"publisher","unstructured":"Morsy DA, Negm M, Diab A, Ahmed G (2018) Postoperative pain and antibacterial effect of 980 nm diode laser versus conventional endodontic treatment in necrotic teeth with chronic periapical lesions: a randomized control trial. 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